Cognitive Impairment and Dementia in Parkinson's Disease - Clinical Features, Diagnosis, and Management

REVIEW ARTICLE
published: 25 May 2012

doi: 10.3389/fneur.2012.00088
Cognitive impairment and dementia in Parkinsons

disease: clinical features, diagnosis, and management
Joana Meireles 1,2 and Joo Massano 1,2,3 *
1
2
3
Department of Neurology, Centro Hospitalar de So Joo, Porto, Portugal

Department of Clinical Neuroscience and Mental Health, Faculty of Medicine University of Porto, Porto, Portugal
Movement Disorders and Functional Surgery Unit, Centro Hospitalar de So Joo, Porto, Portugal
Edited by:
Martin Rhys Farlow, Indiana
University School of Medicine, USA
Reviewed by:
Pablo Martinez, Reina Sophia
Institute, Spain
Jonathan Rohrer, University College
London, UK
*Correspondence:
Joo Massano, Movement Disorders
and Functional Surgery Unit,
Department of Neurology, Centro
Hospitalar de So Joo, Alameda
Professor Hernni Monteiro,
4200-319 Porto, Portugal.
e-mail: [email protected]
Parkinsons disease (PD) is a common, disabling, neurodegenerative disorder. In addition

to classical motor symptoms, non-motor features are now widely accepted as part of the
clinical picture, and cognitive decline is a very important aspect of the disease, as it brings
an additional significant burden for the patient and caregivers. The diagnosis of cognitive
decline in PD, namely mild cognitive impairment (MCI) and dementia, can be extremely
challenging, remaining largely based on clinical and cognitive assessments. Diagnostic criteria and methods for PD dementia and MCI have been recently issued by expert work
groups. This manuscript has synthesized relevant data in order to obtain a pragmatic and
updated review regarding cognitive decline in PD, from milder stages to dementia. This
text will summarize clinical features, diagnostic methodology, and therapeutic issues of
clinical decline in PD. Relevant clinical genetic issues, including recent advances, will also
be approached.
Keywords: dementia, diagnosis, diagnostic criteria, mild cognitive impairment, non-motor symptoms, Parkinsons
disease, Parkinsons disease dementia, cognition
INTRODUCTION
Parkinsons disease (PD) is the second most common neurodegenerative disorder, following Alzheimers disease. Nearly 200 years
have gone by since James Parkinsons original clinical depictions in
his monograph entitled An Essay on the Shaking Palsy (Parkinson,
1817; Goetz, 2011). The text focused mainly on the motor features of PD, overlooking non-motor symptoms, with the notable
exception of melancholy but cognitive impairment was at that
time completely disregarded. It is currently recognized that the
spectrum of non-motor features in PD is broad (Chaudhuri and
Schapira, 2009; Tolosa et al., 2009; Massano and Bhatia, 2012),
but these may often be missed in clinical practice. Nonetheless,
whenever PD is suspected, the routine approach should include a
set of questions aimed at exploring their presence, since they may
be helpful hints for the diagnosis, although they are non-specific
in this regard. On the other hand, it is useful to quantify their
severity and impact, as they carry an important additional burden on the patients, leading to significantly deteriorated quality
of life (QOL), and warranting specific therapeutic interventions,
despite the fact that evidence-based data on treatment are unsatisfactory in many instances (Chaudhuri and Schapira, 2009; Tolosa
et al., 2009; Zesiewicz et al., 2010). Braak and coworkers have
greatly contributed to the awareness of the association between
symptoms and the neuropathological lesions affecting the nervous system (Braak et al., 2003; Hawkes et al., 2010). Indeed, due
to long term progression and the mode of pathological spreading,
some of the non-motor features of PD may be present before any
of the classical motor signs are noticeable, sometimes for years
or even decades, which may lend them potential utility as supportive diagnostic features in early disease stages these include
www.frontiersin.org
hyposmia, rapid eye movement (REM) sleep behavior disorder,

constipation, and depression (Chaudhuri and Schapira, 2009; Lim
et al., 2009; Tolosa et al., 2009; Hawkes et al., 2010; Savica et al.,
2010; Schapira and Tolosa, 2010). Patients may have these and
other symptoms before overt motor signs emerge and the clinical
diagnosis is finally established. On the other hand, features like
dementia and hallucinations tend to occur later in the course of
disease, which might be useful for distinguishing PD from other
disorders. Cognitive impairment is a major non-motor feature
of PD, but the diagnosis is often complex, remaining based on
clinical skills and methods, as no reliable diagnostic biomarkers
have been described yet. Mild cognitive dysfunction is apparent
in many cases from early stages (Aarsland et al., 2009; Barone
et al., 2011; Domellf et al., 2011; Litvan et al., 2011), but recent
research has shown that manifest dementia will occur in over 80%
of patients after 20 years of disease (Hely et al., 2008). Accurate
cognitive assessment and classification is also paramount in the
context of deep brain stimulation for PD, an issue approached in
detail in the article by Massano and Garrett (2012), also part of
this Frontiers Research Topic. The present manuscript will cover
the clinical aspects of cognitive decline in PD, namely mild cognitive impairment (MCI), and dementia (PD-D), including typical
features, diagnosis, and management issues.
METHODS
A comprehensive PubMed literature search was conducted for
papers published until September 2011, using the keywords
Parkinsons disease, Parkinsons disease dementia, mild cognitive impairment. From all the references found, the authors
have consensually chosen those most relevant to the review, in
May 2012 | Volume 3 | Article 88 | 1
Meireles and Massano
order to obtain a clinically oriented perspective of the state of the

art knowledge regarding cognitive decline in PD. Exceptionally,
later references of interest, published in the meantime, have also
been considered.
EPIDEMIOLOGY OF PARKINSONS DISEASE DEMENTIA

Due to differences in diagnostic criteria, methodology, and study
populations, epidemiological numbers regarding PD-D tend to
vary greatly. The prevalence of dementia in community-based
studies has been estimated at 3040% (Aarsland et al., 2005; Aarsland and Kurz, 2010) but figures range from about 10 to 80% of
people with PD (Aarsland et al., 2005; Aarsland and Kurz, 2010).
Even in young onset PD, defined as symptoms emerging from
21 to 40 years (Schrag and Schott, 2006), dementia affects up to
19% of patients after a median of 18 years of disease duration
(Schrag et al., 1998). In addition, cognitive decline is noted in up
to 36% of newly diagnosed cases of PD (Reid et al., 1989; Foltynie
et al., 2004). From the published literature, it seems clear that the
prevalence of dementia increases with age and duration of the disease symptoms (Hughes et al., 2000; Aarsland and Kurz, 2010),
although some have suggested that patient age could be preponderant (Aarsland et al., 2007). The Sydney Multicenter Study has
been an exceptional initiative in this field of research, as one group
of clinicians followed a single cohort of newly diagnosed people
with PD over 20 years. Sydney neurologists were asked to refer
their newly diagnosed PD patients for a 5-year trial comparing
low dose bromocriptine with low dose levodopa/carbidopa (Hely
et al., 1994). During this study, neuropsychological assessments
were performed at baseline and at 3, 5, 10, and 20 years. At baseline, 26 newly diagnosed PD patients were demented by current
definitions, these would be classified as dementia with Lewy bodies (DLB) cases. A neuropsychological diagnosis of dementia was
made on the basis of impairment in memory and at least two other
areas of cognitive functioning. A test score at least two standard
deviations (SD) below the mean score obtained by the control
group was classified as cognitive impairment. The control group
consisted of 50 age-, gender-, and education-matched community living people without PD, who were friends or relatives of the
patients. If no neuropsychological assessment was carried out, a
diagnosis of dementia was based on a Clinical Dementia Rating
score of at least 1, with supporting evidence of gradual cognitive
decline sufficient to impair daily functioning. This was sustained
by performance in Mini-Mental State Examination (MMSE), letter and category fluency, and clock face drawing. At 20 years, 25 of
30 (83%) surviving patients had become demented and 2 others
have developed dementia subsequently (Hely et al., 2008).
In an earlier review of 27 studies, Cummings found a mean
prevalence of dementia in PD of 40%, even though at that
time studies did not include the identification and exclusion of
patients with DLB (Cummings, 1988). The incidence of dementia
is increased by 2.8- to 6-fold in those with PD when compared
to those without the disease (Aarsland et al., 2005; de Lau et al.,
2005; Aarsland and Kurz, 2010). The cumulative prevalence is very
high at least 75% of the patients with PD who survive for more
than 10 years will develop dementia (Aarsland and Kurz, 2010).
Several risk factors for PD-D have been proposed, including certain predominant motor features such as rigidity and gait
Frontiers in Neurology | Dementia
Cognitive impairment and dementia in Parkinsons disease
instability, MCI, and the presence of visual hallucinations (Goetz

et al., 2008). Older age is broadly accepted as a risk factor for
dementia in PD. Some authors have found parameters such as
disease duration, age of onset, and motor symptom severity to
be significant risk factors, but published data are at times contradictory (Aarsland and Kurz, 2010). Interesting findings have been
brought to light regarding genetics and cognitive decline in PD, a
few of them quite recently, as we will further detail in the text.
PARKINSONS DISEASE DEMENTIA: CLINICAL FEATURES

Dementia associated with PD holds suggestive phenotypic cognitive features that make it a recognizable and individualized entity.
This issue will be further detailed, focusing on its mode of onset,
profile of cognitive deficits, behavioral aspects, and motor phenotype, as well as other features. Dementia adds substantially to the
burden of disease for the patient, caregiver, and the community
(Aarsland et al., 1999, 2000), thus warranting accurate diagnosis
and management.
PATTERN OF ONSET AND PROGRESSION
The onset of PD-D is insidious, often making it difficult for the

patient and the family to evoke when the first signs of cognitive
dysfunction started. The evolution is progressive. In one prospective, 4-year study, the mean annual MMSE decline was 1 point
in PD subjects without dementia versus 2.3 points in the PD-D
group, a figure similar to that seen in patients with AD (Aarsland
et al., 2004). During the 5 year follow-up of the CamPaIGN cohort,
researchers have found that MMSE scores declined at a mean rate
of 0.3 0.1 points per year over the 5.2 years of average observation (Williams-Gray et al., 2009). Dementia in the early stages of
PD is not considered a typical feature of the disease (Massano and
Bhatia, 2012); by current consensus definitions, whenever parkinsonism and dementia arise in close temporal relationship, those
cases should be classified as DLB, as the diagnosis of PD-D requires
the preceding diagnosis of PD followed by the later development of
dementia (McKeith et al., 2005; Emre et al., 2007a). Early indicators
associated with cognitive decline may include excessive daytime
sleepiness (Gjerstad et al., 2002). Visual hallucinations are relatively frequent, as are bizarre but ill-defined misperceptions or
psychotic phenomena (such as feeling that there is someone else
in the room, when indeed this is not the case). Increasing apathy, impaired attention and concentration, and forgetfulness are
also frequent features (Goetz et al., 2008), although memory complaints as initial presentation are less frequent than in DLB and,
particularly, AD (Noe et al., 2004). The course of decline in PD-D
is relentless and progressive over time. Patients may remain stable for several months, at times with periods of faster worsening
with no additional obvious cause (Emre, 2010). Fluctuations occur
from day to day and during the same day, which is a similar pattern
to that of DLB (Ballard et al., 2002).
Hobson and coworkers have studied a community based cohort
of PD patients with and without dementia. They found that
standardized mortality ratios (SMR) were significantly higher in
PD-D patients than in PD non-demented individuals (SMR 3.10,
versus 1.15, p < 0.001). Life expectancy in younger-onset PD-D
(5574 years old) was significantly lower than in non-demented
patients (average 7.5 versus 12.4 years), and the estimated age
at death was also much lower in the first group (72.4 versus
77.8 years). Differences regarding life expectancy and age at death
in older-onset PD-D were less obvious (Hobson et al., 2010). Other
authors have also found an increased mortality risk among PD
patients with dementia (Levy et al., 2002; de Lau et al., 2005).
COGNITIVE PHENOTYPE OF PARKINSONS DISEASE DEMENTIA
Assessment of cognition in PD patients can be a demanding

and exhausting mission for both the patient and examiner. Disease symptoms such as tremor, bradykinesia, bradyphrenia, pain,
fatigue, sleepiness, and mood disorders, as well as medication
effects, can interfere with cognitive performance and testing. Also,
timed tests can be seriously affected due to motor slowing, and
those depending on motor capacity to perform the task, such as
drawing, can be interfered by tremor.
Executive functions have been defined as capacities that enable
a person to engage successfully in independent, purposive, and selfserving behavior, and encompass cognitive processes such as initiation, planning, purposive action, self-monitoring, self-regulation,
volition, inhibition, and flexibility (Stuss, 2011). Executive dysfunction has been widely recognized as a very important feature
of the cognitive phenotype of PD, even in non-demented patients,
although published data has been marred by inconsistencies in definitions and research methods (Kudlicka et al., 2011). The most
widely used tests to probe executive functioning in PD have been
verbal fluency, digit span backward, Wisconsin Card Sorting Test,
Stroop Test, and Trail Making Test (Kudlicka et al., 2011). Accumulated research data has shown that executive dysfunction is a
prominent feature in PD-D (Trster, 2008; Kehagia et al., 2010).
There is clinical and electrophysiological evidence of slowed
cognition in PD-D, although this may be apparent even in nondementia stages (Rogers et al., 1987; Owen et al., 1992; OMahony
et al., 1993; Hanes et al., 1996; Turner et al., 2002). Attentional
deficits have been consistently shown in PD-D. In tests such as the
letter cancelation test and others, PD-D patients are slower, tend
to fluctuate more, and incur on a higher number of errors than
AD subjects, whereas the profile of PD-D seems to be similar to
that seen in DLB (Ballard et al., 2002; Noe et al., 2004; Bronnick
et al., 2007).
Visuospatial function is a term used to describe a wide range of
functions that must be assessed by different tests, the unifying feature being that all of them rely on visual function and processing
(Jeannerod and Jacob, 2005). Findings from studies pertaining to
this matter have shown greater deficits in PD-D than AD patients
(Starkstein et al., 1996). It has been shown that visual perception, space-motion, and object-form perception are globally more
impaired in PD-D patients than in control subjects, including normal controls and non-demented PD patients, and AD (Mosimann
et al., 2004).
In PD-D, short term memory is impaired, both for initial
learning and immediate recall. Traditionally, mnesic deficits in
PD have been considered to be mainly of retrieval, rather than
encoding and storage (Pillon et al., 1993). In PD-D, however,
patients may also be impaired on cued recall (Higginson et al.,
2005). A large meta-analysis has shown that verbal fluency impairment is more pronounced than that seen in PD non-demented
patients; also, semantic fluency seems to be more compromised
www.frontiersin.org
than phonemic fluency (Henry and Crawford, 2004). Concept

