Student Guide

Dean: Prof.
Eugenio Gaudio
Student Guide
Degree Course
in Medicine and Surgery F
International Medical School
Academic Year 2013-2014
Dean: Prof. Eugenio Gaudio
Student Guide
Degree Course
in Medicine and Surgery F
International Medical School
Academic Year 2013-2014

farmaciamedicina1.uniroma1.it
INDEX
Greetings to students and teachers
1. Offices Degree Course F
2. Syllabus
3. Courses and course coordinators for each semester
4. Timetable lectures
10
5. Exams and ongoing examinations
16
6. Course organisation: Teaching staff
19
7. Teaching staff: Contact information
22
8. Course Programs
27
9. Electives (ADE)
49
10. Registration to the following years
51
11. Legend and map of Policlinico Umberto I
52
12. Legend and map of Citt Universitaria
54
Greetings to students and teachers

Dear Students, Dear Colleagues,
The Student Guide of the Degree Course F in Medicine and Surgery, academic
year 2013-2014, serves as an orientation to both, students and teachers, in the
complex educational organization of the single cycle degree course in Medicine
and Surgery. The implementation of the Reform of the Educational System, that
started already with the academic year 2009-2010, has perfected the educational
process by realizing a better integration of educational contents especially inside
of the integrated courses and a better coordination between ex-cathedra teaching
and practical activities.
The opinions and potential suggestions by our students, regarding the course
organization and the teaching quality, are essential instruments of information and
as those highly appreciated. They are of high importance for the correct
functioning and the future development of the degree programme. The collection of
evaluation questionnaires, declared mandatory for all Italian public universities by
the law 370/99, last year has been introduced in its digital form and students can
proceed with the compilation in the moment of their online registration for exams.
Of course, privacy is guaranteed within the whole process.
Our goal is the continuous improvement of the teaching activity in the degree
programme, the offered services and its organization.
The main part of the information given by this student guide is also available on
the website http://w3.uniroma1.it/ims/, where all necessary updates and additional
information will be published during the course of the academic year.
One goal of the degree programme in Medicine and Surgery F is inalienable: to
train medical doctors that are not only well educated, but also capable by their
scientific preparation and professional formation of medicating and taking care of
human beings both, in the state of well-being and illness.
It is task of a modern European degree programme to maintain the unity of
knowledge, linking scientific competences to humanistic skills and to the capability
to handle the complex, modern and expensive system of public health. The main
interest remains the protection of the human being, its dignity and psycho-physical
integrity.
Our wish, that we would like to renew with sincerity to all of you, is that we may
proceed successfully in this difficult, but inspiring process of knowledge and life.
The Dean
Prof. Eugenio Gaudio
1. Offices Degree Course F

The administrative office of the single cycle course of study in Medicine and Surgery F (CLMMC F) is located at Palazzina ex
SCRE -Presidenza della Facolt di Farmacia e Medicina-, 1st floor, room 16, Azienda Policlinico Umberto I.
Responsible
E.mail :
Office hours:
Location:
Secretary
Location:
Office hours:
E.mail:
Dean Prof. Eugenio Gaudio

Department of Anatomy
: 06.49918055 - Fax: 06.44918062
[email protected]
Monday 1:00p.m.-2:00p.m., Thursday 10:30 a.m.-11:30 a.m.
Deans office, Department of Anatomy, Via Borelli 50, 2nd floor
Dott.ssa Anja Berger
Palazzina ex SCRE -Presidenza della Facolt di Farmacia e Medicina-, ground floor, Azienda
Policlinico Umberto I.
Monday and Wednesday 09:30 a.m.-11:00 a.m.
: 06.49970858
[email protected]
Responsabilities:
The administrative office of the CLMMC "F" is in charge of the regular function of the
academic activities (teachers, time schedules, lecture rooms, programs, exam calendars,
supervision of learning agreements and change forms for Erasmus scholarships), and the
distribution of useful information to the students through the pin board next to the student
office and through the website (http://w3.uniroma1.it/ims/).
Educational Manager
Location:
Dott. Vincenzo Mancino

Palazzina ex SCRE -Presidenza della Facolt di Farmacia e Medicina-, ground floor, Azienda
Policlinico Umberto I.
Monday and Wednesday 09:30 a.m.-11:00 a.m.
: 06.49970836
[email protected]
Office hours:
E.mail:
Coordinator I year I semester
E.mail:
Coordinator I year II semester
E.mail:
Coordinator II year I semester
E.mail:
Coordinator II year II semester
E.mail:
Coordinator III year I semester
E.mail:
Coordinator III year II semester
E.mail:
Prof. Paolo Sarti

