Systematic Interpretation of Lumbar MRI

2004 Annual Assembly of the American Academy of PM&R

James Rainville, MD Janet Limke, MD

Chief, PM&R, Staff Physiatrist
New England Baptist Hospital New England Baptist Hospital
Assistant Clinical Professor Boston, MA
Department of PM&R
Harvard Medical School
Boston, MA

We gratefully acknowledge the contributions of Harvey Levine, MD Neuroradiologist, New England

Baptist Hospital, Boston, MA.
1. Image Orientation
1. Sagittal Images – Lengthwise view, Anterior to Posterior
Sequences Right £ Center £ Left, or Left £ Center £ Right (no consistency)
2. Axial Images – Cross section of spine
Patient’s feet are towards you so left side of patients is always on the right of the image.
Films arranged superior to inferior or inferior to superior.
Most will be continuous slices. Some will be focal slices only through discs.
3. Coronal – Lengthwise views, Right to Left orientation (Uncommon)

II. MRI Image Type

Identify image type quickly by looking at CSF and Spinal Cord.
T1 £ CSF Dark – Cord Gray
T2 £ CSF Bright – Cord Dark
Fat Suppressed T2 £ Same as T2 plus Vertebrae dark
Intermediate T2 £ CSF Light Gray – Cord Light Gray
Gadolinium T1 £ CSF Dark – Cord Gray – Labeled or marker C+

Table 1. Relative signal intensities of body tissues on different image types

T1 Bright: adipose tissue

gray: cartilage, tumor, abscesses, hyaline cartilage,
dark: CSF, muscle, bone, tendon, ligament, fibrocartilage,
variable: gas
hemorrhage
T2 Bright: water, abscesses, occasionally non-neoplastic tumor
gray: hyaline cartilage, muscle, cartilage, tumor
dark: bone, tendons, ligaments, fibrocartilage,
variable: water, gas, occasionally neoplastic tumor
Intermediate T2 Very dark: ligaments, cartilage
Gadolinium- Bright: Areas of increased vascularity (vascular
Enhanced T1 malformations, inflammation, tumors, scar tissue)

MRI EXAMINATION QUICK REFERENCE SHEET

STEP (1) Verify patient identification, date of scan

STEP (2) Sort Films T1 & T2 Sagittal, T1 and T2 Axial, others

STEP (3) T1 sagittals (spinal fluid is dark and fat is bright)

Determine left-right orientation. May not be labeled. On left, aorta gives off branches at ~L1; On
right, renal artery runs posterior to Inferior Vena Cava. Aorta has anterior branching arteries.
Working from outside to inside, caudal to rostral observe:
Neural foramina and nerve roots: Observe for compression
Intervertebral discs: width, protrusions/ herniations
Spinal column: alignment (spondylolisthesis), vertebral body shape (compression fractures,
Schmorls’ nodes), posterior bony elements (spondylolysis), degenerative end plate changes
(changes in fat content), hemangiomas.
Retroperitoneal space: adenopathy, masses, great vessel aneurysm, etc

STEP (4) T2 sagittals (spinal fluid is bright)

Working from caudal to rostral observe:
Dural sac—cord and rootlets: width, compression, irregularities
Intervertebral discs: width, protrusions/ herniations, hydration, high intensity zones
Spinal column: alignment (spondylolisthesis), vertebral body shape (compression fractures,
Schmorls’ nodes), posterior bony elements (spondylolysis), degenerative end plate changes
(changes in fat content), hemangiomas.
Posterior bony elements: facet joints effusions, etc.

STEP (5) Intermediate +/or Fat Saturated T2 Sagittals

STEP (6) T1 Axials (CSF appears gray and fat appears bright) Proceed sacral to rostral
Orientation – neural foramina lie at level of discs.
Content of the spinal canal and neural foramina: Trace course of nerve roots through neural
foramina
Intervertebral discs— continuity, bulges, etc.
Bone – Vertebral bodies; spondylolisthesis, posterior bony elements (spondylolysis, breakage)
Ligamentam flavum: thickened appearance, impingement
Retroperitoneal space: adenopathy, masses, muscle, etc.

