100% found this document useful (2 votes)
242 views12 pages

Exercise Physiology

fa

Uploaded by

Shyamol Bose
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
100% found this document useful (2 votes)
242 views12 pages

Exercise Physiology

fa

Uploaded by

Shyamol Bose
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

Exercisephysiology
FromWikipedia,thefreeencyclopedia

Exercisephysiologyisthephysiologyofphysicalexercise.It
isthestudyoftheacuteresponsesandchronicadaptationstoa
widerangeofexerciseconditions.
Exercisephysiologistsstudytheeffectofexerciseon
pathology,andthemechanismsbywhichexercisecanreduce
orreversediseaseprogression.

Contents
1 Energyexpenditure
2 Metabolicchanges
2.1 Rapidenergysources
2.2 Plasmaglucose
2.3 Oxygen
2.4 Dehydration
2.5 Other
3 Brain
3.1 Cerebraloxygen
3.2 Glucose
3.3 Hyperthermia
4 Fatigue
4.1 Intenseactivity
4.2 Endurancefailure
4.3 Centralgovernor
4.4 Otherfactors
5 Cardiacbiomarkers
6 Humanadaptations
7 Selectivebreedingexperimentswithrodents
8 Exerciseinducedmusclepain
9 Educationinexercisephysiology
9.1 Curriculum
10 Seealso
11 References

Cyclistsareknownforusingknowledgeinexercise
physiologyinordertooptimizetrainingtoreach
themaximallevelofperformance.

Energyexpenditure
Humanshaveahighcapacitytoexpendenergyformanyhoursduringsustainedexertion.Forexample,one
individualcyclingataspeedof26.4km/h(16.4mph)through8,204km(5,098mi)over50consecutivedays
expendedatotalof1,145MJ(273,850kcal273,850dietercalories)withanaveragepoweroutputof182.5W.[1]
Skeletalmuscleburns90mg(0.5mmol)ofglucoseeachminuteduringcontinuousactivity(suchaswhen
repetitivelyextendingthehumanknee),[2]generating24Wofmechanicalenergy,andsincemuscleenergy
conversionisonly2226%efficient,[3]76Wofheatenergy.Restingskeletalmusclehasabasalmetabolicrate
https://en.wikipedia.org/wiki/Exercise_physiology

1/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

(restingenergyconsumption)of0.63W/kg[4]makinga160folddifferencebetweentheenergyconsumptionof
inactiveandactivemuscles.Forshortdurationmuscularexertion,energyexpenditurecanbefargreater:anadult
humanmalewhenjumpingupfromasquatcanmechanicallygenerate314W/kg.Suchrapidmovementcan
generatetwicethisamountinnonhumananimalssuchasbonobos,[5]andinsomesmalllizards.[6]
Thisenergyexpenditureisverylargecomparedtothebasalrestingmetabolicrateoftheadulthumanbody.This
ratevariessomewhatwithsize,genderandagebutistypicallybetween45Wand85W.[7][8]Totalenergy
expenditure(TEE)duetomuscularexpendedenergyismuchhigheranddependsupontheaveragelevelof
physicalworkandexercisedoneduringaday.[9]Thusexercise,particularlyifsustainedforverylongperiods,
dominatestheenergymetabolismofthebody.Physicalactivityenergyexpenditurecorrelatesstronglywiththe
gender,age,weight,heartrate,andVO2maxofanindividual,duringphysicalactivity.[10]

Metabolicchanges
Rapidenergysources
Energyneededtoperformshortlasting,highintensityburstsofactivityis
derivedfromanaerobicmetabolismwithinthecytosolofmusclecells,as
opposedtoaerobicrespirationwhichutilizesoxygen,issustainable,and
occursinthemitochondria.Thequickenergysourcesconsistofthe
phosphocreatine(PCr)system,fastglycolysis,andadenylatekinase.Allof
thesesystemsresynthesizeadenosinetriphosphate(ATP),whichisthe
universalenergysourceinallcells.Themostrapidsource,butthemost
readilydepletedoftheabovesourcesisthePCrsystemwhichutilizesthe
enzymecreatinekinase.Thisenzymecatalyzesareactionthatcombines
Ergospirometrylaboratoryforthe
phosphocreatineandadenosinediphosphate(ADP)intoATPandcreatine.
measurementofmetabolicchanges
Thisresourceisshortlastingbecauseoxygenisrequiredfortheresynthesis
duringagradedexercisetestona
ofphosphocreatineviamitochondrialcreatinekinase.Therefore,under
treadmill
anaerobicconditions,thissubstrateisfiniteandonlylastsbetween
approximately10to30secondsofhighintensitywork.Fastglycolysis,
however,canfunctionforapproximately2minutespriortofatigue,andpredominatelyusesintracellularglycogen
asasubstrate.Glycogenisbrokendownrapidlyviaglycogenphosphorylaseintoindividualglucoseunitsduring
intenseexercise.Glucoseisthenoxidizedtopyruvateandunderanaerobicconditionisreducedtolacticacid.This
reactionoxidizesNADHtoNAD,therebyreleasingahydrogenion,promotingacidosis.Forthisreason,fast
glycolysiscannotbesustainedforlongperiodsoftime.Lastly,adenylatekinasecatalyzesareactionbywhich2
ADParecombinedtoformATPandadenosinemonophosphate(AMP).Thisreactiontakesplaceduringlow
energysituationssuchasextremeexerciseorconditionsofhypoxia,butisnotasignificantsourceofenergy.The
creationofAMPresultingfromthisreactionstimulatesAMPactivatedproteinkinase(AMPkinase)whichisthe
energysensorofthecell.Aftersensinglowenergyconditions,AMPkinasestimulatesvariousotherintracellular
enzymesgearedtowardsincreasingenergysupplyanddecreasingallanabolic,orenergyrequiring,cellfunctions.

