Bronquiolite Guidelines AAP

Guidance for the Clinician in
Rendering Pediatric Care
CLINICAL PRACTICE GUIDELINE
Clinical Practice Guideline: The Diagnosis, Management,

and Prevention of Bronchiolitis
abstract
This guideline is a revision of the clinical practice guideline, Diagnosis
and Management of Bronchiolitis, published by the American Academy
of Pediatrics in 2006. The guideline applies to children from 1 through
23 months of age. Other exclusions are noted. Each key action statement indicates level of evidence, benet-harm relationship, and level
of recommendation. Key action statements are as follows: Pediatrics
2014;134:e1474e1502
Shawn L. Ralston, MD, FAAP, Allan S. Lieberthal, MD, FAAP,

H. Cody Meissner, MD, FAAP, Brian K. Alverson, MD, FAAP, Jill E.
Baley, MD, FAAP, Anne M. Gadomski, MD, MPH, FAAP,
David W. Johnson, MD, FAAP, Michael J. Light, MD, FAAP,
Nizar F. Maraqa, MD, FAAP, Eneida A. Mendonca, MD, PhD,
FAAP, FACMI, Kieran J. Phelan, MD, MSc, Joseph J. Zorc, MD,
MSCE, FAAP, Danette Stanko-Lopp, MA, MPH, Mark A.
Brown, MD, Ian Nathanson, MD, FAAP, Elizabeth
Rosenblum, MD, Stephen Sayles III, MD, FACEP, and Sinsi
Hernandez-Cancio, JD
KEY WORDS
bronchiolitis, infants, children, respiratory syncytial virus,
evidence-based, guideline
DIAGNOSIS
1a. Clinicians should diagnose bronchiolitis and assess disease severity on the basis of history and physical examination (Evidence
Quality: B; Recommendation Strength: Strong Recommendation).
1b. Clinicians should assess risk factors for severe disease, such as
age less than 12 weeks, a history of prematurity, underlying cardiopulmonary disease, or immunodeciency, when making decisions
about evaluation and management of children with bronchiolitis
(Evidence Quality: B; Recommendation Strength: Moderate Recommendation).
1c. When clinicians diagnose bronchiolitis on the basis of history and
physical examination, radiographic or laboratory studies should
not be obtained routinely (Evidence Quality: B; Recommendation
Strength: Moderate Recommendation).
TREATMENT
2. Clinicians should not administer albuterol (or salbutamol) to infants and children with a diagnosis of bronchiolitis (Evidence Quality: B; Recommendation Strength: Strong Recommendation).
3. Clinicians should not administer epinephrine to infants and children
with a diagnosis of bronchiolitis (Evidence Quality: B; Recommendation Strength: Strong Recommendation).
4a. Nebulized hypertonic saline should not be administered to infants with a diagnosis of bronchiolitis in the emergency department (Evidence Quality: B; Recommendation Strength: Moderate
Recommendation).
4b. Clinicians may administer nebulized hypertonic saline to infants
and children hospitalized for bronchiolitis (Evidence Quality: B;
Recommendation Strength: Weak Recommendation [based on randomized controlled trials with inconsistent ndings]).
e1474
ABBREVIATIONS
AAPAmerican Academy of Pediatrics
AOMacute otitis media
CIcondence interval
EDemergency department
KASKey Action Statement
LOSlength of stay
MDmean difference
PCRpolymerase chain reaction
RSVrespiratory syncytial virus
SBIserious bacterial infection
This document is copyrighted and is property of the American
Academy of Pediatrics and its Board of Directors. All authors have
led conict of interest statements with the American Academy of
Pediatrics. Any conicts have been resolved through a process
approved by the Board of Directors. The American Academy of
Pediatrics has neither solicited nor accepted any commercial
involvement in the development of the content of this publication.
The recommendations in this report do not indicate an exclusive
course of treatment or serve as a standard of medical care. Variations,
taking into account individual circumstances, may be appropriate.
All clinical practice guidelines from the American Academy of
Pediatrics automatically expire 5 years after publication unless
reafrmed, revised, or retired at or before that time.
Dedicated to the memory of Dr Caroline Breese Hall.
www.pediatrics.org/cgi/doi/10.1542/peds.2014-2742
doi:10.1542/peds.2014-2742
PEDIATRICS (ISSN Numbers: Print, 0031-4005; Online, 1098-4275).
Copyright 2014 by the American Academy of Pediatrics
FROM THE AMERICAN ACADEMY OF PEDIATRICS
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5. Clinicians should not administer

systemic corticosteroids to infants
with a diagnosis of bronchiolitis in
any setting (Evidence Quality: A; Recommendation Strength: Strong Recommendation).
6a. Clinicians may choose not to administer supplemental oxygen if
the oxyhemoglobin saturation exceeds 90% in infants and children
with a diagnosis of bronchiolitis
(Evidence Quality: D; Recommendation Strength: Weak Recommendation [based on low level evidence
and reasoning from rst principles]).
6b. Clinicians may choose not to use
continuous pulse oximetry for infants and children with a diagnosis
of bronchiolitis (Evidence Quality:
D; Recommendation Strength: Weak
Recommendation [based on lowlevel evidence and reasoning from
rst principles]).
7. Clinicians should not use chest
physiotherapy for infants and children with a diagnosis of bronchiolitis (Evidence Quality: B;
Recommendation Strength: Moderate Recommendation).
8. Clinicians should not administer
antibacterial medications to infants and children with a diagnosis of bronchiolitis unless there
is a concomitant bacterial infection, or a strong suspicion of one
(Evidence Quality: B; Recommendation Strength: Strong Recommendation).
9. Clinicians should administer nasogastric or intravenous uids for
infants with a diagnosis of bronchiolitis who cannot maintain hydration orally (Evidence Quality: X;
Recommendation Strength: Strong
Recommendation).
PREVENTION
10a. Clinicians should not administer
palivizumab to otherwise healthy
infants with a gestational age of
29 weeks, 0 days or greater

(Evidence Quality: B; Recommendation Strength: Strong
Recommendation).
10b. Clinicians should administer
palivizumab during the rst
year of life to infants with hemodynamically signicant heart
disease or chronic lung disease
of prematurity dened as preterm infants <32 weeks 0 days
gestation who require >21%
oxygen for at least the rst
28 days of life (Evidence Quality:
B; Recommendation Strength:
Moderate Recommendation).
10c. Clinicians should administer
a maximum 5 monthly doses
(15 mg/kg/dose) of palivizumab
during the respiratory syncytial
virus season to infants who
qualify for palivizumab in the
rst year of life (Evidence Quality:
B; Recommendation Strength:
11a. All people should disinfect hands
before and after direct contact
with patients, after contact with
inanimate objects in the direct
vicinity of the patient, and after
removing gloves (Evidence Quality: B; Recommendation Strength:
Strong Recommendation).
11b. All people should use alcoholbased rubs for hand decontamination when caring for children
with bronchiolitis. When alcoholbased rubs are not available,
individuals should wash their
hands with soap and water
(Evidence Quality: B; Recommendation Strength: Strong
Recommendation).
12a. Clinicians should inquire about
the exposure of the infant or
child to tobacco smoke when
assessing infants and children for bronchiolitis (Evidence
Quality: C; Recommendation
PEDIATRICS Volume 134, Number 5, November 2014
12b. Clinicians should counsel caregivers about exposing the infant or child to environmental
tobacco smoke and smoking
cessation when assessing a
child for bronchiolitis (Evidence
Quality: B; Recommendation
Strength: Strong).
13. Clinicians should encourage exclusive breastfeeding for at least
6 months to decrease the morbidity of respiratory infections.
(Evidence Quality: B; Recommendation Strength: Moderate Recommendation).
14. Clinicians and nurses should educate personnel and family members on evidence-based diagnosis,
treatment, and prevention in bronchiolitis. (Evidence Quality: C; observational studies; Recommendation
INTRODUCTION
In October 2006, the American Academy of Pediatrics (AAP) published the
clinical practice guideline Diagnosis
and Management of Bronchiolitis.1
The guideline offered recommendations
ranked according to level of evidence
and the benet-harm relationship. Since
completion of the original evidence review in July 2004, a signicant body of
literature on bronchiolitis has been
published. This update of the 2006 AAP
bronchiolitis guideline evaluates published evidence, including that used in
the 2006 guideline as well as evidence
published since 2004. Key action statements (KASs) based on that evidence
are provided.
The goal of this guideline is to provide
an evidence-based approach to the diagnosis, management, and prevention
of bronchiolitis in children from 1 month
through 23 months of age. The guideline
is intended for pediatricians, family
physicians, emergency medicine specialists, hospitalists, nurse practitioners,
e1475
and physician assistants who care for

these children. The guideline does not
apply to children with immunodeciencies, including those with HIV infection
or recipients of solid organ or hematopoietic stem cell transplants. Children
with underlying respiratory illnesses,
such as recurrent wheezing, chronic
neonatal lung disease (also known as
bronchopulmonary dysplasia), neuromuscular disease, or cystic brosis and
those with hemodynamically signicant
congenital heart disease are excluded
from the sections on management unless otherwise noted but are included in
the discussion of prevention. This guideline will not address long-term sequelae
of bronchiolitis, such as recurrent
wheezing or risk of asthma, which is
a eld with a large and distinct literature.
pneumovirus, inuenza, adenovirus,

coronavirus, human, and parainuenza viruses. In a study of inpatients
and outpatients with bronchiolitis,9
76% of patients had RSV, 39% had
human rhinovirus, 10% had inuenza,
2% had coronavirus, 3% had human
metapneumovirus, and 1% had parainuenza viruses (some patients had
coinfections, so the total is greater than
100%).
Bronchiolitis is the most common cause
of hospitalization among infants during
the rst 12 months of life. Approximately
100 000 bronchiolitis admissions occur
annually in the United States at an
estimated cost of $1.73 billion.10 One
prospective, population-based study
sponsored by the Centers for Disease
Control and Prevention reported the
average RSV hospitalization rate was

5.2 per 1000 children younger than 24
months of age during the 5-year period between 2000 and 2005.11 The
highest age-specic rate of RSV hospitalization occurred among infants
between 30 days and 60 days of age
(25.9 per 1000 children). For preterm
infants (<37 weeks gestation), the
RSV hospitalization rate was 4.6 per
1000 children, a number similar to
the RSV hospitalization rate for term
infants of 5.2 per 1000. Infants born
at <30 weeks gestation had the
highest hospitalization rate at 18.7
children per 1000, although the small
number of infants born before 30
weeks gestation make this number
unreliable. Other studies indicate the
RSV hospitalization rate in extremely
Bronchiolitis is a disorder commonly

caused by viral lower respiratory tract
infection in infants. Bronchiolitis is
characterized by acute inammation,
edema, and necrosis of epithelial cells
lining small airways, and increased
mucus production. Signs and symptoms typically begin with rhinitis and
cough, which may progress to tachypnea, wheezing, rales, use of accessory
muscles, and/or nasal aring.2
Many viruses that infect the respiratory
system cause a similar constellation of
signs and symptoms. The most common etiology of bronchiolitis is respiratory syncytial virus (RSV), with the
highest incidence of infection occurring
between December and March in North
America; however, regional variations
occur3 (Fig 1).4 Ninety percent of children are infected with RSV in the rst
2 years of life,5 and up to 40% will
experience lower respiratory tract infection during the initial infection.6,7
Infection with RSV does not grant permanent or long-term immunity, with
reinfections common throughout life.8
Other viruses that cause bronchiolitis
include human rhinovirus, human metae1476
FIGURE 1
RSV season by US regions. Centers for Disease Control and Prevention. RSV activityUnited States,
July 2011Jan 2013. MMWR Morb Mortal Wkly Rep. 2013;62(8):141144.
preterm infants is similar to that of

term infants.12,13
METHODS
In June 2013, the AAP convened a new
subcommittee to review and revise the
2006 bronchiolitis guideline. The subcommittee included primary care physicians, including general pediatricians,
a family physician, and pediatric subspecialists, including hospitalists, pulmonologists, emergency physicians, a
neonatologist, and pediatric infectious
disease physicians. The subcommittee also included an epidemiologist
trained in systematic reviews, a guideline methodologist/informatician, and a
parent representative. All panel members reviewed the AAP Policy on Conict
of Interest and Voluntary Disclosure and
were given an opportunity to declare any
potential conicts. Any conicts can be
found in the author listing at the end of
this guideline. All funding was provided
by the AAP, with travel assistance from
the American Academy of Family Physicians, the American College of Chest
Physicians, the American Thoracic
Society, and the American College
of Emergency Physicians for their
liaisons.
The evidence search and review included
electronic database searches in The
Cochrane Library, Medline via Ovid,
and CINAHL via EBSCO. The search
strategy is shown in the Appendix. Related article searches were conducted
in PubMed. The bibliographies of articles identied by database searches
were also reviewed by 1 of 4 members
of the committee, and references identied in this manner were added to
the review. Articles included in the
2003 evidence report on bronchiolitis
in preparation of the AAP 2006 guideline2 also were reviewed. In addition,
the committee reviewed articles published after completion of the systematic review for these updated
guidelines. The current literature re-
view encompasses the period from