: 06.49910944
[email protected]
Prof. Francesco Malatesta
: 06.4454952
[email protected]
Prof. Maurizio Muscaritoli
: 06.49972020
[email protected]
Prof.a Francesca Grassi
: 06.49910060
[email protected]
Prof.a Gabriella Palmieri
: 06.4468448
[email protected]
Prof. Enrico De Smaele
: 06.49255659
[email protected]
2. Syllabus
Exam
Course
Year
Semester
Credits
Chemistry and introduction to biochemistry
Medical physics
Biology and genetics (I-II)
1-2
13
Histology and embriology
I
II
I
II
I
II
1-2
1
2
1
1
1-2
Basic medical scientific methods (I-II-III)
15
Biochemistry (I-II)
Human anatomy (I-II-III)
Microbiology
II
Human physiology (I-II-III)
II
III
1-2
1
18
10
Immunology and immunopathology
III
11
Clinical scientific methods (IV-V-VI)
II
III
2
1-2
21
12
Pathology and pathophysiology (I-II)
III
1-2
17
13
Laboratory medicine (I-II)
III
1-2
11
14
Applied pathology I - Diseases of the respiratory system and cardiovascular system
IV
12
15
Applied pathology II - Diseases of kidney and urinary system
IV
16
Applied medical scientific methods (VII-VIII)
IV
1-2
17
Pathological anatomy and associations with clinical anatomy (I-II)
IV
1-2
11
18
Applied pathology III - Diseases of the digestive system, endocrine system and
metabolism
IV
12
19
Diagnostic imaging
IV
20
Applied pathology IV - Diseases of the blood, hematopoietic organs, immune system and
rheumatology
21
Applied pathology V - Infectious diseases and human reproduction
22
Diseases of the nervous system
23
Internal medicine and general surgery I - medical and surgical Oncology
24
Pharmacology (I-II) and toxicology
IV
V
2
1
25
Psychiatry and cinical psychology
26
Movement disorders, rheumatology
27
Dermatology and plastic surgery
28
Diseases of the sensory organs
I
II
III
IV
V
V
VI
2
2
2
1
2
2
1
14
19
29
Scientific English (I-II-III-IV-V) - Journal Club
30
Medical-scientific methods: public health (IX-X)
31
Internal medicine and general surgery II
VI
32
Paediatrics
VI
33
Obstestrics and Gynaecology
VI
34
Medical-scientific methods: forensic medicine, medicine and the law (XI)
VI
35
Internal medicine and general surgery III - medical and surgical therapy and geriatrics
VI
10
36
Emergency medicine and surgery
VI
TOTAL CREDITS FOR EXAMS

Electives (Attivit Didattiche Elettive- ADE)
12
10
334
8
CREDITS for preparation of final thesis
18
TOTAL
360
3. Courses and course coordinators for each semester
I YEAR
Course Coordinator
I SEMESTER
Coordinator of
Semester
P. Sarti
L. Pannarale
F. Citarella
Human Anatomy (I)

Biology and Genetics (I)
Chemistry and Introducation to Biochemistry
B. Vallone
R. Pani
Medical Physics
Basic Medical Scientific Methods (I)
M. Muscaritoli
II SEMESTER
F. Malatesta
F. Malatesta
F. Citarella
Biochemistry (I)
Biology and Genetics (II)
S. Adamo
Histology and Embryology

Scientific English- Journal Club (I)
Basic Medical Scientific Methods (II)
J.F. Osborn
M.S. Cattaruzza
II YEAR
I SEMESTER
M. Muscaritoli
Human Anatomy (II)

Biochemistry (II)
S. Nottola
D. De Biase
Human Physiology (I)
C. Limatola
Basic Medical Scientific Methods (III)
M. Muscaritoli
II SEMESTER
F. Grassi
Human Anatomy (III)

