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Mid-Term Review Practice Questions

This document contains practice questions for a mid-term exam on biomedical research methods. It includes multiple choice and short answer questions testing understanding of experiments on the antibacterial properties of cinnamon oil and tetracycline, a phage lab investigating plaque morphology, experimental design involving variables, and analysis of data and figures from papers on antiviral drugs.

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Yifei He
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95 views2 pages

Mid-Term Review Practice Questions

This document contains practice questions for a mid-term exam on biomedical research methods. It includes multiple choice and short answer questions testing understanding of experiments on the antibacterial properties of cinnamon oil and tetracycline, a phage lab investigating plaque morphology, experimental design involving variables, and analysis of data and figures from papers on antiviral drugs.

Uploaded by

Yifei He
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
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Mid-Term Exam Practice Questions

Biomedical Research Methods Guarraia/Rogers

1. Assume the zone of inhibition (ZOI) of tetracycline is 23 cm and that


of cinnamon oil is 25 cm and answer the questions that follow:
a. What do your result suggest? Explain.
b. What would be your control plates for this experiment?
c. What might the question of this experiment been?
d. What might be some options for future research of this
experiment?
2. Please answer the following questions about the Phage Lab.
a. What differences, if any, did you notice in your plates about
plaque morphology?
b. Were the images in the lab handout for T2 and X similar to
those you saw on your plates? Explain.
c. What role did the soft agar play in the lab?
3. Choose any question below and come up with independent variable(s),
dependent variable(s), and controlled variable(s).
a. Does UV effect plaque formation in T2 phages differently than X
phages?
b. Does green tea have antibacterial properties?
c. Is 10 mg penciclovir more effective at killing alphaherpesvirus
than 10 mg of acyclovir?
d. Is penciclovir more effective in HSV1 than FSV1?
4. True or false (use the three papers to answer these questions).
a. From Dr. Margulies paper
i. Penciclovir is a probable vaccine for HSV1.
ii. ACV is more effect at treating FHV1 than PCV.
iii. Figure 2 clearly shows that silicone implants are an
effective delivery device.
iv. The data suggest that the delivery devices do deliver a
specific and known amount of drug daily.
b. From the Prabu paper
i. The data in this paper suggest that cinnamon oil is the most
effective natural antibiotic tested.
ii. The authors reported their controls in the data table within
the paper.

iii. To be considered effective, the natural oil needs to have


antibacterial effects on all three bacteria tested.
iv. These bacteria were chosen because they are most
commonly found in the guts of humans.

5. Use the following data to answer the questions that follow:

FIG. 1. (A) Plaque morphology of V5, V6, and MDCK-passaged variants containing
introduced amino acid changes. Plaque assay was performed in MDCK cells
incubated at 33C for 4 days and immunostained with polyclonal antiserum
against influenza A virus. (B) Plaque morphology of double mutant V5-119E/186D
compared with that of single 119E and 186D mutants.

a. Explain how the plaques of V5 differ from those of V6 and mutant


V5?
b. Does the data suggest the concentrations of virus plated are all
of the same order of magnitudes? If so, what do you suspect the
concentration is? If not, why not?
c. Are there control plates pictured in Fig 1? If so, which? If not,
why not?

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