STEP (7) T2 Axials (spinal fluid appears bright) Work from sacrum to rostral
Content of the spinal canal and neural foramina: Trace course of nerve roots through neural
foramina
Intervertebral discs— continuity, bulges, etc.
Bone – Vertebral bodies; spondylolisthesis, posterior bony elements (spondylolysis, breakage)
Ligamentam flavum: thickened appearance, impingement
Retroperitoneal space: adenopathy, masses, muscle, etc.

STEP (8) Gadolinium Enhanced T1 images (Marked C+ or with sticker)

Evaluate level of prior surgery for enhancement
May reveal enhancement around inflammation, neoplasms, fractures

STEP (9) Assessment and Plan

Assessment: Summarize your findings. Compare with radiologist report.
Plan: Patient care plan.
Systematic Analysis of Lumbar MRI
Step 1. Identify subject’s NAME and DATE of MRI
Step 2. Sort films.
Sagittal T1
Sagittal T2
Other Sagittal Intermediate T2, Fat suppressed T2, Gadolinium enhanced T1
Axial T1
Axial T2
Other Axial – Gadolinium enhanced T1

Step 3. T1 Sagittal Analysis

Determine right-left orientation. Sagittal images are presented as slices beginning on one side of
the spine and move sequentially through the mid-spine to the other side. Knowing which side is
right or left is therefore essential. This is often labeled as the slice locator printed on each image
(e.g. “R 12.5”, “R10.0”, “R7.5”…”L7.5”, “L10.0”, “L12.5”) or through numbered labeling based
on a scout axial or coronal image. If labeling is not evident, simply recall that the aorta lies on the
left and the inferior vena cava (IVC) runs on the right side of the anterior vertebral body. The
aorta is recognizable by its greater width and also by the superior mesenteric and celiac arteries
branching anteriorly at about the T12/L1 levels. The IVC can be recognized by the right renal
artery that slips between it and the vertebral column near the L1 level
Neural foramina and nerve roots: A normal foramen should appear bright and peanut-
shaped due to the fat within it, and the nerve root as a gray round spot within the fat at the
superior aspect of the foramen. Deformity of the neuroforamen is evident when the fat is
displaced. This is often caused by disc material extending beyond it normal boundary or
alteration of the surrounding bone structures. You may need to scan two or three adjacent
slices to ensure that the foramen is indeed patent throughout its width. Start with the L5 – S1
neural foramina, then move to the more rostral neuroforamina (L4-L5, L3-4, L2-3, L1-2).
Once you have completed this on one side, repeat this on the opposite side of the spine.
Intervertebral discs, spinal canal, dural sac:
Intervertebral discs – Look in turn for the following:
Disc width – reduction in disc width can provide a clue about degeneration
Disc protrusions/ herniations – Posterior extension of disc material (intermediate signal)
beyond its normal margin can often be visualized if it displaces the epidural fat (bright) in the
spinal canal or neuroforamina. As disc material and CSF can appear similar, detection of
central disc herniations can be difficult.
Spinal column:
Vertebral body alignment– Inspection of mid sagittal cuts will demonstrate misalignment
from spondylolisthesis if present. In cases of lumbar scoliosis, the spinal canal comes in and
out of view on different slices at the upper, mid and lower lumbar spine.
Vertebral body shape - Wedge-shaped vertebral bodies may indicate compression fractures.
Schmorls’ nodes, common benign findings, appear as round defects in the vertebral endplates
and represent invagination of the intervertebral disc through the endplates.
Posterior bony elements – If spondylolisthesis is present, evaluate the pars interarticularis of
the superior vertebrae at that level for possible spondylolysis. First identify where the pedicles
leave the vertebral body. Now follow this bone to the superior and inferior facets.
Spondylolysis is identified as a break in the bridge of bone (pars interarticularis) between the
superior and inferior facets, and appears as a malalignment and dark line or gap of the pars.
Degenerative end plate changes- Frequently, the vertebral end plates adjacent to degenerated
discs show changes in signal intensity. Decrease in fat content is indicated by hypointensity
(as part of benign sclerotic changes) and increase in fat by hyperintensity.
Hemangiomas- These slow growing, benign lesions are common findings. They appear as bright,
roundish areas with the vertebral bodies.
Retroperitoneal space – Look for any irregularities in the structures found here such as
adenopathy, masses, great vessel aneurysm, etc.