Human Physiology (II)
E. Gaudio
F. Grassi
Scientific English-Journal Club (II)
J.F. Osborn
Clinical Scientific Methods (IV)
M. Arca
G. Antonelli
Microbiology
III YEAR
I SEMESTER
Human Physiology (III)
Immunology and Immunopathology
Laboratory Medicine (I)
Clinical Scientific Methods (V)
Pathology and Pathophysiology (I)
G. Palmieri
S. Ferraina
A. Santoni
A. Angeloni
M. Arca
G. Giannini
II SEMESTER
Scientific English-Journal Club (III)
Laboratory Medicine (II)
Clinical Scientific Methods (VI)
Pathology and Pathophysiology (II)
E. De Smaele
M. Levrero
A. Angeloni
M. Arca
A. Gulino
4. Timetable lectures
I YEAR I SEMESTER
CLASSROOM: C1 Istituto dIgiene Citt Universitaria Sapienza Universit di Roma
Time
Monday
Tuesday
9 - 10
HUMAN
ANATOMY
BIOLOGY AND
GENETICS
HUMAN
ANATOMY
BASIC
MEDICAL11 - 12
SCIENTIFIC
METHODS
CHEMISTRY
AND
12 - 13 INTRODUCTION
TO
BIOCHEMISTRY
CHEMISTRY
AND
13 - 14 INTRODUCTION
TO
BIOCHEMISTRY
10 - 11
BIOLOGY AND
GENETICS
BASIC
MEDICALSCIENTIFIC
METHODS
BASIC
MEDICALSCIENTIFIC
METHODS
BASIC
MEDICALSCIENTIFIC
METHODS
Wednesday
BASIC
MEDICALSCIENTIFIC
METHODS
MEDICAL
PHYSICS
Thursday
HUMAN
ANATOMY
HUMAN
ANATOMY
MEDICAL
PHYSICS
MEDICAL
PHYSICS
MEDICAL
PHYSICS
MEDICAL
PHYSICS
CHEMISTRY
AND
INTRODUCTION
TO
BIOCHEMISTRY
CHEMISTRY
AND
INTRODUCTION
TO
BIOCHEMISTRY
CHEMISTRY
AND
INTRODUCTION
TO
BIOCHEMISTRY
CHEMISTRY
AND
INTRODUCTION
TO
BIOCHEMISTRY
CHEMISTRY
AND
INTRODUCTION
TO
BIOCHEMISTRY
CHEMISTRY
AND
INTRODUCTION
TO
BIOCHEMISTRY
14 - 15
15 - 16
16 - 17
HUMAN
ANATOMY - LAB*
17- 18
HUMAN
ANATOMY - LAB*
Friday
* Classroom L, Department of Human Anatomy ( Via Borelli, 50)

**This hour will be used only for previously defined Genetics lessons.
BIOLOGY AND
GENETICS
(15:30-16:30)
BIOLOGY AND
GENETICS
(16:30-17:30)
BIOLOGY AND
GENETICS
(17:30-18:30)**
I YEAR II SEMESTER
CLASSROOM: C1 Istituto dIgiene Citt Universitaria Sapienza Universit di Roma
Time
Monday
Tuesday
Wednesday
Thursday
9 - 10
BASIC
MEDICALSCIENTIFIC
METHODS II
BIOCHEMISTRY I
BIOCHEMISTRY I
BASIC MEDICALSCIENTIFIC
BIOCHEMISTRY I
METHODS II
10 - 11
BASIC
MEDICALSCIENTIFIC
METHODS II
BIOCHEMISTRY I
BIOCHEMISTRY I
BIOCHEMISTRY I
METHODS II
11 - 12
BIOLOGY AND
GENETICS II
HISTOLOGY AND
EMBRIOLOGY
BIOLOGY AND
GENETICS II
HISTOLOGY AND HISTOLOGY AND

EMBRIOLOGY
EMBRIOLOGY
12 - 13
BIOLOGY AND
GENETICS II
HISTOLOGY AND
EMBRIOLOGY
BIOLOGY AND
GENETICS II
HISTOLOGY AND HISTOLOGY AND