Plasmaglucose
Plasmaglucoseissaidtobemaintainedwhenthereisanequalrateofglucoseappearance(entryintotheblood)
andglucosedisposal(removalfromtheblood).Inthehealthyindividual,theratesofappearanceanddisposalare
essentiallyequalduringexerciseofmoderateintensityanddurationhowever,prolongedexerciseorsufficiently
intenseexercisecanresultinanimbalanceleaningtowardsahigherrateofdisposalthanappearance,atwhich
pointglucoselevelsfallproducingtheonsetoffatigue.Rateofglucoseappearanceisdictatedbytheamountof
glucosebeingabsorbedatthegutaswellasliver(hepatic)glucoseoutput.Althoughglucoseabsorptionfromthe
https://en.wikipedia.org/wiki/Exercise_physiology

2/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

gutisnottypicallyasourceofglucoseappearanceduringexercise,theliveriscapableofcatabolizingstored
glycogen(glycogenolysis)aswellassynthesizingnewglucosefromspecificreducedcarbonmolecules(glycerol,
pyruvate,andlactate)inaprocesscalledgluconeogenesis.Theabilityofthelivertoreleaseglucoseintotheblood
fromglycogenolysisisunique,sinceskeletalmuscle,theothermajorglycogenreservoir,isincapableofdoingso.
Unlikeskeletalmuscle,livercellscontaintheenzymeglycogenphosphatase,whichremovesaphosphategroup
fromglucose6Ptoreleasefreeglucose.Inorderforglucosetoexitacellmembrane,theremovalofthis
phosphategroupisessential.Althoughgluconeogenesisisanimportantcomponentofhepaticglucoseoutput,it
alonecannotsustainexercise.Forthisreason,whenglycogenstoresaredepletedduringexercise,glucoselevels
fallandfatiguesetsin.Glucosedisposal,theothersideoftheequation,iscontrolledbyuptakeofglucoseatthe
workingskeletalmuscles.Duringexercise,despitedecreasedinsulinconcentrations,muscleincreasesGLUT4
translocationofandglucoseuptake.ThemechanismforincreasedGLUT4translocationisanareaofongoing
research.
glucosecontrol:Asmentionedabove,insulinsecretionisreducedduringexercise,anddoesnotplayamajorrole
inmaintainingnormalbloodglucoseconcentrationduringexercise,butitscounterregulatoryhormonesappearin
increasingconcentrations.Principleamongtheseareglucagon,epinephrine,andgrowthhormone.Allofthese
hormonesstimulateliver(hepatic)glucoseoutput,amongotherfunctions.Forinstance,bothepinephrineand
growthhormonealsostimulateadipocytelipase,whichincreasesnonesterifiedfattyacid(NEFA)release.By
oxidizingfattyacids,thissparesglucoseutilizationandhelpstomaintainbloodsugarlevelduringexercise.
Exercisefordiabetes:Exerciseisaparticularlypotenttoolforglucosecontrolinthosewhohavediabetes
mellitus.Inasituationofelevatedbloodglucose(hyperglycemia),moderateexercisecaninducegreaterglucose
disposalthanappearance,therebydecreasingtotalplasmaglucoseconcentrations.Asstatedabove,themechanism
forthisglucosedisposalisindependentofinsulin,whichmakesitparticularlywellsuitedforpeoplewithdiabetes.
Inaddition,thereappearstobeanincreaseinsensitivitytoinsulinforapproximately1224hourspostexercise.
ThisisparticularlyusefulforthosewhohavetypeIIdiabetesandareproducingsufficientinsulinbutdemonstrate
peripheralresistancetoinsulinsignaling.However,duringextremehyperglycemicepisodes,peoplewithdiabetes
shouldavoidexerciseduetopotentialcomplicationsassociatedwithketoacidosis.Exercisecouldexacerbate
ketoacidosisbyincreasingketonesynthesisinresponsetoincreasedcirculatingNEFA's.
TypeIIdiabetesisalsointricatelylinkedtoobesity,andtheremaybeaconnectionbetweentypeIIdiabetesand
howfatisstoredwithinpancreatic,muscle,andlivercells.Likelyduetothisconnection,weightlossfromboth
exerciseanddiettendstoincreaseinsulinsensitivityinthemajorityofpeople.Insomepeople,thiseffectcanbe
particularlypotentandcanresultinnormalglucosecontrol.Althoughnobodyistechnicallycuredofdiabetes,
individualscanlivenormalliveswithoutthefearofdiabeticcomplicationshowever,regainofweightwould
assuredlyresultindiabetessignsandsymptoms.

Oxygen
Vigorousphysicalactivity(suchasexerciseorhardlabor)increasesthebody'sdemandforoxygen.Thefirstline
physiologicresponsetothisdemandisanincreaseinheartrate,breathingrate,anddepthofbreathing.
Oxygenconsumption(VO2)duringexerciseisbestdescribedbytheFickEquation:VO2=Qx(avO2diff),which
statesthattheamountofoxygenconsumedisequaltocardiacoutput(Q)multipliedbythedifferencebetween
arterialandvenousoxygenconcentrations.Moresimplyput,oxygenconsumptionisdictatedbythequantityof
blooddistributedbytheheartaswellastheworkingmuscle'sabilitytotakeuptheoxygenwithinthatblood
however,thisisabitofanoversimplification.Althoughcardiacoutputisthoughttobethelimitingfactorofthis
relationshipinhealthyindividuals,itisnottheonlydeterminantofVO2max.Thatis,factorssuchastheabilityof
thelungtooxygenatethebloodmustalsobeconsidered.Variouspathologiesandanomaliescauseconditionssuch
asdiffusionlimitation,ventilation/perfusionmismatch,andpulmonaryshuntsthatcanlimitoxygenationofthe
bloodandthereforeoxygendistribution.Inaddition,theoxygencarryingcapacityofthebloodisalsoanimportant
https://en.wikipedia.org/wiki/Exercise_physiology

3/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

determinantoftheequation.Oxygencarryingcapacityisoftenthetargetofexercise(ergogenicaids)aidsusedin
endurancesportstoincreasethevolumepercentageofredbloodcells(hematocrit),suchasthroughblooddoping
ortheuseoferythropoietin(EPO).Furthermore,peripheraloxygenuptakeisreliantonareroutingofbloodflow
fromrelativelyinactivevisceratotheworkingskeletalmuscles,andwithintheskeletalmuscle,capillarytomuscle
fiberratioinfluencesoxygenextraction.