2004 through May 2014.
The evidence-based approach to guideline development requires that the evidence in support of a policy be identied,
appraised, and summarized and that an
explicit link between evidence and recommendations be dened. Evidencebased recommendations reect the
quality of evidence and the balance of
benet and harm that is anticipated
when the recommendation is followed.
The AAP policy statement Classifying Recommendations for Clinical
Practice14 was followed in designating levels of recommendation (Fig 2;
Table 1).
A draft version of this clinical practice
guideline underwent extensive peer
review by committees, councils, and
sections within AAP; the American
Thoracic Society, American College of
Chest Physicians, American Academy
of Family Physicians, and American

College of Emergency Physicians; other
outside organizations; and other individuals identied by the subcommittee as experts in the eld. The
resulting comments were reviewed
by the subcommittee and, when appropriate, incorporated into the guideline.
This clinical practice guideline is not
intended as a sole source of guidance
in the management of children with
bronchiolitis. Rather, it is intended to
assist clinicians in decision-making.
It is not intended to replace clinical
judgment or establish a protocol for
the care of all children with bronchiolitis. These recommendations may not
provide the only appropriate approach
to the management of children with
bronchiolitis.
All AAP guidelines are reviewed every
5 years.
FIGURE 2
Integrating evidence quality appraisal with an assessment of the anticipated balance between benets
and harms leads to designation of a policy as a strong recommendation, moderate recommendation,
or weak recommendation.
e1477
TABLE 1 Guideline Denitions for Evidence-Based Statements

Statement
Denition
Implication
Strong recommendation
A particular action is favored because anticipated benets

clearly exceed harms (or vice versa), and quality of evidence
is excellent or unobtainable.
Moderate recommendation
A particular action is favored because anticipated benets
clearly exceed harms (or vice versa), and the quality of
evidence is good but not excellent (or is unobtainable).
Weak recommendation (based on A particular action is favored because anticipated benets
low-quality evidence
clearly exceed harms (or vice versa), but the quality of
evidence is weak.
Weak recommendation (based on Weak recommendation is provided when the aggregate
balance of benets and harms)
database shows evidence of both benet and harm that
appear similar in magnitude for any available courses of
action
DIAGNOSIS
Key Action Statement 1a
Clinicians should diagnose bronchiolitis and assess disease severity
on the basis of history and physical
examination (Evidence Quality: B;
Recommendation).
uation and management of children

with bronchiolitis (Evidence Quality:
B; Recommendation Strength: Moderate Recommendation).
Risk, harm, cost

Benet-harm
assessment
Value judgments
Intentional vagueness
Role of patient
preferences
Exclusions
Strength
Differences of opinion
B
Inexpensive,
noninvasive, accurate
Missing other
diagnoses
Benets outweigh
harms
None
None
None
None
None
Aggregate
evidence
quality
Benets
Clinicians should assess risk factors for severe disease, such as

age <12 weeks, a history of prematurity, underlying cardiopulmonary disease, or immunodeciency,
when making decisions about eval-
e1478
Aggregate
evidence
quality
Benets
Risk, harm, cost
Benet-harm
assessment
Value judgments
Intentional
vagueness
Role of patient
preferences
Exclusions
Strength
Differences of
opinion
Improved ability to predict

course of illness,
appropriate disposition
Possible unnecessary
hospitalization parental
anxiety
Benets outweigh harms
None
Assess is not dened
Risk, harm, cost
Benet-harm
assessment
Value judgments
Intentional
vagueness
Role of patient
preferences
Exclusions
None
None
None
Key Action Statement 1c

Key Action Statement 1b
Action Statement Prole KAS 1b
Action Statement Prole KAS 1a

Aggregate evidence
quality
Benets
Clinicians should follow a strong recommendation unless

a clear and compelling rationale for an alternative approach
is present.
Clinicians would be prudent to follow a moderate
recommendation but should remain alert to new
information and sensitive to patient preferences.
Clinicians would be prudent to follow a weak recommendation
but should remain alert to new information and very
sensitive to patient preferences.
Clinicians should consider the options in their decision making,
but patient preference may have a substantial role.
When clinicians diagnose bronchiolitis on the basis of history and

physical examination, radiographic
or laboratory studies should not be
obtained routinely (Evidence Quality: B; Recommendation Strength:
Strength
Differences of
opinion
Decreased radiation
exposure, noninvasive
(less procedure-associated
discomfort), decreased
antibiotic use, cost savings,
time saving
Misdiagnosis, missed
diagnosis of comorbid
condition
None
None
None
Infants and children with
unexpected worsening
disease
None
The main goals in the history and

physical examination of infants presenting with wheeze or other lower
respiratory tract symptoms, particularly
in the winter season, is to differentiate
infants with probable viral bronchiolitis
from those with other disorders. In addition, an estimate of disease severity
(increased respiratory rate, retractions,
decreased oxygen saturation) should
be made. Most clinicians recognize

bronchiolitis as a constellation of clinical signs and symptoms occurring in
children younger than 2 years, including a viral upper respiratory tract
prodrome followed by increased respiratory effort and wheezing. Clinical
signs and symptoms of bronchiolitis
consist of rhinorrhea, cough, tachypnea,
wheezing, rales, and increased respiratory effort manifested as grunting,
nasal aring, and intercostal and/or
subcostal retractions.
The course of bronchiolitis is variable
and dynamic, ranging from transient
events, such as apnea, to progressive
respiratory distress from lower airway
obstruction. Important issues to assess
in the history include the effects of respiratory symptoms on mental status,
feeding, and hydration. The clinician
should assess the ability of the family
to care for the child and to return for
further evaluation if needed. History
of underlying conditions, such as prematurity, cardiac disease, chronic
pulmonary disease, immunodeciency,
or episodes of previous wheezing, should
be identied. Underlying conditions that
may be associated with an increased
risk of progression to severe disease
or mortality include hemodynamically
signicant congenital heart disease,
chronic lung disease (bronchopulmonary
dysplasia), congenital anomalies,1517
in utero smoke exposure,18 and the
presence of an immunocompromising
state.19,20 In addition, genetic abnormalities have been associated with more
severe presentation with bronchiolitis.21
Assessment of a child with bronchiolitis,
including the physical examination, can
be complicated by variability in the disease state and may require serial
observations over time to fully assess the
childs status. Upper airway obstruction
contributes to work of breathing. Suctioning and positioning may decrease
the work of breathing and improve the
quality of the examination. Respiratory
rate in otherwise healthy children

changes considerably over the rst
year of life.2225 In hospitalized children,
the 50th percentile for respiratory rate
decreased from 41 at 0 to 3 months of
age to 31 at 12 to 18 months of age.26
Counting respiratory rate over the
course of 1 minute is more accurate
than shorter observations.27 The presence of a normal respiratory rate
suggests that risk of signicant viral
or bacterial lower respiratory tract
infection or pneumonia in an infant is
low (negative likelihood ratio approximately 0.5),2729 but the presence of
tachypnea does not distinguish between viral and bacterial disease.30,31
The evidence relating the presence of
specic ndings in the assessment of
bronchiolitis to clinical outcomes is
limited. Most studies addressing this
issue have enrolled children when
presenting to hospital settings, including a large, prospective, multicenter study that assessed a variety of
outcomes from the emergency department (ED) and varied inpatient
settings.18,32,33 Severe adverse events,
such as ICU admission and need for
mechanical ventilation, are uncommon
among children with bronchiolitis and
limit the power of these studies
to detect clinically important risk factors associated with disease progression.16,34,35 Tachypnea, dened as
a respiratory rate 70 per minute, has
been associated with increased risk of
severe disease in some studies3537 but
not others.38 Many scoring systems
have been developed in an attempt to
objectively quantify respiratory distress, although none has achieved
widespread acceptance and few have
demonstrated any predictive validity,
likely because of the substantial temporal variability in physical ndings in
infants with bronchiolitis.39
Pulse oximetry has been rapidly adopted
into clinical assessment of children
with bronchiolitis on the basis of data
suggesting that it reliably detects hypoxemia not suspected on physical

examination36,40; however, few studies
have assessed the effectiveness of
pulse oximetry to predict clinical outcomes. Among inpatients, perceived
need for supplemental oxygen on the
basis of pulse oximetry has been associated with prolonged hospitalization, ICU admission, and mechanical
ventilation.16,34,41 Among outpatients,
available evidence differs on whether
mild reductions in pulse oximetry (<95%
on room air) predict progression of
disease or need for a return observational visit.38
Apnea has been reported to occur with
a wide range of prevalence estimates
and viral etiologies.42,43 Retrospective,
hospital-based studies have included
a high proportion of infants with risk
factors, such as prematurity or neuromuscular disease, that may have biased
the prevalence estimates. One large
study found no apnea events for infants
assessed as low risk by using several
risk factors: age >1 month for full-term
infants or 48 weeks postconceptional
age for preterm infants, and absence
of any previous apneic event at presentation to the hospital.44 Another
large multicenter study found no association between the specic viral agent
and risk of apnea in bronchiolitis.42
The literature on viral testing for bronchiolitis has expanded in recent years
with the availability of sensitive polymerase chain reaction (PCR) assays.
Large studies of infants hospitalized for
bronchiolitis have consistently found
that 60% to 75% have positive test results
for RSV, and have noted coinfections
in up to one-third of infants.32,33,45
In the event an infant receiving
monthly prophylaxis is hospitalized
with bronchiolitis, testing should be
performed to determine if RSV is the
etiologic agent. If a breakthrough RSV
infection is determined to be present
based on antigen detection or other
e1479
assay, monthly palivizumab prophylaxis

should be discontinued because of the
very low likelihood of a second RSV
infection in the same year. Apart from
this setting, routine virologic testing is
not recommended.
and children with a diagnosis of

bronchiolitis (Evidence Quality: B;
Recommendation).
Infants with non-RSV bronchiolitis, in

particular human rhinovirus, appear to
have a shorter courses and may represent a different phenotype associated
with repeated wheezing.32 PCR assay
results should be interpreted cautiously,
given that the assay may detect prolonged viral shedding from an unrelated
previous illness, particularly with rhinovirus. In contrast, RSV detected by
PCR assay almost always is associated
with disease. At the individual patient
level, the value of identifying a specic viral etiology causing bronchiolitis has not been demonstrated.33
Aggregate
evidence
quality
Benets
Current evidence does not support

routine chest radiography in children
with bronchiolitis. Although many
infants with bronchiolitis have abnormalities on chest radiography, data
are insufcient to demonstrate that
chest radiography correlates well with
disease severity. Atelectasis on chest
radiography was associated with increased risk of severe disease in 1
outpatient study.16 Further studies, including 1 randomized trial, suggest
children with suspected lower respiratory tract infection who had radiography performed were more likely to
receive antibiotics without any difference in outcomes.46,47 Initial radiography
should be reserved for cases in which
respiratory effort is severe enough to
warrant ICU admission or where signs
of an airway complication (such as
pneumothorax) are present.
TREATMENT
ALBUTEROL
Key Action Statement 2
Clinicians should not administer
albuterol (or salbutamol) to infants
e1480
Action Statement Prole KAS 2
Risk, harm, cost

