Scribd Logo
Upload

Welcome to Scribd!

  • 739 views

    PathoPhysiology of Cervical Cancer

    Uploaded by

    Jie Bandelaria
    Cervical cancer is caused by high-risk HPV infection, which integrates its DNA into the host cell's genome and deactivates tumor suppressor genes. This leads to abnormal cell growth and proliferation that results in cervical intraepithelial neoplasia and eventually invasive cancer if left untreated. As the cancer grows, it can spread locally and metastasize to distant organs, causing symptoms like abnormal bleeding, discharge and pain.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd

    PathoPhysiology of Cervical Cancer

    Uploaded by

    Jie Bandelaria
    739 views2 pages
    Cervical cancer is caused by high-risk HPV infection, which integrates its DNA into the host cell's genome and deactivates tumor suppressor genes. This leads to abnormal cell growth and proliferation that results in cervical intraepithelial neoplasia and eventually invasive cancer if left untreated. As the cancer grows, it can spread locally and metastasize to distant organs, causing symptoms like abnormal bleeding, discharge and pain.

    Original Title

    60592422-PathoPhysiology-of-Cervical-Cancer.doc

    Copyright

    © © All Rights Reserved

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Cervical cancer is caused by high-risk HPV infection, which integrates its DNA into the host cell's genome and deactivates tumor suppressor genes. This leads to abnormal cell growth and proliferation that results in cervical intraepithelial neoplasia and eventually invasive cancer if left untreated. As the cancer grows, it can spread locally and metastasize to distant organs, causing symptoms like abnormal bleeding, discharge and pain.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    739 views2 pages

    PathoPhysiology of Cervical Cancer

    Uploaded by

    Jie Bandelaria
    Cervical cancer is caused by high-risk HPV infection, which integrates its DNA into the host cell's genome and deactivates tumor suppressor genes. This leads to abnormal cell growth and proliferation that results in cervical intraepithelial neoplasia and eventually invasive cancer if left untreated. As the cancer grows, it can spread locally and metastasize to distant organs, causing symptoms like abnormal bleeding, discharge and pain.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    of 2

    Pathophysiology of Cervical Cancer

    High risk HPV (16, 18, 31) Risk factors:


    Early age of coitus
    Multiple sexual partners
    Unsafe sexual practices
    Invasion of the basal cell
    of the squamous
    epithelium of the cervix

    Integration of viral DNA

    p53 and pRB tumor


    suppressor genes are Barrel-shaped
    blocked/deactivated cervix

    Mutation and cell


    proliferation

    CIN/SIL Tumor fills the entire


    Co- Carcinoma in situ cervix
    carcinogens

    Metastasis to distant body


    parts Invasive cancer Tissue necrosis and
    sloughing
    Increased tumor growth
    Lymph invasion
    Hypermetabolic Increased pressure to Fistula formation Hemorrhage Infection
    activity of cell the surrounding Enlargement of
    proliferation and tissues, nerves and lymph nodes
    increased tumor bladder
    growth needs Leakage of
    urine and Metrorrhag Foul-
    Venous and feces into ia smelling
    Dysuria Ureteral the vagina Bleeding vaginal
    Pelvic
    obstruction after discharge
    Anorexia and
    coitus
    Weight back
    anemia
    loss pain
    Hydronephrosi Leg edema
    s

    You might also like