STEP 4 T2 sagittals (spinal fluid is bright)

 Dural sac– With T2 sagittal images, we utilize the brightness of CSF to highlight
abnormalities that affect the intradural nerve roots or spinal cord. Trace the course of the dural
sac longitudinally, looking for changes in width or compression by extradural structures.
Look at the posterior wall of the intervertebral discs for displacement of the dural sac by
protruding or herniated disc material. Also observe the effects of the bony structures and
ligamentum flavum of the dural sac. If the nerve rootlets can be visualized, observe the
relationship of any extradural structural abnormalities on their course. When you get to the
images that best visualize the central spinal canal, evaluate for distal spinal cord. This
generally occurs around the level of L1. Look at the cord for any increased signal intensity
(clues to cysts, syrinxes, areas of demyelination, tumors, etc).
Intervertebral discs
Disc degeneration reduces hydration of the nucleus pulposus and thus decreases intensity or
brightness of the disc signal. Look in order at each intervertebral disc for its hydration status.
Disc protrusions/herniations –fluid in the dural sac provides good “contrast” for evaluating
these findings. Dark disc material may bulge, protrude or herniate posteriorly, and thereby
displace the bright CSF filled dural sac.
High Intensity Zones (HIZ)—these areas of increased signal intensity are thought to indicate
tears, scarring, or vascularization of the annulus. These are most common in the posterior
walls of discs.
Spinal Column
As above, study vertebral body alignment, vertebral body shape, and the posterior elements.
Hemangiomas – while these are always bright on T1, they are may be either bright or
isointense on T2 images.
Posterior bony elements – Evaluate the pars interarticularis as above. Degenerative facet
joints may have joint effusions. These appear as bright lines in sequences that cross the joints.

Step 5 – Intermediate T2 Sagittal (CSF and cord appear gray and blend together)
Intervertebral discs
Disruption of the posterior wall of the annulus will appear as a defect in the thin, dark line that
delineates this structure.

Step 6 - T1 Axial Images (CSF appears gray and fat appears bright)