Dehydration
Dehydrationrefersbothtohypohydration(dehydrationinducedpriortoexercise)andtoexerciseinduced
dehydration(dehydrationthatdevelopsduringexercise).Thelatterreducesaerobicenduranceperformanceand
resultsinincreasedbodytemperature,heartrate,perceivedexertion,andpossiblyincreasedrelianceon
carbohydrateasafuelsource.Althoughthenegativeeffectsofexerciseinduceddehydrationonexercise
performancewereclearlydemonstratedinthe1940s,athletescontinuedtobelieveforyearsthereafterthatfluid
intakewasnotbeneficial.Morerecently,negativeeffectsonperformancehavebeendemonstratedwithmodest
(<2%)dehydration,andtheseeffectsareexacerbatedwhentheexerciseisperformedinahotenvironment.The
effectsofhypohydrationmayvary,dependingonwhetheritisinducedthroughdiureticsorsaunaexposure,which
substantiallyreduceplasmavolume,orpriorexercise,whichhasmuchlessimpactonplasmavolume.
Hypohydrationreducesaerobicendurance,butitseffectsonmusclestrengthandendurancearenotconsistentand
requirefurtherstudy.[11]Intenseprolongedexerciseproducesmetabolicwasteheat,andthisisremovedbysweat
basedthermoregulation.Amalemarathonrunnerloseseachhouraround0.83Lincoolweatherand1.2Linwarm
(lossesinfemalesareabout68to73%lower).[12]Peopledoingheavyexercisemaylosetwoandhalftimesas
muchfluidinsweatasurine.[13]Thiscanhaveprofoundphysiologicaleffects.Cyclingfor2hoursintheheat
(35C)withminimalfluidintakecausesbodymassdeclineby3to5%,bloodvolumelikewiseby3to6%,body
temperaturetoriseconstantly,andincomparisonwithproperfluidintake,higherheartrates,lowerstrokevolumes
andcardiacoutputs,reducedskinbloodflow,andhighersystemicvascularresistance.Theseeffectsarelargely
eliminatedbyreplacing50to80%ofthefluidlostinsweat.[12][14]

Other
Plasmacatecholamineconcentrationsincrease10foldinwholebodyexercise.[15]
AmmoniaisproducedbyexercisedskeletalmusclesfromADP(theprecursorofATP)bypurinenucleotide
deaminationandaminoacidcatabolismofmyofibrils.[16]
interleukin6(IL6)increasesinbloodcirculationduetoitsreleasefromworkingskeletalmuscles.[17]This
releaseisreducedifglucoseistaken,suggestingitisrelatedtoenergydepletionstresses.[18]
Sodiumabsorptionisaffectedbythereleaseofinterleukin6asthiscancausethesecretionofarginine
vasopressinwhich,inturn,canleadtoexerciseassociateddangerouslylowsodiumlevels(hyponatremia).
Thislossofsodiuminbloodplasmacanresultinswellingofthebrain.Thiscanbepreventedbyawareness
oftheriskofdrinkingexcessiveamountsoffluidsduringprolongedexercise.[19][20]

Brain
Atrest,thehumanbrainreceives15%oftotalcardiacoutput,anduses20%ofthebody'senergyconsumption.[21]
Thebrainisnormallydependentforitshighenergyexpenditureuponaerobicmetabolism.Thebrainasaresultis
highlysensitivetofailureofitsoxygensupplywithlossofconsciousnessoccurringwithinsixtoseven
seconds,[22]withitsEEGgoingflatin23seconds.[23]Ifitaffectedtheoxygenandglucosesupplytothebrain,the
metabolicdemandsofexercisecouldthereforequicklydisruptitsfunctioning.

https://en.wikipedia.org/wiki/Exercise_physiology

4/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

Protectingthebrainfromevenminordisruptionisimportantsinceexercisedependsuponmotorcontrol,and
particularly,becausehumansarebipeds,themotorcontrolneededforkeepingbalance.Indeed,forthisreason,
brainenergyconsumptionisincreasedduringintensephysicalexerciseduetothedemandsinthemotorcognition
neededtocontrolthebody.[24]

Cerebraloxygen
Cerebralautoregulationusuallyensuresthebrainhasprioritytocardiacoutput,thoughthisisimpairedslightlyby
exhaustiveexercise.[25]Duringsubmaximalexercise,cardiacoutputincreasesandcerebralbloodflowincreases
beyondthebrainsoxygenneeds.[26]However,thisisnotthecaseforcontinuousmaximalexertion:"Maximal
exerciseis,despitetheincreaseincapillaryoxygenation[inthebrain],associatedwithareducedmitochondrialO2
contentduringwholebodyexercise"[27]Theautoregulationofthebrainsbloodsupplyisimpairedparticularlyin
warmenvironments[28]

Glucose
Inadults,exercisedepletestheplasmaglucoseavailabletothebrain:shortintenseexercise(35minergometer
cycling)canreducebrainglucoseuptakeby32%.[29]
Atrest,energyfortheadultbrainisnormallyprovidedbyglucosebutthebrainhasacompensatorycapacityto
replacesomeofthiswithlactate.Researchsuggeststhatthiscanberaised,whenapersonrestsinabrainscanner,
toabout17%,[30]withahigherpercentageof25%occurringduringhypoglycemia.[31]Duringintenseexercise,
lactatehasbeenestimatedtoprovideathirdofthebrainsenergyneeds.[29][32]Thereisevidencethatthebrain
might,however,inspiteofthesealternativesourcesofenergy,stillsufferanenergycrisissinceIL6(asignof
metabolicstress)isreleasedduringexercisefromthebrain.[16][24]

Hyperthermia
Humansusesweatthermoregulationforbodyheatremoval,particularlytoremovetheheatproducedduring
exercise.Moderatedehydrationasaconsequenceofexerciseandheatisreportedtoimpaircognition.[33][34]These
impairmentscanstartafterbodymasslostthatisgreaterthan1%.[35]Cognitiveimpairment,particularlydueto
heatandexerciseislikelytobeduetolossofintegritytothebloodbrainbarrier.[36]Hyperthermiaalsocanlower
cerebralbloodflow,[37][38]andraisebraintemperature.[24]

Fatigue
Intenseactivity
Researchersonceattributedfatiguetoabuildupoflacticacidinmuscles.[39]However,thisisnolonger
believed.[40][41]Rather,lactatemaystopmusclefatiguebykeepingmusclesfullyrespondingtonervesignals.[42]
Theavailableoxygenandenergysupply,anddisturbancesofmuscleionhomeostasisarethemainfactor
determiningexerciseperformance,atleastduringbriefveryintenseexercise.
Eachmusclecontractioninvolvesanactionpotentialthatactivatesvoltagesensors,andsoreleasesCa2+ionsfrom
themusclefibressarcoplasmicreticulum.Theactionpotentialsthatcausethisrequirealsoionchanges:Na
influxesduringthedepolarizationphaseandKeffluxesfortherepolarizationphase.Clionsalsodiffuseintothe
https://en.wikipedia.org/wiki/Exercise_physiology

5/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

sarcoplasmtoaidtherepolarizationphase.Duringintensemusclecontraction,theionpumpsthatmaintain
homeostasisoftheseionsareinactivatedandthis(withotherionrelateddisruption)causesionicdisturbances.This
causescellularmembranedepolarization,inexcitability,andsomuscleweakness.[43]Ca2+leakagefromtype1
ryanodinereceptor)channelshasalsobeenidentifiedwithfatigue.[44]

Endurancefailure
Afterintenseprolongedexercise,therecanbeacollapsein
bodyhomeostasis.Somefamousexamplesinclude:
DorandoPietriinthe1908SummerOlympicmens
marathonranthewrongwayandcollapsedseveral
times.
JimPetersinthemarathonofthe1954Commonwealth
Gamesstaggeredandcollapsedseveraltimes,and
thoughhehadafivekilometre(threemile)lead,failed
tofinish.Thoughitwasformerlybelievedthatthiswas
duetoseveredehydration,morerecentresearchsuggests
itwasthecombinedeffectsuponthebrainof
hyperthermia,hypertonichypernatraemiaassociated
DorandoPietriabouttocollapseattheMarathon
withdehydration,andpossiblyhypoglycaemia.[45]
finishatthe1908LondonOlympicGames
GabrielaAndersenSchiessinthewomansmarathonat
theLosAngeles1984SummerOlympicsintheraces
final400meters,stoppingoccasionallyandshownsignsofheatexhaustion.Thoughshefellacrossthefinish
line,shewasreleasedfrommedicalcareonlytwohourslater.