Benet-harm
assessment
Value judgments
Intentional
vagueness
Role of patient
preferences
Exclusions
Strength
Differences of
opinion
Notes
Avoid adverse effects, avoid

ongoing use of ineffective
medication, lower costs
Missing transient benet of
drug
Overall ineffectiveness
outweighs possible
transient benet
None
None
None
None
This guideline no longer
recommends a trial of
albuterol, as was considered
in the 2006 AAP bronchiolitis
guideline
Although several studies and reviews

have evaluated the use of bronchodilator medications for viral bronchiolitis,
most randomized controlled trials have
failed to demonstrate a consistent benet from - or -adrenergic agents.
Several meta-analyses and systematic
reviews4853 have shown that bronchodilators may improve clinical symptom
scores, but they do not affect disease
resolution, need for hospitalization, or
length of stay (LOS). Because clinical
scores may vary from one observer to
the next39,54 and do not correlate with
more objective measures, such as pulmonary function tests,55 clinical scores
are not validated measures of the efcacy of bronchodilators. Although transient improvements in clinical score
have been observed, most infants
treated with bronchodilators will not
benet from their use.
A recently updated Cochrane systematic review assessing the impact of

bronchodilators on oxygen saturation,
the primary outcome measure, reported
30 randomized controlled trials involving 1992 infants in 12 countries.56
Some studies included in this review
evaluated agents other than albuterol/
salbutamol (eg, ipratropium and metaproterenol) but did not include epinephrine. Small sample sizes, lack of
standardized methods for outcome
evaluation (eg, timing of assessments),
and lack of standardized intervention
(various bronchodilators, drug dosages,
routes of administration, and nebulization delivery systems) limit the interpretation of these studies. Because
of variable study designs as well as the
inclusion of infants who had a history of
previous wheezing in some studies,
there was considerable heterogeneity
in the studies. Sensitivity analysis (ie,
including only studies at low risk of
bias) signicantly reduced heterogeneity measures for oximetry while having
little effect on the overall effect size of
oximetry (mean difference [MD] 0.38,
95% condence interval [CI] 0.75 to
0.00). Those studies showing benet5759
are methodologically weaker than other
studies and include older children with
recurrent wheezing. Results of the
Cochrane review indicated no benet in
the clinical course of infants with
bronchiolitis who received bronchodilators. The potential adverse effects
(tachycardia and tremors) and cost of
these agents outweigh any potential
benets.
In the previous iteration of this guideline,
a trial of -agonists was included as
an option. However, given the greater
strength of the evidence demonstrating no benet, and that there is no
well-established way to determine an
objective method of response to
bronchodilators in bronchiolitis, this
option has been removed. Although it
is true that a small subset of children
with bronchiolitis may have reversible

airway obstruction resulting from
smooth muscle constriction, attempts
to dene a subgroup of responders
have not been successful to date. If
a clinical trial of bronchodilators is
undertaken, clinicians should note that the
variability of the disease process, the hosts
airway, and the clinical assessments, particularly scoring, would limit the clinicians
ability to observe a clinically relevant response to bronchodilators.
Chavasse et al60 reviewed the available
literature on use of -agonists for children younger than 2 years with recurrent wheezing. At the time of that
review, there were 3 studies in the
outpatient setting, 2 in the ED, and 3
in the pulmonary function laboratory
setting. This review concluded there
were no clear benets from the use
of -agonists in this population. The
authors noted some conicting evidence, but further study was recommended only if the population could be
clearly dened and meaningful outcome measures could be identied.
The population of children with bronchiolitis studied in most trials of
bronchodilators limits the ability to
make recommendations for all clinical
scenarios. Children with severe disease
or with respiratory failure were generally excluded from these trials, and
this evidence cannot be generalized to
these situations. Studies using pulmonary function tests show no effect of
albuterol among infants hospitalized
with bronchiolitis.56,61 One study in
a critical care setting showed a small
decrease in inspiratory resistance after albuterol in one group and levalbuterol in another group, but therapy
was accompanied by clinically signicant tachycardia.62 This small clinical
change occurring with signicant adverse effects does not justify recommending albuterol for routine care.
EPINEPHRINE
epinephrine to infants and children
with a diagnosis of bronchiolitis
(Evidence Quality: B; Recommendation Strength: Strong Recommendation).
Aggregate
evidence
quality
Benets
Risk, harm, cost
Avoiding adverse effects, lower

costs, avoiding ongoing use
of ineffective medication
Missing transient benet of
drug
Benet-harm
assessment
Value judgments The overall ineffectiveness
outweighs possible transient
benet
Intentional
None
vagueness
Role of patient
None
preferences
Exclusions
Rescue treatment of rapidly
deteriorating patients
Strength
Differences of
None
opinion
Epinephrine is an adrenergic agent

with both - and -receptor agonist
activity that has been used to treat
upper and lower respiratory tract illnesses both as a systemic agent and
directly into the respiratory tract,
where it is typically administered as
a nebulized solution. Nebulized epinephrine has been administered in
the racemic form and as the puried
L-enantiomer, which is commercially
available in the United States for intravenous use. Studies in other diseases, such as croup, have found no
difference in efcacy on the basis of
preparation,63 although the comparison has not been specically studied
for bronchiolitis. Most studies have
compared L-epinephrine to placebo or
albuterol. A recent Cochrane meta-
analysis by Hartling et al64 systematically evaluated the evidence on this

topic and found no evidence for utility
in the inpatient setting. Two large,
multicenter randomized trials comparing nebulized epinephrine to placebo65 or albuterol66 in the hospital
setting found no improvement in LOS
or other inpatient outcomes. A recent,
large multicenter trial found a similar
lack of efcacy compared with placebo and further demonstrated longer LOS when epinephrine was used
on a xed schedule compared with an
as-needed schedule.67 This evidence
suggests epinephrine should not be
used in children hospitalized for bronchiolitis, except potentially as a rescue
agent in severe disease, although formal study is needed before a recommendation for the use of epinephrine
in this setting.
The role of epinephrine in the outpatient setting remains controversial. A major addition to the evidence
base came from the Canadian Bronchiolitis Epinephrine Steroid Trial.68
This multicenter randomized trial
enrolled 800 patients with bronchiolitis from 8 EDs and compared
hospitalization rates over a 7-day
period. This study had 4 arms: nebulized epinephrine plus oral dexamethasone, nebulized epinephrine
plus oral placebo, nebulized placebo
plus oral dexamethasone, and nebulized placebo plus oral placebo. The
group of patients who received epinephrine concomitantly with corticosteroids had a lower likelihood
of hospitalization by day 7 than the
double placebo group, although this
effect was no longer statistically signicant after adjusting for multiple
comparisons.
The systematic review by Hartling
et al64 concluded that epinephrine
reduced hospitalizations compared
with placebo on the day of the ED visit
but not overall. Given that epinephrine
e1481
has a transient effect and home administration is not routine practice,

discharging an infant after observing
a response in a monitored setting
raises concerns for subsequent progression of illness. Studies have not
found a difference in revisit rates,
although the numbers of revisits are
small and may not be adequately
powered for this outcome. In summary,
the current state of evidence does not
support a routine role for epinephrine for bronchiolitis in outpatients,
although further data may help to
better dene this question.
Recommendation [based on randomized controlled trials with

inconsistent ndings]).
Aggregate
evidence
quality
Benets
May shorten hospital stay if LOS

is >72 h
Risk, harm, cost Adverse effects such as
wheezing and excess
secretions; cost
Benet-harm
Benets outweigh harms for
assessment
longer hospital stays
Value judgments Anticipating an individual
childs LOS is difcult. Most
US hospitals report an
average LOS of <72 h for
patients with bronchiolitis.
This weak recommendation
applies only if the average
length of stay is >72 h
Intentional
This weak recommendation is
vagueness
based on an average LOS and
does not address the
individual patient.
Role of patient
None
preferences
Exclusions
None
Strength
Weak
Differences of
None
opinion
for the analysis of LOS with an aggregate

1-day decrease reported, a result largely
driven by the inclusion of 3 studies with
relatively long mean length of stay of 5 to
6 days. The analysis of effect on clinical
scores included 7 studies involving 640
patients in both inpatient and outpatient
settings and demonstrated incremental
positive effect with each day posttreatment from day 1 to day 3 (0.88 MD on
day 1, 1.32 MD on day 2, and 1.51 MD
on day 3). Finally, Zhang et al73 found no
effect on hospitalization rates in the
pooled analysis of 1 outpatient and 3 ED
studies including 380 total patients.
Nebulized hypertonic saline is an increasingly studied therapy for acute

viral bronchiolitis. Physiologic evidence
suggests that hypertonic saline increases mucociliary clearance in both
normal and diseased lungs.6971 Because
the pathology in bronchiolitis involves
airway inammation and resultant
mucus plugging, improved mucociliary clearance should be benecial, although there is only indirect evidence
to support such an assertion. A more
specic theoretical mechanism of action has been proposed on the basis of
the concept of rehydration of the airway surface liquid, although again,
evidence remains indirect.72
Several randomized trials published after

the Cochrane review period further informed the current guideline recommendation. Four trials evaluated admission
rates from the ED, 3 using 3% saline and 1
using 7% saline.7476 A single trial76 demonstrated a difference in admission rates
from the ED favoring hypertonic saline,
although the other 4 studies were concordant with the studies included in the
Cochrane review. However, contrary to the
studies included in the Cochrane review,
none of the more recent trials reported
improvement in LOS and, when added to
the older studies for an updated metaanalysis, they signicantly attenuate the
summary estimate of the effect on LOS.76,77
Most of the trials included in the Cochrane
review occurred in settings with typical
LOS of more than 3 days in their usual
care arms. Hence, the signicant decrease
in LOS noted by Zhang et al73 may not be
generalizable to the United States where
the average LOS is 2.4 days.10 One other
ongoing clinical trial performed in the
United States, unpublished except in abstract form, further supports the observation that hypertonic saline does not
decrease LOS in settings where expected
stays are less than 3 days.78
Clinicians may administer nebulized

hypertonic saline to infants and
children hospitalized for bronchiolitis (Evidence Quality: B; Recommendation Strength: Weak
A 2013 Cochrane review73 included 11

trials involving 1090 infants with mild to
moderate disease in both inpatient and
emergency settings. There were 6 studies
involving 500 inpatients providing data
The preponderance of the evidence suggests that 3% saline is safe and effective at
improving symptoms of mild to moderate
bronchiolitis after 24 hours of use and
reducing hospital LOS in settings in which
HYPERTONIC SALINE
Nebulized hypertonic saline should
not be administered to infants with
a diagnosis of bronchiolitis in the
emergency department (Evidence
Quality: B; Recommendation Strength:
Aggregate
evidence
quality
Benets
Risk, harm, cost