Identifying Vertebral Level - We recommend that one start with the most caudal images.
These are usually of the easily recognizable sacrum. Examine from the sacrum through the
L5-S1 disc level the structures indicated below. Next proceed to L4-5, L3-4, etc. to complete
your analysis.
Content of the spinal canal and neural foramina – Because of the excellent contrast between
bright epidural fat and the dark nerve roots, T1 axial images are the perfect studies for
following the course of the lumbar nerve roots. With this in mind, identify the right and left
S1 nerve roots, and dural sac within the sacrum. Follow the S1 roots as they track medially in
sequential images until they merge with the dural sac. Note where the epidural fat extends
bilaterally into the L5-S1 neuroforamina. This usually marks the L5-S1 disc level. Look for
extension of disc material into the spinal canal or neuroforamina that displaces fat or contacts
either the dural sac or nerve roots. After following the course of the S1 nerve roots, identify
the L5 nerve roots in the lateral aspect of the L5-S1 neuroforamina. Track their courses
medially through the neuroforamina and into the spinal canal until they merge with the dural
sac, noting any abnormalities. Repeat this process for the L-4 and proximal roots.
Intervertebral discs – The intervertebral disc is imaged at the inferior level of the
neuroforamina. The circumferential margin of the disc must be inspected for evidence of
extension beyond normal boundaries. Do this both within the spinal canal and lateral to the
neuroforamina.
Bone:
Vertebral bodies – examine for integrity. Also, note any changes in intensity, which should
be correlated with the sagittal images.
 Spondylolisthesis— In cases of anterior spondylolisthesis, the posterior wall of the superior
vertebral body is displaced anteriorly as compared to the inferior vertebrae or sacrum. This
elongates the anterior-posterior dimension of the spinal canal and can appear as a double
image.
Posterior bony elements —Spondylolysis manifests itself as a defect in the posterior bony
ring. Examine this region for continuity of bone on images that include the pedicles, the pars
interarticularis, and laminae. Inspect the facet joints for thickening or deformity, findings that
suggest degeneration.
Ligamentum flavum – examine for a thickened appearance. These may narrow the spinal
canal.
Retroperitoneal space — Paraspinal and psoas muscles are nicely seen in these images. Note
any asymmetries of the muscles. The aorta is also well imaged in cross section, as are the
kidneys in upper lumbar images.

Step 7 - T2 Axial Images (spinal fluid appears bright) Just as you did with the T1 images, use the
neural foramina to identify disc level. Starting at the sacrum proceed rostrally one level at a time,
examining the following structures:
Content of the spinal canal and neural foramina
Dural sac — using the bright CSF as contrast, examine the outline of the dural sac itself for
displacement by disc protrusions, disc herniations, bony hypertrophy, ligamentum flavum
hypertrophy or masses. Next, examine the contents of the dural sac for compression or
displacement of nerve rootlets or the spinal cord. Also look for evidence of abnormalities of
the nerve rootlets or spinal cord.
Intervertebral discs –Inspect the margins of discs for extension beyond normal boundaries.
These are the best images for identifying disc herniations within the spinal canal. Look for
areas of brightness in the outer annulus (HIZ - High Intensity Zones)
Bone: Examine the vertebral bodies, and posterior bony elements as in step (3). Note the
facet joints often have a bright signal along the joint line. Effusions within the facet joints will
appear as a widening of that line.
Ligamentum flavum – examine for a thickened appearance, this can impinge upon the dural
sac.
Retroperitoneal space — adenopathy, masses, muscle, etc.

STEP 8 – Gadolinium Enhanced Images Review these as you did the T1 images, paying specific
attention to any areas where prior surgery has been performed. Compare these areas between the two
images and note where any brightening of abnormal (scar) tissue that occurs with gadolinium. If
brightening is not noted, recurrent disk herniations can be suspected.

STEP 9 - Assessment and Plan

Finally, step back and have a last, look at the scans. Now is the time to correlate information
from sagittal and axial images, and to summarize your observations.
Reading the radiologist’s report at the very end can provide invaluable confirmatory
feedback; but sometimes the rewards of systematic MRI examination lie in finding something
previously overlooked.
Abnormality MRI Findings Clinical Significance
Disc
Bulges, protrusions, Extension of disc material beyond Often asymptomatic, but may
herniations normal disc boundaries, lead to radicular symptoms.
sometimes impinging upon neural Bulges, but not herniations,
structures. Contrast enhancement increase in frequency with age
may be seen around disc bulge (Videman, 1995). Anterior
(Komori et al., 1998) bulges are asymptomatic.
Degeneration Dehydration associated with Often asymptomatic; may be
decreased T2 intensity. associated with generalized but
Degenerated discs lose volume, not focal back pain (Luoma,
height, and peripheral annulus 2000).
bulges circumferentially, with
ridging due to bony reaction.
With more marked degeneration,
vacuum phenomenon may occur,
(focal, decreased T1 and T2
intensity in pockets of gas).
Increased disc intensity on T2;
perhaps contrast enhancement
(neovascularity) from disc
disruptions from vertebral end
plate fractures or acute Schmorl’s
nodes.
“High Intensity Zones” High intensity regions in disc Considered to be tears or
(HIZ) annulus (posteriorly/ inflammation in the annulus.
posterolaterally). Contrast High positive predictive value
enhancement can be seen with for painful disc on stress
the associated extradural discography (Aprill & Bogduk,
inflammation (Saifuddin et al., 1992). But often poor clinical
1999) correlation with symptoms
(Kaiser, 1999; Saiffudin, et al.
Feb 1998; Schellhas et al, 1996;
Smith et al., 1998).
Vertebral body
Schmorl’s nodes Endplate concavities; occasional May also present as acute foci
(Vertical prolapses of disc marked invagination of nucleus associated with back pain –
into adjacent body endplates) pulposis into vertebral body. 1 should follow up for infection,
metastases.

