ASHRAE Journal

Designing Clean Room

T
The Institute of Environmental Sci-
he purpose of the clean room air-conditioning system is to supply ences and Technology Recommended
airflow in sufficient volume and cleanliness to support the cleanli- Practice 12 (IEST-CC-RP.012.1) includes
a table with a range of recommended air-
ness rating of the room. Air is introduced into the clean room in a
flow rates for each cleanliness class as does
manner to prevent stagnant areas where particles could accumulate. The air the more recently published ISO 14644-
1 Part Four. Table 1 presents these val-
must also be conditioned to meet the clean-room temperature and humidity
ues. Both are consensus documents that
requirements. In addition, enough conditioned makeup air must be intro- bring together the opinions of clean-room
duced to maintain the specified positive pressurization. designers, builders, and users to arrive at
figures that are known to have worked
This article considers clean-room air- rooms with a greater level of personnel through the years. All such documents
conditioning system design. To simplify activity or particle-generating process pass the responsibility for specifying pa-
the presentation, clean rooms are di- equipment. The lower value is used in rameters onto the shoulders of the buyer
vided into three general levels of clean- rooms with fewer, more sedentary, person- and seller of the clean room, hence the
liness: Stringent, Intermediate, and Less nel and/or equipment with less particle- somewhat cautious wording of the rec-
Stringent (Table 1). generating potential. ommendations presented earlier.
Frequently, knowledgeable clients with
Airflow extensive clean-room experience specify Filtration
The design flow of filtered air through the low-end of the velocity range. Clients For many years, the microelectronics
the clean room is highest in Stringent and designers new to clean rooms or less industry has driven clean-room technol-
clean rooms and decreases as the require- confident that a lower velocity will suf- ogy. The call for higher filter efficiencies
ment for cleanliness decreases. Airflow is fice select the higher end of the scale. There has come from this and related industries.
usually specified either as average air is no single value of average velocity or The ULPA (Ultra Low Penetration Air) fil-
velocity within the room or as air changes air change rate accepted by the industry ter with an efficiency of 99.9995% on 0.12
per hour. for a given clean-room classification. A micron particles has been used effectively
The average room air velocity ap- single exception to this statement is the in the most Stringent clean rooms. Higher
proach typically is used when a full filter 90 20 fpm (0.46 0.10 m/s) velocity efficiency filters are available, but they are
ceiling is to be installed. For years, a value specified by the FDA for critical pharma- costly and have not found widespread use.
of 90 fpm (0.46 m/s) 20% has been used ceutical sterile filling areas. Efficiencies such as 99.99% and 99.999%
to specify the airflow in the cleanest of The air change per hour specification is are available from a number of manufac-
clean rooms. This was based on the de- most commonly found in clean rooms of turers and have proven to be effective in
sign of the earliest clean rooms built to Intermediate or Less Stringent cleanliness. Stringent clean-room applications.
support the space program during the Intermediate clean rooms are usually de-
1960s and 70s. signed with hourly air change rates be- About the Author
In recent years, companies have experi- tween 30 and 160, while Less Stringent Raymond K. Schneider, P.E., is se-
mented with lower velocities and have clean rooms have hourly air change rates nior clean room consultant and prin-
found that airflow velocity specifications up to 20. The designer selects a value based cipal of Practical Technology in
ranging from 70 to 100 fpm (0.35 to 0.51 on his experience and understanding of Greenville, S.C. He is also associate
m/s) 20% could be successful, depend- the particle-generating potential of the professor of construction science and
ing on the activities and equipment within clients process. The trend in recent years management at Clemson University,
the room. The higher values are used in has been to move toward lower airflow Clemson, S.C.
August 2001 ASHRAE Journal 39
 HEPA (High Efficiency Particulate Air) filters, rated at 99.97%
efficiency on 0.3 micron particles, have been the workhorses of
the clean-room industry for many years. They are still widely
used in the pharmaceutical industry to meet even the most de-
manding FDA cleanliness requirements.