EMBRIOLOGY
EMBRIOLOGY
13 - 14
BIOLOGY AND
GENETICS II**
SCIENTIFIC
ENGLISH I
BIOLOGY AND
GENETICS II**
SCIENTIFIC
ENGLISH I
14 15
15 16
HISTOLOGY AND
EMBRIOLOGY
LAB*
16- 17
HISTOLOGY AND
EMBRIOLOGY
LAB*
17 - 18
*Auletta Esercitazioni Dipartimento SAIMAL Sezione Istologia (Via A. Scarpa, 14)
** This hour will be used only for previously defined Genetics lessons.
Friday
II YEAR I SEMESTER
CLASSROOM: D, Ex Officine Ortopediche Citt Universitaria Sapienza Universit di Roma
Time
Monday
9 - 10
METHODS III
10 - 11
METHODS III
11 - 12
BIOCHEMISTRY II
HUMAN
ANATOMY II
12 - 13
BIOCHEMISTRY II
HUMAN
ANATOMY II
13 - 14
14 15
15 16
Tuesday
BASIC
MEDICALSCIENTIFIC
METHODS III
BASIC
MEDICALSCIENTIFIC
METHODS III
Wednesday
Thursday
Friday
BIOCHEMISTRY II
METHODS III
HUMAN
ANATOMY II
BIOCHEMISTRY II
METHODS III
HUMAN
ANATOMY II
BIOCHEMISTRY II
HUMAN
PHYSIOLOGY I
HUMAN
PHYSIOLOGY I
HUMAN
PHYSIOLOGY I
BIOCHEMISTRY II
GENETICS SEMINAR:
NOV 7; DEC 5**
GENETICS SEMINAR:
NOV 7; DEC 5**
GENETICS SEMINAR:
NOV 7; DEC 5**
GENETICS SEMINAR:
NOV 7; DEC 5**
HUMAN
PHYSIOLOGY I
HUMAN
PHYSIOLOGY I
HUMAN ANATOMYLAB*
HUMAN ANATOMY17 - 18
LAB*
* Classroom L, Department of Human Anatomy (Via Borelli, 50)
** Basic Medical-Scientific Methods: Genetics seminars (14:00-18:00) November 7th, 2013; December 5th, 2013.
16- 17
II YEAR II SEMESTER
CLASSROOM: D, Ex Officine Ortopediche Citt Universitaria Sapienza Universit di Roma
Time
Monday
Tuesday
Wednesday
Thursday
Friday
HUMAN
PHYSIOLOGY II
HUMAN
PHYSIOLOGY II
9 - 10
HUMAN
PHYSIOLOGY II
10 - 11
HUMAN
ANATOMY III
CLINICALSCIENTIFIC
METHODS IV
HUMAN
ANATOMY III
HUMAN
PHYSIOLOGY II
11 - 12 MICROBIOLOGY
HUMAN
ANATOMY III
CLINICALSCIENTIFIC
METHODS IV
HUMAN
ANATOMY III
MICROBIOLOGY
SCIENTIFIC
ENGLISH II
CLINICALSCIENTIFIC
METHODS IV
HUMAN
PHYSIOLOGY II
MICROBIOLOGY
SCIENTIFIC
ENGLISH II
HUMAN
PHYSIOLOGY II
CLINICALSCIENTIFIC
METHODS IV*
14 - 15
15 - 16
HUMAN
ANATOMY- LAB
CLINICALSCIENTIFIC
METHODS IV*
16 - 17
HUMAN
ANATOMY- LAB
CLINICALSCIENTIFIC
METHODS IV*
17 - 18
CLINICALSCIENTIFIC
METHODS IV*
18 - 19
CLINICALSCIENTIFIC
METHODS IV*
MICROBIOLOGY
*timetable afternoon lessons: 3p.m.-5p.m. (March 27, April 3, 10, 24, May 15,29), 2.30p.m.-7.30p.m. (April 17, May 8,
22), partially divided into groups
III YEAR I SEMESTER

CLASSROOM: B, Ex Officine Ortopediche Citt Universitaria Sapienza Universit di Roma
Time
Monday
Tuesday
9 - 10
PATHOLOGY AND
PATHOPHYSIOLOGY I
10 - 11
PATHOLOGY AND
PATHOPHYSIOLOGY I
11 - 12
IMMUNOLOGY AND
IMMUNOPATHOLOGY
12 - 13
IMMUNOLOGY AND
IMMUNOPATHOLOGY
LABORATORY
MEDICINE I
LABORATORY HUMAN PHYSIOLOGY
14 15
MEDICINE I
III
HUMAN PHYSIOLOGY
15 16
III
13 - 14
16- 17
17 - 18
Wednesday
Thursday
Friday
IMMUNOLOGY AND
IMMUNOPATHOLOGY
CLINICALSCIENTIFIC
METHODS V
CLINICALSCIENTIFIC
METHODS V
CLINICALSCIENTIFIC
METHODS V
IMMUNOLOGY AND
IMMUNOPATHOLOGY
IMMUNOLOGY AND
IMMUNOPATHOLOGY
PATHOLOGY AND
PATHOPHYSIOLOGY I
PATHOLOGY AND
LABORATORY
PATHOPHYSIOLOGY I
MEDICINE I
LABORATORY
MEDICINE I
III YEAR II SEMESTER

