Doe

Design of Experiments
Principles and Applications
ISBN 91-973730-0-1
L. Eriksson, E. Johansson, N. Kettaneh-Wold, C. Wikstrm, and S. Wold
How to Optimize Products and Processes

Which combination of factors will give the best car engine at low cost, with low fuel consumption and minimal pollution?
A usually complex and costly experimental situation is easily resolved with Design of Experiments (DOE). All factors are considered in a minimal number of experiments, and the results
are verified with recognized statistical methods. The book describes the method in its simple
basis and adds valuable examples from a variety of application areas. The authors provide their
detailed analyses and offer solutions, with the graphical presentation that is the trademark of
Umetrics software MODDE.
Design of Experiments: Principles and Applications is 329 pages and the contents range
from beginners level with initial screening all
the way up to complex mixtures. The authors are
experts in Design of Experiments and have a
vast experience of application areas from years
of consulting and lecturing at Umetrics.
For newcomers in the field of experimental design

the book is very useful.
The book gives a detailed introduction to the principles of experimental design and gives excellent illustrations of the use of the MODDE software as an integrated tool in design and analysis of experiments.
Rolf Carlson in Journal of Chemometrics, 15, 2001,

495-496
Content of Design of Experiments: Principles and Applications

0 Preface 1
Why Design of Experiments (DOE)
is used
Sectors where DOE is used
Three primary experimental
objectives
1 Introduction (Part 1)
When and where DOE is useful
What is DOE?
General Example 1: Screening
General Example 2: Optimization
General Example 3: Robustness
testing
The Cake Mix application
Variability
Reacting to noise
Focusing on effects
Illustration: Cake Mix
Consequence of variability
The model concept
Conceptual basis of semi-empirical
modeling
4 Problem formulation (Part 1)

Stages in the experimental process
Specification of factors
Specification of responses
Selection of model
Generation of design
Creation of experimental worksheet

Qualitative factors at two levels
Qualitative factors at many levels
Regular and irregular experimental
regions
Metric of factors
Metric of responses

Overview of models
Geometry of models
7 Factorial designs (Part 1)

Introduction to full factorial
designs
The 22 full factorial design
construction & geometry
The 23 full factorial design
construction & geometry
The 24 and 25 full factorial designs
Pros and cons of two-level full
factorial designs

Main effect of a factor
www.umetrics.com
Computation of main effects in the

22 case
A second method of understanding
main effects
A quicker by-hand method for
computing effects
Plotting of main and interaction
effects
Interpretation of main and
interaction effects in the 23 case
Computation of effects using least
squares fit

Introduction to least squares
analysis
Least squares analysis applied to
the CakeMix data
The proper way of expressing
regression coefficients
Use of coefficient and effect plots
10 Analysis of factorial
designs (Part 1)
Introduction to the analysis of
factorial designs
Evaluation of raw data Replicate
plot
Regression analysis The R2 /Q2
diagnostic tool
R2 /Q2 pointing to a poor model
Model interpretation Coefficient
plot
Use of model Response contour
plot
Model interpretation and use in
the case of several responses
designs (Part 2)
Evaluation of raw data Condition
number
Evaluation of raw data Scatter
plot
Evaluation of raw data Histogram
of response
Evaluation of raw data
Descriptive statistics of response
Regression analysis Analysis of
variance (ANOVA)
Regression analysis Normal
probability plot of residuals
Use of model Making predictions
Benefits of response
transformation
Cause of poor model. 2. Curvature
Cause of poor model. 3. Bad
replicates
Cause of poor model. 4. Deviating
experiments
Introduction to PLS regression
13 Screening (Part 1)
Selection of experimental objective
Fractional Factorial Designs
A geometric representation of
fractional factorial designs
Resolution of fractional factorial
designs
Laser welding application I
What to do after screening
Gradient techniques
Gradient techniques applied to the
laser welding application
Automatic search for an optimal
point
14 Screening (Part 2)
Confounding pattern
Generators
Defining relation
Resolution
Plackett-Burman designs
15 Optimization (Part 1)
Background to General Example 2
Introduction to response surface
methodology (RSM) designs
Overview of composite designs
Truck engine application
What to do after RSM
Automatic search for an optimal
point
MODDE optimizer applied to the
truck engine data
16 Optimization (Part 2)
Three-Part full factorial designs
Box-Behnken designs
A comparison of Composite, ThreePart factorial, and Box-Behnken
designs
Properties of classical RSM
designs
17 Robustness testing
Cause of poor model. 1. Skew

response distribution
Introduction to robustness testing

HPLC application
First limiting case Inside
specification/Significant model
Second limiting case Inside
specification/Non-significant
model
Third limiting case Outside
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Phone: +46 (0)90 184800
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Email: [email protected]
In USA and Canada:

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Phone: +1 973 492 8355
Fax: +1 973 492 8359
designs (Part 3)
specification/Significant model
Fourth limiting case Outside
specification/Non-significant
model
18 D-optimal design
D-optimal design
When to use D-optimal design
Features of the D-optimal
approach
Evaluation criteria
19 Mixture design
A working strategy for mixture
design
Advanced mixture designs
20 Multi-Level qualitative
factors
Example Cotton cultivation
Regression analysis of Cotton
application Coefficient plot
Regression analysis of Cotton
application Interaction plot
21 Taguchi approach to
robust design
The Taguchi approach
Introduction
Arranging factors in inner and
outer arrays
The classical analysis approach
22 Models of variability:
Distributions
Models of variability - Distributions
The normal distribution
The t-distribution
Confidence intervals
23 Analysis of variance,
ANOVA
Introduction to ANOVA
ANOVA Regression model
significance test
ANOVA Lack of fit test
24 PLS
When to use PLS
The LOWARP application
PLS model interpretation
Statistical Appendix
References
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Principles and Applications
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Design of Experiments

Principles and Applications

L. Eriksson, E. Johansson, N. Kettaneh-Wold, C. Wikstrm, and S. Wold

How to Optimize Products and Processes

For newcomers in the field of experimental design

Rolf Carlson in Journal of Chemometrics, 15, 2001,

Content of Design of Experiments: Principles and Applications

4 Problem formulation (Part 1)

5 Problem formulation (Part 2)

6 Problem formulation (Part 3)

7 Factorial designs (Part 1)

8 Factorial designs (Part 2)

Computation of main effects in the

9 Factorial designs (Part 3)

Cause of poor model. 1. Skew

Introduction to robustness testing

In USA and Canada:

LIVRE PUBLIE PAR UMETRICS ACADEMY

LIVRE UMETRICS ACADEMY

Je commande, au prix de 87 (Tva 7 % et Port inclus), le livre :

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