As filter test instrumentation has matured and smaller par-
ticles can be counted with greater accuracy, test data have shown
that both ULPA and HEPA filters pass more particles in the 0.1
to 0.2 microns range than any other size. In fact, the filters
display their rated efficiency at both 0.12 and 0.3 micron par-
ticle size and have a higher efficiency on both larger and smaller
particles. For Stringent applications, it is common to see filter
efficiency specified based on the most penetrating particle size
(MPPS) rather than a specific 0.12 or 0.3 micron size. The MPPS
may vary slightly between filter lots. Specifying the desired
efficiency at the worst case particle size has found favor with
some designers and filter manufacturers.
Most Stringent and Intermediate clean rooms are built with
the filters in the ceiling. The filters can be installed in groups
housed in a proprietary modular pressure plenum system that
facilitates installation in the clean-room ceiling. They can also
be installed in single filter housings, individually ducted, sus-
pended in an inverted T grid support system, and sealed to
prevent unfiltered bypass air from entering the clean room. Stick
built pressure plenums are still used. However, the various modu-
lar schemes currently available offer both better air velocity con-
Advertisement for the print edition trol and better environmental control and have all but replaced
formerly in this space. the stick built design.
The integrated filter/blower unit or fan filter has come into
widespread use. In some products the filter is replaceable. In
others, the entire module is discarded at the end of its life. They
come in various sizes designed to fit into an inverted T grid
system. Different motor voltages are available to support a va-
riety of electrical design schemes. Some sophisticated control
schemes have been devised to monitor individual filter fan
operation, record energy usage, signal motor failure, control
banks of filter fans, and vary the fan speed for different time of
day operation. They have found application in all classes of
clean rooms.
The face velocity of ceiling-mounted filters generally can be
as high as 130 fpm (0.66 m/s) and as low as 50 fpm (0.25 m/s)
depending on the design of the system. Since the system sup-
porting the filters, such as the inverted T grid, may occupy as
much as 20% of the ceiling area, a 100 fpm (0.51 m/s) filter-face
velocity translates into an 80 fpm (0.41 m/s) average velocity at
the work surface within the clean room.
Installing HEPA/ULPA filters directly in the ceiling of the
clean room is driven by the desire to minimize, if not eliminate,
dust-collecting surfaces, such as the inside of ductwork, between
the downstream face of the filter and the clean room. Remote
mounting of HEPA filters is common in Less Stringent applica-
tions since the number of particles that can be contributed by
ductwork downstream of the HEPA filters is small as a proportion
of the amount that can be tolerated. An exception would be
where a standard air-conditioning system with no cleanliness
classification is being upgraded to support a clean room intended
to carry a cleanliness rating per Federal Standard 209 or ISO
40 ASHRAE Journal August 2001
 Clean Rooms

Figure 2: Non-unidirectional flow clean room using recir-

Standard 14644. In that case, all ductwork and not parallel in other parts. lines are random with no definable pat-
downstream of the filter should be thor- Stringent clean rooms are almost in- tern. While the air entering the room is
oughly cleaned. Cabinet fans or air han- variably designed for unidirectional essentially particle-free, the clean-room
dlers with HEPA filter racks on the dis- airflow. This is achieved by providing particle counts at critical work surfaces
charge side are frequently used in Less 100% coverage of the ceiling with will seek a level based on: the number
Stringent applications. HEPA/ULPA filters and installing a of particles generated in the clean
The HEPA filters used in these applica- raised floor with perforated floor pan- room; the dilution effect of the clean
tions are generally high-velocity filters, els. The air moves vertically downward
based on 500 fpm (2.54 m/s) filter-face ve- from the ceiling through the perforated
locity, with a pressure drop significantly floor panels into a return air plenum
higher than those used in ceiling installa- below the floor. The air then moves lat-
tion. A clean 2 ft 2 ft (600 mm 600 mm) erally to air return ducts at the periph-
high-velocity HEPA filter can have a 1.5 ery of the room and eventually to fans
in. w.c. (375 Pa) pressure drop at 500 fpm for recirculation back to the clean room.