Benet-harm
assessment
Value judgments
Intentional
vagueness
Role of patient
preferences
Exclusions
Strength
Differences of
opinion
e1482
Avoiding adverse effects, such

as wheezing and excess
secretions, cost
None
None
None
None
None
None
the duration of stay typically exceeds 3

days. It has not been shown to be effective
at reducing hospitalization in emergency
settings or in areas where the length
of usage is brief. It has not been
studied in intensive care settings,
and most trials have included only
patients with mild to moderate disease. Most studies have used a 3%
saline concentration, and most have
combined it with bronchodilators
with each dose; however, there is
retrospective evidence that the rate
of adverse events is similar without
bronchodilators,79 as well as prospective evidence extrapolated from
2 trials without bronchodilators.79,80
A single study was performed in the
ambulatory outpatient setting81; however, future studies in the United States
should focus on sustained usage on
the basis of pattern of effects discerned in the available literature.
CORTICOSTEROIDS
systemic corticosteroids to infants
with a diagnosis of bronchiolitis in
any setting (Evidence Quality: A;
Recommendation).
Aggregate
A
evidence quality
Benets
No clinical benet, avoiding
adverse effects
Risk, harm, cost
None
Benet-harm
assessment
Value judgments
None
Intentional
None
vagueness
Role of patient
None
preferences
Exclusions
None
Strength
Differences of
None
opinion
Although there is good evidence of

benet from corticosteroids in other
respiratory diseases, such as asthma

and croup,8284 the evidence on corticosteroid use in bronchiolitis is negative. The most recent Cochrane
systematic review shows that corticosteroids do not signicantly reduce
outpatient admissions when compared
with placebo (pooled risk ratio, 0.92;
95% CI, 0.78 to 1.08; and risk ratio, 0.86;
95% CI, 0.7 to 1.06, respectively) and
do not reduce LOS for inpatients (MD
0.18 days; 95% CI 0.39 to 0.04).85 No
other comparisons showed relevant
differences for either primary or secondary outcomes. This review contained 17 trials with 2596 participants
and included 2 large ED-based randomized trials, neither of which showed
reductions in hospital admissions with
treatment with corticosteroids as compared with placebo.69,86
One of these large trials, the Canadian
Bronchiolitis Epinephrine Steroid Trial,
however, did show a reduction in hospitalizations 7 days after treatment with
combined nebulized epinephrine and
oral dexamethasone as compared with
placebo.69 Although an unadjusted analysis showed a relative risk for hospitalization of 0.65 (95% CI 0.45 to 0.95;
P = .02) for combination therapy as
compared with placebo, adjustment
for multiple comparison rendered the
result insignicant (P = .07). These
results have generated considerable
controversy.87 Although there is no
standard recognized rationale for why
combination epinephrine and dexamethasone would be synergistic in
infants with bronchiolitis, evidence in
adults and children older than 6
years with asthma shows that adding
inhaled long-acting agonists to
moderate/high doses of inhaled corticosteroids allows reduction of the
corticosteroid dose by, on average,
60%.88 Basic science studies focused
on understanding the interaction between agonists and corticosteroids
have shown potential mechanisms for
why simultaneous administration of

these drugs could be synergistic.8992
However, other bronchiolitis trials of
corticosteroids administered by using xed simultaneous bronchodilator regimens have not consistently
shown benet9397; hence, a recommendation regarding the benet of combined dexamethasone and epinephrine
therapy is premature.
The systematic review of corticosteroids in children with bronchiolitis
cited previously did not nd any differences in short-term adverse events
as compared with placebo.86 However,
corticosteroid therapy may prolong
viral shedding in patients with bronchiolitis.17
In summary, a comprehensive systematic review and large multicenter
randomized trials provide clear evidence that corticosteroids alone do
not provide signicant benet to
children with bronchiolitis. Evidence
for potential benet of combined
corticosteroid and agents with both
- and -agonist activity is at best
tentative, and additional large trials
are needed to clarify whether this
therapy is effective.
Further, although there is no evidence
of short-term adverse effects from
corticosteroid therapy, other than
prolonged viral shedding, in infants
and children with bronchiolitis, there
is inadequate evidence to be certain
of safety.
OXYGEN
Clinicians may choose not to administer supplemental oxygen if the
oxyhemoglobin saturation exceeds
90% in infants and children with a
diagnosis of bronchiolitis (Evidence
Quality: D; Recommendation Strength:
Weak Recommendation [based on
low-level evidence and reasoning
from rst principles]).
e1483

Benets
Risk, harm, cost
Decreased hospitalizations,
decreased LOS
Hypoxemia, physiologic stress,
prolonged LOS, increased
hospitalizations, increased
LOS, cost
Benet-harm
assessment
Value judgments Oxyhemoglobin saturation
>89% is adequate to
oxygenate tissues; the risk
of hypoxemia with
oxyhemoglobin saturation
>89% is minimal
Intentional
None
vagueness
Role of patient
Limited
preferences
Exclusions
Children with acidosis or fever
Strength
Weak recommendation (based
on low-level evidence/
reasoning from rst
principles)
Differences of
None
opinion

Clinicians may choose not to use
continuous pulse oximetry for infants and children with a diagnosis
of bronchiolitis (Evidence Quality:
C; Recommendation Strength: Weak
Recommendation [based on lowerlevel evidence]).
Aggregate
evidence
quality
Benets
Risk, harm, cost
Benet-harm
assessment
Value judgments
Intentional
vagueness
Role of patient
preferences
Exclusions
Strength
Differences of
opinion
Shorter LOS, decreased alarm

fatigue, decreased cost
Delayed detection of hypoxemia,
delay in appropriate weaning
of oxygen
None
None
Limited
None
Weak recommendation (based
on lower level of evidence)
None
Although oxygen saturation is a poor

predictor of respiratory distress, it is
e1484
associated closely with a perceived

need for hospitalization in infants with
bronchiolitis.98,99 Additionally, oxygen
saturation has been implicated as
a primary determinant of LOS in
bronchiolitis.40,100,101
Physiologic data based on the oxyhemoglobin dissociation curve (Fig 3)
demonstrate that small increases in
arterial partial pressure of oxygen are
associated with marked improvement
in pulse oxygen saturation when the
latter is less than 90%; with pulse oxygen saturation readings greater than
90% it takes very large elevations in
arterial partial pressure of oxygen to
affect further increases. In infants and
children with bronchiolitis, no data exist
to suggest such increases result in any
clinically signicant difference in physiologic function, patient symptoms, or
clinical outcomes. Although it is well
understood that acidosis, temperature,
and 2,3-diphosphoglutarate inuence
the oxyhemoglobin dissociation curve,
there has never been research to
demonstrate how those inuences
practically affect infants with hypoxemia. The risk of hypoxemia must be
weighed against the risk of hospitalization when making any decisions
about site of care. One study of hospitalized children with bronchiolitis, for
example, noted a 10% adverse error or
near-miss rate for harm-causing interventions.103 There are no studies on the
effect of short-term, brief periods of
hypoxemia such as may be seen in
bronchiolitis. Transient hypoxemia is
common in healthy infants.104 Travel of
healthy children even to moderate altitudes of 1300 m results in transient
sleep desaturation to an average of
84% with no known adverse consequences.105 Although children with
chronic hypoxemia do incur developmental and behavioral problems,
children who suffer intermittent hypoxemia from diseases such as asthma
do not have impaired intellectual abilities or behavioral disturbance.106108

Supplemental oxygen provided for infants not requiring additional respiratory support is best initiated with
nasal prongs, although exact measurement of fraction of inspired oxygen is unreliable with this method.109
Pulse oximetry is a convenient method
to assess the percentage of hemoglobin bound by oxygen in children.
Pulse oximetry has been erroneously
used in bronchiolitis as a proxy for
respiratory distress. Accuracy of pulse
oximetry is poor, especially in the 76%
to 90% range.110 Further, it has been
well demonstrated that oxygen saturation has much less impact on respiratory drive than carbon dioxide
concentrations in the blood.111 There
is very poor correlation between respiratory distress and oxygen saturations among infants with lower
respiratory tract infections.112 Other
than cyanosis, no published clinical
sign, model, or score accurately identies hypoxemic children.113
Among children admitted for bronchiolitis, continuous pulse oximetry measurement is not well studied and
potentially problematic for children who
do not require oxygen. Transient desaturation is a normal phenomenon in
healthy infants. In 1 study of 64 healthy
infants between 2 weeks and 6 months
of age, 60% of these infants exhibited
a transient oxygen desaturation below
90%, to values as low as 83%.105 A retrospective study of the role of continuous measurement of oxygenation in
infants hospitalized with bronchiolitis
found that 1 in 4 patients incur unnecessarily prolonged hospitalization as
a result of a perceived need for oxygen
outside of other symptoms40 and no
evidence of benet was found.
Pulse oximetry is prone to errors of
measurement. Families of infants hospitalized with continuous pulse oximeters
are exposed to frequent alarms that
FIGURE 3
Oxyhemoglobin dissociation curve showing percent saturation of hemoglobin at various partial
pressures of oxygen (reproduced with permission from the educational Web site www.anaesthesiauk.
com).102
may negatively affect sleep. Alarm fatigue is recognized by The Joint

Commission as a contributor toward
in-hospital morbidity and mortality.114
One adult study demonstrated very
poor documentation of hypoxemia alerts by pulse oximetry, an indicator
of alarm fatigue.115 Pulse oximetry
probes can fall off easily, leading to
inaccurate measurements and alarms.116
False reliance on pulse oximetry may
lead to less careful monitoring of respiratory status. In one study, continuous pulse oximetry was associated
with increased risk of minor adverse
events in infants admitted to a general ward.117 The pulse oximetry
monitored patients were found to
have less-effective surveillance of their
severity of illness when controlling for
other variables.
There are a number of new approaches
to oxygen delivery in bronchiolitis, 2
of which are home oxygen and highfrequency nasal cannula. There is
emerging evidence for the role of home
oxygen in reducing LOS or admission
rate for infants with bronchiolitis, in-
cluding 2 randomized trials.118,119 Most

of the studies have been performed in
areas of higher altitude, where prolonged hypoxemia is a prime determinant of LOS in the hospital.120,121
Readmission rates may be moderately
higher in patients discharged with
home oxygen; however, overall hospital
use may be reduced,122 although not in
all settings.123 Concerns have been
raised that home pulse oximetry may
complicate care or confuse families.124
Communication with follow-up physicians is important, because primary
care physicians may have difculty determining safe pulse oximetry levels
for discontinuation of oxygen.125 Additionally, there may be an increased
demand for follow-up outpatient visits
associated with home oxygen use.124
Use of humidied, heated, high-ow
nasal cannula to deliver air-oxygen
mixtures provides assistance to infants with bronchiolitis through multiple proposed mechanisms.126 There
is evidence that high-ow nasal cannula improves physiologic measures
of respiratory effort and can generate
continuous positive airway pressure

