Scribd Logo
Upload

Welcome to Scribd!

  • 181 views

    Aspirin Capsules

    Uploaded by

    Abby Lumanglas
    Aspirin capsules are solid dosage forms that enclose medicinal agents or inert substances within a small gelatin shell. There are two main types - hard shell capsules made of gelatin and sugar, and softer gelatin capsules containing glycerin as a plasticizer. Capsules provide convenient oral dosing and accurate strengths, but some drugs have poor absorption or are irritants when taken orally. The gelatin shell can become distorted in high humidity or brittle in extreme dryness. Capsules come in a range of sizes and are used to encapsulate liquids, suspensions, powders, or tablets for oral administration.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd

    Aspirin Capsules

    Uploaded by

    Abby Lumanglas
    181 views2 pages
    Aspirin capsules are solid dosage forms that enclose medicinal agents or inert substances within a small gelatin shell. There are two main types - hard shell capsules made of gelatin and sugar, and softer gelatin capsules containing glycerin as a plasticizer. Capsules provide convenient oral dosing and accurate strengths, but some drugs have poor absorption or are irritants when taken orally. The gelatin shell can become distorted in high humidity or brittle in extreme dryness. Capsules come in a range of sizes and are used to encapsulate liquids, suspensions, powders, or tablets for oral administration.

    Original Description:

    Aspirin

    Copyright

    © © All Rights Reserved

    Available Formats

    DOCX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Aspirin capsules are solid dosage forms that enclose medicinal agents or inert substances within a small gelatin shell. There are two main types - hard shell capsules made of gelatin and sugar, and softer gelatin capsules containing glycerin as a plasticizer. Capsules provide convenient oral dosing and accurate strengths, but some drugs have poor absorption or are irritants when taken orally. The gelatin shell can become distorted in high humidity or brittle in extreme dryness. Capsules come in a range of sizes and are used to encapsulate liquids, suspensions, powders, or tablets for oral administration.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    181 views2 pages

    Aspirin Capsules

    Uploaded by

    Abby Lumanglas
    Aspirin capsules are solid dosage forms that enclose medicinal agents or inert substances within a small gelatin shell. There are two main types - hard shell capsules made of gelatin and sugar, and softer gelatin capsules containing glycerin as a plasticizer. Capsules provide convenient oral dosing and accurate strengths, but some drugs have poor absorption or are irritants when taken orally. The gelatin shell can become distorted in high humidity or brittle in extreme dryness. Capsules come in a range of sizes and are used to encapsulate liquids, suspensions, powders, or tablets for oral administration.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    ASPIRIN CAPSULES 3.

    Some have poor oral bioavailability/ poor


    water solubility
    Capsules solid dosage forms n which 4. Some have irritant effect on the git when
    medicinal agents and/or inert substances are taken orally
    enclosed within a small shell of gelatin Gelatin - obtained by partial hydrolysis of
    - Made up of gelatin but may also be made collagen from the skin, white connective tissue,
    from starch or other suitable substances and bones of animals
    TYPES: Properties:
    1. Hard shell/ gelatin or dry-filled - Stable in air
    capsules made up of gelatin, sugar - Subject to microbial decomposition
    and water - Insoluble in cold water, softens through
    o Clear, colorless and essentially absorption of up to 10 times its weight of
    tasteless water
    o Colored with various FD&C and - Soluble in hot water
    D&C dyes and made opaque by - A protein, digested by proteolylic enzyme
    adding agents such as titanium and absorbed
    dioxide to conceal solid contents HIGH HUMIDITY
    o Consists of two pieces, a body and a - Additional moisture in absorbed
    cap - Becomes distorted and lose their rigid
    o Hand-filled with powder contents by shape
    - REMEDY: use desiccant material (silica gel,
    punch method or filling machines
    2. Soft Gelatin Capsules made up of clay or activated charcoal)
    EXTREME DRYNESS
    gelatin but more pliable due to the
    - Moisture is lost
    presence of glycerine or a polyhydric
    - Becomes brittle and crumbled when
    alcohol such as sorbitol, each of which
    handled
    act as a plasticizer EXAMPLE OF FILL IN HARD GELATIN
    o Usually filled with liquid or a solid
    CAPSULES
    active ingredient suspended in a - Powder or granules
    liquid vehicle approved for oral use - Pellet mixture
    such as vegetable oil or a non- - Paste
    aqueous, water miscible glycol such - Capsule
    as polyethylene glycol 400 or - Tablet
    polyethylene glycol Soft gelatin capsules
    o Equipment required in preparing soft o Characteristics:
    gelatin is not usually available in Contains more moisture
    pharmacies, so this dosage form is Oblong, oral or mound
    not prepared extemporaneously Elegant
    - Preservatives (methyl & propylparabens, Single color or two toned
    sorbic acid) to retard microbial growth With identifying markings
    - Cotton used to absorb mixture Easily swallowed
    - Are preferred when administered orally by o Uses: to encapsulate and hermetically
    adults: seal:
    1. Conveniently carried Liquids
    2. Readily identified Suspensions
    3. Easily taken Dry powder
    - Variety of dosage strengths, providing: Preformed tablets
    1. Flexibility to the prescriber Pasty materials
    2. Accurate individualized dosage for the o Drugs prepared: Digoxin; Vitamin A,E
    patient Capsule Size:
    Disadvantages:
    1. Swallowing for children and elderly 000 15 grains
    2. Formulation difficulties
    00 10 grains
    0 7.5 grains
    1 5 grains
    2 4 grains
    3 3 grains
    4 2 grains
    5 1 grain

    You might also like