formation is also impaired in PD-D (Cahn-Weiner et al., 2002,
2003). The Clock-Drawing Test displays marked changes in PD-D,
although it is similar to that found in DLB, and AD. PD-D and
DLB patients demonstrate more planning errors, as compared to
AD (Cahn-Weiner et al., 2003).
Significant dysphasia is not typically seen in PD-D, and language deficits occur much less frequently in PD-D than in AD
(Pillon et al., 1993; Frank et al., 1996; Kramer and Duffy, 1996).
Certain phenotypic characteristics pertaining to cognitive
decline have been used to differentiate cortical from subcortical dementia syndromes (Darvesh and Freedman, 1996; Salmon
and Filoteo, 2007; Bonelli and Cummings, 2008). Cortical dementia syndromes display impairments of cognitive domains such as
episodic memory, praxis, language, and calculation, whereas subcortical dementias tend to show slowed mental processing speed
and frontal lobe changes such as apathy, irritability, and dysexecutive impairment. The cortical profile is typical of AD, whereas
PD-D and DLB typify the subcortical dementia type, but many
cases fit the opposite prototype (Janvin et al., 2006). Characteristically, early impairment of episodic memory is seen in AD, in
accordance to the pathological changes seen in this disorder (Weintraub et al., 2012). For more details on the clinical features of AD
please refer to the manuscript by Alves et al. (2012) included in
this Frontiers Research Topic.
BEHAVIORAL OR NEUROPSYCHIATRIC SYMPTOMS
Psychotic symptoms
Hallucinations occur in 4565% of PD-D patients, a higher rate

than in the general population of PD; these come about usually in
the visual perceptual modality (Aarsland et al., 2001a,b,c). In PD
patients without dementia, hallucinations are an important predictor for the development of dementia and institutionalization
(Giladin et al., 2000). Hallucinations tend to be more common
in DLB than in PD-D and in these more frequent than in AD
(Hirono et al., 1999; Aarsland et al., 2000, 2001a,b; Benoit et al.,
2005). Hallucinations in PD-D and DLB tend to present similar
characteristics, as they are usually complex and well formed, often
colorful moving images, with people and animals being a frequent
motif (Williams and Lees, 2005; Janvin et al., 2006). Brief, illdefined peripheral images (de passage) may also occur and be less
appreciated by the patient (Fenelon et al., 2000). Delusions seem
to be less frequent than hallucinations in PD-D, and are estimated
to occur in about 30% of patients; this rate is greater than in AD
but lower than in DLB (Aarsland et al., 2001b). Delusional activity in PD-D includes feeling of presence, phantom boarder (the
delusional belief that there are foreign people in the house, who
may even interfere with the patients life, e.g., eat their food or misplace their objects), paranoid, or grandiose delusions; delusional
activity may be broad or isolated to a single subject.
Mood and anxiety
Aarsland and coworkers have conducted a community-based study

and have documented major depression in 13% of PD-D subjects, compared with 9% of non-demented PD patients. This rate
is lower than in DLB, but greater than in AD (Starkstein et al.,
1996; Aarsland et al., 2001a). Dysphoric mood with depressive
symptoms occurs with approximately the same frequency in PD-D

and AD (4058%) patients (Aarsland et al., 2001b). Anxiety occurs
at a similar frequency (3049%) as depressed mood, and these
symptoms may frequently co-exist in the same patient (Menza
et al., 1993; Bronnick et al., 2005). Irritable mood, anger, and
aggression are common in AD, but uncommon in PD-D (Engelborghs et al., 2005). Manic or hypomanic mood is infrequently
seen in PD-D (Starkstein et al., 1996).
Apathy
It has been reported in 54% of patients in a large sample of mild to

moderate PD-D (Aarsland et al., 2001b). Prominent apathy is very
common in other forms of dementia, including frontotemporal
dementia (Kertesz, 2003), progressive supranuclear palsy (Aarsland et al., 2001c), AD (Benoit et al., 2005), and DLB (Engelborghs
et al., 2005); thus, this feature is not specific enough to guide
diagnosis.
NON-COGNITIVE FEATURES OF PARKINSONS DISEASE

DEMENTIA
Non-motor complications of PD-D are frequent, and those features are now assumed to be an intrinsic part of the pathological
processes involved. Therefore, it seems legitimate to assume that
motor and non-motor features must be interrelated. PD-D neuropathological findings are detailed in the manuscript by Taipa
et al. (2012), included in this Frontiers Research Topic.
MOTOR PHENOTYPE
There is the notion that certain motor features, such as postural

instability and gait disorder (PIGD) are associated with a faster
progression rate of cognitive decline in PD, being a risk factor
for dementia (Burn et al., 2006). Levy et al. (2002) have documented that older patients with more severe parkinsonian signs
had a relatively increased risk for incident dementia than younger
and mildly affected subjects. Tremor predominance as the initial
presentation has been associated with a lower risk for cognitive
decline in some studies. These patients seem to remain protected
against cognitive decline, unless they evolve to the PIGD phenotype (Elizan et al., 1986; Reid et al., 1989; Wood et al., 2002).
Clinicopathological studies have shown that dementia is most
common in PD patients with akinesia/rigidity than in the tremor
dominant and mixed phenotypes (Rajput et al., 2009; Selikhova
et al., 2009). Poorer cognitive performance is also associated with
poorer outcomes in motor and non-motor domains, as a study
by Papapetropoulos et al. (2004) has shown. PD-D also seems to
be an independent risk factor for falls; other predictors of cognitive decline include previous falls, longer time from disease onset,
and decreased arm swing (Wood et al., 2002; Pickering et al.,
2007). For levodopa responsivity, data are inconsistent in showing
any pattern that differentiates PD-D patients from PD patients
without dementia (Stern et al., 1993; Bonelli et al., 2004). A 3year longitudinal study, however, documented greater cognitive
decline in PD patients with less than a 50% levodopa-induced
improvement at baseline (Caparros-Lefebvre et al., 1995). Furthermore, an autopsy study has suggested that loss of levodopa
responsivity is correlated with dementia due to greater loss of
striatal D3 receptors (Joyce et al., 2002). Although fewer dyskinesias were reported in PD-D patients in a cross-sectional study, a
longitudinal study found greater mental deterioration in those PD

patients with baseline levodopa-induced dyskinesias (Elizan et al.,
1986; Caparros-Lefebvre et al., 1995).
SLEEP DISORDERS
REM sleep behavior disorder (RBD) is characterized by dream

enacting behavior, such as jumping out of bed, talking, or kicking. While in REM sleep, abnormal electromyographic activity
is present, thus demonstrating the anomalous absence of muscle
atonia during this stage of sleep (Olson et al., 2000; Iranzo et al.,
2006; Frauscher et al., 2008). The pathophysiology is thought to
be related to lesions inflicted on the brainstem REM sleep centers
that inhibit the spinal cord motoneurons and their connections,
as these structures are usually damaged in PD (Boeve et al., 2009;
Iranzo, 2011).
REM sleep behavior disorder may be idiopathic or linked to
several neurodegenerative diseases such as PD, DLB, and multiple
system atrophy. A study by Iranzo and collaborators has reported
that 45% of the idiopathic RBD patients studied developed a neurological disorder after a mean of 11.5 years from the reported
onset of RBD PD in nine patients (two of them with dementia),
DLB in six, MSA in one, and MCI in four by the end of the 5 year
follow-up period. Neuropsychological evaluation disclosed cognitive decline of various degrees of severity; three of the four MCI
patients showed visuospatial deficits and short term free recall
impairment that benefited from external cues (Iranzo et al., 2006).
Patients with idiopathic RBD usually do not report cognitive
problems, but Terzaghi et al. (2008) demonstrated that a visuospatial construction deficit was present in 44% of the patients who suffered from idiopathic RBD. The cognitive profile found in patients
with idiopathic RBD usually comprises visuospatial capacities,
verbal memory, attention, and executive function impairment.
Usually these subjects show no impairment in semantic memory and language, deficits commonly seen in AD (Ferrini-Strambi
et al., 2004; Weintraub et al., 2012). Similarities have also been
found between EEG patterns of idiopathic RBD, with cortical EEG
slowing (abundant delta and theta waves) in frontal, temporal, and
occipital regions, also found in PD and DLB patients (Kai et al.,
2005; Caviness et al., 2007b). Some studies have tried to characterize RBD patients with MCI. Gagnon and coworkers have found
that most PD patients (73%) with RBD display MCI, while many
patients with idiopathic RBD (50%) also show MCI. The main
subtypes of MCI seem to be single domain non-amnestic and
amnestic in PD, while in idiopathic RBD the predominant subtype
was non-amnestic MCI; all these patients displayed predominantly
executive-attentional impairment (Gagnon et al., 2009). It is currently accepted that RBD occurs in PD patients with associated
MCI and dementia, however RBD may also occur in PD patients
with no associated cognitive deficits (Iranzo et al., 2005; Gagnon
et al., 2009).
AUTONOMIC SYMPTOMS
Dementia and significant autonomic features may develop in the

course of PD, especially in later stages (Hely et al., 2005; Hawkes
et al., 2010), hence one could presumably postulate an association
between autonomic symptoms and PD-D. This is however yet to
be proven by comprehensive studies. The amount of data on the
relative frequency of autonomic features in demented compared

to non-demented PD patients is scarce. Idiaquez and collaborators have assessed 40 PD patients and 30 age matched controls
for cognitive and behavioral manifestations using standardized
neuropsychological tools. These subjects were assessed for orthostatic hypotension, heart rate, and responses to deep breathing
(SCOPA-AUT): 11 of these patients fulfilled the DSM-IV criteria
for dementia and a higher incidence of cardiovascular dysfunction
were found amongst demented patients (Idiaquez et al., 2007).
The presence of autonomic dysfunction has also been reported in
the Sydney multicenter study, after 15 years follow-up. Orthostatic hypotension was found in 35% and urinary hypotension has
also been reported in 41% of PD patients and these were most frequent among those with higher Hohen and Yahr scores (Hely et al.,
2005). In this study, however, it was not specified whether or not
autonomic symptoms were more frequent in demented patients.
The pathophysiological mechanisms of autonomic dysfunction
seem to be related to typical synuclein deposits throughout the
central and peripheral autonomic nervous systems. The extension
of these deposits to the limbic and cortical areas may be the cause
for the associated development of dementia. Trying to define the
neural substrate of autonomic dysfunction is difficult, as both systems may be implicated. Comorbidities are also important, as the
presence of symptoms, such as orthostatic hypotension, constipation, and urinary incontinence may be due to other causes besides
autonomic dysfunction. For instance, dopaminergic drugs may
also cause dysautonomic symptoms, leading to constipation, and
urinary incontinence (Winge and Fowler, 2006; Allan et al., 2007).
In summary, PD-D patients typically present with dysexecutive
syndrome, fluctuating attentional deficits, visuospatial impairment, and memory dysfunction, associated with behavioral symptoms (Emre et al., 2007a), which include depression, anxiety,
apathy, delusions, and recurrent prominent complex visual hallucinations that may seem disproportionate to the severity of
dementia. PD-D is most frequently associated with the postural
imbalance gait disability motor phenotype of PD. The evolution
is progressive. These clinical features are in many aspects similar
to those seen in DLB, and distinguishing both disorders from each
other can be challenging (McKeith, 2005; Metzler-Baddeley, 2007).
DIAGNOSTIC CRITERIA FOR PARKINSONS DISEASE

DEMENTIA
For a long time, specific diagnostic criteria did not exist for PD-D.
Clinicians and researchers had to formally support this diagnosis with the help of generic criteria for dementia, such as those
set by the Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV; American Psychiatric Association,
1994). Finally, criteria aimed specifically at the diagnosis of PD-D
have been published in 2007, proposed by a Movement Disorder
Society task force. Two levels of clinical diagnostic certainty have
been defined: possible and probable PD-D (Emre et al., 2007a).
According to this document, the essential defining feature of PDD is the emergence of dementia in the setting of established PD,
as diagnosed according to the Queen Square Brain Bank criteria.
Dementia is defined as a syndrome of insidious onset and progressive decline of cognition and functional capacity from a premorbid
level, that is not attributable to motor or autonomic symptoms.
www.frontiersin.org
Impairment in at least two of the four typically involved cognitive domains (impaired and often fluctuating attention; dysexecutive changes; impaired visuospatial abilities; and impaired free
recall that improves with cueing) must be documented without
prominent language dysfunction, as demonstrated by clinical and
cognitive examination. The authors take into account that the
main behavioral or neuropsychiatric symptoms seen in PD-D
include visual hallucinations, delusions, apathy, depressed mood,
anxiety, and excessive daytime sleepiness. These features are frequent in PD-D, but their presence is not invariable. The presence
of at least one symptom from this set supports, but is not required
for, the diagnosis of PD-D. Further details on diagnostic criteria
for PD-D can be found in Emre et al. (2007a) and the proposed
neuropsychological assessment methods to be carried out with
these patients have been published in Dubois et al. (2007), from
the same workgroup.
Clinical validation efforts have been carried out from experienced groups in this field, regarding this proposal. Dujardin and
coworkers have enrolled 188 PD patients, which have been assessed
using the two-step cognitive evaluation recommended by the MDS
task force (shorter battery followed by longer comprehensive cognitive assessment battery), recording also the presence or absence
of dementia after each step had been taken. After the short battery
had been applied 18.62% of PD patients were suspected of having
dementia, whereas 21.81% fulfilled criteria for probable PD-D
following the longer battery. The authors have found that the
short batterys sensitivity and specificity were 65.85 and 94.56%,
respectively but using specific cutoff scores the sensitivity would
increase considerably without significant loss of specificity, thus
suggesting that PD-D can be diagnosed accurately with the shorter
battery as well as the longer assessment method. Specifically, an
MMSE score <27, the inability to recall five words immediately
after learning, being unable to generate >7 words beginning with
S within 60 s, the lack of full personal independence in managing antiparkinsonian medications, and age >69 years seem to be
associated with a high probability of PD-D (Dujardin et al., 2010).
Martinez-Martin and coworkers have compared the MDS criteria for the diagnosis of PD-D with dementia criteria established
by the DSM-IV. In this study, 299 PD patients have been enrolled,
and the authors have found out that the DSM-IV criteria failed to
identify 22% of patients fulfilling the MDS criteria. False negative
cases were older and had more severe motor symptoms, but less
psychosis than those true non-demented PD. False positives had
less severe motor symptoms than true PD-D, although the difference did not reach statistical significance. These findings suggest
that the MDS criteria are more sensitive than DSM-IV for diagnosing PD-D, and that it could be more difficult to diagnose PD-D
in older patients, as well as those with less psychotic symptoms or
severe motor impairment (Martinez-Martin et al., 2011).
Another clinical study aimed at comparing the diagnostic
acuity for PD-D of the eight-item screening checklist proposed
by the MDS task force, as compared to full neuropsychological assessment. This is an important issue since comprehensive
neuropsychological testing is not widely available in every practice
setting, thus short screening tools would be most welcome. The
authors have assessed 91 PD patients of these 7 (7.7% of all
subjects) met criteria for probable PD-D based on the screening
checklist, whereas 15 patients (16.5%) were detected using full

neuropsychological testing; of note, all patients that met criteria
for PD-D according to the screening checklist also did with longer
neuropsychological testing (100% specificity). These results imply
that the screening checklist performed at 46% sensitivity for the
diagnosis of PD-D, although agreement was moderate between
both methods ( 0.59, p < 0.001). The most common reasons for
false negative misclassification by the screening checklist were that
subjects were not deemed to be free of depression (5 patients),
they had an MMSE score of at least 26 (6 patients), and they were
not rated as impaired in activities of daily living (1 patient). Altogether, these results suggest that the screening checklist proposed
by the MDS task force for the diagnosis of PD-D is specific when
all eight items are met, but sensitivity is low, thus a significant
number of false negative cases are to be expected. Therefore, this
does not seem to be an ideal screening instrument. The authors
have also demonstrated that the sensitivity of this tool could be
largely increased if two problem items would be removed (absence
of depression, abnormal MMSE score), something that should be
considered in future research (Barton et al., 2012).
Ideally, clinicopathological validation studies should also be
carried out in the future using the MDS criteria for the diagnosis of PD-D, in order to promote in-depth understanding of their
diagnostic acuity. Hopefully, the proposal from the MDS task force
will at least bring uniform definitions and methods into clinical
care and research in the setting of PD-D.
MILD COGNITIVE IMPAIRMENT IN PD