in bronchiolitis.127130 Clinical evidence
suggests it reduces work of breathing131,132 and may decrease need for
intubation,133136 although studies are
generally retrospective and small. The
therapy has been studied in the ED136,137
and the general inpatient setting,134,138
as well as the ICU. The largest and most
rigorous retrospective study to date
was from Australia,138 which showed
a decline in intubation rate in the subgroup of infants with bronchiolitis (n =
330) from 37% to 7% after the introduction of high-ow nasal cannula,
while the national registry intubation
rate remained at 28%. A single pilot
for a randomized trial has been published to date.139 Although promising,
the absence of any completed randomized trial of the efcacy of high-ow
nasal cannula in bronchiolitis precludes
specic recommendations on it use at
present. Pneumothorax is a reported
complication.
CHEST PHYSIOTHERAPY
Clinicians should not use chest physiotherapy for infants and children
with a diagnosis of bronchiolitis (Evidence Quality: B; Recommendation
Aggregate
evidence
quality
Benets
Risk, harm, cost
Benet-harm
assessment
Value judgments
Intentional
vagueness
Role of patient
preferences
Exclusions
Strength
Differences of
opinion
Decreased stress from

therapy, reduced cost
None
None
None
None
None
None
e1485
Airway edema, sloughing of respiratory

epithelium into airways, and generalized hyperination of the lungs, coupled
with poorly developed collateral ventilation, put infants with bronchiolitis at
risk for atelectasis. Although lobar atelectasis is not characteristic of this
disease, chest radiographs may show
evidence of subsegmental atelectasis,
prompting clinicians to consider ordering chest physiotherapy to promote
airway clearance. A Cochrane Review140
found 9 randomized controlled trials
that evaluated chest physiotherapy in
hospitalized patients with bronchiolitis.
No clinical benet was found by using
vibration or percussion (5 trials)141144
or passive expiratory techniques (4 trials).145148 Since that review, a study149
of the passive expiratory technique
found a small, but signicant reduction
in duration of oxygen therapy, but no
other benets.
Suctioning of the nasopharynx to remove secretions is a frequent practice
in infants with bronchiolitis. Although
suctioning the nares may provide
temporary relief of nasal congestion
or upper airway obstruction, a retrospective study reported that deep
suctioning150 was associated with
longer LOS in hospitalized infants 2
to 12 months of age. The same study
also noted that lapses of greater
than 4 hours in noninvasive, external
nasal suctioning were also associated with longer LOS. Currently, there
are insufcient data to make a recommendation about suctioning, but
it appears that routine use of deep
suctioning151,153 may not be benecial.

Aggregate
evidence
quality
Benets
Fewer adverse effects, less

resistance to
antibacterial agents,
lower cost
Risk, harm, cost None
Benet-harm
assessment
Value judgments None
Intentional
Strong suspicion is not
vagueness
specically dened
and requires clinician
judgment. An evaluation
for the source of possible
serious bacterial infection
should be completed
before antibiotic use
Role of patient None
preferences
Exclusions
None
Strength
Differences of
None
opinion
Infants with bronchiolitis frequently receive antibacterial therapy because of

fever,152 young age,153 and concern for
secondary bacterial infection.154 Early
randomized controlled trials 155,156
showed no benet from routine antibacterial therapy for children with
bronchiolitis. Nonetheless, antibiotic
therapy continues to be overused in
young infants with bronchiolitis because
of concern for an undetected bacterial
infection. Studies have shown that febrile
infants without an identiable source of
fever have a risk of bacteremia that may
be as high as 7%. However, a child with
a distinct viral syndrome, such as
bronchiolitis, has a lower risk (much
less than 1%) of bacterial infection of the
cerebrospinal uid or blood.157

antibacterial medications to infants
and children with a diagnosis of
bronchiolitis unless there is a concomitant bacterial infection, or a
strong suspicion of one. (Evidence
Ralston et al158 conducted a systematic

review of serious bacterial infections
(SBIs) occurring in hospitalized febrile
infants between 30 and 90 days of age
with bronchiolitis. Instances of bacteremia or meningitis were extremely rare.
ANTIBACTERIALS
e1486
Enteritis was not evaluated. Urinary tract

infection occurred at a rate of approximately 1%, but asymptomatic bacteriuria may have explained this nding. The
authors concluded routine screening for
SBI among hospitalized febrile infants
with bronchiolitis between 30 and 90
days of age is not justied. Limited data
suggest the risk of bacterial infection in
hospitalized infants with bronchiolitis
younger than 30 days of age is similar to
the risk in older infants. An abnormal
white blood cell count is not useful for
predicting a concurrent SBI in infants
and young children hospitalized with RSV
lower respiratory tract infection.159 Several retrospective studies support this
conclusion.160166 Four prospective studies of SBI in patients with bronchiolitis
and/or RSV infections also demonstrated
low rates of SBI.167171
Approximately 25% of hospitalized infants with bronchiolitis have radiographic evidence of atelectasis, and it
may be difcult to distinguish between
atelectasis and bacterial inltrate or
consolidation.169 Bacterial pneumonia
in infants with bronchiolitis without
consolidation is unusual.170 Antibiotic
therapy may be justied in some children with bronchiolitis who require
intubation and mechanical ventilation
for respiratory failure.172,173
Although acute otitis media (AOM) in
infants with bronchiolitis may be attributable to viruses, clinical features
generally do not permit differentiation of
viral AOM from those with a bacterial
component.174 Two studies address the
frequency of AOM in patients with
bronchiolitis. Andrade et al175 prospectively identied AOM in 62% of 42
patients who presented with bronchiolitis. AOM was present in 50% on entry
to the study and developed in an additional 12% within 10 days. A subsequent
report176 followed 150 children hospitalized for bronchiolitis for the development of AOM. Seventy-nine (53%)
developed AOM, two-thirds within the
rst 2 days of hospitalization. AOM did

not inuence the clinical course or
laboratory ndings of bronchiolitis. The
current AAP guideline on AOM177 recommends that a diagnosis of AOM
should include bulging of the tympanic
membrane. This is based on bulging
being the best indicator for the presence of bacteria in multiple tympanocentesis studies and on 2 articles
comparing antibiotic to placebo therapy that used a bulging tympanic
membrane as a necessary part of the
diagnosis.178,179 New studies are needed
to determine the incidence of AOM in
bronchiolitis by using the new criterion
of bulging of the tympanic membrane.
Refer to the AOM guideline180 for recommendations regarding the management of AOM.
NUTRITION AND HYDRATION

Clinicians should administer nasogastric or intravenous uids for
infants with a diagnosis of bronchiolitis who cannot maintain hydration orally (Evidence Quality: X;
Recommendation).
Aggregate evidence quality
Benets
Risk, harm, cost
Benet-harm assessment
Value judgments
Role of patient preferences
Exclusions
Strength
chiolitis. One study found that food intake at less than 50% of normal for the
previous 24 hours is associated with
a pulse oximetry value of <95%.180
Infants with mild respiratory distress
may require only observation, particularly if feeding remains unaffected.
When the respiratory rate exceeds 60
to 70 breaths per minute, feeding may
be compromised, particularly if nasal
secretions are copious. There is limited
evidence to suggest coordination of
breathing with swallowing may be
impaired among infants with bronchiolitis.181 These infants may develop
increased nasal aring, retractions,
and prolonged expiratory wheezing
when fed and may be at increased risk
of aspiration.182
One study estimated that one-third of
infants hospitalized for bronchiolitis
require uid replacement.183 One
case series184 and 2 randomized
trials,185,186 examined the comparative efcacy and safety of the intravenous and nasogastric routes
for uid replacement. A pilot trial
in Israel that included 51 infants
younger than 6 months demonstrated no signicant differences in
the duration of oxygen needed or
time to full oral feeds between
X
Maintaining hydration
Risk of infection, risk of aspiration with nasogastric tube, discomfort,
hyponatremia, intravenous inltration, overhydration
None
None
Shared decision as to which mode is used
None
None
The level of respiratory distress

attributable to bronchiolitis guides
the indications for uid replacement.
Conversely, food intake in the previous
24 hours may be a predictor of oxygen
saturation among infants with bron-
infants receiving intravenous 5%

dextrose in normal saline solution
or nasogastric breast milk or formula.187 Infants in the intravenous
group had a shorter LOS (100 vs 120
hours) but it was not statistically
signicant. In a larger open randomized trial including infants between 2 and 12 months of age and
conducted in Australia and New
Zealand, there were no signicant
differences in rates of admission to
ICUs, need for ventilatory support,
and adverse events between 381
infants assigned to nasogastric hydration and 378 infants assigned to
intravenous hydration.188 There was
a difference of 4 hours in mean LOS
between the intravenous group (82.2
hours) and the nasogastric group
(86.2 hours) that was not statistically signicant. The nasogastric
route had a higher success rate of
insertion than the intravenous
route. Parental satisfaction scores
did not differ between the intravenous and nasogastric groups.
These studies suggest that infants
who have difculty feeding safely
because of respiratory distress can
receive either intravenous or nasogastric uid replacement; however,
more evidence is needed to increase
the strength of this recommendation.
The possibility of uid retention related to production of antidiuretic
hormone has been raised in patients
with bronchiolitis.187189 Therefore,
receipt of hypotonic uid replacement and maintenance uids may
increase the risk of iatrogenic hyponatremia in these infants. A recent
meta-analysis demonstrated that among
hospitalized children requiring maintenance uids, the use of hypotonic
uids was associated with signicant
hyponatremia compared with isotonic uids in older children.190 Use
of isotonic uids, in general, appears
to be safer.
PREVENTION
palivizumab to otherwise healthy
e1487
infants with a gestational age of 29

weeks, 0 days or greater (Evidence
Aggregate evidence
quality
Benets
Reduced pain of
injections, reduced
use of a medication
that has shown
minimal benet,
reduced adverse
effects, reduced
visits to health care
provider with less
exposure to illness
Risk, harm, cost
Minimal increase in risk
of RSV hospitalization
Benet-harm assessment Benets outweigh
harms
Value judgments
None
None
Role of patient
Parents may choose to
preferences
not accept
palivizumab
Exclusions
Infants with chronic
lung disease of
prematurity and
hemodynamically
signicant cardiac
disease (as described
in KAS 10b)
Strength
Recommendation
None
Notes
This KAS is harmonized
with the AAP policy
statement on
palivizumab

Benets
B
Reduced risk of RSV
hospitalization
Risk, harm, cost
Injection pain;
increased risk of
illness from
increased visits to
clinician ofce or
clinic; cost; side
effects from
palivizumab
Benets outweigh
harms
Value judgments
None
None
Role of patient preferences Parents may choose
to not accept
palivizumab
Exclusions
None
Strength
Moderate
recommendation
None
Notes
This KAS is
harmonized with
the AAP policy
statement on
palivizumab191,192
Key Action Statement 10c

Clinicians should administer a maximum 5 monthly doses (15 mg/kg/
dose) of palivizumab during the
RSV season to infants who qualify
for palivizumab in the rst year
of life (Evidence Quality: B, Recommendation Strength: Moderate
Recommendation).
Action Statement Prole KAS 10c
Benets
Risk, harm, cost

Clinicians should administer palivizumab during the rst year of
life to infants with hemodynamically signicant heart disease or
chronic lung disease of prematurity dened as preterm infants
<32 weeks, 0 days gestation who
require >21% oxygen for at least
the rst 28 days of life (Evidence
e1488
Value judgments
Exclusions
Strength
Notes
Palivizumab was licensed by the US

