C HROM ATO G R A P H Y

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Thermo Scientific
Dionex Integrion HPIC System

The Thermo Scientific Dionex Integrion HPIC

System is a fast, simple and secure solution to
provide the performance you need today while
protecting your investment for tomorrow.

Your Results, Faster

Pump
The Dionex Integrion HPIC system pump
features a variable flow, serial-piston design
that delivers consistent flow rates with low
pulsation, resulting in low detector noise.
By increasing the pressure tolerance of the
pump up to 6000 psi, and allowing linear
flow rates from 0.001 to 10 mL/min, the
Dionex Integrion HPIC system can achieve
substantially shorter run times, providing
increased throughput and productivity.

Integrated system
The integrated system performs all typical
ion chromatography (IC) separations using
conductivity or amperometric detection
modes.
The integrated design of the Dionex Integrion
HPIC system delivers high performance in a
small footprint, saving critical bench space
while ensuring convenient access to all
components for upgrades or maintenance.
The bottle tray holds a 2 L eluent bottle in
the front compartment allowing easy viewing
of eluent levels, and can hold additional
bottles of up to 4 L in the rear compartment.

Your Workflow, Simplified

Consumable Tracking
The Dionex Integrion HPIC system enables
tracking and monitoring of performance and
usage across all consumables to enable
proactive maintenance and replacement.
Consumables tracking of electrolytic
consumables is standard on all systems;
tracking via radio frequency identification
(RFID)* is standard on models equipped with
a column oven.
* The wireless transmitter devices may not be
authorized as required by the laws of your country;
and these features will not be, offered for sale or
lease, or sold or leased, until proper authorization is obtained. Please consult your local sales
representative for details.

Metrics
1. Date of First Install
2. Number of Injections
3. Number of Samples Concentrated
4. Total Volume of Injections
5. Total Volume Concentrated
6. Maximum Flow Rate Seen
7. Maximum Temperature Seen
8. Maximum Pressure Seen
9. Maximum Voltage Seen
10. Maximum Current Seen
11. Last Separator Column Paired With
12. Last Guard Column Paired With
13. Total Eluent Volume Seen
14. Total Voltage Hours Seen
15. Total Current Hours Seen
16. Eluent Types Exposed To
17. Weekly Flow Rate Data Array
18. Weekly Pump Pressure Data Array
19. Weekly Background Conductivity Data
Array
20. Weekly Current Data Array
21. Weekly Voltage Data Array
Consumables
a.
b.
c.
d.
e.

Guard Columns (GC)

Separator Columns (SC)
Concentrator Columns (CC)
Trap Columns (TC)
Constant Current Electrolytically
Regenerated Suppressors (CCERS)
f. Constant Voltage Electrolytically
Regenerated Suppressors (CVERS)
g. Continuously Regenerated Trap Columns
(CRTC)

Information stays with the consumable,

regardless of which system it is installed
in
Monitors up to 16 key performance
metrics on each of up to 7 different
consumables simultaneously
Verifies consumable performance against
product specifications and production
quality assurance data
Facilitates checks of inter-consumable
compatibility
Tablet
The Dionex Integrion HPIC system supports
wireless tablet control, providing the ability to
have full, detailed system control and status
wherever you need it.
Secured WiFi communication direct to the
instrument with no broadcast data
Control and monitor one instrument at a
time, with instrument switching as easy
connecting to a new wireless network
Range up to 9 m (30 feet)
Remote Monitoring
Optional remote monitoring and diagnostic
software notifies operators, lab managers,
or other personnel when maintenance is
required. Alerts are sent to service engineers
at Unity Lab Services when the system is
not functioning correctly so that remote
troubleshooting can be performed.
Monitors only instrument performance, not
sample data
Features encrypted 128-bit SSL point-topoint communication
Works with most commercially available
antivirus and firewall software