In a way somewhat analogous to what can be perceived in the
course of Alzheimers disease, a pre-dementia period exists in PD
(see Figure 1). In a wide-ranging manner, MCI can be defined as
a cognitive decline from a previous performance baseline, that is
considered abnormal for the patients age, but with retention of
normal daily functioning. Such a condition appears to be quite
frequent in PD, even in early stages and also prior to the initiation
of dopaminergic therapy (Muslimovic et al., 2005; Caviness et al.,
2007a; Domellf et al., 2011; Litvan et al., 2011). In clinical and
research settings, the term is applied to PD patients who present
cognitive complains and whose neuropsychological examinations
confirm the deficits, but PD-D criteria cannot be fulfilled due to the
lack of overt functional decline related to cognitive impairment.
Deterioration can occur in a range of cognitive domains. However, non-amnestic single domain MCI seems to be more common
than amnestic single domain MCI (Pillon et al., 1993; Caviness
et al., 2007a; Litvan et al., 2011). Nonetheless, the predictive value
regarding the future risk of dementia of each of the MCI subtypes
has not been thoroughly assessed in prospective studies (Barone
et al., 2011).
From the published data, it is apparent that most PD patients
will develop dementia, provided that enough time elapses since
disease onset. Since PD-MCI precedes PD-D, one could postulate
that the lifelong cumulative prevalence of PD-MCI must be at least
as high as that of PD-D. Approximately 27% of PD patients will
meet criteria for PD-MCI at any given time (Litvan et al., 2011).
Aarsland et al. (2010) have reported that PD-MCI affects 25.8% of
PD patients (ranging between 23.5 and 28.8%). There is significant
variability among the numbers reported, which may be justified by
methodological differences, namely definitions used, the cognitive

domains assessed, how impairment was defined for the test, and
the fact that different patient populations have been enrolled.
An interesting population based study using a sample of 239
newly diagnosed PD patients has found an incidence rate of cognitive impairment of 36%. From this subgroup, 21% scored 1 or
more SD below the mean on a pattern recognition memory test,
being subsequently classified as having temporal lobe impairment.
Thirteen percent scored below the cut off score on a test evaluating frontostriatal deficit, and 15% were impaired in both tests,
suggesting a more global impairment (Foltynie et al., 2004). A
second study used an extensive neuropsychological test battery to
compare the performance of a sample of 115 newly diagnosed PDD patients (mean disease duration of 19 months) and 70 healthy
controls. Using a definition for impairment as <2 SD below the
normative sample mean score on at least 3 tests, PD patients performed significantly worse across most tests, and 24% of them
were deemed cognitively impaired. The patient group performed
worse in executive function, memory, complex attention, and psychomotor speed tests (Muslimovic et al., 2005). Several studies
have found that increasing age, late disease onset, severity of PD,
and lower educational level are risk factors associated with PDMCI (Pai and Chan, 2001; Foltynie et al., 2004; Muslimovic et al.,
2005; Mamikonyan et al., 2009).
The complexity of defining MCI in early stages of PD is high,
for significant confusion with early DLB should be anticipated.
On the other hand, there is a concern that the definitions used
to determine MCI may lack sensitivity to detect early cognitive decline in high functioning people, as these have to suffer
added decline before they reach the defined cutoff below normative means. Hence they may potentially be classified cognitively
unimpaired when in fact a decline from baseline performance has
already occurred. It is commonly argued that high functioning
people may have additional protection from dementia but their
work and social settings also tend to be more demanding, and
subtle cognitive decline may thus become more apparent. Importantly, the clinical definition of MCI requires that the person has
experienced a change in cognition, compared to baseline (Litvan
et al., 2011).
PROFILE OF COGNITIVE IMPAIRMENT
A number of studies assessing cognitive functioning in nondemented PD have been published. Cognitive deficits in PD are
traditionally seen as subcortical in their nature, as several studies have demonstrated that there is a significant impairment in
executive functions such as poor planning, sequencing, cognitive
flexibility, and problem solving capacities (Pai and Chan, 2001;
Muslimovic et al., 2005; Barone et al., 2011). Memory impairments, including encoding, recall, and procedural memory are also
affected (Foltynie et al., 2004). Recognition is thought to remain
relatively well preserved (Foltynie et al., 2004). Language dysfunction is rarely reported, with an exception of deficits in phonemic
and semantic tasks, which exist and tend to decline over time and
with disease severity, as evaluated by the Hoehn and Yahr stage,
predicting also a future diagnosis of dementia (Barone et al., 2011).
Identifying PD-MCI is clinically relevant, given that these
patients appear to be at increased risk for developing PD-D
FIGURE 1 | schematic representation of the progression of PD patients

until the stage of dementia. Functional impairment in PD is multifactorial
(motor symptoms, cognitive decline, other non-motor symptoms). Please
(Litvan et al., 2011). On the other hand, one wonders if drug therapy known to be effective in PD-D could be also of benefit at the
stage of MCI, although this has not been formally studied in large
trials. A contributing factor for this might be the lack of broadly
accepted definitions and efficacy endpoints. In this regard, a very
recent advance has been achieved, as the first set of consensus
diagnostic criteria for PD-MCI have been proposed (Litvan et al.,
2012).
DIAGNOSTIC CRITERIA FOR MCI IN PARKINSONS DISEASE
The clinical validity of PD-MCI has found strong support in the

published literature (Litvan et al., 2011). This concept has been formally accepted and used for several years, but only very recently
has the first set of criteria for the formal diagnosis of PD-MCI
been proposed (Litvan et al., 2012). A great contributor to a stagnant state regarding concrete definitions and criteria has been the
scarcity of long term in-depth prospective studies that would allow
better characterization of the phenotype of PD-MCI, to establish biomarker correlates, and to clearly define the progression
and risk of dementia for PD-MCI patients. The MDS task force
on PD-MCI has built this concept on the previous classic definitions of MCI and made the necessary adjustments regarding the
specificities of PD. The diagnosis of this condition requires a few
key points. First of all, the diagnosis of PD should be well established. Then, cognitive decline must be reported by the patient
or caregiver, or documented by the clinician. These are subsequently documented by means of formal cognitive assessment.
www.frontiersin.org
note that this graph is merely pictorial; it is not intended to represent

proportions between variables nor is the progression linear, despite the
drawing.
Lastly, cognitive impairment must not cause significant functional

decline. Exclusion criteria have also been described and two levels
of assessment and diagnostic certainty have been proposed (Litvan et al., 2012). The manuscript issued by this task force also
proposes specific assessment tests and scales, which will hopefully
expedite the homogenization and alliance of procedures throughout practice and research settings all over the world. However, no
biomarkers could be recommended at this stage to incorporate the
diagnostic criteria, as evidence is still scarce concerning this matter
in the field of PD-D (Litvan et al., 2012).
GENETICS AND COGNITIVE DECLINE IN PD

HEREDITARY FORMS OF PARKINSONS DISEASE AND COGNITION
Ten to 15% of PD patients disclose a family history suggesting

Mendelian inheritance, either autosomal dominant or recessive.
These tend to be younger than the typical PD patients (Schrag
and Schott, 2006; Tan and Jankovic, 2006). A number of levodopa responsive parkinsonian syndromes have been described
and linked to a specific locus or gene, and 18 of these so far
have been classified as PARK syndromes (Klein and Westenberger,
2012). While some of these represent true PD, others denote more
complex phenotypes and different diseases (Gasser, 2007; Klein
et al., 2009), which we will not address in this manuscript.
Several autosomal dominant forms of PD have been described,
the most important being PARK1/PARK4 (gene SNCA, synuclein) and PARK8 (gene LRRK2, leucine-rich repeat kinase 2).
In PARK1/PARK4, which are infrequent forms of PD, symptoms
usually emerge in the fourth or fifth decades, and patients display typical PD features, except that early prominent cognitive
decline and dementia is a common event. Hence, the clinical picture may resemble DLB, although age at onset is much lower than
in the classical cases. PARK1 and PARK4 are due to SNCA mutations and duplications/triplications, respectively (Polymeropoulos
et al., 1997; Spira et al., 2001; Zarranz et al., 2004). PARK8 is probably the most common type of inherited PD. It has been reported
that mutation frequency is about 40% in North African Arabs and
Ashkenazi Jewish populations; high mutation frequency has also
been reported in populations from southern Europe (Healy et al.,
2008). The clinical picture resembles that of classical sporadic PD
(Wszolek et al., 2004; Healy et al., 2008), and cognitive singularities
have not been reported in this form of the disease, with a dementia
prevalence of about 11% (Kasten et al., 2010).
Three forms of autosomal recessive PD have been described:
PARK2 (gene Parkin), PARK6 (gene PINK1, PTEN-induced putative kinase 1), and PARK7 (gene DJ-1), here listed by decreasing
order of frequency. The clinical pattern of PARK2 includes, in
addition to typical PD features, a variety of symptoms such as
hyperreflexia, prominent dystonia, sensory axonal neuropathy,
increased sensitivity to levodopa induced dyskinesias, and psychosis (Abbas et al., 1999; Klein et al., 2000; Lcking et al., 2000;
Gouider-Khouja et al., 2003; Khan et al., 2003; Deng et al., 2006;
Wickremaratchi et al., 2009). Notably, non-motor symptoms seem
to be less prevalent than in sporadic PD, except anxiety (Kgi et al.,
2010). Therefore, cognitive decline is apparently less frequent,
as compared to sporadic PD. Lewy bodies were absent in most
patients that came to autopsy (Farrer et al., 2001; Gouider-Khouja
et al., 2003). Age at onset of symptoms ranges from childhood
to mid-fifties. It accounts for most PD cases under the age of
30 years. PARK6 and PARK7 share many common clinical features with PARK2, including early onset, excellent response to
levodopa, and frequent levodopa induced dyskinesias, but psychiatric features may be more prominent in PARK6 (Valente et al.,
2001, 2002, 2004; van Duijn et al., 2001; Abou-Sleiman et al.,
2003; Dekker et al., 2003; Bonifati et al., 2005; Ibez et al., 2006;
Leutenegger et al., 2006; Steinlechner et al., 2007; Kasten et al.,
2010).
GLUCOCEREBROSIDASE MUTATIONS: MORE THAN A SIMPLE RISK
FACTOR FOR PD
Interesting observations have been made in the last few years in

families with members suffering from Gauchers disease, an autosomal recessive disorder caused by homozygous mutations in the
GBA gene encoding the lysosomal enzyme glucocerebrosidase.
Some years ago, heterozygous GBA mutations have been associated with a higher risk of PD (Aharon-Peretz et al., 2004; Sidransky
et al., 2009), and data even suggested that these patients could have
an increased risk for cognitive impairment. For instance, Brockmann et al. (2011) have found that non-motor symptoms, among
them dementia, seem to be more prevalent in GBA-associated
PD than in mutation non-carriers. Two pathogenic mutations
(L444P and N470S) seem to be particularly prevalent, but others have been described (DePaolo et al., 2009; Neumann et al.,
2009; Sidransky et al., 2009; Velayati et al., 2010). Interestingly,
GBA heterozygosity has also been associated with DLB, another
synucleinopathy that shares clinical and pathological features with