Centralgovernor
TimNoakes,basedonanearlierideabythe1922NobelPrizeinPhysiologyorMedicinewinnerArchibaldHill[46]
hasproposedtheexistenceofacentralgovernor.Inthis,thebraincontinuouslyadjuststhepoweroutputby
musclesduringexerciseinregardtoasafelevelofexertion.Theseneuralcalculationsfactorinpriorlengthof
strenuousexercise,theplanneddurationoffurtherexertion,andthepresentmetabolicstateofthebody.This
adjuststhenumberofactivatedskeletalmusclemotorunits,andissubjectivelyexperiencedasfatigueand
exhaustion.Theideaofacentralgovernorrejectstheearlierideathatfatigueisonlycausedbymechanicalfailure
oftheexercisingmuscles("peripheralfatigue").Instead,thebrainmodels[47]themetaboliclimitsofthebodyto
ensurethatwholebodyhomeostasisisprotected,inparticularthattheheartisguardedfromhypoxia,andan
emergencyreserveisalwaysmaintained.[48][49][50][51]Theideaofthecentralgovernorhasbeenquestionedsince
physiologicalcatastrophescananddooccursuggestingathletes(suchasDorandoPietri,JimPetersandGabriela
AndersenSchiess)canoverridethecentralgovernor.[52]

Otherfactors
Theexercisefatiguehasalsobeensuggestedtobeeffectedby:
brainhyperthermia[53]
glycogendepletioninbraincells[32][54]
reactiveoxygenspeciesimpairingskeletalmusclefunction[55]
reducedlevelofglutamatesecondarytouptakeofammoniainthebrain[16]
Fatigueindiaphragmandabdominalrespiratorymuscleslimitingbreathing[56]
Impairedoxygensupplytomuscles[57]
https://en.wikipedia.org/wiki/Exercise_physiology

6/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

Ammoniaeffectsuponthebrain[16]
Serotoninpathwaysinthebrain[58]

Cardiacbiomarkers
Prolongedexercisesuchasmarathonscanincreasecardiacbiomarkerssuchastroponin,Btypenatriureticpeptide
(BNP),andischemiamodified(akaMI)albumin.Thiscanbemisinterpretedbymedicalpersonnelassignsof
myocardialinfarction,orcardiacdysfunction.Intheseclinicalconditions,suchcardiacbiomarkersareproduced
byirreversibleinjuryofmuscles.Incontrast,theprocessesthatcreatethemafterstrenuousexertioninendurance
sportsarereversible,withtheirlevelsreturningtonormalwithin24hours(furtherresearch,however,isstill
needed).[59][60][61]

Humanadaptations
Humansarespecificallyadaptedtoengageinprolongedstrenuousmuscularactivity(suchasefficientlong
distancebipedalrunning).[62]Thiscapacityforendurancerunningevolvedtoallowtherunningdownofgame
animalsbypersistentslowbutconstantchaseovermanyhours.[63]
Centraltothesuccessofthisistheabilityofthehumanbody,unlikethatoftheanimalstheyhunt,toeffectively
removemuscleheatwaste.Inmostanimals,thisisstoredbyallowingatemporaryincreaseinbodytemperature.
Thisallowsthemtoescapefromanimalsthatquicklyspeedafterthemforashortduration(thewaynearlyall
predatorscatchtheirprey).Humans,unlikeotheranimalsthatcatchprey,removeheatwithaspecialized
thermoregulationbasedonsweatevaporation.Onegramofsweatcanremove2,598Jofheatenergy.[64]Another
mechanismisincreasedskinbloodflowduringexercisethatallowsforgreaterconvectiveheatlossthatisaidedby
ouruprightposture.Thisskinbasedcoolinghasresultedinhumansacquiringanincreasednumberofsweat
glands,combinedwithalackofbodyfurthatwouldotherwisestopaircirculationandefficientevaporation.[65]
Becausehumanscanremoveexerciseheat,theycanavoidthefatiguefromheatexhaustionthataffectsanimals
chasedinapersistentmanner,andsoeventuallycatchthem.[66]

Selectivebreedingexperimentswithrodents
Rodentshavebeenspecificallybredforexercisebehaviororperformanceinseveraldifferentstudies.[67]For
example,laboratoryratshavebeenbredforhighorlowperformanceonamotorizedtreadmillwithelectrical
stimulationasmotivation.[68]Thehighperformancelineofratsalsoexhibitsincreasedvoluntarywheelrunning
behaviorascomparedwiththelowcapacityline.[69]Inanexperimentalevolutionapproach,fourreplicatelinesof
laboratorymicehavebeenbredforhighlevelsofvoluntaryexerciseonwheels,whilefouradditionalcontrollines
aremaintainedbybreedingwithoutregardtotheamountofwheelrunning.[70]Theseselectedlinesofmicealso
showincreasedendurancecapacityintestsofforcedendurancecapacityonamotorizedtreadmill.[71]However,in
neitherselectionexperimenthavetheprecisecausesoffatigueduringeitherforcedorvoluntaryexercisebeen
determined.

