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BACILLUS THURINGIENSIS
GENERAL FACT SHEET

What is Bacillus thuringiensis (Bt)
Bt is a microbe naturally found in soil. It makes proteins that are toxic
to immature insects (larvae). There are many types of Bt. Each targets
different insect groups. Target insects include beetles, mosquitoes, black
flies, caterpillars, and moths.
With Bt pesticides, routine testing is required to ensure that unwanted
toxins and microbes are not present. Bt has been registered for use in
pesticides by the US Environmental Protection Agency (EPA) since 1961.
What are some products that contain Bacillus thuringiensis (Bt)

Currently, Bt strains are found in over 180 registered pesticide products. Bt products are used on crops and ornamental
plants. Others are used in and around buildings, in aquatic settings, and in aerial applications. These products are
commonly sprays, dusts, granules, and pellets. Some of these products are approved for use in organic agriculture.
Some crops have been engineered to make the Bt toxin. These plant-incorporated protectants include corn, cotton,
and soybeans.
Always follow label instructions and take steps to minimize exposure. If any exposures occur, be sure to follow the
First Aid instructions on the product label carefully. For additional treatment advice, contact the Poison Control
Center at 1-800-222-1222. If you wish to discuss a pesticide problem, please call 1-800-858-7378.
How does Bacillus thuringiensis (Bt) work

Bt makes toxins that target insect larvae when eaten. In their gut,
the toxins are activated. The activated toxin breaks down their gut,
and the insects die of infection and starvation. Death can occur
within a few hours or weeks.
The different types of Bt create toxins that can only be activated
by the target insect larvae. In contrast, when people eat the same
toxins, the toxins are not activated and no harm occurs.
Each type of Bt toxin is highly specific to the target insect. For example, the kurstaki type targets caterpillars. The
isrealensis type targets immature flies and mosquitoes. Little to no direct toxicity to non-target insects has been
observed.
National Pesticide Information Center
1.800.858.7378
GENERAL FACT SHEET
How might I be exposed to Bacillus thuringiensis (Bt)
People are most commonly exposed to Bt through their diet, at very low levels.
Exposure can also occur if you breathe it in or get it on your skin or eyes. For example,
this can occur while applying sprays or dusts during windy conditions. You may also
be exposed after using a product if you dont wash your hands before eating or
smoking. Since Bt is commonly found in soils, exposures not related to pesticides
are also possible.
Pets might be exposed to this product in treated birdbaths or water fountains.
You can limit your exposure and reduce the risk by carefully following the label
instructions.
What are some signs and symptoms from a brief exposure to Bacillus thuringiensis (Bt)
Bt is low in toxicity to people and other mammals. Several studies have found no evidence of sickness or infection as
a result of exposure. However, some products with Bt have caused eye and skin irritation. In one study, rats breathed
in very high doses of concentrated Bt. Some had runny noses, crusty eyes, and goose bumps. Others were less active
or lost weight.
In another study, people were surveyed before and after aerial applications of Bt. Most people were not affected.
However, some people with hay fever reported certain symptoms. These included difficulty with sleep and
concentration, stomach upset, and nose/throat irritation. Seasonal factors, such as pollen, may have contributed to
some of the effects.
Scientists also evaluated whether Bt can cause allergic reactions. Researchers found that farmworkers exposed for
one to four months did not experience any problems related to their airways, nose, or skin. However, further exposure
showed evidence of an immune response and the potential for skin allergies to develop.
What happens to Bacillus thuringiensis (Bt) when it enters the body

When eaten, Bt is confined to the gut. It does not reproduce, and the toxin is broken down like other proteins in the
diet. Bt leaves the body within 2 to 3 days.
If breathed in, Bt can move to the lungs, blood, lymph, and kidneys. Bt is then attacked by the immune system. Levels
of Bt decrease quickly one day after exposure.
Is Bacillus thuringiensis (Bt) likely to contribute to the development of cancer