(2.54 m/s). The typical ceiling-mounted Where the clean space is fairly nar-
clean filter is designed for a pressure drop row, on the order of 14 to 16 ft (4.2 to 4.8
on the order of 0.5 in. w.c. (125 Pa) at a face m) from wall to wall, the raised floor is
velocity of 100 fpm (0.51 m/s). often eliminated in favor of low sidewall
return grilles. The air will move verti-
Room Air Patterns cally downward to within 2 to 3 ft (0.6
The air introduced to the clean room, to 0.9 m) of the floor before splitting and
having gone through HEPA or ULPA fil- moving toward he sidewall returns. This Advertisement for the print edition
ters, is essentially free of particles. The air has proven to be acceptable in many formerly in this space.
entering the room has two purposes. First, Stringent clean-room applications, par-
it needs to dilute particle concentrations ticularly when upgrading an existing
that may have formed in the room due to space with insufficient overhead clear-
personnel or process activity. Second, it ance is encountered.
needs to entrain such particles in the air- In a unidirectional clean room, furni-
stream and carry them from the room. ture and equipment will affect the air-
Three types of airflow are identified. flow pattern. Placing these obstructions
1. Unidirectional flow (formerly re- in a manner that prevents dead air spaces
ferred to as laminar flow), where the from developing will minimize their ef-
air streamlines are essentially parallel fect on cleanliness.
to one another. Non-unidirectional airflow is often
2. Non-unidirectional flow (formerly used in Intermediate clean rooms. HEPA
turbulent), where air streamlines are filters are installed in the ceiling in a
other than parallel to one another. pattern that provides fairly uniform
3. Mixed flow, where air streamlines may coverage. The air moves downward into
be parallel in one part of the clean room the clean room. However, the air stream-
August 2001 ASHRAE Journal 41
ASHRAE Journal
air change rate; and the speed with ISO Federal Federal Airflow Airflow
Guideline
Classifications Standard 209E Standard 209E (fpm) (ACH)
which particles are removed from the 1 No Equiv. No Equiv. Stringent 70100
critical work zone. In general, the 2 No Equiv. No Equiv. Stringent 70100
higher the air change rate, the cleaner 3 1 M1.5 Stringent 70100
the Intermediate room, but airflow pat- 4 10 M2.5 Stringent 70100
terns also play a role. Stringent
5 100 M3.5 70100 225275
Intermediate
Air return is particularly important in
6 1,000 M4.5 Intermediate N/A 70160
non-unidirectional clean rooms. 7 10,000 M5.5 Intermediate N/A 3070
Sidewall air return grilles are widely 8 100,000 M.6.5 Less Stringent N/A 1020
used in these rooms. The grilles should 9 No Equiv. No Equiv. Less Stringent N/A As Req.
be uniformly distributed around the pe- Table 1: The new ISO clean-room classifications are shown at left. U.S. Federal
riphery of the room. This can pose a chal- Standard 209E classifications in English and Metric designations are also shown.
lenge when process equipment is The Guideline column indicates the three categories described for the purpose
intended to occupy wall space. When of this article. Note that Class 100 may be considered a Stringent clean room when
possible, the equipment should be it is designed for unidirectional flow and an Intermediate clean room when it is
moved off the wall to permit air to flow designed for non-unidirectional flow in non-critical applications. The right-hand
behind it. Equipment can also be raised columns provide airflow guidelines in feet per minute average room velocity for
on a platform (plinth) with air flowing Stringent clean rooms and air changes per hour for Intermediate and Less Strin-
beneath it. In most cases the clean-room gent clean rooms.
designer intends to facilitate movement
of particles from a tabletop height work surface to the floor Zones are created by adjusting the filter pattern in the ceiling. In
and then laterally to low wall returns. This flow pattern carries a critical area, more filters are installed in the ceiling. In a less
the particles out of the room and eventually to filters where critical area, fewer filters are installed. Supply air may have to be
they are trapped. Exceptions might involve process equip- canalized downward over the critical zone before it diffuses to
ment that generates particles at a location above a critical the general space. Depending on clean-room ceiling height, a 2
work surface. Some sort of high return capture mechanism ft (0.6 m) high Plexiglas shield, or even a flexible plastic curtain
may have to be designed. Generally, the high-to-low flow is draped to within 12 to 18 in. (304 mm to 457 mm) of the floor,
suggested. can be used.