PD-D (Clark et al., 2009). Further clarifying these issues, SetSalvia and coworkers have recently investigated GBA mutations in
DLB and PD-D, by fully sequencing the gene in 225 PD patients, 17
pathologically proven DLB patients and 186 controls. Mutations
were significantly more frequent in PD and DLB as compared to
controls, and PD patients carrying GBA mutations were at higher
risk of dementia, with an estimated adjusted odds ratio of 5.8,
p = 0.001 (Set-Salvia et al., 2012). In fact, previous research has
shown that GBA mutations are associated with more diffuse Lewy
body neuropathology and greater neocortical involvement, which
might explain the higher risk of cognitive decline in these PD
patients (Neumann et al., 2009; Nishioka et al., 2011). Speculation has been brought to light about the putative association of
other lysosomal disorders and parkinsonism (Shachar et al., 2011).
For further details on this topic please refer to the manuscript
by Almeida included in this Frontiers Research Topic (Almeida,
2012).
A word of caution should be given regarding GBA testing in
clinical practice. Current evidence clearly shows that heterozygous
pathogenic mutations are a risk factor for PD and DLB. Thus, it
has not been demonstrated that GBA mutations cause a monogenic form of PD or DLB. Therefore, similarly to what has been
suggested for ApoE genotyping in AD (Goldman et al., 2011),
testing for GBA mutations is not currently recommended with
clinical diagnostic purposes. Similarly, testing cannot be recommended for the diagnosis of PD-D. Nonetheless, further scientific
research should be encouraged regarding GBA in PD, as many
aspects remain enigmatic.
MICROTUBULE ASSOCIATED PROTEIN TAU AND COGNITIVE DECLINE
IN PD
Traditionally, microtubule associated protein tau (MAPT) gene

mutations have been linked to autosomal dominant frontotemporal dementia, usually the behavioral variant, in particular the clinical forms also displaying parkinsonism (Galimberti and Scarpini,
2012). In addition, MAPT haplotype H1 has been associated with
increased susceptibility for the development of PD (Elbaz et al.,
2011; Trotta et al., 2012). In recent years, an interesting relationship has been acknowledged between MAPT haplotype H1 and
clinical progression in PD, specifically with regard to cognitive
decline. Williams-Gray and coworkers have followed up their incident community PD CamPaIGN cohort and at 5 years (n = 162)
have found that 17% of patients had developed dementia. In this
study MAPT haplotype H1 was associated with accelerated cognitive decline, and was also a significant independent predictor of
dementia, along with older age, and poor performance on semantic
fluency and pentagon copy at diagnosis. The authors have conducted additional postmortem research using brain bank tissue,
demonstrating that the H1 haplotype was also associated with
20% more deposit load of 4 repeat tau in Brodmann area 46 in
Lewy body disease brains (PD or DLB), as compared to the H2
haplotype (Williams-Gray et al., 2009). The same working group
subsequently assessed a representative group of 132 PD patients
from this cohort for up to 7.9 years from diagnosis, and tau haplotype H1 remained a strong risk factor for dementia at this time
point (Evans et al., 2011).
In a Spanish case-control study MAPT haplotypes were determined in 202 PD patients (48 of these with dementia), 41 patients
with DLB (pathologically confirmed in 17), 164 patients with AD,
and 374 controls. The authors have found that the haplotype H1 is
significantly overrepresented in PD patients compared with controls and that the association was significantly stronger in PD-D
than in non-demented PD patients, suggesting that MAPT H1
haplotype seems to be a strong risk factor for PD and for dementia
in PD patients. In addition, no association could be found between
any of the MAPT subhaplotypes and DLB or AD (Set-Salvia et al.,
2011).
The groups led by Andrew Siderowf has studied genotypic variants of apolipoprotein E (APOE), catechol-O-mehyltransferase
(COMT ), and MAPT, and whether these could be correlated with
cognitive decline in PD in 212 clinically diagnosed patients followed up prospectively. APOE allele E4 was associated with faster
decline, and MAPT and COMT could be correlated with performance in memory and attention, respectively, but not with the rate
of general cognitive decline, as assessed with the Mattis Dementia
Rating Scale version 2. Of note, 96% of patients in this cohort were
assessed no later than at 3 years of follow-up (Morley et al., 2012).
MANAGEMENT OF PD-D: GENERAL PRINCIPLES

Parkinsons disease patients suffer significant decline in their QOL,
due to motor symptoms, motor complications induced by progressive neurodegeneration and medication effects, and non-motor
symptoms (Chaudhuri and Schapira, 2009; Lim et al., 2009; Tolosa
et al., 2009; Calabresi et al., 2010; Hawkes et al., 2010; Savica
et al., 2010; Schapira and Tolosa, 2010). Among these, dementia is a particularly important aspect, since it brings an additional
and important burden of functional impairment associated with
significant cognitive deterioration and further loss of QOL. The
achievements in the last few decades regarding cognitive and
behavioral issues in PD have been important scientific progresses
(Weintraub and Burn, 2011), but research on clinical management
is still scarce, particularly concerning randomized trials. There are
no known disease modifying strategies in PD-D and every therapy
here mentioned is currently seen as purely symptomatic.
Treating physicians should encourage an open dialog with the
patient and family regarding the issue of cognitive decline in PD,
especially when symptoms are brought to light by the patient or
the caregivers, or uncovered by the clinician. Subjective cognitive complains should be noted and delved in detail. Functional
impairment due to cognitive deterioration should be searched
for in the several daily life environments, such as at home or at
work, by questioning the patient and significant others. Sensitive and user friendly screening scales like the Montreal Cognitive
Assessment (MoCA; Dalrymple-Alford et al., 2010) can be used to
quickly probe the severity of cognitive decline, although comprehensive neuropsychological assessment is the best way of defining
the profile of impairment in detail. Associated neuropsychiatric
symptoms should be searched for, so that they can be properly
addressed.
Common sense advises that, as in other circumstances
when cognitive decline is apparent, with or without concomitant functional impairment (i.e., dementia), treatable causes
should be ruled out through suitable laboratory testing, such as
www.frontiersin.org
hypothyroidism, vitamin B12 or folate deficiencies, renal, or liver

failure, anemia, and exceptionally even VDRL or HIV antibodies
in the appropriate setting (i.e., classical risk factors). Structural
brain imaging should be considered in the context of new onset
cognitive decline, including when brain vascular disease or atypical degenerative parkinsonian disorders are suspected; magnetic
resonance imaging would be the modality of choice in this regard
(Bohnen and Albin, 2011; Wattjes, 2011). Exceptionally, genetic
testing can be considered, in carefully selected circumstances above
mentioned in the text.
Marked cholinergic deficits can be found in the brain of PD-D
patients (Kehagia et al., 2010), thus providing the rational basis
for cholinesterase inhibitor therapy in this condition. Only one
large randomized placebo-controlled trial has been published so
far regarding the use of cholinesterase inhibitors in PD-D (Emre
et al., 2004). Emre and collaborators have demonstrated that
rivastigmine, a dual inhibitor of acetylcholinesterase and butyrylcholinesterase, brings modest but significant improvements in
mild to moderate PD-D. As expected, gastrointestinal adverse
events such as nausea and vomiting were more common in the
group treated with rivastigmine. One wonders whether newer formulations (i.e., transdermal patch) would reduce gastrointestinal
adverse events as compared to capsules, which has already been
demonstrated for AD in the large randomized, controlled, doubleblind, double-dummy IDEAL trial (Winblad et al., 2007). Interestingly, visual hallucinations seem to predict better clinical outcomes
under rivastigmine, as a mean statistically significant difference of
2.3 points on the Progressive Deterioration Scale has been documented in rivastigmine- versus placebo-treated patients without
hallucinations at baseline, compared with a mean statistically significant difference of 5.3 points in patients with hallucinations at
baseline (Emre et al., 2007b). Memantine has also been studied in
PD-D, with two randomized double-blind placebo-controlled trials published thus far. One trial demonstrated marginal efficacy of
memantine over placebo, regarding global clinical impression, and
attention, whereas it failed to establish significant improvements
in other secondary outcome measures (Aarsland et al., 2009). The
second trial has shown clinical benefits of memantine on global
clinical status and behavioral symptoms, but activities of daily living and caregiver burden did not improve (Emre et al., 2010). Both
trials enrolled a mixed population of PD-D and DLB patients.
Behavioral or neuropsychiatric symptoms are common in PDD and often exceedingly disturbing for the patient and caregivers.
They must be properly explored and managed. Thorough questioning of both the patient and caregiver is paramount in this
regard. For instance, visual hallucinations are commonly uncovered in clinic during patient interview, which were previously not
suspected at all by the astonished family.
No randomized controlled trials have been conducted regarding the treatment of depression in PD-D. Tricyclic antidepressants
have been found superior to placebo in PD (Devos et al., 2008;
Menza et al., 2009), but their anticholinergic effects advises against
their use in PD-D, since the risk of additional cognitive deterioration and new onset confusion would be significantly increased
(Labbate et al., 2009). Thus, depression in PD-D is usually treated
with serotonin selective reuptake inhibitors (SSRIs), such as sertraline and citalopram, although evidence in favor of this practice
is scarce (Wermuth et al., 1998; Leentjens et al., 2003; Weintraub

et al., 2006; Devos et al., 2008). Noradrenaline and serotonin reuptake inhibitors like venlafaxine could be an alternative, but no
trials have been published so far in this setting. Nonetheless, clinical practice has brought an overall positive experience with these
drugs. Bupropion, that inhibits the reuptake of dopamine and
noradrenaline, has been suggested by some to have a role in the
treatment of depression in PD (Raskin and Durst, 2010; Zaluska
and Dyduch, 2011), but controlled trials are also lacking. In any
case, it appears that sedation and sexual dysfunction are lower with
bupropion, when compared to SSRIs (Labbate et al., 2009). Recent
research has found that pramipexole, a dopamine agonist widely
used in the treatment of PD motor symptoms, improves depressive symptoms in PD (Barone et al., 2010), but the prescription
should be carefully considered in PD-D due to the risk of visual
hallucinations and confusion with this drug class.
Psychotic symptoms can be a challenging clinical problem
in PD-D. Patients should be questioned about the content of
their visual hallucinations and whether these are disturbing or
not. They can be a source of significant anxiety and agitation
or, on the other hand, be felt by the patient as friendly or at
least non-threatening. At times the diagnosis of delirium is considered in PD-D, as patients may appear confuse and attention
may become more volatile than usual. In this case, comorbid
medical conditions should be searched for and treated, such
as urinary tract infections, pneumonia, gastroenteritis, dehydration, or aggravated pre-existent disorders (e.g., renal or cardiac
failure). Certain drugs seem prone to cause psychosis and confusional states, thus pharmacological therapy should be thoroughly reviewed and optimized. Antiparkinsonian drugs are often
implicated anticholinergics, selegiline, amantadine, dopamine
agonists, and catechol-O-methyltransferase inhibitors should be
discontinued, and lastly, a reduction in levodopa dosage should
be considered. However, this approach is also not evidence-based.
Antipsychotics should be used only as a last resort in PD-D. Atypical agents such as quetiapine can be used, despite the fact that
trial results do not support this strategy (Ondo et al., 2005; Rabey
et al., 2007; Shotbolt et al., 2009). Clozapine has been studied with
a few positive results in PD patients (The Parkinson Study Group,
REFERENCES
Aarsland, D., Andersen, K., Larsen, J. P.,
Perry, R., Wentzel-Larsen, T., Lolk,
A., and Kragh-Srensen, P. (2004).
The rate of cognitive decline in
Parkinson disease. Arch. Neurol. 61,
19061911.
Aarsland, D., Ballard, C., Larsen, J. P.,
and McKeith, I. (2001a). A comparative study of psychiatric symptoms
in dementia with Lewy bodies and
Parkinsons disease with and without
dementia. Int. J. Geriatr. Psychiatry
16, 528536.
Aarsland, D., Cummings, J. L., and
Larsen, J. P. (2001b). Neuropsychiatric
differences
between
Parkinsons disease with dementia and Alzheimers disease.
Int. J. Geriatr. Psychiatry 16,

184191.
Aarsland, D., Litvan, I., and Larsen, J.
P. (2001c). Neuropsychiatric symptoms of patients with progressive supranuclear palsy and Parkinsons disease. J. Neuropsychiatry Clin.
Neurosci. 13, 4249.
Aarsland, D., Ballard, C., Walker, Z.,
Bostrom, F., Alves, G., Kossakowski,
K., Leroi, I., Pozo-Rodriguez, F.,
Minthon, L., and Londos, E. (2009).
Memantine in patients with Parkinsons disease dementia or dementia with Lewy bodies: a doubleblind, placebo-controlled, multicentre trial. Lancet Neurol. 8, 613618.
Aarsland, D., Bronnick, K., WilliamsGray, C., Weintraub, D., Marder, K.,
1999; Fernandez et al., 2004), but the hematological safety profile

and significant muscarinic receptor affinity (Bymaster et al., 2003;
Gareri et al., 2008) advise against its use in PD-D. Ondansetron, a
5-HT3 receptor antagonist used for the treatment of severe vomiting, especially in the setting of cancer chemotherapy, has also
been tried as an antipsychotic agent, based on the rational that
psychotic symptoms could be due to central serotoninergic overstimulation; Zoldan and coworkers conducted an open-label trial
for 48 weeks, enrolling 16 PD patients with psychosis (daily dose
1224 mg). They have found that psychotic symptoms were significantly improved, with good tolerability and no repercussion
on PD motor symptoms, levodopa efficacy, or general cognitive
state (Zoldan et al., 1995). However, this line of research has not
been followed subsequently by any other group, probably due to
the high cost of the drug. Coping strategies to deal with hallucinations might be helpful for patients and caregivers (Diederich et al.,
2009).
CONCLUSION
Parkinsons disease is much more than a motor disorder and a
wide range of non-motor symptoms have been recognized along
the years, especially in the last decades. Among them, cognitive
decline, in a wide range of severity, is particularly important to
recognize, due to the meaningful impact on the life of patients
and caregivers, as well as the social and economic burden brought
about by this condition. Expert consensus guidelines have been
recently issued specifically for the diagnosis of MCI in PD and PD
dementia. These have not been prospectively assessed so far, but
might prove useful both in clinical and research settings, as clinical decisions and research methods will hopefully become more
homogeneous. An array of cognitive and behavioral symptoms has
been associated with PD-D, which should be properly characterized and managed, as patients benefit from specific interventions.
Nevertheless, many clinical decisions and practices do not find
solid support on evidence-based data, and rely on the older and less
objective experience-based medicine practices. This is an important point to be addressed in the future, as multicenter randomized
trials using recent consensus definitions should be considered in
relevant clinical areas.
Kulisevsky, J., Burn, D., Barone, P.,
Pagonabarraga, J., Allcock, L., Santangelo, G., Foltynie, T., Janvin, C.,
Larsen, J. P., Barker, R. A., and Emre,
M. (2010). Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis. Neurology 75,
10621069.
Aarsland, D., and Kurz, M. W.
(2010). The epidemiology of
dementia associated with Parkinson disease. J. Neurol. Sci. 289,
1822.
Aarsland, D., Kvaloy, J. T., Anderson, K.,
Larsen, J. P., Tang, M. X., Lolk, A.,
Kragh-Srensen, P., and Marder, K.
(2007). The effect of age of onset of
PD on risk of dementia. J. Neurol.
254, 3845.
Aarsland, D., Larsen, J. P., Karlsen,

K., Lim, N. G., and Tandberg,
E. (1999). Mental symptoms in
Parkinsons disease are important contributors to caregiver distress. Int. J. Geriatr. Psychiatry 14,
866874.
Aarsland, D., Larsen, J. P., Tandberg, E., and Laake, K. (2000).
Predictors of nursing home placement in Parkinsons disease: a
population based, prospective
study. J. Am. Geriatr. Soc. 48,
938942.
Aarsland, D., Zaccai, J., and Brayne,
C. (2005). A systematic review of
prevalence studies of dementia in
Parkinsons disease. Mov. Disord. 20,
12551263.
Abbas, N., Lcking, C. B., Ricard, S.,

