Tetracycline HCL Drug Study

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The document discusses the generic and brand names, actions, indications, pregnancy category, drug classification, contraindications, adverse effects, drug interactions, and nursing considerations of tetracycline.

Tetracycline is indicated to treat infections caused by various bacteria, rickettsiae, and other microorganisms. It is also used as an adjunct treatment for acute intestinal amebiasis and to treat acne.

Some potential adverse effects of tetracycline include phototoxic reactions, gastrointestinal issues, liver toxicity, hematological abnormalities, and allergic reactions ranging from rash to anaphylaxis.

Tetracycline HCl Drug Study

In making a Drug Study, the following elements must be present:


Generic Name and the Brand name (not all brands, just the brand
used by the patient), Action, Indication, Pregnancy Category, Drug
Classification, and Contraindication, Adverse Effect, Drug
interaction and Nursing Consideration/Intervention. Most clinical
instructors preferred this to be in a long bond paper in printed or
handwritten with paper in landscape.

Tetracycline hydrochloride
Brand Name: Apo-Tetra (CAN), Novo-Tetra (CAN), Nu-Tetra
(CAN), Panmycin, Sumycin, Tetracap, Tetracyn, Tetralan, Topicycline
Pregnancy Category D, Pregnancy Category B (Topicycline only)
Drug classes: Antibiotic, Tetracycline
Therapeutic actions
Bacteriostatic: inhibits protein synthesis of susceptible bacteria, preventing
cell replication.
Indications
Systemic administration
Infections caused by rickettsiae; Mycoplasma pneumoniae; agents of
psittacosis, ornithosis, lymphogranuloma venereum and granuloma ing
uinale; Borrelia recurrentis, Haemophilusducreyi, Yersinia pestis, Yersin
ia tularensis, Bartonellabacilliformis, Bacteroides, Vibrio cholerae,
Campylobacter fetus, Brucella, Escherichia
coli, Enterobacter aerogenes, Shigella, Acinetobacter calcoaceticus, Ha
emophilus influenzae, Klebsiella, Streptococcus pneumoniae

When penicillin is contraindicated, infections caused


by Neisseria gonorrhoeae, Treponema pallidum, Treponemapertenue, L
isteria monocytogenes, Clostridium,
Bacillus anthracis, Fusobacterium fusiforme, Actinomyces, Neisseriame
ningitidis
Adjunct to amebicides in acute intestinal amebiasis
Treatment of acne (oral)
Uncomplicated urethral, endocervical or rectal infections in adults
caused by Chlamydia trachomatis
Instilled in a chest tube, unlabeled use: pleural sclerosing agent in
malignant pleural effusions
Treatment of trachoma
Contraindications
Systemic administration and dermatologic solution
Contraindicated with allergy to any of the tetracyclines; allergy
to tartrazine (in 250-mg capsules of Panmycin); pregnancy (toxic to the
fetus); lactation (causes damage to the teeth of infant).
Adverse effects
Phototoxic reactions, rash, exfoliative dermatitis
Discoloring and inadequate calcification of primary teeth of fetus if used by
pregnant women, discoloring and inadequate calcification of permanent
teeth if used during period of dental development, fatty liver, liver
failure, anorexia, nausea, vomiting,
diarrhea, glossitis, dysphagia, enterocolitis, esophageal ulcers

Hemolytic anemia,
thrombocytopenia, neutropenia, eosinophilia, leukocytosis, leukopenia
Reactions from urticaria to anaphylaxis, including intracranial hypertension
Superinfections, local irritation at parenteral injection sites
Drug Interactions:
Decreased absorption with calcium salts, magnesium salts, zinc salts,
aluminum salts, bismuth salts, iron, urinary alkalinizers, food, dairy
products, charcoal
Increased digoxin toxicity
Increased nephrotoxicity with methoxyflurane
Decreased effectiveness of hormonal contraceptives, though rare, has
been reported with a risk of breakthrough bleeding or pregnancy
Decreased activity of penicillins
Nursing considerations
Administer oral medication on an empty stomach, 1 hr before or 23
hr after meals. Do not give with antacids. If antacids must be used,
give them 3 hr after the dose of tetracycline.
Culture infection before beginning drug therapy.
Do not administer during pregnancy; drug is toxic to the fetus.
Do not use outdated drugs; degraded drug is highly nephrotoxic and
should not be used.
Do not give oral drug with meals, antacids, or food.

Arrange for regular renal function tests with long-term therapy.


Use topical preparations of this drug only when clearly indicated.
Sensitization from the topical use may preclude its later use in serious
infections. Topical preparations containing antibiotics that are not
ordinarily given systemically are preferable.

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