It is good practice to limit the horizontal distance air must Return air patterns are adjusted by appropriately locating
travel to a return in an Intermediate clean room. A horizontal return grilles to accommodate the varying filtered air quanti-
distance of 14 to 16 ft (4.2 to 4.8 m) should be a design goal. ties and to prevent cross contamination. A raised floor with air
Therefore, a room 28 to 32 ft (8.4 to 9.6 m) wide only needs return plenum would be even more effective. However, it is
return grilles located in the peripheral walls. The potential often precluded by the clients budget, which usually drives
for cross contamination caused by particles dropping out the choice of a mixed flow room as a cost-effective solution
of the airstream, or otherwise being attracted to critical sur- for extending a clients limited resources.
faces, while traveling long horizontal flow paths suggests A shortcoming of non-unidirectional clean rooms is pock-
this limitation. ets of air with high particle counts. These pockets can per-
For wider rooms, it is common practice to box in support sist for a period of time, and then disappear. This is due to
columns and incorporate return grilles and return air ductwork currents that are set up within the room due to process-re-
within the box. In the absence of conveniently located col- lated activity combined with the random nature of the down-
umns, a vertical return plenum can be constructed of suitable ward airflow. An effort has been made to simulate
clean room compatible material. unidirectional flow by creating a positive pressure plenum
In Less Stringent clean rooms, with remote-mounted HEPA below the main clean-room ceiling, then installing an air-
filters, standard air-conditioning diffusers can be installed in the diffusion mechanism as a second ceiling. Perforated plastic
ceiling. Air patterns similar to those in standard air-conditioned or aluminum panels have been used, as has a proprietary
spaces can be created. Low wall returns are suggested to follow screening system composed of woven or non-woven fabric.
the standard clean-room design practice of bringing clean air in The result has been flow characteristics approaching unidi-
high and removing it low. Where ceiling returns are used, there rectional flow at velocities significantly lower than those seen
may be areas of high particle count in the clean space, particu- in Stringent clean rooms. The airflow patterns piston effect
larly during periods of high activity. Ceiling returns have been prevents formation of particle-laden pockets and generally re-
used in some Less Stringent clean rooms. Success is related more sults in a more predictable cleanliness level. This performance
to the level of particles generated than the ability of the system is achieved at the lower air velocities that are characteristic of the
to remove them. Intermediate and Less Stringent clean-room designs (Figure 1).
The mixed-flow approach has been used where critical and
non-critical processes are in the same clean space. If space is not Sensible Cooling Load
available to house critical operations in a separate room, a single The cooling load sensible heat ratio in most clean rooms
clean room can be created with differing zones of cleanliness. exceeds 95%. Cooling is usually required year-round due to
42 ASHRAE Journal w w w. a s h r a e j o u r n a l . o r g August 2001
 Clean Rooms
the high fan heat contribution to the airstream as well as the ate and Less Stringent clean rooms often have only two stages
heat generated within the clean room by process equipment. of filtration, a 30% pre-filter, and a 95% final filter. As the
The small latent load is generated by personnel. Each clean name suggests, the final filter is at the discharge of the unit.
room is a unique project and should be analyzed carefully to Preheating is commonly provided where the outside tem-
confirm the nature of the cooling load. perature falls below 40F (4C) in winter. Cooling and dehu-
In Stringent and Intermediate clean rooms, most of the large midification is accomplished in the cooling coil where the
amount of air flowing through the room is generally not con- dew point in the clean room is 42F (5.6C). Since Stringent
ditioned. It is recirculated by fans. The conditioning is done clean rooms with fully garbed workers may be maintained at
by air handlers with sensible cooling coils that draw off a a dry-bulb temperature as low as 66F (19C), this puts the
percentage of the total airflow, condition it, and then dis- lower end of effective humidity control through refrigeration
charge the air back into the main airstream before it reaches alone at about 40% relative humidity. Reheating is required
the recirculating fans (Figure 2). The temperature of the air to raise the low temperature coming off the cooling coil after
entering the Stringent clean room might only be a few de- dehumidification. In calculating reheat, the heat added to the
grees cooler than the return air due to the large air volume airstream by the recirculating fans is taken into account. This
being cooled. This temperature difference will usually permit can be quite significant in Stringent clean rooms.