CLASSROOM: B, Ex Officine Ortopediche Citt Universitaria Sapienza Universit di Roma
Time
Monday
Tuesday
Wednesday
Thursday
9 - 10
PATHOLOGY AND
PATHOPHYSIOLOGY II
10 - 11
PATHOLOGY AND
PATHOPHYSIOLOGY II
SCIENTIFIC ENGLISH
III
PATHOLOGY AND
PATHOPHYSIOLOGY II*
11 - 12
LABORATORY
MEDICINE II
SCIENTIFIC ENGLISH
III
PATHOLOGY AND
PATHOPHYSIOLOGY II*
12 - 13
LABORATORY
MEDICINE II
SCIENTIFIC ENGLISH
III
PATHOLOGY AND
PATHOPHYSIOLOGY II*
PATHOLOGY AND
PATHOPHYSIOLOGY II*
13 - 14
14 15
15 16
16 - 17
CLINICAL SCIENTIFIC
METHODS VI
CLINICAL SCIENTIFIC
METHODS VI
CLINICAL SCIENTIFIC
METHODS VI
Friday
CLINICAL SCIENTIFIC
METHODS VI
CLINICAL SCIENTIFIC
METHODS VI
CLINICAL SCIENTIFIC
METHODS VI
LABORATORY
MEDICINE II*
LABORATORY
MEDICINE II*
LABORATORY
MEDICINE II*
17 - 18
*The schedule for the Thursday lessons at 9:30, and all the lessons start on the half hour (i.e. Pathology and Pathophysiology is from
9:30 to 12:30, and Laboratory Medicine is from 13:30 to 15:30)
5. Exams and ongoing examinations
I YEAR
Courses
Credits (CFU)
I Year
60
Courses
CFU
I SEMESTER
31
Human anatomy (I)
Biology and genetics (I)
Chemistry and
introduction to
biochemistry
Medical physics
Basic medical scientific

methods (I)
Exam/ongoing
examination
Ongoing
examination
Ongoing
examination
Courses
CFU
II SEMESTER
29
Exam/ongoing
examination
Biochemistry (I)
Ongoing
examination
Biology and genetics (II)
Exam
Exam
Histology and
embriology
Exam
Exam
Scientific English (I)
Ongoing
examination
Ongoing
examination

methods (II)
Ongoing
examination
Electives
II YEAR
Courses
Credits (CFU)
II Year
60
Courses
CFU
I SEMESTER
29
Human anatomy (II)
Biochemistry (II)
Human physiology (I)

methods (III)
Electives
Exam/ongoing
examination
Exam/ongoing
examination
Courses
CFU
II SEMESTER
31
Ongoing
examination
Human anatomy (III)
Exam
Exam
Human physiology (II)
Ongoing
examination
Ongoing
examination
Scientific English (II)
Ongoing
examination
Microbiology
Exam
Clinical scientific
methods (IV)
Ongoing
examination
Electives
Exam
III YEAR
Courses
Credits (CFU)
III Year
60
Courses
CFU
I SEMESTER
31
Exam/ongoing
examination
Exam
Immunology and
Immunopathology
Exam
Laboratory Medicine (I)
Pathology and
Pathophysiology (I)
Clinical scientific
Methods (V)
Ongoing
examination
Ongoing
examination
Ongoing
examination
Courses
CFU
II SEMESTER
29
Exam/ongoing
examination
Ongoing
examination
Exam
10
Exam
Clinical scientific
Methods (VI)
Exam
Electives
Scientific English (III)

Laboratory Medicine
(II)
Pathology and
Pathophysiology (II)
6. Course organisation: Teaching staff

In bold = Course coordinators
Students should contact the course coordinators in the start of the new semester
I YEAR
I SEMESTER (coordinator of semester: P. Sarti )
Teachers
Basic medical scientific methods (I)
M. Capocci A. Farcomeni M. Muscaritoli
Chemistry and introduction to biochemistry

A.E. Miele P. Sarti B. Vallone
Medical physics
R. Pani A.D. Polosa
Additional activities: E. Preziosi
Biology and genetics (I)