Hemangioma Pathognomonic: bright on T1 Generally benign; seen in 10%

(mixtures of thin walled and T2 sequences (but asymptomatics. But
sinusoidal vessels and a fatty sometimes not too visible on hemangiomas with no obvious
stroma) T2’s). Enhance with contrast in fatty stroma may mimic
proportion to vascularity. metastases and myeloma. CT
scan may resolve issue.

1
Acute Schmorl’s nodes: reactive changes in adjacent bone, with decreased T1 intensity, increased T2
intensity, and contrast enhancement. With time: fatty replacement and /or sclerosis similar to Modic
changes. site of herniation may have focal T2 hyperintensity and contrast enhancement. Older lesions:
sharply defined margins.
Vertebral body endplate changes Degenerative disc pathology Often asymptomatic, seen in
adjacent to degenerative discs may incite end plate changes one-fifth or more of
known as Modic Changes symptomatic patients referred
changes. (Modic et al, 1988)2 for MRIs. (Braithwaite et al.,
Increase or decrease in fat on 1998; Modic et al., 1988)
T1’s at endplates; sometimes
increased vascularity on T2’s.
Reactive bone changes (ridging
and focal spurring) due to disc
bulging, intraosseous herniations
of discs, fractures of vertebral
bodies or ring apophyses.

Facet Joints
Arthropathy Hypertrophy, spurring, joint Can contribute to back pain by:
space narrowing, osteophytes, (1) nerve root compression, (2)
sclerosis. May cause stenosis of direct irritation of local pain
lateral recess in spinal canal. fibers in facet joint.
Often found in association with: Degenerative arthritis is most
degenerative disc disease common cause. Facet
(Fujiwara 1999), scoliosis, bone asymmetry may predispose to
hypertrophy, subluxations, clinical symptoms. (Dai & Jia,
effusions, synovial cysts, 1996).
ganglia, ligamenta flava
thickening, fusions,
anterolisthesis.
Dural sac
Dural arteriovenous Cord edema (marked by An arteriovenous communication
fistula increased T2 intensity and resulting in pressure on spinal
swelling), as well as prominent cord veins. Uncommon but
tortuous veins on the cord important to treat to prevent
surface that may enhance neurologic deficits. May be
diffusely. associated with myelopathy
and/or radiculopathy.
Neoplasms Contrast enhancement should be Differential diagnosis includes
used in evaluating possible schwanoma, meningioma,
intradural neoplasm. ependymoma, hematogenous
metastases, and "drop
metastases” from epidermoid/
dermoid malignancy.
Arachnoiditis Clumping" of nerve roots; Previous inflammatory disease,
adherence to dural sac edge injection of diagnostic or
("empty sac" appearance); therapeutic agents, or prior
subarachnoid space loculations surgery may result in adhesion.
Fitt and Stevens, 1995

