5th Jan 17 Patho 04 Adrenals DR - Aznar

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Endocrinology

PETER S. AZNAR, MD, FPSP, MHPE


Adrenal Gland
Adrenal Gland Cross Section
Zona Glomerulosa Mineralocorticoids Aldosterone Increased Conn Syndrome
Decreased Addisons Disease

Adrenal Cushings
Cortex Zona Fasiculata Glucorticoids Cortisol Increased Syndrome

Decreased Addison's Disease


Zona Reticularis Sex Hormones Estrogen Increased
Decreased

Adrenal Medulla Norepinephrine Vanillyl Mandelic Acid (VMA) Pheochromocytoma

Dopamine Homovanillic Acid (HVA) Neuroblastoma


Cushings Syndrome

ACTH
Increased = Cushings disease
Decreased = Addisons disease
Cushings Syndrome
Normal Cushings
Estrogen

Estradiol- most potent


Estriol- increase in pregnancy
Estrone- increase in
postmenopausal women
Zona
Glomerulosa Mineralocorticoids Aldosterone Increased Conn Syndrome
Addisons
Decreased Disease

Adrenal Cushings
Cortex Zona Fasiculata Glucorticoids Cortisol Increased Syndrome
Addison's
Decreased Disease
Zona
Reticularis Sex Hormones Estrogen Increased
Decreased

Vanillyl Mandelic Acid


Adrenal Medulla Norepinephrine (VMA) Pheochromocytoma

Dopamine Homovanillic Acid (HVA) Neuroblastoma


Infectious Diseases of the Adrenal Gland

- Tuberculosis (1855) Addisons Disease

- N. meningitidis (1878) Waterhouse


Friderichsen Syndrome

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