Comment

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United Nations General Assembly. United Nations Millennium Declaration:

resolution adopted by the General Assembly 55/2. 8th Plenary Meeting,
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(accessed Jan 25, 2005).
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Millennium Project Task Force 4: child health and maternal health interim
report. New York, Millennium Project, 2004: http//:www.unmillennium
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neonatal care in countries. Lancet 2005: http://image.thelancet.com/
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AbouZhar C, Wardlaw T. Maternal mortality in 2000: estimates developed
by WHO, UNICEF and UNFPA. 139. Geneva: WHO, 2003: http://www.
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mme.pdf (accessed on Jan 31, 2005).
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Gwatkin D, Bhuiya A, Victora C. Making health systems more equitable.

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Epidemiological transition, medicalisation of childbirth, and

neonatal mortality: three Brazilian birth-cohorts
Over the past two decades, Brazil has seen improvements
in womens nutritional status, education, smoking habits,
and antenatal care. Neonatal mortality rates (deaths of
liveborn infants up to 1 month of age), however, have
changed little. In this issue of The Lancet, Fernando Barros
and colleagues present fascinating data from three birthcohorts which suggest that falling mortality in term
infants (37 weeks gestation or more) has been offset by a
rise in preterm births and deaths, resulting in little change
in neonatal mortality. Brazilian health authorities can
claim fairly that more preterm infants survive because of
better neonatal care: gestation-specic mortality rates
have fallen by 50% since 1982. Nonetheless, many
preterm deliveries result from pregnancy interruption,
either by caesarean section or induction. Such early
delivery is often a direct consequence of inappropriate
medicalisation.
The road to hell is paved with good intentions, and
efforts to improve perinatal care have often had unintended consequences.1 Diethylstilbestrol was used in
www.thelancet.com Vol 365 March 5, 2005

millions of pregnancies before its association with vaginal

cancer in offspring was noted. Uncontrolled use of
oxygen and sulphonamides to treat respiratory distress in
premature infants in the 1950s triggered epidemics of
retinopathy and kernicterus, respectively. A proportion of
the epidemic of sudden infant deaths was attributable
to paediatricians encouraging prone sleeping for term
infants, drawing incorrectly on their experience of nursing
preterm infants in this position to avoid aspiration.2
Arguably the most pernicious example of medicalisation,
however, is the promotion of formula milks. The increased health risks of formula feeding have been well
documented in communities where illiteracy, poverty,
and lack of a clean supply of water are the norm. Formulafed infants aged under 2 months are nearly six times more
likely to die than breastfed infants,3 but inappropriate
promotion by milk companies remains widespread.4
Two medical interventions that are potentially lifesaving, antenatal ultrasonography and caesarean section,
are particularly prone to misuse. Sen estimates that over

See Comment pages 821, 822,

and 827
See Articles page 847
See Series page 891

825

Comment

Still Pictures

Rights were not granted to include this

image in electronic media. Please refer to
the printed journal.

Child healthcare, Siquiere, Brazil

100 million women are missing as a result of sex bias in

health care and termination of pregnancy after antenatal
ultrasound.5 Despite parliamentary legislation against sex
determination, Indias northern and western states still
have much lower female-to-male birth ratios than
expected. Barros and colleagues document another
potential adverse effect of ultrasound, suggesting that
overestimation of gestational age by private-sector scans
can lead to unnecessarily preterm delivery. This result is
worrying given that premature birth in itself is probably a
greater risk for neonatal mortality than low birthweight in
term infants.6
It is unwise to assume that the wholesale adoption of
medical activities will lead to better childbirth outcomes.
We have little evidence, for example, that the average
eight antenatal visits documented by Barros and colleagues translates into better outcomes.7 A caesarean
section rate of 1015% is generally considered appropriate for obstetric complications. Lower rates in poor
countries do indicate a lack of access, but operative
delivery rates in Latin America are the highest in the
world. In the Brazilian cohorts, rates rose from 28% to
43% over 20 years, with a staggering 82% in the private
sector. This rate rise accompanied a rise in induction rates
from 3% to 45%. In Chile, women with private obstetricians also have consistently higher rates of caesarean
section than those cared for in public hospitals.8
In the broader context, medicalisation might be an
inappropriately narrow strategy to tackle a public-health
problem. Many policymakers and academics attribute the
826

continuing high maternal mortality ratios in the developing worldwhere more than 50 countries have a
maternal mortality ratio greater than 400 per 100 000
livebirthsto a lack of access to obstetric and midwifery
care. Yet history and recent trials suggest that large
reductions in maternal mortality ratio in the poorest
countries can be achieved by social or community interventions, particularly when service use is low.9,10 Access to
essential and emergency obstetric care is certainly a key
component of any national programme for safer motherhood, but broader public-health measures deserve similar
investment.
In middle-income countries with high use of institutions for health care, a focus on the quality of perinatal
care is a priority, and health outcomes must be monitored
rigorously. Doing the simple things better is probably the
most cost-effective policy: increasing coverage of syphilis
screening, making sure that unimmunised women
receive tetanus toxoid, and careful monitoring in labour.
As Barros and colleagues show, the risks of medicalisation
should not be ignored because they might offset the
gains resulting from improved maternal health and
survival of newborn infants.
*Anthony Costello, David Osrin
International Perinatal Care Unit, Institute of Child Health,
University College London, London WC1N 1EH, UK
[email protected]
We declare that we have no conict of interest.
1

Silverman W. Collateral damage in perinatal warfare.

Paediatr Perinat Epidemiol 2002; 16: 9899.
2
Mitchell E, Scragg R, Stewart A, et al. Results from the rst year of the
New Zealand cot death study. NZ Med J 1991; 104: 7176.
3
WHO Collaborative Study Team on the Role of Breastfeeding on the
Prevention of Infant Mortality. Effect of breastfeeding on infant and child
mortality due to infectious diseases in less developed countries: a pooled
analysis. Lancet 2000; 355: 45155.
4
Aguayo V, Ross J, Kanon S, Ouedraogo A. Monitoring compliance with
the International Code of Marketing of Breastmilk Substitutes in west
Africa: multisite cross sectional survey in Togo and Burkina Faso.
BMJ 2003; 326: 12732.
5
Sen A. Missing womenrevisited. BMJ 2003; 327: 129798.
6
Yasmin S, Osrin D, Paul E, Costello A. Neonatal mortality of
low-birth-weight infants in Bangladesh. Bull World Health Organ 2001;
79: 60814.
7
Carroli G, Rooney C, Villar J. WHO programme to map the best
reproductive health practices: how effective is antenatal care in
preventing maternal mortality and serious morbidity?
Paediatr Perinatal Epidemiol 2001; 15 (suppl 1): 142.
8
Murray S. Relation between private health insurance and high rates of
caesarian section in Chile: qualitative and quantitative study. BMJ 2000;
321: 150105.
9
Manandhar D, Osrin D, Shrestha B, et al. Effect of a participatory
intervention with womens groups on birth outcomes in Nepal: cluster
randomized controlled trial. Lancet 2004; 364: 97079.
10 West K, Katz J, Khatry S, et al. Double blind, cluster randomised trial of low
dose supplementation with vitamin A or beta carotene on mortality
related to pregnancy in Nepal. BMJ 1999; 318: 57075.

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