Exerciseinducedmusclepain
Physicalexercisemaycausepainbothasanimmediateeffectthatmayresultfromstimulationoffreenerve
endingsbylowpH,aswellasadelayedonsetmusclesoreness.Thedelayedsorenessisfundamentallytheresultof
ruptureswithinthemuscle,althoughapparentlynotinvolvingtheruptureofwholemusclefibers.[72]
https://en.wikipedia.org/wiki/Exercise_physiology

7/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

Musclepaincanrangefromamildsorenesstoadebilitatinginjurydependingonintensityofexercise,levelof
training,andotherfactors.[73]

Educationinexercisephysiology
Accreditationprogramsexistwithprofessionalbodiesinmostdevelopedcountries,ensuringthequalityand
consistencyofeducation.InCanada,onemayobtaintheprofessionalcertificationtitleCertifiedExercise
Physiologistforthoseworkingwithclients(bothclinicalandnonclinical)inthehealthandfitnessindustry.An
exercisephysiologist'sareaofstudymayincludebutisnotlimitedtobiochemistry,bioenergetics,
cardiopulmonaryfunction,hematology,biomechanics,skeletalmusclephysiology,neuroendocrinefunction,and
centralandperipheralnervoussystemfunction.Furthermore,exercisephysiologistsrangefrombasicscientists,to
clinicalresearchers,toclinicians,tosportstrainers.
Collegesanduniversitiesofferexercisephysiologyasaprogramofstudyonvariousdifferentlevels,including
undergraduate,graduate,anddoctoralprograms.ThebasisofExercisePhysiologyasamajoristopreparestudents
foracareerinfieldofhealthsciences.Aprogramthatfocusesonthescientificstudyofthephysiological
processesinvolvedinphysicalormotoractivity,includingsensorimotorinteractions,responsemechanisms,and
theeffectsofinjury,disease,anddisability.Includesinstructioninmuscularandskeletalanatomymolecularand
cellularbasisofmusclecontractionfuelutilizationneurophysiologyofmotormechanicssystemicphysiological
responses(respiration,bloodflow,endocrinesecretions,andothers)fatigueandexhaustionmuscleandbody
trainingphysiologyofspecificexercisesandactivitiesphysiologyofinjuryandtheeffectsofdisabilitiesand
disease.CareersavailablewithadegreeinExercisePhysiologycaninclude:nonclinical,clientbasedwork
strengthandconditioningspecialistscardiopulmonarytreatmentandclinicalbasedresearch.[74]
Inordertogaugethemultipleareasofstudy,studentsaretaughtprocessesinwhichtofollowonaclientbased
level.Practicalandlectureteachingsareinstructedintheclassroomandinalaboratorysetting.Theseinclude:
Healthandriskassessment:Inordertosafelyworkwithaclientonthejob,youmustfirstbeabletoknow
thebenefitsandrisksassociatedwithphysicalactivity.Examplesofthisincludeknowingspecificinjuries
thebodycanexperienceduringexercise,howtoproperlyscreenaclientbeforetheirtrainingbegins,and
whatfactorstolookforthatmayinhibittheirperformance.
Exercisetesting:Coordinatingexercisetestsinordertomeasurebodycompositions,cardiorespiratory
fitness,muscularstrength/endurance,andflexibility.Functionaltestsarealsousedinordertogain
understandingonamorespecificpartofthebody.Oncetheinformationisgatheredaboutaclient,exercise
physiologistsmustalsobeabletointerpretthetestdataanddecidewhathealthrelatedoutcomeshavebeen
discovered.
Exerciseprescription:Formingtrainingprogramsthatbestmeetanindividualshealthandfitnessgoals.
Mustbeabletotakeintoaccountdifferenttypesofexercises,thereasons/goalforaclientsworkout,andpre
screenedassessments.Knowinghowtoprescribeexercisesforspecialconsiderationsandpopulationsisalso
required.Thesemayincludeagedifferences,pregnancy,jointdiseases,obesity,pulmonarydisease,etc.[75]

Curriculum
Thecurriculumforexercisephysiologyincludesbiology,chemistry,andappliedsciences.Thepurposeofthe
classesselectedforthismajoristohaveaproficientunderstandingofhumananatomy,humanphysiology,and
exercisephysiology.Includesinstructioninmuscularandskeletalanatomymolecularandcellularbasisofmuscle
contractionfuelutilizationneurophysiologyofmotormechanicssystemicphysiologicalresponses(respiration,
bloodflow,endocrinesecretions,andothers)fatigueandexhaustionmuscleandbodytrainingphysiologyof
specificexercisesandactivitiesphysiologyofinjuryandtheeffectsofdisabilitiesanddisease.Notonlyisafull
classscheduleneededtocompleteadegreeinExercisePhysiology,butaminimumamountofpracticum
experienceisrequiredandinternshipsarerecommended.[76]
https://en.wikipedia.org/wiki/Exercise_physiology

8/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

Seealso
Bioenergetics
Excesspost
exerciseoxygen
consumption
(EPOC)
Exercise

Exercise
Fitnessprofessional
Hill'smodel
Metabolism
Musclecontraction
Musclesexercised

Musclesexercised
Physicaltherapy
Skeletalmuscle
Sportsscience
Sportsmedicine
TheMechanicsof