Drr, A., Bonifati, V., De Michele, G.,
Bouley, S., Vaughan, J. R., Gasser, T.,
Marconi, R., Broussolle, E., BrefelCourbon, C., Harhangi, B. S., Oostra, B. A., Fabrizio, E., Bhme, G.
A., Pradier, L., Wood, N. W., Filla,
A., Meco, G., Denefle, P., Agid, Y.,
and Brice, A. (1999). A wide variety
of mutations in the parkin gene are
responsible for autosomal recessive
parkinsonism in Europe. Hum. Mol.
Genet. 8, 567574.
Abou-Sleiman, P. M., Healy, D. G.,
Quinn, N., Lees, A. J., and Wood,
N. W. (2003). The role of pathogenic DJ-1 mutations in Parkinsons disease. Ann. Neurol. 54,
283286.
Aharon-Peretz, J., Rosenbaum, H., and
Gershoni-Baruch, R. (2004). Mutations in the glucocerebrosidase gene
and Parkinsons disease in Ashkenazi Jews. N. Engl. J. Med. 351,
19721977.
Allan, L. M., Ballard, C. G., Allen, J.,
Murray, A., Davidson, A. W., McKeith, I. G., and Kenny, R. A. (2007).
Autonomic dysfunction in dementia. J. Neurol. Neurosurg. Psychiatr.
78, 671677.
Almeida, M. R. (2012). Glucocerebrosidase involvement in Parkinson disease and other synucleinopathies. Front. Neurol. 3:65.
doi:10.3389/fneur.2012.00065
Alves, L., Correia, A. S. A., Miguel,
R., Alegria, P., and Bugalho,
P. (2012). Alzheimers disease:
a
clinical
practice-oriented
review. Front. Neurol. 3:63.
doi:10.3389/fneur.2012.00063
American Psychiatric Association.
(1994). Diagnostic, and Statistical
Manual of Mental Disorders, DSMIV, 4th Edn. Arlington: American
Psychiatric Press Inc.
Ballard, C. G., Aarsland, D., McKeith,
I., OBrien, J., Gray, A., Cormack, F.,
Burn, D., Cassidy, T., Starfeldt, R.,
Larsen, J. P., Brown, R., and Tovee,
M. (2002). Fluctuations in attention
in PD dementia vs DLB with parkinsonism. Neurology 59, 17141720.
Barone, P., Aarsland, D., Burn, D., Emre,
M., Kulisevsky, J., and Weintraub,
D. (2011). Cognitive impairment in
nondemented Parkinsons disease.
Mov. Disord. 26, 24832495.
Barone, P., Poewe, W., Albrecht, S.,
Debieuvre, C., Massey, D., Rascol,
O., Tolosa, E., and Weintraub, D.
(2010). Pramipexole for the treatment of depressive symptoms in
patients with Parkinsons disease: a
randomised, double-blind, placebocontrolled trial. Lancet Neurol. 9,
573580.
www.frontiersin.org
Barton, B., Grabli, D., Bernard, B., Czernecki, V., Goldman, J. G., Stebbins, G., Dubois, B., and Goetz,
C. G. (2012). Clinical validation
of movement disorder societyrecommended diagnostic criteria for
Parkinsons disease with dementia.
Mov. Disord. 27, 248253.
Benoit, M., Robert, P. H., Staccini, P.,
Brocker, P., Guerin, O., Lechowski,
L., Vellas, B., and REAL.FR Group.
(2005). One-year longitudinal evaluation of neuropsychiatric symptoms in Alzheimers disease. The
REAL.FR Study. J. Nutr. Health
Aging 9, 9599.
Boeve, B. F., Silber, M. H., Saper, C. B.,
Ferman, T. J., Dickson, D. W., Parisi,
J. E., Benarroch, E. E., Ahlskog, J. E.,
Smith, G. E., Caselli, R. C., TippmanPeikert, M., Olson, E. J., Lin, S.
C., Young, T., Wszolek, Z., Schenck,
C. H., Mahowald, M. W., Castillo,
P. R., Del Tredici, K., and Braak,
H. (2009). Pathophysiology of REM
sleep behaviour disorder and relevance to neurodegenerative disease.
Brain 130, 27702788.
Bohnen, N. I., and Albin, R. L. (2011).
White matter lesions in Parkinson
disease. Nat. Rev. Neurol. 7, 229236.
Bonelli, R. M., and Cummings, J. L.
(2008). Frontal-subcortical dementias. Neurologist 14, 100107.
Bonelli, S. B., Ransmayr, G., Steffelbauer, M., Lukas, T., Lampl, C., and
Deibl, M. (2004). L-dopa responsiveness in dementia with Lewy
bodies, Parkinson disease with and
without dementia. Neurology 63,
376378.
Bonifati, V., Roh, C. F., Breedveld, G.
J., Fabrizio, E., De Mari, M., Tassorelli, C., Tavella, A., Marconi, R.,
Nicholl, D. J., Chien, H. F., Fincati,
E., Abbruzzese, G., Marini, P., De
Gaetano, A., Horstink, M. W., MaatKievit, J. A., Sampaio, C., Antonini,
A., Stocchi, F., Montagna, P., Toni, V.,
Guidi, M., Dalla Libera, A., Tinazzi,
M., De Pandis, F., Fabbrini, G., Goldwurm, S., de Klein, A., Barbosa, E.,
Lopiano, L., Martignoni, E., Lamberti, P., Vanacore, N., Meco, G.,
Oostra, B. A., and Italian Parkinson
Genetics Network. (2005). Earlyonset parkinsonism associated with
PINK1 mutations: frequency, genotypes, and phenotypes. Neurology
65, 8795.
Braak, H., Del Tredici, K., Rb, U.,
de Vos, R. A., Jansen Steur, E. N.,
and Braak, E. (2003). Staging of
brain pathology related to sporadic
Parkinsons disease. Neurobiol. Aging
24, 197211.
Brockmann, K., Srulijes, K., Hauser, A.
K., Schulte, C., Csoti, I., Gasser, T.,
and Berg, D. (2011). GBA-associated

PD presents with nonmotor characteristics. Neurology 77, 276280.
Bronnick, K., Aarsland, D., and Larsen,
J. P. (2005). Neuropsychiatric disturbances in Parkinsons disease clusters
in five groups with different prevalence of dementia. Acta Psychiatr.
Scand. 112, 201207.
Bronnick, K., Emre, M., Lane, R., Tekin,
S., and Aarsland, D. (2007). Profile
of cognitive impairment in dementia
associated with Parkinsons disease
compared with Alzheimers disease.
J. Neurol. Neurosurg. Psychiatr. 78,
10641068.
Burn, D. J., Rowan, E. N., Allan, L.
M., Molloy, S., OBrien, J. Y., and
McKeith, I. J. (2006). Motor subtype and cognitive decline in Parkinsons disease, Parkinsons disease
with dementia, and dementia with
Lewy bodies. J. Neurol. Neurosurg.
Psychiatr. 77, 585589.
Bymaster, F. P., Felder, C. C., Tzavara, E.,
Nomikos, G. G., Calligaro, D. O., and
Mckinzie, D. L. (2003). Muscarinic
mechanisms of antipsychotic atypicality. Prog. Neuropsychopharmacol.
Biol. Psychiatry 27, 11251143.
Cahn-Weiner, D. A., Grace, J., Ott, B.
R., Fernandez, H. H., and Friedman,
J. H. (2002). Cognitive and behavioral features discriminate between
Alzheimers and Parkinsons disease. Neuropsychiatry Neuropsychol.
Behav. Neurol. 15, 7987.
Cahn-Weiner, D. A., Williams, K., Grace,
J., Tremont, G., Westervelt, H., and
Stern R. A. (2003). Discrimination
of dementia with lewy bodies from
Alzheimer disease and Parkinson
disease using the clock drawing test.
Cogn. Behav. Neurol. 16, 8592.
Calabresi, P., Di Filippo, M., Ghiglieri,
V., Tambasco, N., and Picconi, B.
(2010). Levodopa-induced dyskinesias in patients with Parkinsons disease: filling the bench-to-bedside
gap. Lancet Neurol. 9, 11061117.
Caparros-Lefebvre, D., Pecheux, N., and
Petit, V. (1995). Which factors predict cognitive decline in Parkinsons
disease? J. Neurol. Neurosurg. Psychiatr. 58, 5155.
Caviness, J. N., Driver-Dunckley, E.,
Connor, D. J., Sabbagh, M. N., Hentz,
J. G., Noble, B., Evidente, V. G. H.,
Shill, H., and Adler, C. H. (2007a).
Defining mild cognitive impairment
in Parkinsons disease. Mov. Disord.
22, 12721277.
Caviness, J. N., Hentz, J. G., Evidente,
V. G., Driver-Dunckley, E., Samanta,
J., Mahant, P., Connor, D. J., Sabbagh, M. N., Shill, H. A., and
Adler, C. H. (2007b). Both early and
late cognitive dysfunction affects
the electroencephalogram in Parkinsons disease. Parkinsonism Relat.

Disord. 13, 348354.
Chaudhuri, K. R., and Schapira, A.
H. V. (2009). Non-motor symptoms
of Parkinsons disease: dopaminergic pathophysiology and treatment.
Lancet Neurol. 8, 464474.
Clark, L. N., Kartsaklis, L. A., Wolf
Gilbert, R., Dorado, B., Ross, B. M.,
Kisselev, S., Verbitsky, M., MejiaSantana, H., Cote, L. J., Andrews,
H., Vonsattel, J. P., Fahn, S., Mayeux,
R., Honig, L. S., and Marder, K.
(2009). Association of glucocerebrosidase mutations with dementia
with Lewy bodies. Arch. Neurol. 66,
578583.
Cummings, J. L. (1988). The dementias of Parkinsons disease: prevalence, characteristics, neurobiology,
and comparison with dementia of
the Alzheimer type. Eur. Neurol.
28(Suppl. 1), 1523.
Dalrymple-Alford, J. C., MacAskill, M.
R., Nakas, C. T., Livingston, L., Graham, C., Crucian, G. P., Melzer, T.
R., Kirwan, J., Keenan, R., Wells, S.,
Porter, R. J., Watts, R., and Anderson, T. J. (2010). The MoCA: wellsuited screen for cognitive impairment in Parkinson disease. Neurology 75, 17171725.
Darvesh, S., and Freedman, M. (1996).
Subcortical dementia: a neurobehavioral approach. Brain Cogn. 31,
230249.
de Lau, L. M., Schipper, C. M., Hofman,
A., Koudstaal, P. J., and Breteler, M.
M. (2005). Prognosis of Parkinson
disease: risk of dementia and mortality: the Rotterdam Study. Arch.
Neurol. 62, 12651269.
Dekker, M., Bonifati, V., van Swieten, J.,
Leenders, N., Galjaard, R. J., Snijders,
P., Horstink, M., Heutink, P., Oostra,
B., and van Duijn, C. (2003). Clinical features and neuroimaging of
PARK7-linked parkinsonism. Mov.
Disord. 18, 751757.
Deng, H., Le, W., Guo, Y., Hunter,
C. B., Xie, W., Huang, M., and
Jankovic, J. (2006). Genetic analysis
of LRRK2 mutations in patients with
Parkinson disease. J. Neurol. Sci. 251,
102106.
DePaolo, J., Goker-Alpan, O., Samaddar, T., Lopez, G., and Sidransky,
E. (2009). The association between
mutations in the lysosomal protein
glucocerebrosidase and parkinsonism. Mov. Disord. 24, 15711578.
Devos, D., Dujardin, K., Poirot, I.,
Moreau, C., Cottencin, O., Thomas,
P., Deste, A., Bordet, R., and
Defebvre, L. (2008). Comparison of
desipramine and citalopram treatments for depression in Parkinsons
disease: a double-blind, randomized,

placebo-controlled study. Mov. Disord. 23, 850857.
Diederich, N. J., Fnelon, G., Stebbins,
G., and Goetz, C. G. (2009). Hallucinations in Parkinson disease. Nat.
Rev. Neurol. 5, 331342.
Domellf, M. E., Elgh, E., and Forsgren, L. (2011). The relation between
cognition and motor dysfunction in
drug-naive newly diagnosed patients
with Parkinsons disease. Mov. Disord. 26, 21832189.
Dubois, B., Burn, D., Goetz, C., Aarsland, D., Brown, R. G., Broe, G.
A., Dickson, D., Duyckaerts, C.,
Cummings, J., Gauthier, S., Korczyn, A., Lees, A., Levy, R., Litvan, I., Mizuno, Y., McKeith, I. G.,
Olanow, C. W., Poewe, W., Sampaio,
C., Tolosa, E., and Emre, M. (2007).
Diagnostic procedures for Parkinsons disease dementia: recommendations from the movement disorder
society task force. Mov. Disord. 22,
23142324.
Dujardin, K., Dubois, B., Tison, F.,
Durif, F., Bourdeix, I., Pr, J.-J.,
and Duhamel, A. (2010). Parkinsons disease dementia can be easily
detected in routine clinical practice.
Mov. Disord. 25, 27692776.
Elbaz, A., Ross, O. A., Ioannidis, J. P.
A., Soto-Ortolaza, A. I., Moisan, F.,
and Aasly, J., Annesi, G., Bozi, M.,
Brighina, L., Chartier-Harlin, M.-C.,
Deste, A., Ferrarese, C., Ferraris, A.,
Gibson, J. M., Gispert, S., Hadjigeorgiou, G. M., Jasinska-Myga, B.,
Klein, C., Krger, R., Lambert, J.
C., Lohmann, K., van de Loo, S.,
Loriot, M. A., Lynch, T., Mellick, G.
D., Mutez, E., Nilsson, C., Opala,
G., Puschmann, A., Quattrone, A.,
Sharma, M., Silburn, P. A., Stefanis, L., Uitti, R. J., Valente, E. M.,
Vilario-Gell, C., Wirdefeldt, K.,
Wszolek, Z. K., Xiromerisiou, G.,
Maraganore, D. M., Farrer, M. J., and
Genetic Epidemiology of Parkinsons Disease (GEO-PD) Consortium. (2011). Independent and joint
effects of the MAPT and SNCA genes
in Parkinson disease. Ann. Neurol.
69, 778792.
Elizan, T. S., Sroka, H., Maker, H.,
Smith, H., and Yahr, M. D. (1986).
Dementia in idiopathic Parkinsons
disease: variables associated with its
occurrence in 203 patients. J. Neural
Transm. 65, 285302.
Emre, M. (2010). General features,
mode of onset and course of dementia in Parkinsons disease, in Cognitive Impairment and Dementia in
Parkinsons Disease, ed. M. Emre
(Oxford: Oxford University Press),
1522.
Emre, M., Aarsland, D., Albanese, A.,