ceiling-mounted HEPA/ULPA filters to be used, with down- Achieving coil temperatures that can produce a room dew
ward airflow that does not produce uncomfortable conditions point lower than 42F (5.6C) can pose problems. When less
for workers. than 40% RH is required, the common practice is to use a desic-
In Less Stringent clean rooms the total airflow may, in cant system of some type.
some cases, be close to that required for a normal cooling In the system described here, the makeup air unit provides
application. That is, the air temperature entering the room all the latent cooling and humidification. The assumption is
may be 15F to 20F (8.3C to 11C) colder than the return that the properties of the makeup air can be adjusted to ac-
air. In such cases, standard ceiling diffusers or other strate- commodate the latent capacity added by the workers and any
gies intended to minimize uncomfortable drafts within the moisture that penetrates through the clean-room walls. It also
room should be used. assumes that the latent load throughout the facility is more or
less uniform. These assumptions should be tested in each ap-
Makeup Air plication. They depend on the conditions surrounding the
Outside air is required to makeup for the process exhaust and clean room, outside air conditions, and any process within
exfiltration that typically occurs in trying to maintain a posi- the clean room that might add moisture to the airstream.
tive pressure within the clean space. Makeup air is very expen- In smaller clean rooms with low outside air quantity, the sen-
sive in that it must be tempered, humidity adjusted, and cleaned sible cooling air handler described earlier can be designed as
before being introduced into the clean room. While makeup air a sensible/latent air handler that conditions the makeup air as
is unavoidable, it should be minimized to the extent possible well as recirculation air. In this case, there is a mixed airstream
in the interest of energy conservation and economy. composed of clean-room air and outside air that must be con-
Clean-room pressures are usually positive relative to unrated ditioned. Mixing dampers proportion the volume of each air-
areas. Generally, a value of 0.05 in. w.c. (12 Pa) pressure for the stream in response to clean-room pressure. As clean-room
clean space relative to unrated areas is recommended. Higher pressure falls, the outside air damper opens and the recirculat-
pressures tend to result in whistling noises and make doors ing air damper throttles closed. The air from this unit is dis-
difficult to open (or close). In clean suites with multiple clean- tributed to the recirculating fans.
liness classes, the trend is to maintain a positive pressure of In Less Stringent clean-room applications, the total volume of
0.02 in. w.c. (5 Pa) between adjacent clean spaces of differing recirculation air may be close to the air volume required for
ratings, with the higher pressure in the space at the higher clean- conditioning. In that case, there may be no recirculating fans at
liness rating. all but rather the air handler, or multiple air handlers, condition
The quantity of makeup air can be determined by summing and recirculate all the air needed by the clean room.
all the process exhaust volumes in the space and then adding
two additional air changes per hour. This semi-empirically de- Summary
rived value has proven to be a safe quantity to use to size the The trend in clean-room guidelines is to cast the designer in
makeup air handler. Actual makeup air introduced at any one the role of expert generalist able to fulfill the wishes of the
time will vary depending on door openings, leakage, and ac- client, once those wishes are known. The guidelines typically
tual exhaust in operation. use words such as subject to agreement between buyer and
The makeup air handler must condition the outside air so it is seller to draw the client into the decision-making process
compatible with the clean-room design parameters. This typi- since there are as many variations on clean-room design as
cally requires filtration, pre-heating, cooling, reheating, dehu- there are designers that create them. The guidelines presented
midification, and humidification. here have proven effective in use and represent the consensus
In Stringent clean rooms, the unit frequently has three stages of technical opinion as the author understands it. As with any
of filtration, a 30% ASHRAE efficiency pre-filter, a 95% effi- guidelines, they must be shaped to each situation to accom-
ciency intermediate filter and a final HEPA filter. Intermedi- modate the varying conditions encountered in the field.
August 2001 ASHRAE Journal 43