Tetracycline HCL Drug Study
Tetracycline HCL Drug Study
Tetracycline HCL Drug Study
Tetracycline hydrochloride
Brand Name: Apo-Tetra (CAN), Novo-Tetra (CAN), Nu-Tetra
(CAN), Panmycin, Sumycin, Tetracap, Tetracyn, Tetralan, Topicycline
Pregnancy Category D, Pregnancy Category B (Topicycline only)
Drug classes: Antibiotic, Tetracycline
Therapeutic actions
Bacteriostatic: inhibits protein synthesis of susceptible bacteria, preventing
cell replication.
Indications
Systemic administration
Infections caused by rickettsiae; Mycoplasma pneumoniae; agents of
psittacosis, ornithosis, lymphogranuloma venereum and granuloma ing
uinale; Borrelia recurrentis, Haemophilusducreyi, Yersinia pestis, Yersin
ia tularensis, Bartonellabacilliformis, Bacteroides, Vibrio cholerae,
Campylobacter fetus, Brucella, Escherichia
coli, Enterobacter aerogenes, Shigella, Acinetobacter calcoaceticus, Ha
emophilus influenzae, Klebsiella, Streptococcus pneumoniae
Hemolytic anemia,
thrombocytopenia, neutropenia, eosinophilia, leukocytosis, leukopenia
Reactions from urticaria to anaphylaxis, including intracranial hypertension
Superinfections, local irritation at parenteral injection sites
Drug Interactions:
Decreased absorption with calcium salts, magnesium salts, zinc salts,
aluminum salts, bismuth salts, iron, urinary alkalinizers, food, dairy
products, charcoal
Increased digoxin toxicity
Increased nephrotoxicity with methoxyflurane
Decreased effectiveness of hormonal contraceptives, though rare, has
been reported with a risk of breakthrough bleeding or pregnancy
Decreased activity of penicillins
Nursing considerations
Administer oral medication on an empty stomach, 1 hr before or 23
hr after meals. Do not give with antacids. If antacids must be used,
give them 3 hr after the dose of tetracycline.
Culture infection before beginning drug therapy.
Do not administer during pregnancy; drug is toxic to the fetus.
Do not use outdated drugs; degraded drug is highly nephrotoxic and
should not be used.
Do not give oral drug with meals, antacids, or food.