Food and Drug Administration in June
1998 largely on the basis of results of 1
clinical trial.193 The results of a second
clinical trial among children with congenital heart disease were reported in
December 2003.194 No other prospective, randomized, placebo-controlled
trials have been conducted in any
subgroup. Since licensure of palivizumab, new peer-reviewed publications provide greater insight into
the epidemiology of disease caused by
RSV.195197 As a result of new data, the
Bronchiolitis Guideline Committee and
the Committee on Infectious Diseases
have updated recommendations for
use of prophylaxis.
PREMATURITY
Monthly palivizumab prophylaxis should
be restricted to infants born before 29
weeks, 0 days gestation, except for
infants who qualify on the basis of
congenital heart disease or chronic
lung disease of prematurity. Data
show that infants born at or after 29
weeks, 0 days gestation have an RSV
hospitalization rate similar to the rate
of full-term infants.11,198 Infants with
a gestational age of 28 weeks, 6 days
or less who will be younger than 12
months at the start of the RSV season should receive a maximum of 5
B
Reduced risk of hospitalization; reduced admission to ICU
Injection pain; increased risk of illness from increased visits to clinician
ofce or clinic; cost; adverse effects of palivizumab
None
None
None
Fewer doses should be used if the bronchiolitis season ends before the
completion of 5 doses; if the child is hospitalized with a breakthrough RSV,
monthly prophylaxis should be discontinued
None
This KAS is harmonized with the AAP policy statement on palivizumab191,192
Detailed evidence to support the policy

statement on palivizumab and this
palivizumab section can be found in the
technical report on palivizumab.192
monthly doses of palivizumab or until

the end of the RSV season, whichever
comes rst. Depending on the month
of birth, fewer than 5 monthly doses
will provide protection for most infants for the duration of the season.
CONGENITAL HEART DISEASE

Despite the large number of subjects
enrolled, little benet from palivizumab prophylaxis was found in
the industry-sponsored cardiac study
among infants in the cyanotic group
(7.9% in control group versus 5.6% in
palivizumab group, or 23 fewer hospitalizations per1000 children; P =
.285).197 In the acyanotic group (11.8%
vs 5.0%), there were 68 fewer RSV
hospitalizations per 1000 prophylaxis
recipients (P = .003).197,199,200
CHRONIC LUNG DISEASE OF

PREMATURITY
Palivizumab prophylaxis should be
administered to infants and children
younger than 12 months who develop
chronic lung disease of prematurity,
dened as a requirement for 28 days
of more than 21% oxygen beginning
at birth. If a child meets these criteria and is in the rst 24 months of
life and continues to require supplemental oxygen, diuretic therapy,
or chronic corticosteroid therapy
within 6 months of the start of the
RSV season, monthly prophylaxis should
be administered for the remainder of
the season.
NUMBER OF DOSES
Community outbreaks of RSV disease
usually begin in November or December,
peak in January or February, and end by
late March or, at times, in April.4 Figure 1
shows the 20112012 bronchiolitis season, which is typical of most years.
Because 5 monthly doses will provide
more than 24 weeks of protective serum palivizumab concentration, administration of more than 5 monthly doses
is not recommended within the continental United States. For infants who
qualify for 5 monthly doses, initiation of
prophylaxis in November and continua-
tion for a total of 5 doses will provide

protection into April.201 If prophylaxis is
initiated in October, the fth and nal
dose should be administered in February, and protection will last into March
for most children.
SECOND YEAR OF LIFE

Because of the low risk of RSV hospitalization in the second year of life,
palivizumab prophylaxis is not recommended for children in the second year
of life with the following exception.
Children who satisfy the denition of
chronic lung disease of infancy and
continue to require supplemental oxygen, chronic corticosteroid therapy,
or diuretic therapy within 6 months
of the onset of the second RSV season may be considered for a second
season of prophylaxis.
OTHER CONDITIONS
Insufcient data are available to recommend routine use of prophylaxis in
children with Down syndrome, cystic
brosis, pulmonary abnormality, neuromuscular disease, or immune compromise.
Down Syndrome
Routine use of prophylaxis for children
in the rst year of life with Down
syndrome is not recommended unless
the child qualies because of cardiac
disease or prematurity.202
Cystic Fibrosis
Routine use of palivizumab prophylaxis
in patients with cystic brosis is not
recommended.203,204 Available studies
indicate the incidence of RSV hospitalization in children with cystic brosis
is low and unlikely to be different from
children without cystic brosis. No evidence suggests a benet from palivizumab prophylaxis in patients with
cystic brosis. A randomized clinical
trial involving 186 children with cystic
brosis from 40 centers reported 1

subject in each group was hospitalized
because of RSV infection. Although this
study was not powered for efcacy, no
clinically meaningful differences in
outcome were reported.205 A survey of
cystic brosis center directors published in 2009 noted that palivizumab
prophylaxis is not the standard of care
for patients with cystic brosis.206 If
a neonate is diagnosed with cystic brosis by newborn screening, RSV
prophylaxis should not be administered if no other indications are present. A patient with cystic brosis with
clinical evidence of chronic lung disease in the rst year of life may be
considered for prophylaxis.
Neuromuscular Disease and
Pulmonary Abnormality
The risk of RSV hospitalization is not
well dened in children with pulmonary
abnormalities or neuromuscular disease that impairs ability to clear
secretions from the lower airway because of ineffective cough, recurrent
gastroesophageal tract reux, pulmonary malformations, tracheoesophageal
stula, upper airway conditions, or
conditions requiring tracheostomy. No
data on the relative risk of RSV hospitalization are available for this cohort.
Selected infants with disease or congenital anomaly that impairs their
ability to clear secretions from the
lower airway because of ineffective
cough may be considered for prophylaxis during the rst year of life.
Immunocompromised Children
Population-based data are not available on the incidence or severity of RSV
hospitalization in children who undergo solid organ or hematopoietic
stem cell transplantation, receive
chemotherapy, or are immunocompromised because of other conditions.
Prophylaxis may be considered for
hematopoietic stem cell transplant
e1489
patients who undergo transplantation

and are profoundly immunosuppressed during the RSV season.207
MISCELLANEOUS ISSUES
Prophylaxis is not recommended for
prevention of nosocomial RSV disease
in the NICU or hospital setting.208,209
No evidence suggests palivizumab is
a cost-effective measure to prevent
recurrent wheezing in children. Prophylaxis should not be administered
to reduce recurrent wheezing in later
years.210,211

All people should use alcohol-based
rubs for hand decontamination when
caring for children with bronchiolitis. When alcohol-based rubs are
not available, individuals should
wash their hands with soap and
water (Evidence Quality: B; Recommendation Strength: Strong Recommendation).
Benets
Risk, harm, cost
Monthly prophylaxis in Alaska Native

children who qualify should be determined by locally generated data
regarding season onset and end.
Continuation of monthly prophylaxis
for an infant or young child who experiences breakthrough RSV hospitalization is not recommended.
HAND HYGIENE
All people should disinfect hands
before and after direct contact
with patients, after contact with
inanimate objects in the direct vicinity of the patient, and after removing gloves (Evidence Quality: B;
Recommendation).
Benets
Risk, harm, cost

Value judgments
Exclusions
Strength
e1490
B
Decreased
transmission
of disease
Possible hand
irritation
Benets outweigh
harms
None
None
None
None
Strong
recommendation
None
Value judgments
Exclusions
Strength
B
Less hand irritation
If there is visible
dirt on the
hands, hand
washing is
necessary;
alcohol-based
rubs are not
effective for
Clostridium
difcile, present
a re hazard,
and have a slight
increased cost
Benets outweigh
harms
None
None
None
None
Strong
recommendation
None
Efforts should be made to decrease the

spread of RSV and other causative
agents of bronchiolitis in medical
settings, especially in the hospital.
Secretions from infected patients can
be found on beds, crib railings, tabletops, and toys.12 RSV, as well as
many other viruses, can survive better
on hard surfaces than on porous
surfaces or hands. It can remain infectious on counter tops for 6 hours,
on gowns or paper tissues for 20
to 30 minutes, and on skin for up to
20 minutes.212
It has been shown that RSV can be carried
and spread to others on the hands of
caregivers.213 Studies have shown that

health care workers have acquired infection by performing activities such as
feeding, diaper change, and playing
with the RSV-infected infant. Caregivers
who had contact only with surfaces
contaminated with the infants secretions or touched inanimate objects in
patients rooms also acquired RSV. In
these studies, health care workers
contaminated their hands (or gloves)
with RSV and inoculated their oral or
conjunctival mucosa.214 Frequent hand
washing by health care workers has
been shown to reduce the spread of
RSV in the health care setting.215
The Centers for Disease Control and
Prevention published an extensive review of the hand-hygiene literature and
made recommendations as to indications for hand washing and hand
antisepsis.216 Among the recommendations are that hands should be
disinfected before and after direct
contact with every patient, after contact with inanimate objects in the direct vicinity of the patient, and before
putting on and after removing gloves.
If hands are not visibly soiled, an
alcohol-based rub is preferred. In
guidelines published in 2009, the
World Health Organization also recommended alcohol-based hand-rubs
as the standard for hand hygiene in
health care.217 Specically, systematic
reviews show them to remove organisms more effectively, require less
time, and irritate skin less often than
hand washing with soap or other antiseptic agents and water. The availability
of bedside alcohol-based solutions increased compliance with hand hygiene
among health care workers.214
When caring for hospitalized children
with clinically diagnosed bronchiolitis, strict adherence to hand decontamination and use of personal
protective equipment (ie, gloves and
gowns) can reduce the risk of crossinfection in the health care setting.215
Other methods of infection control in

viral bronchiolitis include education of
personnel and family members, surveillance for the onset of RSV season, and
wearing masks when anticipating exposure to aerosolized secretions while
performing patient care activities. Programs that implement the aforementioned principles, in conjunction with
effective hand decontamination and
cohorting of patients, have been shown
to reduce the spread of RSV in the
health care setting by 39% to 50%.218,219
TOBACCO SMOKE
Clinicians should inquire about the
exposure of the infant or child to
tobacco smoke when assessing
infants and children for bronchiolitis (Evidence Quality: C; Recommendation Strength: Moderate
Recommendation).
Benets
Risk, harm, cost

Value judgments
Exclusions
Strength
C
Can identify infants
and children at
risk whose
family may
benet from
counseling,
predicting risk of
severe disease
Time to inquire
Benets outweigh
harms
None
None
Parent may choose
to deny tobacco
use even though
they are, in fact,
users
None
Moderate
recommendation
None

Clinicians should counsel caregivers about exposing the infant or
child to environmental tobacco

smoke and smoking cessation
when assessing a child for bronchiolitis (Evidence Quality: B; Recommendation Strength: Strong
Recommendation).
tis.222225 The AAP issued a technical

report on the risks of secondhand
smoke in 2009. The report makes recommendations regarding effective ways
to eliminate or reduce secondhand
smoke exposure, including education of
parents.226
Despite our knowledge of this important risk factor, there is evidence to

suggest health care providers identify
fewer than half of children exposed to
tobacco smoke in the outpatient, inpatient, or ED settings.227229 Furthermore, there is evidence that
counseling parents in these settings is
well received and has a measurable
impact. Rosen et al230 performed a
meta-analysis of the effects of interventions in pediatric settings on parental cessation and found a pooled
risk ratio of 1.3 for cessation among
the 18 studies reviewed.