TheMechanicsof
RunningBlades

References
1.Gianetti,GBurton,LDonovan,RAllen,GPescatello,LS(2008)."Physiologicandpsychologicalresponsesofan
athletecycling100+milesdailyfor50consecutivedays".Currentsportsmedicinereports7(6):3437.
doi:10.1249/JSR.0b013e31818f0670.PMID19005357..Thisindividualwhileexceptionalwasnotphysiologically
extraordinarysincehewasdescribedas"subelite"duetohisnotbeing"abletoadjustpoweroutputtoregulateenergy
expenditureasoccurswitheliteathletesduringultracyclingevents"page347.
2.Richter,EAKiens,BSaltin,BChristensen,NJSavard,G(1988)."Skeletalmuscleglucoseuptakeduringdynamic
exerciseinhumans:Roleofmusclemass".TheAmericanjournalofphysiology254(5Pt1):E55561.PMID3284382.
3.Bangsbo,J(1996)."Physiologicalfactorsassociatedwithefficiencyinhighintensityexercise".Sportsmedicine
(Auckland,N.Z.)22(5):299305.doi:10.2165/0000725619962205000003.PMID8923647.
4.Elia,M.(1992)"Energyexpenditureinthewholebody".Energymetabolism.Tissuedeterminantsandcellular
corollaries.6179RavenPressNewYork.ISBN9780881678710
5.Scholz,MNd'Aot,KBobbert,MFAerts,P(2006)."Verticaljumpingperformanceofbonobo(Panpaniscus)
suggestssuperiormuscleproperties".Proceedings.Biologicalsciences/theRoyalSociety273(1598):217784.
doi:10.1098/rspb.2006.3568.PMC1635523.PMID16901837.
6.Curtin,NAWoledge,RCAerts,P(2005)."Muscledirectlymeetsthevastpowerdemandsinagilelizards".
Proceedings.Biologicalsciences/theRoyalSociety272(1563):5814.doi:10.1098/rspb.2004.2982.PMC1564073.
PMID15817432.http://journals.royalsociety.org/content/gdgkj59wydr0vca7/fulltext.pdf
7.Henry,CJ(2005)."Basalmetabolicratestudiesinhumans:Measurementanddevelopmentofnewequations".Public
healthnutrition8(7A):113352.doi:10.1079/phn2005801.PMID16277825.
8.Henry2005providesBMRformulavariousagesgivenbodyweight:thoseforBMRaged1830inMJ/day(wheremass
isbodyweightinkg)are:maleBMR=0.0669mass+2.28femalesBMR=0.0546mass+2.331MJperday=11.6
W.Thedataprovidingtheseformulahideahighvariance:formenweighing70kg,measuredBMRisbetween50and
110W,andwomenweighing60kg,between40Wand90W.
9.Torun,B(2005)."Energyrequirementsofchildrenandadolescents".Publichealthnutrition8(7A):96893.
doi:10.1079/phn2005791.PMID16277815.
10.Keytel,L.R.(March2005)."Predictionofenergyexpenditurefromheartratemonitoringduringsubmaximalexercise."
(PDF).JournalofSportsSciences:10.Retrieved16April2015.
11.Barr,SI(1999)."Effectsofdehydrationonexerciseperformance".CanadianJournalofAppliedPhysiology24(2):164
72.doi:10.1139/h99014.PMID10198142.
12.CheuvrontSN,HaymesEM.(2001)Thermoregulationandmarathonrunning:biologicalandenvironmentalinfluences.
SportsMed.31:74362.
13.Porter,AM(2001)."Whydowehaveapocrineandsebaceousglands?".JournaloftheRoyalSocietyofMedicine94(5):
2367.PMC1281456.PMID11385091.
14.GonzlezAlonso,JMoraRodrguez,RBelow,PRCoyle,EF(1995)."Dehydrationreducescardiacoutputand
increasessystemicandcutaneousvascularresistanceduringexercise".Journalofappliedphysiology(Bethesda,Md.:
1985)79(5):148796.PMID8594004.
15.Holmqvist,NSecher,NHSanderJensen,KKnigge,UWarberg,JSchwartz,TW(1986)."Sympathoadrenaland
parasympatheticresponsestoexercise".Journalofsportssciences4(2):1238.doi:10.1080/02640418608732108.
PMID3586105.
16.Nybo,LDalsgaard,MKSteensberg,AMller,KSecher,NH(2005)."Cerebralammoniauptakeandaccumulation
duringprolongedexerciseinhumans".TheJournalofPhysiology563(Pt1):28590.doi:10.1113/jphysiol.2004.075838.
PMC1665558.PMID15611036.
17.Febbraio,MAPedersen,BK(2002)."Musclederivedinterleukin6:Mechanismsforactivationandpossiblebiological
roles".FASEBJournal16(11):133547.doi:10.1096/fj.010876rev.PMID12205025.
https://en.wikipedia.org/wiki/Exercise_physiology

9/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

18.Febbraio,MASteensberg,AKeller,CStarkie,RLNielsen,HBKrustrup,POtt,PSecher,NHPedersen,BK
(2003)."Glucoseingestionattenuatesinterleukin6releasefromcontractingskeletalmuscleinhumans".TheJournalof
Physiology549(Pt2):60712.doi:10.1113/jphysiol.2003.042374.PMC2342952.PMID12702735.
19.Siegel,AJVerbalis,JGClement,SMendelson,JHMello,NKAdner,MShirey,TGlowacki,Jetal.(2007).
"Hyponatremiainmarathonrunnersduetoinappropriateargininevasopressinsecretion".TheAmericanJournalof
Medicine120(5):461.e117.doi:10.1016/j.amjmed.2006.10.027.PMID17466660.
20.Siegel,AJ(2006)."Exerciseassociatedhyponatremia:Roleofcytokines".TheAmericanJournalofMedicine119(7
Suppl1):S748.doi:10.1016/j.amjmed.2006.05.012.PMID16843089.
21.Lassen,NA(1959)."Cerebralbloodflowandoxygenconsumptioninman".Physiologicalreviews39(2):183238.
PMID13645234.
22.RossenR,KabatH,AndersonJP(1943)."Acutearrestofcerebralcirculationinman".ArchNeurolPsychiat50:51028.
23.Todd,MMDunlop,BJShapiro,HMChadwick,HCPowell,HC(1981)."Ventricularfibrillationinthecat:Amodel
forglobalcerebralischemia".Strokeajournalofcerebralcirculation12(6):80815.doi:10.1161/01.STR.12.6.808.
PMID7303071.
24.Secher,NHSeifert,TVanLieshout,JJ(2008)."Cerebralbloodflowandmetabolismduringexercise:Implicationsfor
fatigue".Journalofappliedphysiology(Bethesda,Md.:1985)104(1):30614.doi:10.1152/japplphysiol.00853.2007.
PMID17962575.
25.Ogoh,SDalsgaard,MKYoshiga,CCDawson,EAKeller,DMRaven,PBSecher,NH(2005)."Dynamiccerebral
autoregulationduringexhaustiveexerciseinhumans".AmericanJournalofPhysiology.HeartandCirculatory
Physiology288(3):H14617.doi:10.1152/ajpheart.00948.2004.PMID15498819.
26.Ide,KHorn,ASecher,NH(1999)."Cerebralmetabolicresponsetosubmaximalexercise".Journalofapplied
physiology(Bethesda,Md.:1985)87(5):16048.PMID10562597.
27.Secher,NHSeifert,TVanLieshout,JJ(2008)."Cerebralbloodflowandmetabolismduringexercise:Implicationsfor
fatigue".Journalofappliedphysiology(Bethesda,Md.:1985)104(1):30614.doi:10.1152/japplphysiol.00853.2007.
PMID17962575.page309
28.Watson,PShirreffs,SMMaughan,RJ(2005)."Bloodbrainbarrierintegritymaybethreatenedbyexerciseinawarm
environment".AmericanJournalofPhysiology.Regulatory,IntegrativeandComparativePhysiology288(6):R168994.
doi:10.1152/ajpregu.00676.2004.PMID15650123.
29.Kemppainen,JAalto,SFujimoto,TKalliokoski,KKLngsj,JOikonen,VRinne,JNuutila,PKnuuti,J(2005).
"Highintensityexercisedecreasesglobalbrainglucoseuptakeinhumans".TheJournalofPhysiology568(Pt1):32332.
doi:10.1113/jphysiol.2005.091355.PMC1474763.PMID16037089.
30.Smith,DPernet,AHallett,WABingham,EMarsden,PKAmiel,SA(2003)."Lactate:Apreferredfuelforhuman
brainmetabolisminvivo".Journalofcerebralbloodflowandmetabolism:officialjournaloftheInternationalSociety
ofCerebralBloodFlowandMetabolism23(6):65864.doi:10.1097/01.WCB.0000063991.19746.11.PMID12796713.
31.Lubow,JMPin,IGAvogaro,ACobelli,CTreeson,DMMandeville,KAToffolo,GBoyle,PJ(2006)."Brain
oxygenutilizationisunchangedbyhypoglycemiainnormalhumans:Lactate,alanine,andleucineuptakearenotsufficient
tooffsetenergydeficit".AmericanJournalofPhysiology.EndocrinologyandMetabolism290(1):E149E153.
doi:10.1152/ajpendo.00049.2005.PMID16144821.
32.Dalsgaard,MK(2006)."Fuellingcerebralactivityinexercisingman".Journalofcerebralbloodflowandmetabolism:
officialjournaloftheInternationalSocietyofCerebralBloodFlowandMetabolism26(6):73150.
doi:10.1038/sj.jcbfm.9600256.PMID16395281.
33.Baker,LBConroy,DEKenney,WL(2007)."Dehydrationimpairsvigilancerelatedattentioninmalebasketball
players".Medicineandscienceinsportsandexercise39(6):97683.doi:10.1097/mss.0b013e3180471ff2.
PMID17545888.
34.Cian,CBarraud,PAMelin,BRaphel,C(2001)."Effectsoffluidingestiononcognitivefunctionafterheatstressor
exerciseinduceddehydration".Internationaljournalofpsychophysiology:officialjournaloftheInternational
OrganizationofPsychophysiology42(3):24351.doi:10.1016/S01678760(01)001428.PMID11812391.
35.Sharma,VMSridharan,KPichan,GPanwar,MR(1986)."Influenceofheatstressinduceddehydrationonmental
functions".Ergonomics29(6):7919.doi:10.1080/00140138608968315.PMID3743537.
36.Maughan,RJShirreffs,SMWatson,P(2007)."Exercise,heat,hydrationandthebrain".JournaloftheAmerican
CollegeofNutrition26(5Suppl):604S612S.doi:10.1080/07315724.2007.10719666.PMID17921473.
37.Nybo,LMller,KVolianitis,SNielsen,BSecher,NH(2002)."Effectsofhyperthermiaoncerebralbloodflowand
metabolismduringprolongedexerciseinhumans".Journalofappliedphysiology93(1):5864.
doi:10.1152/japplphysiol.00049.2002.PMID12070186.
38.Nybo,LNielsen,B(2001)."Middlecerebralarterybloodvelocityisreducedwithhyperthermiaduringprolonged
exerciseinhumans".TheJournalofPhysiology534(Pt1):27986.doi:10.1111/j.14697793.2001.t01100279.x.
PMC2278686.PMID11433008.
https://en.wikipedia.org/wiki/Exercise_physiology