2
In a study by Modic et al (1988) of 474 consecutive patients referred for MRI lumbar spine imaging, 4%
had Type 1 changes (inflammatory-like reaction with decreased TI and increased T2 intensity ), 16% had
Type 2 changes (fatty replacement of marrow in vertebral body). Focal increased intensity on TI and fast
spin echo T2 scans (but low T2 intensity on fat suppressed scans). Type 3 involves a sclerotic pattern
(decreased TI and T2 intensity; tiny end plate erosions).
Posterior Bony
Ring
Spondylolysis Defect in posterior bony ring. Spondylolysis/listhesis are
Early findings may include often a cause of back pain in
hypointensity in pars on T1 adolescents engaged in spinal
coronals (Yamane, 1993) extension activities (e.g.
gymnastics)
Spondylolisthesis Superior vertebral body is Can produce back pain. When
displaced anteriorly or posteriorly stenosis develops, can produce
as a result of spondylolysis or radiculopathies.
incompetence of facet joints from
degeneration. Can distort the
spinal canal and produce stenosis.
When advanced, can also result in
distortion and stenosis of neural
foramina.

Disc space/ vertebral Progressive and relentless back

Infection osteomyelitis: increases T2 pain usually the presenting
intensity and contrast symptom. Fever only
enhancement (Grane et al, occasionally present.
1998). Vertebral end plate often
is eroded.
Intradiscal abscess: focal fluid
collection (focus of non-
enhancement in otherwise bright
disc on T2)
Established infection: Often soft
tissue swelling in epidural space,
neural foramina, paraspinal
tissues.
Atraumatic
fractures
Insufficiency fractures Typically affect vertebral bodies, May present as acute back pain
causing loss of anterior height.
Occasional mild retropulsion of
part of body. Acute fractures can
have < 1 cm soft tissue swelling.
Vertebral body intensity relates to
acuteness.
Pathologic fractures Often associated with bone May be associated with tumor
destruction – especially posterior
vertebra (where metastases are
more common) – and well-defined
soft tissue masses. Acute reactive
changes may confuse matters.
Fatigue fractures Typically involve posterior
element, especially pars, lamina,
pedicle
 Abnormal number (4 or 6) of Important for localization for
Transitional lumbar vertebrae. Various invasive procedures. (Driscoll et
vertebra hybrid configurations of lumbar al, 1996)
and sacral vertebrae possible
Narrowing of the lateral May cause neurogenic
Stenosis recesses, central spinal canal, or claudication: radicular pain,
neural foramina sensory disturbances, motor
deficits developed while standing
or walking.
Usually due to degenerative disc
and facets; but also from
spondylolisthesis, facet joint
synovial cysts, Paget’s disease.
Marked by hyperintensity and Distinguishing between scar
Scar gadolinium enhancement . and recurrent disc herniation is
important for establishing plan
of care. (Bundschuh et al,
1988; Ross et al, 1990)
REFERENCES

Aprill, Bogduk, “High-Intensity Zones: a diagnostic sign of painful lumbar disk on magnetic
resonance imaging.” British J of Radiol. 1992, 65: 361-9.

Bernard TN Jr, “Using computed tomography/discography and enhanced magnetic resonance

imaging to distinguish between scar tissue and recurrent lumbar disc herniation.” Spine. 1994 Dec
15;19(24):2826-32.

Boden SD, “The use of radiographic imaging studies in the evaluation of patients who have
degenerative disorders of the lumbar spine.” J Bone Joint Surg Am. 1996 Jan;78(1):114-24.

Boden SD, Davis DO, Dina TS, Patronas NJ, Wiesel SW, “Abnormal magnetic-resonance scans
of the lumbar spine in asymptomatic subjects. A prospective investigation.” J Bone Joint Surg
Am. 1990 Mar;72(3):403-8.

Braithwaite I, White J, Saifuddin A, Renton P, Taylor BA, “Vertebral end-plate (Modic) changes
on lumbar spine MRI: correlation with pain reproduction at lumbar discography.” Eur Spine J.
1998;7(5):363-8.

