Scribd Logo
Upload

Welcome to Scribd!

  • 575 views

    HTTPS://WWW - Scribd.com/doc/235802538/karp Cell and Molecular Biology Concepts and Experiments 7ed PDF 179 MB

    Uploaded by

    Ashley Mathis
    Natural Killer (NK) cells play an important role in the immune system by fighting pathogens and diseases. However, their nonspecific nature may contribute to autoimmune disorders like multiple sclerosis (MS). The student hypothesizes that the site of NK cells in the peripheral or central nervous system determines the level of inflammation they cause in MS. An experiment is proposed to compare genes in mice and humans related to NK cell function and MS symptoms. The results are predicted to show that different genes in the central and peripheral nervous system control the inflammatory response of NK cells.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    HTTPS://WWW - Scribd.com/doc/235802538/karp Cell and Molecular Biology Concepts and Experiments 7ed PDF 179 MB

    Uploaded by

    Ashley Mathis
    575 views2 pages
    Natural Killer (NK) cells play an important role in the immune system by fighting pathogens and diseases. However, their nonspecific nature may contribute to autoimmune disorders like multiple sclerosis (MS). The student hypothesizes that the site of NK cells in the peripheral or central nervous system determines the level of inflammation they cause in MS. An experiment is proposed to compare genes in mice and humans related to NK cell function and MS symptoms. The results are predicted to show that different genes in the central and peripheral nervous system control the inflammatory response of NK cells.

    Original Description:

    bjhlkjn

    Original Title

    https://www.scribd.com/doc/235802538/Karp-Cell-and-Molecular-Biology-Concepts-and-Experiments-7ed-pdf-179-Mb

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Natural Killer (NK) cells play an important role in the immune system by fighting pathogens and diseases. However, their nonspecific nature may contribute to autoimmune disorders like multiple sclerosis (MS). The student hypothesizes that the site of NK cells in the peripheral or central nervous system determines the level of inflammation they cause in MS. An experiment is proposed to compare genes in mice and humans related to NK cell function and MS symptoms. The results are predicted to show that different genes in the central and peripheral nervous system control the inflammatory response of NK cells.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    575 views2 pages

    HTTPS://WWW - Scribd.com/doc/235802538/karp Cell and Molecular Biology Concepts and Experiments 7ed PDF 179 MB

    Uploaded by

    Ashley Mathis
    Natural Killer (NK) cells play an important role in the immune system by fighting pathogens and diseases. However, their nonspecific nature may contribute to autoimmune disorders like multiple sclerosis (MS). The student hypothesizes that the site of NK cells in the peripheral or central nervous system determines the level of inflammation they cause in MS. An experiment is proposed to compare genes in mice and humans related to NK cell function and MS symptoms. The results are predicted to show that different genes in the central and peripheral nervous system control the inflammatory response of NK cells.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    Ashley Mathis

    Biology 640:
    Professor Owens
    Tuesday, January 31/2017

    Neuroscientist Journal Prompt #3

    1.
    Question : How does the site of Natural Killer (NK) cells, such as in the PNS or CNS,
    determine the inflammation it can cause in the disorder MS.
    Hypothesis: If Natural Killer cells are supposed to fight off pathogens, then there will be
    miscommunication in their function causing NK cells to inflame the body and cause a
    disorder.
    Why? : I have asked this question because Natural Killer (NK) cells are known for being
    lymphocytes that work hand and hand with the innate immune system. Their main
    function is to fight off pathogens and diseases that will prevent tumors and other viral
    infected cells from spreading in the body. Although lymphocytes fight off these things,
    they are nonspecific. I wonder if the fact that they are nonspecific play the biggest role in
    why the disorder MS can occur in the body, or if MS occurs in the body due to the fact
    that there is a NK type that inhibits the symptoms of MS.
    Importance/Interesting: I think my question is interesting or important because Natural
    Killer (NK) cells are known for being good, yet they may not be as efficient as claimed to
    be if MS is occurring in the body. Some people would like to state that Natural Killer
    (NK) cells get weaker over time in the body; however, MS can occur at any age. I think it
    is important to determine the different types of NK cells, so that we understand their
    proper function in the body. They are very crucial to the body in my eyes, so I think that
    it is important for science to spot the bad NK cells or figure out a way that the good NK
    cells can get rid of the bad ones.
    2. Experimental Design: I would start off by learning all the information I can about NK
    cells in the CNS and PNS areas in the body. Also, I would determine the role that NK
    cells share in relation to glia. Because NK cells are hard to work with in lab, especially
    because a lot of mice dont have sets of NK cells, I would start off by comparing different
    genes in mice to a human body. Thus, I will hopefully come close to finding out what
    genes are responsible for causing various disorder symptoms in the mouses body
    compared to the human body. After determining the genes in both mice and humans that
    cause similar disorder symptoms, I would start tweaking genes in the mice and steady the
    various reactions.
    3. Predicted Results:

    Graph I. Natural Killer Cells Effectiveness in Inflammation at Different Sites

    Graph I. indicates the effectiveness(magnitude) of inflammation in CNS and PNS caused by


    Natural Killer Cells based on the different cells tested on in the mice.

    4. Interpretations and Discussion: If I got the following results in my graph, I would


    interpret the chart as different genes in different areas (CNS/PNS) play a role in
    determining the magnitude of inflammation caused by the NK cells. I would also focus
    more on the set of results pertaining to the CNS area since MS develops there commonly.
    I would analyze the role that NK cells play with that particular gene in each trial as well.
    I would chronologically order the effectiveness of each gene pertaining to NKs role in
    causing the development of MS in the body. Another possible interpretation could be
    made. There is always a question that a NK cell can be mutated and cause the
    development of MS at random. The limitations I would mainly be faced with is that NK
    cells are hard to study and obtain in a laboratory surrounding. Also, mice is a usual tested
    animal for science; but they do not have NK cells. That means that testing different cells
    and their functions in their bodies compared to the cells and functions in the human body
    have to be extremely accurate. It is hard to test for safety and accuracy when two
    organisms dont share the main cell in topic: Natural Killer (NK) cells.

    You might also like