Byrne, E. J., Deuschl, G., De Deyn,
P. P., Durif, F., Kulisevsky, J., van
Laar, T., Lees, A., Poewe, W., Robillard, A., Rosa, M. M., Wolters, E.,
Quarg, P., Tekin, S., and Lane, R.
(2004). Rivastigmine for dementia
associated with Parkinsons disease.
N. Engl. J. Med. 351, 25092518.
Emre, M., Aarsland, D., Brown, R., Burn,
D. J., Duyckaerts, C., Mizuno, Y.,
Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., Goldman, J.,
Goetz, C., Korczyn, A., Lees, A., Levy,
R., Litvan, I., McKeith, I., Olanow,
W., Poewe, W., Quinn, N., Sampaio, C., Tolosa, E., and Dubois,
B. (2007a). Clinical diagnostic criteria for dementia associated with
16891707.
Emre, M., Cummings, J. L., and Lane, R.
M. (2007b). Rivastigmine in dementia associated with Parkinsons disease and Alzheimers disease: similarities and differences. J. Alzheimers
Dis. 11, 509519.
Emre, M., Tsolaki, M., Bonuccelli,
U., Deste, A., Tolosa, E., Kutzelnigg, A., Ceballos-Baumann, A.,
Zdravkovic, S., Bladstrm, A., Jones,
R., and 11018 Study Investigators. (2010). Memantine for patients
with Parkinsons disease dementia
or dementia with Lewy bodies: a
randomised, double-blind, placebocontrolled trial. Lancet Neurol. 9,
969977.
Engelborghs, S., Maertens, K., Nagels,
G., Vloeberghs, E., Marin, P.,
Symons, A., Ketels, V., Estercam, S.,
Somers, N., and De Deyn, P. P.
(2005). Neuropsychiatric symptoms
of dementia: cross-sectional analysis
from a prospective, longitudinal Belgian study. Int. J. Geriatr. Psychiatry
20, 10281037.
Evans, J. R., Mason, S. L., WilliamsGray, C. H., Foltynie, T., Brayne,
C., Robbins, T. W., and Barker, R.
A. (2011). The natural history of
treated Parkinsons disease in an
incident, community based cohort.
11121118.
Farrer, M., Chan, P., Chen, R., Tan, L.,
Lincoln, S., Hernandez, D., Forno,
L., Gwinn-Hardy, K., Petrucelli, L.,
Hussey, J., Singleton, A., Tanner, C.,
Hardy, J., and Langston, J. W. (2001).
Lewy bodies and parkinsonism in
families with parkin mutations. Ann.
Neurol. 50, 293300.
Fenelon, G., Mahieux, F., Huon, R., and
Ziegler, M. (2000). Hallucinations in
Parkinsons disease: prevalence, phenomenology and risk factors. Brain
123, 733745.
Fernandez, H. H., Donnelly, E. M.,

and Friedman, J. H. (2004). Longterm outcome of clozapine use for
psychosis in parkinsonian patients.
Mov. Disord. 19, 831833.
Ferrini-Strambi, L., Di Gioia, M. R.,
Castronovo, V., Oldani, A., Zucconi,
M., and Cappa, S. F. (2004). Neuropsychological assessment in idiopathic REM sleep behavior disorder.
Neurology 61, 4145.
Foltynie, T., Brayne, C. E. G., Robbins,
T. W., and Barker, R. A. (2004).
The cognitive ability of an incident
cohort of Parkinsons patients in the
UK. The CamPaIGN study. Brain
127, 111.
Frank, E. M., McDade, H. L., and Scott,
W. K. (1996). Naming in dementia secondary to Parkinsons, Huntingtons, and Alzheimers diseases. J.
Commun. Disord. 29, 183197.
Frauscher, B., Iranzo, A., Hgl, B.,
Casanova-Molla, J., and Salamero,
M., Gschliesser, V., Tolosa, E.,
Poewe, W., Santamaria, J., SINBAR (Sleep Innsbruck Barcelona
group). (2008). Quantification of
electromyographic activity during
REM sleep in multiple muscles in
REM sleep behavior disorder. Sleep
31, 724731.
Gagnon, J. F., Vendette, M., Postuma,
R. B., Desjardins, C., MassicotteMarquez, J., Panisset, M., and Montplaisir, J. (2009). Mild cognitive
impairment in rapid eye movement
sleep behavior disorder and Parkinsons disease. Ann. Neurol. 66, 3947.
Galimberti, D., and Scarpini, E. (2012).
Genetics of frontotemporal lobar
degeneration. Front. Neurol. 3:52.
doi:10.3389/fneur.2012.00052
Gareri, P., De Fazio, P., Russo, E.,
Marigliano, N., De Fazio, S., and De
Sarro, G. (2008). The safety of clozapine in the elderly. Expert Opin. Drug
Saf. 7, 525538.
Gasser, T. (2007). Update on the genetics
of Parkinsons disease. Mov. Disord.
22(Suppl. 17), S343S350.
Giladin, N., Treves, T. A., Paleacu, D.,
Shabtai, H., Orlov, Y., Kandinov,
B., Simon, E. S., and Korczyn, A.
D. (2000). Risk factors for dementia and depression and psychosis in
long standing Parkinsons disease. J.
Neural Transm. 107, 5971.
Gjerstad, M. D., Aarsland, D., and
Larsen, J. P. (2002). Development
of daytime somnolence over time
in Parkinsons disease. Neurology 18,
15441546.
Goetz, C. G. (2011). The history of
Parkinsons disease: early clinical
descriptions and neurological therapies. Cold Spring Harb. Perspect.
Med. 1, a008862.
Goetz, C. G., Emre, M., and Dubois,

B. (2008). Parkinsons disease
dementia:
definitions,
guidelines, and research perspectives
in diagnosis. Ann. Neurol. 64,
S81S92.
Goldman, J. S., Hahn, S. E., Catania, J. W., LaRusse-Eckert, S., Butson, M. B., Rumbaugh, M., Strecker,
M. N., Roberts, J. S., Burke, W.,
Mayeux, R., and Bird, T., American College of Medical Genetics
and the National Society of Genetic
Counselors. (2011). Genetic counseling and testing for Alzheimer disease: joint practice guidelines of
the American College of Medical
Genetics and the National Society of
Genetic Counselors. Genet. Med. 13,
597605.
Gouider-Khouja, N., Larnaout, A.,
Amouri, R., Sfar, S., Belal, S., Ben
Hamida, C., Ben Hamida, M., Hattori, N., Mizuno, Y., and Hentati, F.
(2003). Autosomal recessive parkinsonism linked to parkin gene in
a Tunisian family. Clinical, genetic
and pathological study. Parkinsonism Relat. Disord. 9, 247251.
Hanes, K. R., Pantelis, C., Andrewes, D.
G., and Chiu, E. (1996). Brief report:
bradyphrenia in Parkinsons disease,
Huntingtons disease, and schizophrenia. Cogn. Neuropsychiatry 1,
165170.
Hawkes, C. H., Del Tredici, K., and
Braak, H. (2010). A timeline for
Parkinsons disease. Parkinsonism
Relat. Disord. 16, 7984.
Healy, D. G., Falchi, M., OSullivan, S.
S., Bonifati, V., Durr, A., Bressman,
S., Brice, A., Aasly, J., Zabetian, C.
P., Goldwurm, S., Ferreira, J. J.,
Tolosa, E., Kay, D. M., Klein, C.,
Williams, D. R., Marras, C., Lang,
A. E., Wszolek, Z. K., Berciano, J.,
Schapira, A. H., Lynch, T., Bhatia, K.
P., Gasser, T., Lees, A. J., Wood, N.
W., and International LRRK2 Consortium. (2008). Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinsons disease: a case-control study.
Hely, M. A., Morris, J. G., Reid, W. G.,
OSullivan, D. J., Williamson, P. M.,
Rail, D., Broe, G. A., and Margrie,
S. (1994). The Sydney Multicentre
Study of Parkinsons disease: a randomised, prospective five year study
comparing low dose bromocriptine
with low dose levodopa-carbidopa.
903910.
Hely, M. A., Morris, J. G., Reid, W. G.,
and Trafficante, R. (2005). Sydney
multicenter study of Parkinsons
disease:
non-L-dopa-responsive
problems dominate at 15 years. Mov.

Disord. 20, 190199.
Hely, M. A., Reid, W. G., Adena, M.
A., Halliday, G. M., and Morris, J.
G. (2008). The Sydney multicenter study of Parkinsons disease: the
inevitability of dementia at 20 years.
Mov. Disord. 23, 837844.
Henry, J. D., and Crawford, J. R. (2004).
Verbal fluency deficits in Parkinsons disease: a meta-analysis. J. Int.
Neuropsychol. Soc. 10, 608622.
Higginson, C. I., Wheelock, V. L., Carroll, K. E., and Sigvardt, K. A. (2005).
Recognition memory in Parkinsons
disease with and without dementia: evidence inconsistent with the
retrieval deficit hypothesis. J. Clin.
Exp. Neuropsychol. 27, 516528.
Hirono, N., Mori, E., Tanimukai, S.,
Kazui, H., Hashimoto, M., Hanihara, T., and Imamura, T. (1999).
Distinctive neurobehavioral features
among neurodegenerative dementias. J. Neuropsychiatry Clin. Neurosci. 11, 498503.
Hobson, P., Meara, J., and IshiharaPaul, L. (2010). The estimated life
expectancy in a community cohort
of Parkinsons disease patients with
and without dementia, compared
with the UK population. J. Neurol.
Neurosurg. Psychiatr. 81, 10931098.
Hughes, T. A., Ross, H. F., Musa, S., Bhattacherjee, S., Nathan, R. N., Mindham, R. H., and Spokes, E. G. (2000).
A 10-year study of the incidence of
and factors predicting dementia in
Parkinsons disease. Neurology 54,
15961602.
Ibez, P., Lesage, S., Lohmann, E.,
Thobois, S., De Michele, G., Borg,
M., Agid, Y., Drr, A., Brice, A., and
French Parkinsons Disease Genetics Study Group. (2006). Mutational
analysis of the PINK1 gene in earlyonset parkinsonism in Europe and
North Africa. Brain 129, 686694.
Idiaquez, J., Benarroch, E. E., Rosales,
H., Milla, P., and Ros, L. (2007).
Autonomic and cognitive dysfunction in Parkinsons disease. Clin.
Auton. Res. 17, 9398.
Iranzo, A. (2011). Sleep-wake changes
in the premotor stage of Parkinson
disease. J. Neurol. Sci. 310, 283285.
Iranzo, A., Molinuevo, J. L., Santamara, J., Serradell, M., Mart, M.
J., Valldeoriola, F., and Tolosa, E.
(2006). Rapid-eye-movement sleep
behavior disorder as an early marker
for a neurodegenerative disease: a
descriptive study. Lancet Neurol. 5,
572577.
Iranzo, A., Santamara, J., Rye, D. B.,
Valldeoriola, F., Mart, M. J., Muoz,
E., Vilaseca, I., and Tolosa, E. (2005).
Characteristics of idiopathic REM
www.frontiersin.org
sleep behavior disorder and that

associated with MSA and PD. Neurology 65, 247252.
Janvin, C. C., Larsen, J. P., Salmon, D. P.,
Galasko, D., Hugdahl, K., and Aarsland, D. (2006). Cognitive profiles of
individual patients with Parkinsons
disease and dementia: comparison
with dementia with Lewy bodies and
Alzheimers disease. Mov. Disord. 21,
337342.
Jeannerod, M., and Jacob, P. (2005).
Visual cognition: a new look at
the two-visual systems model. Neuropsychologia 43, 301312.
Joyce, J. N., Ryoo, H. L., Beach, T.
B., Caviness, J. N., Stacy, M., Gurevich, E. V., Reiser, M., and Adler, C.
H. (2002). Loss of response to levodopa in Parkinsons disease and cooccurrence with dementia: role of
D3 and not D2 receptors. Brain Res.
955, 138152.
Kgi, G., Klein, C., Wood, N. W., Schneider, S. A., Pramstaller, P. P., Tadic,
V., Quinn, N. P., van de Warrenburg,
B. P., and Bhatia K. P. (2010). Nonmotor symptoms in Parkin generelated parkinsonism. Mov. Disord.
25, 12791284.
Kai, T., Asai, T., Sakuma, K., Koeda, T.,
and Nakashima, K. (2005). Quantitative electroencephalogram analysis in dementia with Lewy Bodies
and Alzheimer disease. J. Neurol. Sci.
237, 8995.
Kasten, M., Kertelge, L., Brggemann,
N., van der Vegt, J., Schmidt, A.,
Tadic, V., Buhmann, C., Steinlechner, S., Behrens, M. I., Ramirez,
A., Binkofski, F., Siebner, H., Raspe,
H., Hagenah, J., Lencer, R., and
Klein, C. (2010). Nonmotor symptoms in genetic Parkinson disease.
Arch. Neurol. 67, 670676.
Kehagia, A. A., Barker, R. A., and Robbins, T. W. (2010). Neuropsychological and clinical heterogeneity of
cognitive impairment and dementia
in patients with Parkinsons disease.
Kertesz, A. (2003). Pick complex: an
integrative approach to frontotemporal dementia: primary progressive
aphasia, corticobasal degeneration,
and progressive supranuclear palsy.
Neurologist 9, 311317.
Khan, N. L., Graham, E., Critchley, P.,
Schrag, A. E., Wood, N. W., Lees,
A. J., Bhatia, K. P., and Quinn, N.
(2003). Parkin disease: a phenotypic
study of a large case series. Brain 126,
12791292.
Klein, C., Pramstaller, P. P., Kis, B., Page,
C. C., Kann, M., Leung, J., Woodward, H., Castellan, C. C., Scherer,
M., Vieregge, P., Breakefield, X. O.,
Kramer, P. L., and Ozelius, L. J.
(2000). Parkin deletions in a family

