Please Answer 3 Questions From The Following 8 Presentation Questions

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Please Answer 3 Questions From The Following 8 Presentation Questions

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CBE555TakehomeFinal2014

Pleaseanswer**3questions**fromthefollowing8Presentationquestions.
WriteyouranswersintheFinalExamWhiteBook.
MakeSureyousignyourname&adheretotheethicscode.Haveagoodbreak!
1.Whatistheratiooftheacceptorphotoncountratekatothedonorphotoncountratekd
whenFRETefficiencyEiis0.5and0.75?
Paper:ComplexRNAFoldingKineticsRevealedbySingleMoleculeFRETandHiddenMarkov
Models.Keller,Kobitski,Jaschke

2.Whataretheprosandconsofusingliposomesascandidatesfornewdrugdeliverysystem?
Paper:ItakuraSetal.(2014)DevelopmentofNanoparticlesIncorporatingaNovelLiposomal
MembraneDestabilizationPeptideforefficientreleaseofCargosintoCancerCells

3.Giventhelowercriticalsolutiontemperature(42C)forthecarrier,whatconformationwas
adoptedduringcarrierassembly?Whatwerethemeritsoftheconformationsadoptedbelow
andabovetheLCST,andhowdothesefacilitateeffectivedrugdeliverytocancertissue?
Paper:Thermoresponsiveandshapetransformableamphiphilicscaffoldsforloadingand
deliveringanticancerdrugs

4.WhatwerethetwowaysLMDPcleavageactivitybysecretasewasevaluated?
Paper:DevelopmentofNanoparticlesIncorporatingaNovelLiposomalMembrane
DestabilizationPeptideforefficientreleaseofCargosintoCancerCells

5.Releaseddrug%fromMOFsoftenbehaveasalogarithmicfunctionwithrespecttotime.If
thepercentageofdrug,CDV,thatisreleasedfromaMOF,MIL88Aisrelatedtotimeas
[22.28ln(t)+80.11],(tisinhours)Howlongwillittakefor50%ofCDVtobereleasedfromthis
MIL88A.(theunitsfor80.11and22.28arein%)
Paper:Porousmetalorganicframeworknanoscalecarriersasapotentialplatformfordrug
deliveryandimaging.

6Paper:

7.Paper:

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Please Answer 3 Questions From The Following 8 Presentation Questions

Uploaded by

Please Answer 3 Questions From The Following 8 Presentation Questions

Uploaded by

CBE555TakehomeFinal2014

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