Simplified System Performance

Eluent Generation
The eluent generator electrolytically
generates high-purity eluents on-line,
ensuring perfectly consistent performance
day to day, lab to lab, and operator to
operator. With eluent generation, gradient
separations can be as easy as isocratic
applications.
The eluent generator delivers eluent
concentrations from 0.1100 mM for KOH
and MSA at typical application flow rates
(1 mL/min or lower) and high pressures
of up to 5000 psi. High purity eluents are
generated from deionized (DI) water using
the Thermo Scientific Dionex EGC Eluent
Generator Cartridge and then polished of
contaminants using one of the Thermo
Scientific Dionex CR-TC Continuously
Regenerating Trap Columns. Control, status,
and diagnostics are provided with the
Thermo Scientific Dionex Chromeleon
Chromatography Data System (CDS)
Software. Since the pump delivers only
water and eluents are generated on-line,
the lifetime of the pump pistons and seals
extended, and piston contamination during
seal wash is eliminated.
Detector options
The Dionex Integrion HPIC system can be
configured with either a conductivity detector
(CD) or an electrochemical detector (ED).
Any of the detectors can be easily installed
by the user.
Control using Chromeleon CDS software
or locally through TTL (Transistor
Transistor Logic) inputs
Electronics are integrated between cell
and detector for greater stability
Built-in electronics allow for easy
calibration and diagnostics
Conductivity Detector Features
Microprocessor-controlled digital signal
processing detects both high and low
concentrations of analytes smoothly and
without range changes
Supports all IC and reagent-free ion
chromatography (RFIC) system
applications with maximum range up
to 15,000 S/cm
For easy calibration and diagnostics

Electrochemical Detector Features

Cell body design provides defined and
consistent torque to cell gasket for
consistent unit-to-unit response
of working electrodes
Uses microprocessor-controlled digital
signal processing
Supports DC amperometry, pulsed
amperometry, or integrated pulsed
amperometry detection modes
Uses either pH-Ag/AgCl, Ag/AgCl, or
Palladium Hydrogen (PdH) reference
electrode; new one-piece PdH reference
electrode provides consistency and
reliability

Thermal Control
Column Oven
The column oven provides precise
temperature control over a wide temperature
range with fast heat-up times.
Supports all standard bore and microbore
guard and separator column sizes,
in addition to single and dual valve
configurations
Forced-air, in-line temperature control
stabilizes operating conditions and
reduces temperature gradients to ensure
consistent separations
Temperature is user-settable from 5 C
above ambient to 80 C
Configurable for microbore (2 mm i.d.),
standard bore (4 mm i.d.), and 9 mm
i.d. columns

SPECIFICATIONS
Pump
Type

Dual-piston (in series), microprocessor controlled, constant 10 mm primary

stroke length, variable speed Isokinetic with Eluent Precompression

Construction

Chemically inert, metal-free PEEK pump heads and flow path; compatible
with aqueous eluents from pH 014 and reversed-phase solvents such as
methanol and acetonitrile

Pressure Range

041 MPa (06000 psi)

Flow Rate Range

10 mL/min with alternative pump heads

Flow Rate Precision

< 0.1%

Flow Rate Accuracy

< 0.1%

Pressure Ripple

< 1% at 1.0 mL/min, typical

Vacuum Degasser

Integrated, optional

Piston Seal Wash

Optional, automatic operation

Eluent On/Off Valve

Electrically actuated, standard

Leak Sensor

Optical, standard

Eluent Generator

Eluent Types

Up to two eluent generator cartridges

KOH, LiOH, NaOH; Carbonate; Carbonate/Bicarbonate; MSA

Eluent Concentration Range

0.1100 mM

Flow Rates

0.13 mL/min

1.0 mL/min eluent concentration is limited

Maximum Operating Pressure

Dionex EGC 500 cartridge: 35 MPa (5000 psi)

Maximum Solvent Concentration

Cations: 0%

Anions (hydroxide): 25% methanol (KOH, NaOH and LiOH cartridges);

Anions (carbonate/bicarbonate): None

Gradient Profiles

Standard - any combination of linear, convex and concave positive and

negative gradient profiles

Column Compartment
Injection Valves

Up to two high-pressure valves, either 6- or 10-port

Detector Compartment
The detector compartment provides a
thermally controlled environment for
superior electrolytic suppression and
suppressor lifetime. In addition, the detector
compartment is thermally stable for optimum
conductivity and electrochemical detection
consistency.

Columns Supported

Up to two 1-9 mm i.d., maximum length 250 mm analytical column with

50mm guard column

Constant Temperature Zone

Optional

Temp. Range: 30 to 80 C (86 to 176 F); minimum 5 C above ambient

Temperature Accuracy: 0.5 C at 30 C)

Temperature Stability: 0.2 C (at 30 C)

Time to Equilibration (ambient to ambient plus 20 C): 20 minutes

Forced-air, Peltier temperature control

stabilizes operating conditions and
reduces temperature gradients during
chromatography

Detector Compartment

Temperature-controlled zone stabilizes

operation of suppressors and detectors
Temperature is user-settable from 15 C
(or 20 C below ambient) to 40 C.