with adult-onset, tremor-dominant
parkinsonism: expanding the phenotype. Ann. Neurol. 48, 6571.
Klein, C., Schneider, S. A., and Lang, A.
E. (2009). Hereditary parkinsonism:
Parkinson disease look alikes an
algorithm for clinicians to PARK
genes and beyond. Mov. Disord. 24,
20422058.
Klein, C., and Westenberger, A. (2012).
Genetics of Parkinsons disease.
Cold Spring Harb. Perspect. Med. 2,
a008888.
Kramer, J. H., and Duffy, J. M. (1996).
Aphasia, apraxia, and agnosia in the
diagnosis of dementia. Dementia 7,
2326.
Kudlicka, A., Clare, L., and Hindle,
J. V. (2011). Executive functions
in Parkinsons disease: systematic
review and meta-analysis. Mov. Disord. 26, 23052315.
Labbate, L. A., Fava, M., and Rosenbaum, J. F. and Arana G. W. (2009).
Handbook of Psychiatric Drug Therapy, 6th Edn. Philadelphia: Lippincott Williams & Wilkins.
Leentjens, A. F., Vreeling, F. W., Luijckx, G. J., and Verhey, F. R.
(2003). SSRIs in the treatment
of depression in Parkinsons disease. Int. J. Geriatr. Psychiatry 18,
552554.
Leutenegger, A. L., Salih, M. A., Ibez,
P., Mukhtar, M. M., Lesage, S.,
Arabi, A., Lohmann, E., Drr, A.,
Ahmed, A. E., and Brice, A. (2006).
Juvenile-onset parkinsonism as a
result of the first mutation in the
adenosine triphosphate orientation
domain of PINK1. Arch. Neurol. 63,
12571261.
Levy, G., Tang, M. X., Louis, E. D.,
Ct, L. J., Alfaro, B., Mejia, H.,
Stern, Y., and Marder, K. (2002).
The association of incident dementia with mortality in PD. Neurology
59, 17081713.
Lim, S. Y., Fox, S. H., and Lang, A. E.
(2009). Overview of the extranigral
aspects of Parkinson disease. Arch.
Neurol. 66, 167172.
Litvan, I., Aarsland, D., Adler, C. H.,
Goldman, J. G., Kulisevsky, J., Mollenhauer, B., Rodriguez-Oroz, M. C.,
Trster, A. I., and Weintraub, D.
(2011). MDS Task Force on mild
cognitive impairment in Parkinsons
disease: critical review of PD-MCI.
Mov. Disord. 15, 18141824.
Litvan, I., Goldman, J. G., Trster, A.
I., Schmand, B. A., Weintraub, D.,
Petersen, R. C., Mollenhauer, B.,
Adler, C. H., Marder, K., WilliamsGray, C. H., Aarsland, D., Kulisevsky,
J., Rodriguez-Oroz, M. C., Burn, D.
J., Barker, R. A., and Emre, M. (2012).
Diagnostic criteria for mild cognitive impairment in Parkinsons disease: Movement Disorder Society
Task Force guidelines. Mov. Disord.
24, 489495.
Lcking, C. B., Drr, A., Bonifati,
V., Vaughan, J., De Michele, G.,
Gasser, T., Harhangi, B. S., Meco, G.,
Denfle, P., Wood, N. W., Agid, Y.,
Brice, A., French Parkinsons Disease
Genetics Study Group, and European Consortium on Genetic Susceptibility in Parkinsons Disease.
(2000). Association between earlyonset Parkinsons disease and mutations in the parkin gene. N. Engl. J.
Med. 342, 15601567.
Mamikonyan, E., Moberg, P. J.,
Siderowf, A., Duda, J. E., Have, T. T.,
Hurtig, H. I., Stern, M. B., and Weintraub, D. (2009). Mild cognitive
impairment is common in Parkinsons disease patients with normal
Mini-Mental State Examination
(MMSE) scores. Parkinsonism Relat.
Disord. 15, 226231.
Martinez-Martin, P., Falup-Pecurariu,
C.,
Rodriguez-Blazquez,
C.,
Serrano-Dueas, M., Carod Artal, F.
J., Rojo Abuin, J. M., and Aarsland,
D. (2011). Dementia associated with
Parkinsons disease: applying the
Movement Disorder Society Task
Force criteria. Parkinsonism Relat.
Disord. 17, 621624.
Massano, J., and Bhatia, K. P. (2012).
Clinical approach to Parkinsons disease: features, diagnosis,
and principles of management.
Cold Spring Harb. Perspect. Med.
doi:10.1101/cshperspect.000870. (in
press).
Massano, J., and Garrett, C. (2012).
Deep brain stimulation and cognitive decline in Parkinsons disease: a
clinical review. Front. Neurol. 3:66.
doi:10.3389/fneur.2012.00066
McKeith, I. (2005). Dementia with Lewy
bodies and Parkinsons disease with
dementia: where two worlds collide.
Pract. Neurol. 7, 374382.
McKeith, I. G., Dickson, D. W., Lowe,
J., Emre, M., OBrien, J. T., Feldman, H., Cummings, J., Duda, J.
E., Lippa, C., Perry, E. K., Aarsland, D., Arai, H., Ballard, C. G.,
Boeve, B., Burn, D. J., Costa, D.,
Del Ser, T., Dubois, B., Galasko, D.,
Gauthier, S., Goetz, C. G., GomezTortosa, E., Halliday, G., Hansen, L.
A., Hardy, J., Iwatsubo, T., Kalaria, R.
N., Kaufer, D., Kenny, R. A., Korczyn,
A., Kosaka, K., Lee, V. M., Lees, A.,
Litvan, I., Londos, E., Lopez, O. L.,
Minoshima, S., Mizuno, Y., Molina,
J. A., Mukaetova-Ladinska, E. B.,
Pasquier, F., Perry, R. H., Schulz, J. B.,
Trojanowski, J. Q., Yamada, M., and
Consortium on DLB. (2005). Diagnosis and management of dementia

with Lewy bodies: third report of
the DLB Consortium. Neurology 65,
18631872.
Menza, M., Dobkin, R. D., Marin, H.,
Mark, M. H., Gara, M., Buyske, S.,
Bienfait, K., and Dicke, A. (2009). A
controlled trial of antidepressants in
patients with Parkinsons disease and
depression. Neurology 72, 886892.
Menza, M. A., Robertson, H. D., and
Bonapace, A. S. (1993). Parkinsons
disease and anxiety: comorbidity
with depression. Biol. Psychiatry 34,
465470.
Metzler-Baddeley, C. (2007). A review
of cognitive impairments in dementia with Lewy bodies relative to
Alzheimers disease and Parkinsons
disease with dementia. Cortex 43,
583600.
Morley, J. F., Xie, S. X., Hurtig, H.
I., Stern, M. B., Colcher, A., Horn,
S., Dahodwala, N., Duda, J. E.,
Weintraub, D., Chen-Plotkin, A.
S., Van Deerlin, V., Falcone, D.,
and Siderowf, A. (2012). Genetic
influences on cognitive decline in
512518.
Mosimann, U. P., Mather, G., and
Wesnes, K. A. (2004). Visual
perception in Parkinson disease
dementia and dmentia with Lewy
bodies. Neurology 63, 20912096.
Muslimovic, D., Post, B., Speelman, J. D.,
and Schmand, B. (2005). Cognitive
profile of patients with newly diagnosed Parkinson disease. Neurology
65, 12391245.
Neumann, J., Bras, J., Deas, E.,
OSullivan, S. S., Parkkinen, L., Lachmann, R. H., Li, A., Holton, J., Guerreiro, R., Paudel, R., Segarane, B.,
Singleton, A., Lees, A., Hardy, J.,
Houlden, H., Revesz, T., and Wood,
N. W. (2009). Glucocerebrosidase
mutations in clinical and pathologically proven Parkinsons disease.
Brain 132, 17831794.
Nishioka, K., Ross, O. A.,Vilario-Gell,
C., Cobb, S. A., Kachergus, J. M.,
Mann, D. M., Snowden, J., Richardson, A. M., Neary, D., Robinson, C.
A., Rajput, A., Papapetropoulos, S.,
Mash, D. C., Pahwa, R., Lyons, K. E.,
Wszolek, Z. K., Dickson, D. W., and
Farrer, M. J. (2011). Glucocerebrosidase mutations in diffuse Lewy body
disease. Parkinsonism Relat. Disord.
17, 5557.
Noe, E., Marder, K., Bell, K. L., Jacobs, D.
M., Manly, J. J., and Stern, Y. (2004).
Comparison of dementia with Lewy
bodies to Alzheimers disease and
Parkinsons disease with dementia.
Mov. Disord. 19, 6067.
Olson, E. J., Boeve, B. F., and Silber,

M. H. (2000). Rapid eye movement
sleep behaviour disorder: demographic, clinical and laboratory findings in 93 cases. Brain 123, 331339.
OMahony, D., Rowan, M., Feely, J.,
ONeill, D., Walsh, J. B., and Coakley,
D. (1993). Parkinsons dementia and
Alzheimers dementia: an evoked
potential comparison. Gerontology
39, 228240.
Ondo, W. G., Tintner, R., Voung, K.
D., Lai, D., and Ringholz, G. (2005).
Double-blind, placebo controlled,
unforced titration parallel trial
of quetiapine for dopaminergicinduced hallucinations in Parkinsons disease. Mov. Disord. 20,
958963.
Owen, A. M., James, M., Leigh, P. N.,
Summers, B. A., Marsden, C. D.,
Quinn, N. P., Lange, K. W., and Robbins, T. W. (1992). Fronto-striatal
cognitive deficits at different stages
of Parkinsons disease. Brain 115,
17271751.
Pai, M. C., and Chan, S. H. (2001).
Education and cognitive decline in
Parkinsons disease: a study of 102
patients. Acta Neurol. Scand. 103,
243247.
Papapetropoulos, S., Ellul, J., Polychronopoulos, P., and Chroni, E.
(2004). A registry-based, case
control investigation of Parkinsons
disease with and without cognitive impairment. Eur. J. Neurol. 11,
347351.
Parkinson, J. (1817). An Essay on the
Shaking Palsy. London: Sherwood,
Neely, and Jones.
Pickering, R. M., Grimbergen, Y. A.,
Rigney, U., Ashburn, A., Mazibrada,
G., Wood, B., Gray, P., Kerr, G., and
Bloem, B. R. (2007). A meta-analysis
of six prospective studies of falling
in Parkinsons disease. Mov. Disord.
22, 18921900.
Pillon, B., Deweer, B., Agid, Y., and
Dubois, B. (1993). Explicit memory
in Alzheimers, Huntingtons, and
Parkinsons diseases. Arch. Neurol.
50, 374349.
Polymeropoulos, M. H., Lavedan, C.,
Leroy, E., Ide, S. E., Dehejia, A.,
Dutra, A., Pike, B., Root, H.,
Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S.,
Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini,
A. M., Duvoisin, R. C., Di Iorio,
G., Golbe, L. I., and Nussbaum, R.
L. (1997). Mutation in the alphasynuclein gene identified in families with Parkinsons disease. Science
276, 20452047.
Rabey, J. M., Prokhorov, T., Miniovitz,
A., Dobronevsky, E., and Klein, C.
(2007). Effect of quetiapine in psychotic Parkinsons disease patients:

a double-blind labeled study of 3
months duration. Mov. Disord. 22,
313318.
Rajput, A. H., Voll, A., Rajput, M. L.,
Robinson, C. A., and Rajput, A.
(2009). Course in Parkinson disease
subtypes: a 39-year clinicopathologic study. Neurology 73, 206212.
Raskin, S., and Durst, R. (2010).
Bupropion as the treatment of
choice in depression associated with
Parkinsons disease and its various treatments. Med. Hypotheses 75,
544546.
Reid, W. G., Broe, G. A., Hely, M. A.,
Morris, J. G., Williamson, P. M.,
OSullivan, D. J., Rail, D., Genge, S.,
and Moss, N. G. (1989). The neuropsychology of de novo patients
with idiopathic Parkinsons disease:
the effects of age of onset. Int. J.
Neurosci. 48, 205217.
Rogers, D., Lees, A. J., Smith, E., Trimble, M., and Stern, G. M. (1987).
Bradyphrenia in Parkinsons disease and psychomotor retardation in
depressive illness. An experimental
study. Brain 110, 761776.
Salmon, D. P., and Filoteo, J. V. (2007).
Neuropsychology of cortical versus subcortical dementia syndromes.
Semin. Neurol. 27, 721.
Savica, R., Rocca, W. A., and Ahlskog,
J. E. (2010). When does Parkinson disease start? Arch. Neurol. 67,
798801.
Schapira, A. H., and Tolosa, E. (2010).
Molecular and clinical prodrome
of Parkinson disease: implications
for treatment. Nat. Rev. Neurol. 6,
309317.
Schrag, A., Ben-Shlomo, Y., Brown, R.,
Marsden, C. D., and Quinn, N.
(1998). Young-onset Parkinsons disease revisited clinical features, natural history, and mortality. Mov.
Disord. 13, 885894.
Schrag, A., and Schott, J. M. (2006). Epidemiological, clinical, and genetic
characteristics of early-onset parkinsonism. Lancet Neurol. 5, 355363.
Selikhova, M., Williams, D. R., Kempster, P. A., Holton, J. L., Revesz,
T., and Lees, A. J. (2009). A
clinico-pathological study of subtypes in Parkinsons disease. Brain
132, 29472957.
Set-Salvia, N., Clarimn, J., Pagonabarraga, J., Pascual-Sedano, B.,
Campolongo, A., Combarros, O.,
Mateo, J. I., Regaa, D., MartnezCorral, M., Marqui, M., Alcolea, D.,
Surez-Calvet, M., Molina-Porcel, L.,
Dols, O., Gmez-Isla, T., Blesa, R.,
Lle, A., and Kulisevsky, J. (2011).
Dementia risk in Parkinson disease:
disentangling the role of MAPT haplotypes. Arch. Neurol. 68, 359364.

Set-Salvia, N., Pagonabarraga, J.,
Houlden, H., Pascual-Sedano, B.,
Dols-Icardo, O., Tucci, A., PaisnRuiz, C., Campolongo, A., AntnAguirre, S., Martn, I., Muoz, L.,
Bufill, E., Vilageliu, L., Grinberg,
D., Cozar, M., Blesa, R., Lle,
A., Hardy, J., Kulisevsky, J., and
Clarimn, J. (2012). Glucocerebrosidase mutations confer a greater risk
of dementia during Parkinsons disease course. Mov. Disord. 3, 393399.
Shachar, T., Lo Bianco, C., Recchia, A.,
Wiessner, C., Raas-Rothschild, A.,
and Futerman, A. H. (2011). Lysosomal storage disorders and Parkinsons disease: Gaucher disease and
beyond. Mov. Disord. 26, 15931604.
Shotbolt, P., Samuel, M., Fox, C., and
David, A. S. (2009). A randomized controlled trial of quetiapine
for psychosis in Parkinsons disease. Neuropsychiatr. Dis. Treat. 5,
327332.
Sidransky, E., Nalls, M. A., Aasly, J. O.,
Aharon-Peretz, J., Annesi, G., Barbosa, E. R., Bar-Shira, A., Berg, D.,
Bras, J., Brice, A., Chen, C. M., Clark,
L. N., Condroyer, C., De Marco, E. V.,
Drr,A., Eblan, M. J., Fahn, S., Farrer,
M. J., Fung, H. C., Gan-Or, Z., Gasser,
T., Gershoni-Baruch, R., Giladi, N.,
Griffith, A., Gurevich, T., Januario,
C., Kropp, P., Lang, A. E., Lee-Chen,
G. J., Lesage, S., Marder, K., Mata, I.
F., Mirelman, A., Mitsui, J., Mizuta,
I., Nicoletti, G., Oliveira, C., Ottman,
R., Orr-Urtreger, A., Pereira, L. V.,
Quattrone, A., Rogaeva, E., Rolfs,
A., Rosenbaum, H., Rozenberg, R.,
Samii, A., Samaddar, T., Schulte, C.,
Sharma, M., Singleton, A., Spitz,
M., Tan, E. K., Tayebi, N., Toda,
T., Troiano, A. R., Tsuji, S., Wittstock, M., Wolfsberg, T. G., Wu, Y. R.,
Zabetian, C. P., Zhao, Y., and Ziegler,
S. G. (2009). Multicenter analysis
of glucocerebrosidase mutations in
Parkinsons disease. N. Engl. J. Med.
361, 16511661.
Spira, P. J., Sharpe, D. M., Halliday,
G., Cavanagh, J., and Nicholson, G.
A. (2001). Clinical and pathological
features of a Parkinsonian syndrome
in a family with an Ala53Thr alphasynuclein mutation. Ann. Neurol. 49,
313319.
Starkstein, S. E., Sabe, L., and Petracca,
G. (1996). Neuropsychological and
psychiatric differences between
Alzheimers disease and Parkinsons
disease with dementia. J. Neurol.
Steinlechner, S., Stahlberg, J., Vlkel, B.,
Djarmati, A., Hagenah, J., Hiller, A.,
Hedrich, K., Knig, I., Klein, C., and
Lencer, R. (2007). Co-occurrence