10/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

39.Hermansen,L(1981)."Effectofmetabolicchangesonforcegenerationinskeletalmuscleduringmaximalexercise".
CibaFoundationsymposium82:7588.PMID6913479.
40.Brooks,GA(2001)."Lactatedoesn'tnecessarilycausefatigue:Whyarewesurprised?".TheJournalofPhysiology536
(Pt1):1.doi:10.1111/j.14697793.2001.t01100001.x.PMC2278833.PMID11579151.
41.Gladden,LB(2004)."Lactatemetabolism:Anewparadigmforthethirdmillennium".TheJournalofPhysiology558(Pt
1):530.doi:10.1113/jphysiol.2003.058701.PMC1664920.PMID15131240.
42.PedersenTH,NielsenOB,LambGD,StephensonDGNielsenLambStephenson(2004)."Intracellularacidosis
enhancestheexcitabilityofworkingmuscle".Science305(5687):11447.Bibcode:2004Sci...305.1144P.
doi:10.1126/science.1101141.PMID15326352.
43.McKenna,MJBangsbo,JRenaud,JM(2008)."MuscleK+,Na+,andCldisturbancesandNa+K+pumpinactivation:
Implicationsforfatigue".Journalofappliedphysiology(Bethesda,Md.:1985)104(1):28895.
doi:10.1152/japplphysiol.01037.2007.PMID17962569.
44.Bellinger,AMReiken,SDura,MMurphy,PWDeng,SXLandry,DWNieman,DLehnart,SEetal.(2008).
"Remodelingofryanodinereceptorcomplexcauses"leaky"channels:Amolecularmechanismfordecreasedexercise
capacity".ProceedingsoftheNationalAcademyofSciencesoftheUnitedStatesofAmerica105(6):2198202.
Bibcode:2008PNAS..105.2198B.doi:10.1073/pnas.0711074105.PMC2538898.PMID18268335.
45.Noakes,TMekler,JPedoe,DT(2008)."JimPeters'collapseinthe1954VancouverEmpireGamesmarathon".South
Africanmedicaljournal98(8):596600.PMID18928034.
46.Hill,A.V.,Long,C.N.H.andLupton,H.(1924).Muscularexercise,lacticacidandthesupplyandutilisationof
oxygen(http://journals.royalsociety.org/content/k51611345m783727/fulltext.pdf).PartsIIII.Proc.R.Soc.Lond.97,
438475.
47.StClairGibson,ABaden,DALambert,MILambert,EVHarley,YXHampson,DRussell,VANoakes,TD(2003).
"Theconsciousperceptionofthesensationoffatigue".Sportsmedicine(Auckland,N.Z.)33(3):16776.
doi:10.2165/0000725620033303000001.PMID12656638.
48.Noakes,TDStClairGibson,ALambert,EV(2005)."Fromcatastrophetocomplexity:Anovelmodelofintegrative
centralneuralregulationofeffortandfatigueduringexerciseinhumans:Summaryandconclusions".Britishjournalof
sportsmedicine39(2):1204.doi:10.1136/bjsm.2003.010330.PMC1725112.PMID15665213.
49.Noakes,TDPeltonen,JERusko,HK(2001)."Evidencethatacentralgovernorregulatesexerciseperformanceduring
acutehypoxiaandhyperoxia".TheJournalofExperimentalBiology204(Pt18):322534.PMID11581338.
50.Noakes,TD(2000)."Physiologicalmodelstounderstandexercisefatigueandtheadaptationsthatpredictorenhance
athleticperformance".Scandinavianjournalofmedicine&scienceinsports10(3):12345.doi:10.1034/j.1600
0838.2000.010003123.x.PMID10843507.
51.StClairGibson,ALambert,MLNoakes,TD(2001)."Neuralcontrolofforceoutputduringmaximalandsubmaximal
exercise".Sportsmedicine(Auckland,N.Z.)31(9):63750.doi:10.2165/0000725620013109000001.PMID11508520.
52.EsteveLanao,JLucia,ADekoning,JJFoster,C(2008).Earnest,ConradP.,ed."Howdohumanscontrol
physiologicalstrainduringstrenuousenduranceexercise?".PLoSONE3(8):e2943.Bibcode:2008PLoSO...3.2943E.
doi:10.1371/journal.pone.0002943.PMC2491903.PMID18698405.
53.Nybo,L(2008)."Hyperthermiaandfatigue".Journalofappliedphysiology(Bethesda,Md.:1985)104(3):8718.
doi:10.1152/japplphysiol.00910.2007.PMID17962572.
54.Dalsgaard,MKSecher,NH(2007)."Thebrainatwork:Acerebralmetabolicmanifestationofcentralfatigue?".Journal
ofneuroscienceresearch85(15):33349.doi:10.1002/jnr.21274.PMID17394258.
55.Ferreira,LFReid,MB(2008)."MusclederivedROSandthiolregulationinmusclefatigue".Journalofapplied
physiology(Bethesda,Md.:1985)104(3):85360.doi:10.1152/japplphysiol.00953.2007.PMID18006866.
56.Romer,LMPolkey,MI(2008)."Exerciseinducedrespiratorymusclefatigue:Implicationsforperformance".Journalof
appliedphysiology(Bethesda,Md.:1985)104(3):87988.doi:10.1152/japplphysiol.01157.2007.PMID18096752.
57.Amann,MCalbet,JA(2008)."Convectiveoxygentransportandfatigue".Journalofappliedphysiology(Bethesda,
Md.:1985)104(3):86170.doi:10.1152/japplphysiol.01008.2007.PMID17962570.
58.Newsholme,EABlomstrand,E(1995)."Tryptophan,5hydroxytryptamineandapossibleexplanationforcentral
fatigue".Advancesinexperimentalmedicineandbiology.AdvancesinExperimentalMedicineandBiology384:31520.
doi:10.1007/9781489910165_25.ISBN9781489910189.PMID8585461.
59.Scharhag,JGeorge,KShave,RUrhausen,AKindermann,W(2008)."Exerciseassociatedincreasesincardiac
biomarkers".Medicineandscienceinsportsandexercise40(8):140815.doi:10.1249/MSS.0b013e318172cf22.
PMID18614952.
60.Lippi,GSchena,FSalvagno,GLMontagnana,MGelati,MTarperi,CBanfi,GGuidi,GC(2008)."Influenceofa
halfmarathonrunonNTproBNPandtroponinT".Clinicallaboratory54(78):2514.PMID18942493.
61.TheLabSaysHeartAttack,butthePatientIsFine(http://www.nytimes.com/2008/11/27/health/nutrition/27best.html)
NewYorkTimes,27November2008
https://en.wikipedia.org/wiki/Exercise_physiology