No data were found on the carcinogenic effects of Bt in humans. However, in one animal study, rats were fed very high
doses of Bt for 2 years. No evidence of cancer was observed.
1.800.858.7378
GENERAL FACT SHEET
Has anyone studied non-cancer effects from long-term exposure to Bacillus thuringiensis (Bt)
In a 2-year study, rats were fed high doses of Bt daily. Female rats had lower body weights. However, no evidence of
an infection was found.
Bt is only activated in the alkaline environment of the insect gut, compared to the acidic environment of human
stomachs. In human stomachs, it is easily digested. As such, no adverse effects are expected after long-term dietary
exposure to Bt, whether its proteins are sprayed on plants or grown within plant tissues.
Are children more sensitive to Bacillus thuringiensis (Bt) than adults

Children may be especially sensitive to pesticides compared to adults. However, there are currently no data showing
that children have increased sensitivity specifically to Bt.
What happens to Bacillus thuringiensis (Bt) in the environment

Toxins created by Bt are rapidly broken down by sunlight and in acidic soil.
Other microbes in soil can also break it down. Bt does not readily leach in
soil. It typically remains in the top several inches of soil. Bt remains dormant
in most natural soil conditions. However, there has been some reproduction
in nutrient rich soils. On the soil surface, dormant Bt cells last only a few
days. However, below the soil surface, they can last for months or years. The
half-life in unfavorable soil is about 4 months. Bt toxins break down much
faster. In one study, 12% remained after 15 days.
In water, Bt does not readily reproduce. A study found Bt toxins in the air
were broken down rapidly by sunlight. Forty-one percent (41%) of the toxin
remained after 24 hours. On plant surfaces, sunlight breaks down Bt; the
half-life of Bt toxins is 1-4 days.
Can Bacillus thuringiensis (Bt) affect birds, fish, or other wildlife

Bt is practically non-toxic and non-pathogenic to birds, fish, and shrimp. No adverse effect or infection was found in
rats given large doses of two different Bt strains. There is no evidence that Bt can cause a disease outbreak among
wild animals.
Little to no direct toxicity to non-target insects and other shelled invertebrates has been observed. Bt does not seem
to hurt earthworms. However, the aizawai strain is highly toxic to honeybees. Other strains have minimal toxicity to
honeybees.
1.800.858.7378
GENERAL FACT SHEET
Water fleas exposed to the kurstaki and israelensis strains showed moderate toxicity. The aizawai strains are highly
toxic to water fleas. However, evidence suggests that toxicity to these non-targets may be related to impurities from
the production of Bt.
Where can I get more information

For more detailed information about Bacillus thuringiensis (Bt) please visit the list of referenced resources or call the
National Pesticide Information Center, between 8:00 AM and 12:00 PM Pacific Time (11:00 AM to 3:00 PM Eastern
Time), Monday - Friday, at 1-800-858-7378 or visit us on the web at http://npic.orst.edu. NPIC provides objective,
science-based answers to questions about pesticides.
Date Reviewed: February 2015
NPIC is a cooperative agreement between Oregon State University and the U.S. Environmental Protection
Agency (U.S. EPA, cooperative agreement # X8-83560101). The information in this publication does not in any
way replace or supercede the restrictions, precautions, directions, or other information on the pesticide label
or any other regulatory requirements, nor does it necessarily reflect the position of the U.S. EPA.
1.800.858.7378

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BACILLUS THURINGIENSIS

GENERAL FACT SHEET

What are some products that contain Bacillus thuringiensis (Bt)

How does Bacillus thuringiensis (Bt) work

What happens to Bacillus thuringiensis (Bt) when it enters the body

Is Bacillus thuringiensis (Bt) likely to contribute to the development of cancer

Are children more sensitive to Bacillus thuringiensis (Bt) than adults

What happens to Bacillus thuringiensis (Bt) in the environment

Can Bacillus thuringiensis (Bt) affect birds, fish, or other wildlife

National Pesticide Information Center

Where can I get more information

Date Reviewed: February 2015

National Pesticide Information Center

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