Constant Temperature Zone

Optional

Temp. Range: 15 (or 20 C below ambient) to 40 C (59 to 104 F)

Temperature Accuracy: 0.5 C (at 15 C)

Temperature Stability: 0.2 C (at 15 C)

Time to Equilibration (ambient to ambient minus 20C): 30 minutes

Suppression Modes
Chemical Suppression

2 mm and 4 mm, anion and cation, membrane suppression

Electrolytic Suppression Recycle Mode 2 mm and 4 mm, anion and cation, membrane suppression
Electrolytic Suppression External
Water Mode

2 mm and 4 mm, anion and cation, membrane suppression

Non-Suppressed Conductivity

Supported - both anion and cation

SPECIFICATIONS (contd)
Conductivity Detector
Electronics Type

Microprocessor controlled digital signal processing, autoranging

Cell Drive

8 kHz square wave

Linearity 1%
Resolution

0.00238 nS/cm

Output Range

Digital Signal Range: 015,000 S/cm

Analog Signal Range: 015,000 S/cm

Noise, Wet

0.2 nS at 23 S/cm background

0.1 nS at 1 S/cm background

Filter

Rise times 0 to 10 s, programmable

Sampling Rate

1 to 100 Hz, user settable or automatic

Cell Temperature

7 C above ambient to 60 C maximum

Cell Temperature Stability

< 0.001 C

Cell Temperature Compensation

Default 1.7% per C; programmable from 03% per C

Flow Cell Maximum Pressure

10 MPa (1500 psi)

Flow Cell Volume

0.7 L

Cell Electrodes

Passivated 316 stainless steel. Compatible with MSA

Cell Body

Chemically inert polymeric material

Heat Exchanger

Inert, tortuous-path for low longitudinal dispersion

Electrochemical Detector
Electronics Type

Microprocessor controlled digital signal processing

Electronic Noise, Wet

IPAD (Au electrode) < 50 pC at 10 mM KOH, DC Amperometry (GC) < 10 pA

Potential Range

-2.0 to 2.0 V in 0.001 V increments

Signal range (Digital and Analog)

Integrated Amperometry: 50 pC to 200 C DC Amperometry: 5 pA to 74 A

Filter

010 s response time, user settable

Control Mode

Local or remote control using relay closures or TTL, or control using Chromeleon CDS software via
DC module

Cell Body

Titanium body. Compatible with 27 mm i.d. columns

Working Electrodes

Conventional: gold, glassy carbon, platinum, and silver

Disposable: gold, platinum, carbon, and silver

Reference Electrode

pH-Ag/AgCl combination, one piece design

PdH, one piece design

Autoranging Yes
Analog Output

User selectable full scale of 10, 100, or 1000 mV

Cell Volume at Working Electrode

< 0.2 L

Maximum Cell Operating Pressure

0.7 MPa (100 psi)

Internal Power Supplies

Internal Power supplies

Constant current (CC) or constant voltage (CV) power supplies

Option 1: 1 channel CC [0 - 500 mA] or CV [0 36 V]

Option 2: 2 channels CC [0 - 500 mA] or CV [0 36 V]

Option 3: 1 channel CC [0 - 500 mA] & 2 channels CC [0 - 500 mA] or CV [0 36 V]

Option 4: 1 channel CC [0 - 500 mA] & 4 channels CC [0 - 500 mA] or CV [0 36 V]

SPECIFICATIONS (contd)
Software

Chromeleon CDS software, version 7.2 or higher

Automated Workflow Wizards

Standard feature

System Smart Startup and Shutdown

Standard feature

Automation Support of 3rd

Party Instruments

Fully controls over 400 different instruments from more than 30 manufacturers, including GC, HPLC,
and MS

Customizable System Control Panels

Standard feature

Signal Channels

Detector signals and pump pressure as standard

Data Trending Plots

All numerical device parameters

System Status Virtual Channels

Standard feature

Network Failure Protection

Standard feature for networked installations

System Trigger Commands

and Conditionals

Standard feature

Daily Audit Trail

Standard feature

Sample Audit Trail

Standard feature

System Calibration Storage

Factory, present and previous. Completely user selectable.

Customized Reporting

Standard feature with unlimited report sheets

GLP Compliance

Optional

Physical Specifications
Power Requirements

100240 V ac, 50-60 Hz autoranging

Operating Temperature

440 C (40104 F); cold-room compatible (4 C) as long as system power remains on

Operating Humidity Range

595% relative, noncondensing

Control Modes

Full control through front panel and Chromeleon CDS software; alternative control through TTL or relay
closures; two relay outputs, two TTL outputs, four programmable inputs

USB Communication Protocol

One USB input; one built-in two-output USB hub

Leak Detection

Built-in, optical sensor

Dimensions (h w d)

62.5 30.0 55.9 cm

(24.6 11.8 22 inches)

Weight

41 kg (90 lb)

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P rod u ct S p ecif ica t ions

System Software