11/12

7/3/2016

ExercisephysiologyWikipedia,thefreeencyclopedia

62.Bramble,DMLieberman,DE(2004)."EndurancerunningandtheevolutionofHomo"(PDF).Nature432(7015):345
52.Bibcode:2004Natur.432..345B.doi:10.1038/nature03052.PMID15549097.
63.Carrier,DavidR.(1984)."TheEnergeticParadoxofHumanRunningandHominidEvolution".CurrentAnthropology25
(4):483.doi:10.1086/203165.
64.Snellen,JWMitchell,DWyndham,CH(1970)."Heatofevaporationofsweat".Journalofappliedphysiology29(1):
404.PMID5425034.
65.Lupi,O(2008)."Ancientadaptationsofhumanskin:Whydoweretainsebaceousandapocrineglands?".International
JournalofDermatology47(7):6514.doi:10.1111/j.13654632.2008.03765.x.PMID18613867.
66.Liebenberg,Louis(2006)."PersistenceHuntingbyModernHunterGatherers".CurrentAnthropology47(6):1017
1026.doi:10.1086/508695.
67.Feder,MEGarlandJr,TMarden,JHZera,AJ(2010)."Locomotioninresponsetoshiftingclimatezones:Notsofast"
(PDF).AnnualReviewofPhysiology72:16790.doi:10.1146/annurevphysiol021909135804.PMID20148672.
68.Koch,L.G.Britton,S.L.(2001)."Artificialselectionforintrinsicaerobicendurancerunningcapacityinrats".
PhysiologicalGenomics5(1):4552.PMID11161005.
69.Waters,RPRenner,KJPringle,RBSummers,CHBritton,SLKoch,LGSwallow,JG(2008)."Selectionforaerobic
capacityaffectscorticosterone,monoaminesandwheelrunningactivity".Physiology&Behavior93(45):104454.
doi:10.1016/j.physbeh.2008.01.013.PMC2435267.PMID18304593.
70.Swallow,JGCarter,PAGarlandJr,T(1998)."Artificialselectionforincreasedwheelrunningbehaviorinhousemice".
Behaviorgenetics28(3):22737.doi:10.1023/A:1021479331779.PMID9670598.
71.Meek,THLonquich,BPHannon,RMGarlandJr,T(2009)."Endurancecapacityofmiceselectivelybredforhigh
voluntarywheelrunning".TheJournalofExperimentalBiology212(18):290817.doi:10.1242/jeb.028886.
PMID19717672.
72.Nosaka,Ken(2008)."MuscleSorenessandDamageandtheRepeatedBoutEffect".InTiidus,PeterM.Skeletalmuscle
damageandrepair.HumanKinetics.pp.5976.ISBN9780736058674.
73.Cheung,KarolineHume,PatriaA.Maxwell,Linda(20121023)."DelayedOnsetMuscleSoreness".SportsMedicine
33(2):145164.doi:10.2165/0000725620033302000005.ISSN01121642.
74.Davis,Paul."CareersinExercisePhysiology".
75.AmericanCollegeofSportsMedicine(2010).ACSM'sguidelinesforexercisetestingandprescription(8thed.).
Philadelphia:LippincottWilliams&Wilkins.ISBN9780781769037.
76.University,Ohio."ClassRequirements".

Retrievedfrom"https://en.wikipedia.org/w/index.php?title=Exercise_physiology&oldid=725128629"
Categories: Athletictraining Endurancesports Evolutionarybiology Exercisephysiology Humanevolution
Physiology
Thispagewaslastmodifiedon13June2016,at19:11.
TextisavailableundertheCreativeCommonsAttributionShareAlikeLicenseadditionaltermsmayapply.
Byusingthissite,youagreetotheTermsofUseandPrivacyPolicy.Wikipediaisaregisteredtrademark
oftheWikimediaFoundation,Inc.,anonprofitorganization.

https://en.wikipedia.org/wiki/Exercise_physiology

12/12

You might also like