Benets
Risk, harm, cost

Value judgments
Exclusions
Strength
Notes
B
Reinforces the
detrimental
effects of
smoking,
potential to
decrease
smoking
Time to counsel
Benets outweigh
harms
None
None
Parents may choose
to ignore
counseling
None
Moderate
recommendation
None
Counseling for
tobacco smoke
prevention
should begin in
the prenatal
period and
continue in
family-centered
care and at all
well-infant visits
Tobacco smoke exposure increases the

risk and severity of bronchiolitis. Strachan and Cook220 rst delineated the
effects of environmental tobacco smoke
on rates of lower respiratory tract disease in infants in a meta-analysis including 40 studies. In a more recent
systematic review, Jones et al221 found
a pooled odds ratio of 2.51 (95% CI 1.96
to 3.21) for tobacco smoke exposure
and bronchiolitis hospitalization among
the 7 studies specic to the condition.
Other investigators have consistently
reported tobacco smoke exposure
increases both severity of illness and
risk of hospitalization for bronchioli-
In contrast to many of the other

recommendations, protecting children from tobacco exposure is
a recommendation that is primarily
implemented outside of the clinical
setting. As such, it is critical that
parents are fully educated about the
importance of not allowing smoking
in the home and that smoke lingers
on clothes and in the environment
for prolonged periods.231 It should
be provided in plain language and
in a respectful, culturally effective
manner that is family centered, engages parents as partners in their
childs health, and factors in their
literacy, health literacy, and primary
language needs.
BREASTFEEDING
Clinicians should encourage exclusive
breastfeeding for at least 6 months
to decrease the morbidity of respiratory infections (Evidence Quality:
Grade B; Recommendation Strength:
e1491

Benets
Risk, harm, cost

Value judgments
Exclusions
Strength
Notes
B
May reduce the risk
of bronchiolitis
and other
illnesses;
multiple benets
of breastfeeding
unrelated to
bronchiolitis
None
Benets outweigh
risks
None
None
Parents may choose
to feed formula
rather than
breastfeed
None
Moderate
recommendation
Education on
breastfeeding
should begin in
the prenatal
period
In 2012, the AAP presented a general

policy on breastfeeding.232 The policy
statement was based on the proven
benets of breastfeeding for at least 6
months. Respiratory infections were
shown to be signicantly less common
in breastfed children. A primary resource was a meta-analysis from the
Agency for Healthcare Research and
Quality that showed an overall 72%
reduction in the risk of hospitalization
secondary to respiratory diseases in
infants who were exclusively breastfed
for 4 or more months compared with
those who were formula fed.233
The clinical evidence also supports
decreased incidence and severity of
illness in breastfed infants with bronchiolitis. Dornelles et al234 concluded
that the duration of exclusive breastfeeding was inversely related to the
length of oxygen use and the length of
hospital stay in previously healthy
infants with acute bronchiolitis. In
a large prospective study in Australia,
Oddy et al235 showed that breastfeeding
for less than 6 months was associated
e1492
with an increased risk for 2 or more

medical visits and hospital admission
for wheezing lower respiratory illness.
In Japan, Nishimura et al236 looked
at 3 groups of RSV-positive infants
dened as full, partial, or token breastfeeding. There were no signicant
differences in the hospitalization rate
among the 3 groups; however, there
were signicant differences in the
duration of hospitalization and the
rate of requiring oxygen therapy, both
favoring breastfeeding.
FAMILY EDUCATION
Clinicians and nurses should educate personnel and family members on evidence-based diagnosis,
treatment, and prevention in
bronchiolitis (Evidence Quality: C;
observational studies; Recommendation Strength; Moderate Recommendation).
Benets
Risk, harm, cost

Value judgments

Exclusions
Strength
C
Decreased
transmission of
disease, benets
of breastfeeding,
promotion of
judicious use of
antibiotics, risks
of infant lung
damage
attributable to
tobacco smoke
Time to educate
properly
Benets outweigh
harms
None
Personnel is not
specically
dened but
should include
all people who
enter a patients
room
None
None
Moderate
recommendation
None
Shared decision-making with parents

about diagnosis and treatment of
bronchiolitis is a key tenet of patientcentered care. Despite the absence of
effective therapies for viral bronchiolitis, caregiver education by clinicians
may have a signicant impact on care
patterns in the disease. Children with
bronchiolitis typically suffer from
symptoms for 2 to 3 weeks, and
parents often seek care in multiple
settings during that time period.237
Given that children with RSV generally shed virus for 1 to 2 weeks and
from 30% to 70% of family members
may become ill,238,239 education about
prevention of transmission of disease
is key. Restriction of visitors to newborns during the respiratory virus
season should be considered. Consistent evidence suggests that parental education is helpful in the
promotion of judicious use of antibiotics and that clinicians may misinterpret parental expectations about
therapy unless the subject is openly
discussed.240242
FUTURE RESEARCH NEEDS
Better algorithms for predicting

the course of illness
Impact of clinical score on patient

outcomes
Evaluating different ethnic groups

and varying response to treatments
Does epinephrine alone reduce admission in outpatient settings?
Additional studies on epinephrine

in combination with dexamethasone or other corticosteroids
Hypertonic saline studies in the

outpatient setting and in in hospitals with shorter LOS
More studies on nasogastric hydration
More studies on tonicity of intravenous uids
Incidence of true AOM in bronchiolitis by using 2013 guideline

denition
More studies on deep suctioning and nasopharyngeal suctioning
Strategies for monitoring oxygen

saturation
Use of home oxygen

Appropriate cutoff for use of oxygen in high altitude
Oxygen delivered by high-ow nasal cannula
RSV vaccine and antiviral agents

Use of palivizumab in special
populations, such as cystic brosis, neuromuscular diseases,

Down syndrome, immune deciency
Emphasis on parent satisfaction/

patient-centered outcomes in all
research (ie, not LOS as the only
measure)
SUBCOMMITTEE ON BRONCHIOLITIS
(OVERSIGHT BY THE COUNCIL ON
QUALITY IMPROVEMENT AND PATIENT
SAFETY, 20132014)
Shawn L. Ralston, MD, FAAP: Chair, Pediatric
Hospitalist (no nancial conicts; published
research related to bronchiolitis)
Allan S. Lieberthal, MD, FAAP: Chair, General
Pediatrician with Expertise in Pulmonology (no
conicts)
Brian K. Alverson, MD, FAAP: Pediatric Hospitalist, AAP Section on Hospital Medicine
Representative (no conicts)
Jill E. Baley, MD, FAAP: Neonatal-Perinatal
Medicine, AAP Committee on Fetus and Newborn Representative (no conicts)
Anne M. Gadomski, MD, MPH, FAAP: General
Pediatrician and Research Scientist (no nancial
conicts; published research related to bronchiolitis including Cochrane review of bronchodilators)
David W. Johnson, MD, FAAP: Pediatric Emergency Medicine Physician (no nancial conicts;
published research related to bronchiolitis)
Michael J. Light, MD, FAAP: Pediatric Pulmonologist, AAP Section on Pediatric Pulmonology
Nizar F. Maraqa, MD, FAAP: Pediatric Infectious Disease Physician, AAP Section on Infectious Diseases Representative (no conicts)
H. Cody Meissner, MD, FAAP: Pediatric Infectious Disease Physician, AAP Committee on
Infectious Diseases Representative (no conicts)

Eneida A. Mendonca, MD, PhD, FAAP, FACMI:
Informatician/Academic Pediatric Intensive
Care Physician, Partnership for Policy Implementation Representative (no conicts)
Kieran J. Phelan, MD, MSc: General Pediatrician (no conicts)
Joseph J. Zorc, MD, MSCE, FAAP: Pediatric
Emergency Physician, AAP Section on Emergency
Medicine Representative (no nancial conicts;
published research related to bronchiolitis)
Danette Stanko-Lopp, MA, MPH: Methodologist, Epidemiologist (no conicts)
Mark A. Brown, MD: Pediatric Pulmonologist,
American Thoracic Society Liaison (no conicts)
Ian Nathanson, MD, FAAP: Pediatric Pulmonologist, American College of Chest Physicians
Liaison (no conicts)
Elizabeth Rosenblum, MD: Academic Family
Physician, American Academy of Family Physicians liaison (no conicts).
Stephen Sayles, III, MD, FACEP: Emergency
Medicine Physician, American College of
Emergency Physicians Liaison (no conicts)
Sinsi Hernndez-Cancio, JD: Parent/Consumer
STAFF
Caryn Davidson, MA
Linda Walsh, MAB
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APPENDIX 1 SEARCH TERMS BY

TOPIC
Introduction
MedLine
((bronchiolitis[MeSH]) OR (respiratory syncytial viruses[MeSH]) NOT
bronchiolitis obliterans[All Fields])
1. and exp Natural History/
2. and exp Epidemiology/
3. and (exp economics/ or exp
costs and cost analysis/ or
exp cost allocation/ or exp
cost-benet analysis/ or exp
cost control/ or exp cost of
illness/ or exp cost sharing/
or exp health care costs/ or
exp health expenditures/)
4. and exp Risk Factors/
Limit to English Language AND Humans
AND (all infant (birth to 23 months)
or newborn infant (birth to 1 month)
or infant (1 to 23 months))
*Upper Respiratory Infection Symptoms
Bronchiolitis AND (bronchodilator OR

epinephrine OR albuterol OR salbutamol OR corticosteroid OR steroid)
MedLine
*Hypertonic Saline
(exp Bronchiolitis/ OR exp Bronchiolitis, Viral/) AND exp *Respiratory Tract

Infections/
MedLine
Limit to English Language

Limit to all infant (birth to 23
months) OR newborn infant (birth
to 1 month) OR infant (1 to 23
months))
CINAHL
(MM Bronchiolitis+) AND (MM Respiratory Tract Infections+)

AND (exp Saline Solution, Hypertonic/
OR (aerosolized saline.mp. OR (exp
AEROSOLS/ AND exp Sodium Chloride/))
OR (exp Sodium Chloride/ AND exp
Nebulizers and Vaporizers/) OR nebulized saline.mp.)
Bronchiolitis AND Respiratory Infection

months) OR newborn infant (birth to
1 month) OR infant (1 to 23 months))
Inhalation Therapies
CINAHL
*Bronchodilators & Corticosteroids
(MM Bronchiolitis+) AND (MM Saline Solution, Hypertonic)
The Cochrane Library
MedLine
Oxygen
exp BRONCHIOLITIS/di [Diagnosis] OR

exp Bronchiolitis, Viral/di [Diagnosis]
AND (exp Receptors, Adrenergic, -2/

OR exp Receptors, Adrenergic, / OR
exp Receptors, Adrenergic, -1/ OR
adrenergic*.mp. OR exp ALBUTEROL/
OR levalbuterol.mp. OR exp EPINEPHRINE/ OR exp Cholinergic Antagonists/
OR exp IPRATROPIUM/ OR exp Anti-Inammatory Agents/ OR ics.mp. OR inhaled corticosteroid*.mp. OR exp
Adrenal Cortex Hormones/ OR exp Leukotriene Antagonists/ OR montelukast.
mp. OR exp Bronchodilator Agents/)
limit to English Language AND (all

infant (birth to 23 months) or newborn infant (birth to 1 month) or
infant (1 to 23 months))
Limit to English Language AND (all

infant (birth to 23 months) or newborn infant (birth to 1 month) or
infant (1 to 23 months))
CINAHL
CINAHL
(MH Bronchiolitis/DI)
(MM Bronchiolitis+) AND

Bronchodilator Agents)
CINAHL
(MM Bronchiolitis+) AND (natural
history OR (MM Epidemiology) OR
(MM Costs and Cost Analysis) OR
(MM Risk Factors))
Bronchiolitis AND (epidemiology OR
risk factor OR cost)
Diagnosis/Severity
MedLine

Bronchiolitis AND Diagnosis
(MM
Bronchiolitis AND Hypertonic Saline
MedLine
1. AND (exp Oxygen Inhalation Therapy/
OR supplemental oxygen.mp. OR oxygen saturation.mp. OR *Oxygen/ad,
st [Administration & Dosage, Standards] OR oxygen treatment.mp.)
2. AND (exp OXIMETRY/ OR oximeters.mp.) AND (exp Reproducibility of Results/ OR reliability.
mp. OR function.mp. OR technical
specications.mp.) OR (percutaneous measurement*.mp. OR
exp Blood Gas Analysis/)
e1501
CINAHL
((MM Oxygen Therapy) OR (MM Oxygen+) OR (MM Oxygen Saturation)
OR (MM Oximetry+) OR (MM Pulse
Oximetry) OR (MM Blood Gas Monitoring, Transcutaneous))
NOT bronchiolitis obliterans[All

