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    The Robustness and Ruggedness Tests For The GC-MS

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    Raditya Pramayudha
    The robustness and ruggedness of a GC-MS method for analyzing metformin were tested using a Plackett-Burman experimental design with five variables. Twelve experimental runs were performed in random order. The peak area ratio of metformin to an internal standard was used as the response. ANOVA analysis showed that the selected variables did not have a significant effect on the response. Therefore, the method was considered robust and rugged with respect to the variations tested.

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    The Robustness and Ruggedness Tests For The GC-MS

    Uploaded by

    Raditya Pramayudha
    60 views1 page
    The robustness and ruggedness of a GC-MS method for analyzing metformin were tested using a Plackett-Burman experimental design with five variables. Twelve experimental runs were performed in random order. The peak area ratio of metformin to an internal standard was used as the response. ANOVA analysis showed that the selected variables did not have a significant effect on the response. Therefore, the method was considered robust and rugged with respect to the variations tested.

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    Hanya translate dari berbagai jurnal yanga da di dunia fana ini

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    The Robustness and Ruggedness Tests for the GC-MS

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    The robustness and ruggedness of a GC-MS method for analyzing metformin were tested using a Plackett-Burman experimental design with five variables. Twelve experimental runs were performed in random order. The peak area ratio of metformin to an internal standard was used as the response. ANOVA analysis showed that the selected variables did not have a significant effect on the response. Therefore, the method was considered robust and rugged with respect to the variations tested.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    60 views1 page

    The Robustness and Ruggedness Tests For The GC-MS

    Uploaded by

    Raditya Pramayudha
    The robustness and ruggedness of a GC-MS method for analyzing metformin were tested using a Plackett-Burman experimental design with five variables. Twelve experimental runs were performed in random order. The peak area ratio of metformin to an internal standard was used as the response. ANOVA analysis showed that the selected variables did not have a significant effect on the response. Therefore, the method was considered robust and rugged with respect to the variations tested.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    The robustness and ruggedness tests for the GC-MS method were simultaneously

    carried out using the PlackettBurman experimental design. Five variables were
    selected, which were significant in the performance of the method and twelve
    experimental runs were performed (Tables 2 and 3). Experimental runs were
    done in a random order to minimize the effect of unexplained variability on the
    response.
    The peak area ratio of metformin to IS was accepted as a response. The results
    were assessed using the Minitab statistical software.

    Robustness and ruggedness. The ANOVA test with the PlackettBurman


    experimental design was used to identify the effects of each factor on the
    response (peak area ratio of metformin to IS). The results showed that the effects
    of selected variables on the response were not significant (P > 0.05). In addition,
    the normal probability plot of the standardized effects was constructed. The
    normal probabilities (z score) of the rank-ordered variables were plotted on the yaxis, and the standardized variables were plotted on the x-axis. All the points
    showing the parameters formed a straight line in the probability curves. In other
    words, the variables for this study did not have significant effects on the peak
    area ratios of metformin to IS.
    Therefore, the method can be considered robust and rugged with regard to the
    variations tested in this study.
    Translate:
    Ketahanan dan kekasaran tes untuk metode GC-MS secara bersamaan dilakukan
    dengan menggunakan desain eksperimen rancangan Plackett-Burman. Lima
    variabel yang dipilih, yang signifikan dalam kinerja metode dan dua belas
    berjalan eksperimental dilakukan (Tabel 2 dan 3). berjalan eksperimental
    dilakukan dalam urutan acak untuk meminimalkan efek dari variabilitas
    dijelaskan pada respon.
    Rasio daerah puncak metformin untuk IS diterima sebagai respon. Hasil
    dinilai dengan menggunakan perangkat lunak statistik Minitab.
    Ketahanan dan kekasaran. Tes ANOVA dengan desain eksperimental rancangan
    Plackett-Burman digunakan untuk mengidentifikasi efek dari masing-masing
    faktor pada respon (rasio luas puncak dari metformin untuk IS). Hasil
    penelitian menunjukkan bahwa efek dari variabel yang dipilih pada respon
    tidak signifikan (P> 0,05). Selain itu, plot probabilitas normal dari efek
    standar dibangun. Probabilitas normal (skor z) dari variabel rankmemerintahkan diplotkan pada sumbu y, dan variabel standar yang diplot pada
    sumbu x. Semua poin yang menunjukkan parameter membentuk garis lurus di
    kurva probabilitas. Dengan kata lain, variabel penelitian ini tidak
    memiliki pengaruh yang signifikan terhadap rasio luas puncak dari metformin
    untuk IS.
    Oleh karena itu, metode ini dapat dianggap kuat dan kasar berkaitan dengan
    variasi diuji dalam penelitian ini.

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