Brant-Zawadzki MN, Jensen MC, Obuchowski N, Ross JS, Modic MT, “Interobserver and
intraobserver variability in interpretation of lumbar disc abnormalities. A comparison of two
nomenclatures.” Spine. 1995 Jun 1;20(11):1257-63; discussion 1264.

Bundschuh CV, Modic MT, Ross JS, Masaryk TJ, Bohlman H, “Epidural fibrosis and recurrent
disk herniation in the lumbar spine: MR imaging assessment.” AJR Am J Roentgenol. 1988
Apr;150(4):923-32.

Dai L, Jia L, “Role of facet asymmetry in lumbar spine disorders.” Acta Orthop Belg. 1996
Jun;62(2):90-3.

Farrokh D, “Lumbar intraspinal synovial cysts of different etiologies: diagnosis by CT and MR

imaging.” J Belge Radiol. 1998 Dec;81(6):275-8.

Fitt GJ, Stevens JM, “Postoperative arachnoiditis diagnosed by high resolution fast spin-echo MRI
of the lumbar spine.” Neuroradiology. 1995 Feb;37(2):139-45.

Fujiwara A, Tamai K, Yamato M, An HS, Yoshida H, Saotome K, Kurihashi. “The relationship

between facet joint osteoarthritis and disc degeneration of the lumbar spine: an MRI study.” Eur
Spine J. 1999;8(5):396-401.

Glickstein MF, Sussman SK Skeletal Radiol. “Time-dependent scar enhancement in magnetic

resonance imaging of the postoperative lumbar spine.” 1991;20(5):333-7.

Grane P, Lindqvist M, “Evaluation of the post-operative lumbar spine with MR imaging. The role
of contrast enhancement and thickening in nerve roots.” Acta Radiol. 1997 Nov;38(6):1035-42.

Greenberg JO, Schnell RG, “Magnetic resonance imaging of the lumbar spine in asymptomatic
adults. Cooperative study--American Society of Neuroimaging.” J Neuroimaging. 1991
Feb;1(1):2-7.
Grenier N, Greselle JF, Vital JM, Kien P, Baulny D, Broussin J, Senegas J, Caille JM, “Normal
and disrupted lumbar longitudinal ligaments: correlative MR and anatomic study.” Radiology.
1989 Apr;171(1):197-205.

Hueftle MG, Modic MT, Ross JS, Masaryk TJ, Carter JR, Wilber RG, Bohlman HH, Steinberg
PM, Delamarter RB, “Lumbar spine: postoperative MR imaging with Gd-DTPA.” Radiology.
1988 Jun;167(3):817-24.

Jensen MC, Brant-Zawadzki MN, Obuchowski N, Modic MT, Malkasian D, Ross JS, “Magnetic
resonance imaging of the lumbar spine in people without back pain.” N Engl J Med. 1994 Jul
14;331(2):69-73.

Jinkins JR, Matthes JC, Sener RN, Venkatappan S, and Rauch R, “Spondylolysis,
spondylolisthesis, and associated nerve root entrapment in the lumbosacral spine: MR
evaluation.” AJR Am J Roentgenol. 1992 Oct;159:799-803.

Johnson DW, Farnum GN, Latchaw RE, Erba SM, “MR imaging of the pars interarticularis.”
AJR Am J Roentgenol. 1989 Feb;152(2):327-32.

Kaiser J, “Point of view.” Spine. 1999 24(18): 1920.

Komori H, Okawa A, Haro H, Muneta T, Yamamoto H, Shinomiya K. “Contrast-enhanced

magnetic resonance imaging in conservative management of lumbar disc herniation.” Spine. 1998
Jan 1;23(1):67-73.

Luoma K, Riihimaki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen. “Low back

pain in relation to lumbar disc degeneration.” Spine. 2000 Feb 15;25(4):487-92.