Fields])
Urinary Tract Infections+) OR (MM

Bacteremia))
AND (exp Fluid Therapy/ AND (exp

infusions, intravenous OR exp administration, oral))

Limit to (all infant (birth to 23
months) or newborn infant (birth to
1 month) or infant (1 to 23 months))
Bronchiolitis AND (oxygen OR oximetry)

CINAHL
Chest Physiotherapy and
Suctioning
MedLine
1. AND (Chest physiotherapy.mp. OR
(exp Physical Therapy Techniques/
AND exp Thorax/))
2. AND (Nasal Suction.mp. OR (exp
Suction/))
CINAHL
(MM Bronchiolitis+)
1. AND ((MH Chest Physiotherapy
(Saba CCC)) OR (MH Chest Physical Therapy+) OR (MH Chest
Physiotherapy (Iowa NIC)))
2. AND (MH Suctioning, Nasopharyngeal)
Bronchiolitis AND (chest physiotherapy
OR suction*)
Hydration
MedLine
((bronchiolitis[MeSH]) OR (respiratory syncytial viruses[MeSH])
e1502

((MM Fluid Therapy+) OR (MM Hydration Control (Saba CCC)) OR (MM
Hydration (Iowa NOC)))
Bronchiolitis AND (hydrat* OR uid*)
SBI and Antibacterials
MedLine
AND
(exp Bacterial Infections/ OR exp Bacterial Pneumonia/ OR exp Otitis Media/
OR exp Meningitis/ OR exp *Anti-bacterial Agents/ OR exp Sepsis/ OR exp
Urinary Tract Infections/ OR exp Bacteremia/ OR exp Tracheitis OR serious
bacterial infection.mp.)
CINAHL
((MM Pneumonia, Bacterial+) OR
(MM Bacterial Infections+) OR (MM
Otitis Media+) OR (MM Meningitis,
Bacterial+) OR (MM Antiinfective
Agents+) OR (MM Sepsis+) OR (MM
Bronchiolitis AND (serious bacterial

infection OR sepsis OR otitis media OR
meningitis OR urinary tract infection or
bacteremia OR pneumonia OR antibacterial OR antimicrobial OR antibiotic)
Hand Hygiene, Tobacco,
Breastfeeding, Parent Education
MedLine
1. AND (exp Hand Disinfection/ OR
hand decontamination.mp. OR
handwashing.mp.)
2. AND exp Tobacco/
3. AND (exp Breast Feeding/ OR
exp Milk, Human/ OR exp Bottle
Feeding/)
CINAHL
(MM Bronchiolitis+)
1. AND (MH Handwashing+)
2. AND (MH Tobacco+)
3. AND (MH Breast Feeding+ OR
MH Milk, Human+ OR MH Bottle
Feeding+)
Bronchiolitis
1. AND (Breast Feeding OR breastfeeding)
2. AND tobacco
3. AND (hand hygiene OR handwashing OR hand decontamination)
2. On page e1358, in the section on Spinosad (0.9% Suspension), the second sentence
should have read: It is not recommended for children younger than 6 months
because it also contains benzyl alcohol. (instead of It is contraindicated).
3. On page e1358, in the section on Spinosad (0.9% Suspension), the last
sentence, which read, Safety in children younger than 4 years has not been
established. should have been deleted.
doi:10.1542/peds.2015-2696
Campbell et al. Critical Elements in the Medical Evaluation of Suspected Child

Physical Abuse. Pediatrics. 2015;136(1):3543
An error occurred in the article by Campbell et al, titled Critical Elements in the
Medical Evaluation of Suspected Child Physical Abuse published in the July 2015
issue of Pediatrics (2015;136[1]:3543; doi:10.1542/peds.2014-4192). On page 41,
in Table 2, under Radiology and Skull Fracture, this reads: Head CT,a skeletal
surveya. This text should have read: Head CT,b skeletal surveyb (footnotes were
incorrectly assigned).
doi:10.1542/peds.2015-2823
Ralston SL, Lieberthal AS, Meissner HC, et al. Clinical Practice Guideline: The
Diagnosis, Management, and Prevention of Bronchiolitis. Pediatrics. 2014;134
(5):e1474e1502
An error occurred in the American Academy of Pediatrics article, titled Clinical

Practice Guideline: The Diagnosis, Management, and Prevention of Bronchiolitis
published in the November 2014 issue of Pediatrics (2014;134[5]:e1474e1502).
On page e1484, in the discussion after Key Action Statement 6b, in the fth
paragraph, the sentence reading In 1 study of 64 healthy infants between 2 weeks
and 6 months of age, 60% of these infants exhibited a transient oxygen desaturation
below 90%, to values as low as 83%. should have been attributed to reference
104 (Hunt CE et al) instead of 105.
doi:10.1542/peds.2015-2862
Kurowski et al. Online Problem-Solving Therapy for Executive Dysfuntion After

Child Traumatic Brain Injury. Pediatrics. 2013;132(1):e158e166
An error occurred in the article by Kurowski et al, titled Online Problem-Solving

Therapy for Executive Dysfunction After Child Traumatic Brain Injury published in the
July 2013 issue of Pediatrics (2013;132[1]:e158e166; doi: 10.1542/peds.2012-4040). On
page e163, under the Results section, in Tables 3 and 4, the baseline and 6 month
TABLE 3 Improvements From Baseline to Follow-up on the Global Executive Composite (GEC) in the CAPS Versus IRC Treatments in the Entire Sample
Older Teens (9th12th Grade) and Younger Teens (6th8th Grade)
Entire Samplea
Older Teensa
Younger Teens
CAPS (n 5 57)
IRC (n 5 62a)
Mean (SD)
Mean (SD)
Baseline
6 Month
Change
Baseline
6 Month
Change
58.53 (10.11)
60.15 (10.51)
57.07 (9.69)
57.00 (11.40)
55.37 (11.44)
58.47 (11.37)
21.53 (8.75)
24.78 (6.66)
1.40 (9.46)
61.56 (10.74)
61.54 (10.98)
61.59 (10.63)
60.16 (12.16)
60.69 (10.94)
59.48 (13.77)
21.40 (7.43)
20.86 (5.98)
22.11 (9.06)
F (df )
Pb
0.17 (118)
6.74 (61)
1.27 (56)
0.68
0.01
0.27
CAPS 5 Counselor Assisted Problem Solving, IRC 5 Internet Resource Comparison

a
The total study participants for IRC was 63; however, one participant did not completed the Behavioral Rating Inventory (BRIEF)-Behavioral Regulation Index (BRI) Inhibit subscale, so the
GEC could not calculated for this participant and they were excluded from this analysis.
b
P values apply to differences between CAPS and IRC groups as measured by general linear models after controlling for baseline scores.
782
ERRATA
Clinical Practice Guideline: The Diagnosis, Management, and Prevention of

Bronchiolitis
Shawn L. Ralston, Allan S. Lieberthal, H. Cody Meissner, Brian K. Alverson, Jill E.
Baley, Anne M. Gadomski, David W. Johnson, Michael J. Light, Nizar F. Maraqa,
Eneida A. Mendonca, Kieran J. Phelan, Joseph J. Zorc, Danette Stanko-Lopp, Mark
A. Brown, Ian Nathanson, Elizabeth Rosenblum, Stephen Sayles III and Sinsi
Hernandez-Cancio
Pediatrics; originally published online October 27, 2014;
DOI: 10.1542/peds.2014-2742
The online version of this article, along with updated information and services, is
located on the World Wide Web at:
/content/early/2014/10/21/peds.2014-2742
PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly

publication, it has been published continuously since 1948. PEDIATRICS is owned,
published, and trademarked by the American Academy of Pediatrics, 141 Northwest Point
Boulevard, Elk Grove Village, Illinois, 60007. Copyright 2014 by the American Academy
of Pediatrics. All rights reserved. Print ISSN: 0031-4005. Online ISSN: 1098-4275.
Clinical Practice Guideline: The Diagnosis, Management, and Prevention of

Bronchiolitis
Shawn L. Ralston, Allan S. Lieberthal, H. Cody Meissner, Brian K. Alverson, Jill E.
Baley, Anne M. Gadomski, David W. Johnson, Michael J. Light, Nizar F. Maraqa,
Eneida A. Mendonca, Kieran J. Phelan, Joseph J. Zorc, Danette Stanko-Lopp, Mark
A. Brown, Ian Nathanson, Elizabeth Rosenblum, Stephen Sayles III and Sinsi
Hernandez-Cancio
Pediatrics; originally published online October 27, 2014;
DOI: 10.1542/peds.2014-2742
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PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly

publication, it has been published continuously since 1948. PEDIATRICS is owned, published,
and trademarked by the American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk
Grove Village, Illinois, 60007. Copyright 2014 by the American Academy of Pediatrics. All
rights reserved. Print ISSN: 0031-4005. Online ISSN: 1098-4275.

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What are the recommendations regarding the administration of albuterol or salbutamol to infants and children with bronchiolitis?

What are the recommendations regarding the administration of albuterol or salbutamol to infants and children with bronchiolitis?

What are the recommendations regarding the administration of epinephrine to infants and children with bronchiolitis?

What are the recommendations regarding the administration of epinephrine to infants and children with bronchiolitis?

Guidance for the Clinician in

Rendering Pediatric Care

CLINICAL PRACTICE GUIDELINE

Clinical Practice Guideline: The Diagnosis, Management,

Shawn L. Ralston, MD, FAAP, Allan S. Lieberthal, MD, FAAP,

FROM THE AMERICAN ACADEMY OF PEDIATRICS

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FROM THE AMERICAN ACADEMY OF PEDIATRICS

5. Clinicians should not administer

29 weeks, 0 days or greater

PEDIATRICS Volume 134, Number 5, November 2014

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and physician assistants who care for

pneumovirus, inuenza, adenovirus,

average RSV hospitalization rate was

Bronchiolitis is a disorder commonly

FROM THE AMERICAN ACADEMY OF PEDIATRICS

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FROM THE AMERICAN ACADEMY OF PEDIATRICS

preterm infants is similar to that of

view encompasses the period from

of Family Physicians, and American

PEDIATRICS Volume 134, Number 5, November 2014

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TABLE 1 Guideline Denitions for Evidence-Based Statements

A particular action is favored because anticipated benets

uation and management of children

Risk, harm, cost

Clinicians should assess risk factors for severe disease, such as

Risk, harm, cost

Improved ability to predict

Risk, harm, cost

Key Action Statement 1c

Action Statement Prole KAS 1b

Action Statement Prole KAS 1b

Action Statement Prole KAS 1a

Clinicians should follow a strong recommendation unless

When clinicians diagnose bronchiolitis on the basis of history and

FROM THE AMERICAN ACADEMY OF PEDIATRICS

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The main goals in the history and

FROM THE AMERICAN ACADEMY OF PEDIATRICS

be made. Most clinicians recognize

rate in otherwise healthy children

PEDIATRICS Volume 134, Number 5, November 2014

suggesting that it reliably detects hypoxemia not suspected on physical

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assay, monthly palivizumab prophylaxis

and children with a diagnosis of

Infants with non-RSV bronchiolitis, in

Current evidence does not support

Action Statement Prole KAS 2

Risk, harm, cost

Avoid adverse effects, avoid

Although several studies and reviews

FROM THE AMERICAN ACADEMY OF PEDIATRICS