of affective and schizophrenia spectrum disorders with PINK1 mutations. J. Neurol. Neurosurg. Psychiatr.
78, 532535.
Stern, Y., Marder, K., Tang, M. X., and
Mayeux, R. (1993). Antecedent clinical features associated with dementia
in Parkinsons disease. Neurology 43,
16901692.
Stuss, D. T. (2011). Functions of the
frontal lobes: relation to executive
functions. J. Int. Neuropsychol. Soc.
17, 759765.
Taipa, R., Pinho, J., and Melo-Pires,
M. (2012). Clinico-pathological
correlations of the most common
neurodegenerative
dementias.
Front. Neurol. 3:68. doi:10.3389/
fneur.2012.00068
Tan, E. K., and Jankovic, J. (2006).
Genetic testing in Parkinson disease:
promises and pitfalls. Arch. Neurol.
63, 12321237.
Terzaghi, M., Sinforiani, E., and Zucchella, C. (2008). Cognitive performance in REM sleep behaviour
disorder: a possible early marker
of neurodegenerative disease? Sleep
Med. 9, 343351.
The Parkinson Study Group. (1999).
Low-dose clozapine for the treatment of drug-induced psychosis in
Parkinsons disease. N. Engl. J. Med.
340, 757763.
Tolosa, E., Gaig, C., Santamara, J., and
Compta, Y. (2009). Diagnosis and
the premotor phase of Parkinson
disease. Neurology 27, S12S20.
Trster, A. I. (2008). Neuropsychological characteristics of dementia with
Lewy bodies and Parkinsons disease with dementia: differentiation,
early detection, and implications for
mild cognitive impairment and
biomarkers. Neuropsychol. Rev. 18,
103119.
Trotta, L., Guella, I., Sold, G., Sironi,
F., Tesei, S., Canesi, M., Pezzoli, G.,
Goldwurm, S., Duga, S., and Asselta,
R. (2012). SNCA and MAPT genes:
Independent and joint effects in
Parkinson disease in the Italian population. Parkinsonism Relat. Disord.
18, 257162.
Turner, M. A., Moran, N. F., and
Kopelman, M. D. (2002). Subcortical dementia. Br. J. Psychiatry 180,
148151.
Valente, E. M., Abou-Sleiman, P. M.,
Caputo, V., Muqit, M. M., Harvey, K., Gispert, S., Ali, Z., Del
Turco, D., Bentivoglio, A. R., Healy,
D. G., Albanese, A., Nussbaum,
R., Gonzlez-Maldonado, R., Deller,
www.frontiersin.org
T., Salvi, S., Cortelli, P., Gilks, W.

P., Latchman, D. S., Harvey, R.
J., Dallapiccola, B., Auburger, G.,
and Wood, N. W. (2004). Hereditary early-onset Parkinsons disease
caused by mutations in PINK1. Science 304, 11581160.
Valente, E. M., Bentivoglio, A. R.,
Dixon, P. H., Ferraris, A., Ialongo,
T., Frontali, M., Albanese, A., and
Wood, N. W. (2001). Localization
of a novel locus for autosomal
recessive early-onset parkinsonism,
PARK6, on human chromosome
1p35-p36. Am. J. Hum. Genet. 68,
895900.
Valente, E. M., Brancati, F., Ferraris,
A., Graham, E. A., Davis, M. B.,
Breteler, M. M., Gasser, T., Bonifati,
V., Bentivoglio, A. R., De Michele, G.,
Drr, A., Cortelli, P., Wassilowsky, D.,
Harhangi, B. S., Rawal, N., Caputo,
V., Filla, A., Meco, G., Oostra, B. A.,
Brice, A., Albanese, A., Dallapiccola,
B., Wood, N. W., and European Consortium on Genetic Susceptibility in
Parkinsons Disease. (2002). PARK6linked parkinsonism occurs in several European families. Ann. Neurol.
51, 1418.
van Duijn, C. M., Dekker, M. C., Bonifati, V., Galjaard, R. J., HouwingDuistermaat, J. J., Snijders, P. J.,
Testers, L., Breedveld, G. J., Horstink,
M., Sandkuijl, L. A., van Swieten, J. C., Oostra, B. A., and
Heutink, P. (2001). Park7, a novel
locus for autosomal recessive earlyonset parkinsonism, on chromosome 1p36. Am. J. Hum. Genet. 69,
629634.
Velayati, A., Yu, W. H., and Sidransky, E.
(2010). The role of glucocerebrosidase mutations in Parkinson disease and Lewy body disorders. Curr.
Neurol. Neurosci. Rep. 10, 190198.
Wattjes, M. P. (2011). Structural MRI.
Int. Psychogeriatr. 23(Suppl. 2),
S13S24.
Weintraub, D., and Burn, D. J. (2011).
Parkinsons disease: the quintessential neuropsychiatric disorder. Mov.
Disord. 26, 10221031.
Weintraub, D., Taraborelli, D., Morales,
K. H., Duda, J. E., Katz, I. R., and
Stern, M. B. (2006). Escitalopram for
major depression in Parkinsons disease: an open-label, flexible-dosage
study. J. Neuropsychiatry Clin. Neurosci. 18, 377383.
Weintraub, S., Wicklund, A. H., and
Salmon, D. P. (2012). The neuropsychological profile of Alzheimer
disease. Cold Spring Harb. Perspect.
Med. 2, a006171.
Wermuth, L., Sorensen, P. S., Timm,

S., Christensen, B., Utzon, N. P.,
Boas, J., Dupont, E., Hansen, E.,
Magnussen, I., Mikkelsen, B., WormPetersen, J., Lauritzen, L., Bayer, L.,
and Bech, P. (1998). Depression
in idiopathic Parkinsons disease
treated with citalopram: a placebocontrolled trial. Nord. J. Psychiatry
52, 163169.
Wickremaratchi, M. M., Majounie, E.,
Morris, H. R., Williams, N. M.,
Lewis, H., Gill, S. S., Khan, S.,
Heywood, P., Hardy, J., Wiles, C.
M., Singleton, A. B., and Quinn,
N. P. (2009). Parkin-related disease
clinically diagnosed as a pallidopyramidal syndrome. Mov. Disord.
24, 138140.
Williams, D. R., and Lees, A. J. (2005).
Visual hallucinations in the diagnosis of idiopathic Parkinsons disease:
a retrospective autopsy study. Lancet
Neurol. 4, 605610.
Williams-Gray, C. H., Evans, J. R., Goris,
A., Foltynie, T., Ban, M., Robbins,
T. W., Brayne, C., Kolachana, B.
S., Weinberger, D. R., Sawcer, S. J.,
and Barker, R. A. (2009). The distinct cognitive syndromes of Parkinsons disease: 5 year follow-up of
the CamPaIGN cohort. Brain 132,
29582969.
Winblad, B., Cummings, J., Andreasen,
N., Grossberg, G., Onofrj, M.,
Sadowsky, C., Zechner, S., Nagel,
J., and Lane, R. (2007). A sixmonth double-blind, randomized,
placebo-controlled study of a transdermal patch in Alzheimers disease rivastigmine patch versus capsule. Int. J. Geriatr. Psychiatry 22,
456567.
Winge, K., and Fowler, C. J. (2006).
Bladder dysfunction in Parkinsonism: mechanisms, prevalence, symptoms, and management. Mov. Disord. 21, 737745.
Wood, B. H., Bilclough, J. A., Bowron,
A., and Walker, R. W. (2002). Incidence and prediction of falls in
Parkinsons disease: a prospective
multidisciplinary study. J. Neurol.
Wszolek, Z. K., Pfeiffer, R. F., Tsuboi, Y.,
Uitti, R. J., McComb, R. D., Stoessl,
A. J., Strongosky, A. J., Zimprich,
A., Mller-Myhsok, B., Farrer, M. J.,
Gasser, T., Calne, D. B., and Dickson,
D. W. (2004). Autosomal dominant
parkinsonism associated with variable synuclein and tau pathology.
Neurology 62, 16191622.
Zarranz, J. J., Alegre, J., Gmez-Esteban,
J. C., Lezcano, E., Ros, R., Ampuero,
I., Vidal, L., Hoenicka, J., Rodriguez,

O., Atars, B., Llorens, V., Gomez
Tortosa, E., del Ser, T., Muoz, D. G.,
and de Yebenes, J. G. (2004). The new
mutation, E46K, of alpha-synuclein
causes Parkinson and Lewy body
dementia. Ann. Neurol. 55, 164173.
Zaluska, M., and Dyduch, A. (2011).
Bupropion in the treatment
of depression in Parkinsons
disease. Int. Psychogeriatr. 23,
325327.
Zesiewicz, T. A., Sullivan, K. L., Arnulf,
I., Chaudhuri, K. R., Morgan, J. C.,
Gronseth, G. S., Miyasaki, J., Iverson, D. J., and Weiner, W. J. (2010).
Quality Standards Subcommittee of
the American Academy of Neurology. Practice Parameter: treatment
of nonmotor symptoms of Parkinson disease: report of the Quality Standards Subcommittee of the
American Academy of Neurology.
Neurology 74, 924931.
Zoldan, J., Friedberg, G., Livneh, M., and
Melamed, E. (1995). Psychosis in
advanced Parkinsons disease: treatment with ondansetron, a 5-HT3
receptor antagonist. Neurology 45,
13051308.
Conflict of Interest Statement: Joana

Meireles has received financial support
to attend meetings from Biogen Idec
and Novartis companies. Joo Massano
has acted as an advisor and received
honoraria and financial support to
speak or attend meetings from Bial,
Grnenthal, Lundbeck, Novartis, and
Tecnifar companies. Off label drug therapies are discussed in the text, for which
the authors are exclusively responsible.
Received: 24 February 2012; paper pending published: 22 March 2012; accepted:
07 May 2012; published online: 25 May
2012.
Citation: Meireles J and Massano
J (2012) Cognitive impairment
and dementia in Parkinsons disease: clinical features, diagnosis, and
management. Front. Neur. 3:88. doi:
10.3389/fneur.2012.00088
This article was submitted to Frontiers
in Dementia, a specialty of Frontiers in
Neurology.
Copyright 2012 Meireles and Massano. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits noncommercial use, distribution, and reproduction in other forums, provided the
original authors and source are credited.

Cognitive Impairment and Dementia in Parkinson's Disease - Clinical Features, Diagnosis, and Management

Uploaded by

Copyright:

Available Formats

Cognitive Impairment and Dementia in Parkinson's Disease - Clinical Features, Diagnosis, and Management

Uploaded by

Document Information

Original Title

Copyright

Available Formats

Share this document

Share or Embed Document

Sharing Options

Did you find this document useful?

Is this content inappropriate?

Copyright:

Available Formats

Cognitive Impairment and Dementia in Parkinson's Disease - Clinical Features, Diagnosis, and Management

Uploaded by

Copyright:

Available Formats

REVIEW ARTICLE

published: 25 May 2012

Cognitive impairment and dementia in Parkinsons

Department of Neurology, Centro Hospitalar de So Joo, Porto, Portugal

Parkinsons disease (PD) is a common, disabling, neurodegenerative disorder. In addition

hyposmia, rapid eye movement (REM) sleep behavior disorder,

May 2012 | Volume 3 | Article 88 | 1

Meireles and Massano

order to obtain a clinically oriented perspective of the state of the

EPIDEMIOLOGY OF PARKINSONS DISEASE DEMENTIA

Frontiers in Neurology | Dementia

Cognitive impairment and dementia in Parkinsons disease

instability, MCI, and the presence of visual hallucinations (Goetz

PARKINSONS DISEASE DEMENTIA: CLINICAL FEATURES

The onset of PD-D is insidious, often making it difficult for the

May 2012 | Volume 3 | Article 88 | 2

Meireles and Massano

Assessment of cognition in PD patients can be a demanding

Cognitive impairment and dementia in Parkinsons disease

than phonemic fluency (Henry and Crawford, 2004). Concept

Hallucinations occur in 4565% of PD-D patients, a higher rate

Aarsland and coworkers have conducted a community-based study

May 2012 | Volume 3 | Article 88 | 3

Meireles and Massano

symptoms occurs with approximately the same frequency in PD-D

It has been reported in 54% of patients in a large sample of mild to

NON-COGNITIVE FEATURES OF PARKINSONS DISEASE

There is the notion that certain motor features, such as postural

Frontiers in Neurology | Dementia

Cognitive impairment and dementia in Parkinsons disease

longitudinal study found greater mental deterioration in those PD

REM sleep behavior disorder (RBD) is characterized by dream

Dementia and significant autonomic features may develop in the

May 2012 | Volume 3 | Article 88 | 4

Meireles and Massano

relative frequency of autonomic features in demented compared

DIAGNOSTIC CRITERIA FOR PARKINSONS DISEASE

Cognitive impairment and dementia in Parkinsons disease

May 2012 | Volume 3 | Article 88 | 5

Meireles and Massano

checklist, whereas 15 patients (16.5%) were detected using full

MILD COGNITIVE IMPAIRMENT IN PD

Frontiers in Neurology | Dementia

Cognitive impairment and dementia in Parkinsons disease

methodological differences, namely definitions used, the cognitive

May 2012 | Volume 3 | Article 88 | 6

Meireles and Massano

FIGURE 1 | schematic representation of the progression of PD patients

The clinical validity of PD-MCI has found strong support in the

Cognitive impairment and dementia in Parkinsons disease

note that this graph is merely pictorial; it is not intended to represent

Lastly, cognitive impairment must not cause significant functional

GENETICS AND COGNITIVE DECLINE IN PD

Ten to 15% of PD patients disclose a family history suggesting

May 2012 | Volume 3 | Article 88 | 7

Meireles and Massano

Interesting observations have been made in the last few years in

Frontiers in Neurology | Dementia

Cognitive impairment and dementia in Parkinsons disease