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B. Cysteine: Number of Chiral Center 1 Number of Chiral Center 0

The document contains 11 multiple choice questions testing knowledge of amino acids, protein structure and formation of peptide bonds. Key points covered include: - Cysteine can form disulfide linkages. There are 2 torsion angles in a peptide backbone. Alanine has 1 chiral center, glycine has 0. - Peptide bonds are planar, covalent and rigid with partial double bond character. Protein structure hierarchy goes from primary to secondary to tertiary to quaternary. - Peptide bond formation is a condensation reaction. Cis isomers have both C-alpha atoms on the same side. Parallel beta strands cannot be adjacent in primary structure. - Helical wheels plot each residue every

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Susheel Srinivas
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55 views

B. Cysteine: Number of Chiral Center 1 Number of Chiral Center 0

The document contains 11 multiple choice questions testing knowledge of amino acids, protein structure and formation of peptide bonds. Key points covered include: - Cysteine can form disulfide linkages. There are 2 torsion angles in a peptide backbone. Alanine has 1 chiral center, glycine has 0. - Peptide bonds are planar, covalent and rigid with partial double bond character. Protein structure hierarchy goes from primary to secondary to tertiary to quaternary. - Peptide bond formation is a condensation reaction. Cis isomers have both C-alpha atoms on the same side. Parallel beta strands cannot be adjacent in primary structure. - Helical wheels plot each residue every

Uploaded by

Susheel Srinivas
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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1.

The amino acid that can form a disulfide linkage is


a. methionine
b. cysteine
c. histidine
2. The number of torsion angles in a peptide backbone are
a. 1
b. 2
c. 3

d. proline

d. 4

3. How many chiral centers are there in the amino acids alanine and glycine?
Alanine: number of chiral center = 1
Glycine: number of chiral center = 0

4. Peptide bond is
a. covalent

b. Planar, covalent

c. rigid with partial double bond character

d. all of the above

5. Arrange the following in the increasing order of protein structure hierarchy:


A: -helix
B: amino acid sequence
C: quaternary structure
D: folded structure
a. A, D, C, B
b. A, D, B, C
c. B, A, D, C
d. B, A, C, D
6. Formation of peptide bond is a
a. ligation reaction
c. hydrolysis reaction

b. oxidation reaction
d. condensation reaction

7. When both C-alpha atoms are on the same side of a peptide bond, it is called a
_____Cis______ isomer.
8. Which of the following CAN NOT be close (adjacent) in primary structure
a. two -helices
c. parallel -strands
b. anti-parallel -strands
d. an -helix and a -strand

9. In a helical wheel each residue can be plotted every ____100____ degree around a spiral
path.

10. Mention the interactions/bonds required to get a tertiary protein structure from its primary
structure:
Ans:
(i) hydrogen bonds between polar R- groups
(ii) ionic bonds between charged R-groups
(iii) Hydrophobic interactions between nonpolar R-groups
(iv) covalent bonds: The R-group of the amino acid cysteine contains a sulphur atom and this
sulphur atom is capable of forming a covalent bond with another sulphur atom on a different
cysteine molecule somewhere else on the chain. This bond is known as a disulphide bond and it
stabilizes the tertiary structure of a protein.

11. Draw the helical wheel for the sequence KERAGSKDRE (Think about this question, you
don't need to send answer of this question.)
Discussed before and this will be discussed again during our next class.

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