Malko JA, Hutton WC, Fajman WA. “An in vivo magnetic resonance imaging study of changes
in the volume (and fluid content) of the lumbar intervertebral discs during a simulated diurnal load
cycle.” Spine. 1999 May 15;24(10):1015-22.

Maubon AJ, Ferru JM, Berger V, Soulage MC, DeGraef M, Aubas P, Coupeau P, Dumont E,
Rouanet JP, “Effect of field strength on MR images: comparison of the same subject at 0.5, 1.0,
and 1.5 T.” Radiographics. 1999 Jul-Aug;19(4):1057-67.

Modic MT, Steinberg PM, Ross JS, Masaryk TJ, Carter JR, “Degenerative disk disease:
assessment of changes in vertebral body marrow with MR imaging.” Radiology. 1988 Jan;166(1
Pt 1):193-9.

O'Driscoll CM, Irwin A, Saifuddin A, “Variations in morphology of the lumbosacral junction on

sagittal MRI: correlation with plain radiography.” Skeletal Radiol. 1996 Apr;25(3):225-30.

Rankine JJ, Gill KP, Hutchinson CE, Ross ER, Williamson. “The clinical significance of the
high-intensity zone on lumbar spine magnetic resonance imaging.” Spine. 1999 Sep
15;24(18):1913-9.

Ross JS, Masaryk TJ, Schrader M, Gentili A, Bohlman H, Modic MT, “MR imaging of the
postoperative lumbar spine: assessment with gadopentetate dimeglumine.” AJR Am J Roentgenol.
1990 Oct;155(4):867-72.

Saifuddin A, Braithwaite I, White J, Taylor BA, Renton P. “The value of lumbar spine magnetic
resonance imaging in the demonstration of anular tears.” Spine. 1998 Feb 15;23(4):453-7.

Saifuddin A, Burnett SJ, White J. “The variation of position of the conus medullaris in an adult
population. A magnetic resonance imaging study.” Spine. 1998 Jul 1;23(13):1452-6.
Saifuddin A, Mitchell R, Taylor BA, “Extradural inflammation associated with annular tears:
demonstration with gadolinium-enhanced lumbar spine MRI.” Eur Spine J. 1999;8(1):34-9.

Schellhas KP, Pollei SR, Gundry CR, Heithoff KB, “Lumbar disc high-intensity zone. Correlation
of magnetic resonance imaging and discography.” Spine. 1996 Jan 1;21(1):79-86.

Silcox DH 3rd, Horton WC, Silverstein AM, “MRI of lumbar intervertebral discs. Diurnal
variations in signal intensities.” Spine. 1995 Apr 1;20(7):807-11; discussion 811-2.

Smith BM, Hurwitz EL, Solsberg D, Rubinstein D, Corenman DS, Dwyer AP, Kleiner J.
“Interobserver reliability of detecting lumbar intervertebral disc high-intensity zone on magnetic
resonance imaging and association of high-intensity zone with pain and anular disruption.”
Spine. 1998 Oct 1;23(19):2074-80.

Udeshi UL, Reeves D, “Routine thin slice MRI effectively demonstrates the lumbar pars
interarticularis.” Clin Radiol. 1999 Sep;54(9):615-9.

Ulmer JL, Elster AD, Mathews VP, King JC, “Distinction between degenerative and isthmic
spondylolisthesis on sagittal MR images: importance of increased anteroposterior diameter of the
spinal canal ("wide canal sign").” AJR Am J Roentgenol. 1994 Aug;163(2):411-6.

Videman T, Battie MC, Gill K, Manninen H, Gibbons LE, Fisher LD, “Magnetic resonance
imaging findings and their relationships in the thoracic and lumbar spine. Insights into the
etiopathogenesis of spinal degeneration.” Spine. 1995 Apr 15;20(8):928-35.

Yamane T, Yoshida T, Mimatsu K, “Early diagnosis of lumbar spondylolysis by MRI.” J Bone

Joint Surg Br. 1993 Sep;75(5):764-8.