F. Citarella M. Devoto P. Fortina
Human anatomy (I)
L. Pannarale R. Mancinelli
Time
Classroom
(ongoing examination)
Mon
11-12
C1 Istituto dIgiene
Tue
11-14
C1 Istituto dIgiene
Wed
09-10
C1 Istituto dIgiene
(exam n. 1)
12-14
12-14
12-14
12-14
C1 Istituto dIgiene
C1 Istituto dIgiene
C1 Istituto dIgiene
C1 Istituto dIgiene
(exam n. 2)
Wed
10-12
Thu
11-12
Fri
10-12
C1 Istituto dIgiene
C1 Istituto dIgiene
C1 Istituto dIgiene
Mon
Wed
Thu
Fri
Tue
09-11
C1 Istituto dIgiene
Thu
1530-1730
C1 Istituto dIgiene
Mon
Thu
09-11
C1 Istituto dIgiene
09-11
C1 Istituto dIgiene
Mon
Thu
09-11
C1 Istituto dIgiene
09-11
C1 Istituto dIgiene
II SEMESTER (coordinator of semester: F. Malatesta)

Basic medical scientific methods (II)
M.S. Cattaruzza P. Fiori Nastro
Biology and genetics (II)

F. Citarella M. Devoto P. Fortina
Histology and embryology

E. Vicini S. Adamo M. Bouch
Biochemistry (I)
F. Malatesta - M. Perluigi D. De Biase
Scientific English Journal Club (I)

J.F. Oborn
(exam n. 3)
Mon
11-14
Wed
11-14
C1 Istituto dIgiene
C1 Istituto dIgiene
(exam n. 4)
11-13
11-13
11-13
C1 Istituto dIgiene
C1 Istituto dIgiene
C1 Istituto dIgiene
Tue
Thu
Fri
Tue
09-11
C1 Istituto dIgiene
Wed
09-11
C1 Istituto dIgiene
Fri
09-11
C1 Istituto dIgiene
Tue
Thu
13-14
C1 Istituto dIgiene
13-14
C1 Istituto dIgiene
II Year
I SEMESTER (coordinator of semester: M. Muscaritoli )
Basic medical scientific methods (III)
M. Muscaritoli A. Farcomeni M. Capocci - P.
Grammatico
(exam n. 5)
Mon
09-11
Tue
09-11
Thu
09-11
Ex Officine Ortopediche
Biochemistry (II)
D. De Biase - F. Malatesta - M. Perluigi
(exam n. 6)
Mon
11-13
Wed
09-11
Thu
11-13
Human anatomy (II)

G. Familiari - E. Gaudio S. Nottola M. Relucenti
Additional activities: A. Renzi, G. Vivacqua
Human physiology (I)

C. Limatola G. Tanzilli
Tue
Fri
11-13
09-11
Wed
Fri
12-14
11-14
II SEMESTER (coordinator of semester: F. Grassi)

Clinical scientific methods (IV)
M. Arca L. Giacomelli
Additional activities: S. Guarino
Human anatomy (III)

E. Gaudio M. Relucenti - S. Nottola R. Mancinelli
Additional activities: A. Renzi, G. Vivacqua
Human physiology (II)

F. Grassi P. Palange A.P. Mitterhofer M. Merli
Microbiology
G. Antonelli A.T. Palamara D. Modiano
Scientific English Journal Club (II)

J.F. Osborn
Wed
Wed
Tue
Thu
10-13
15-17/
14.3019.30
(exam n. 7)
10-12
10-12
09-10
09-10
12-14
Fri
09-11
Tue
Thu
(exam n. 8)
Mon
11-14
Thu
15-16
Fri
11-13
Tue
12-14
III YEAR
I SEMESTER (coordinator of semester: G. Palmieri)
Clinical scientific methods (V)
L. Giacomelli M. Arca R. Cangemi P. Fiori Nastro
Human physiology (III)

S. Ferraina
Wed
10-13
Wed
15-18
Tue
(exam n. 9)
14-16
Tue
Thu
(exam n. 10)
11-13
09-12
Additional activities: E. Brunamonti
Immunology and immunopathology

S. Mardente A. Santoni G. Palmieri
Laboratory medicine (I)

P. Valenti D. Modiano A. Bellelli A. Angeloni
Pathology and pathophysiology (I)

G. Giannini G. Canettieri M. Felli
Mon
13-15
Fri
13-15
Tue
Thu
09-11
12-14
II SEMESTER (coordinator of semester: E. De Smaele)

Clinical scientific methods (VI)
M. Arca L. Giacomelli F. Consorti
Pathology and pathophysiology (II)

E. De Smaele M. Felli G. Canettieri A. Gulino
Laboratory medicine (II)

F. Mainiero A. Angeloni A. Bellelli
Scientific English Journal Club (III)

M. Levrero
(exam n. 11)
Tue
14-17
Wed
14-17
Tue
Thu
(exam n. 12)
09-11
9:3012:30
Tue
Thu
(exam n. 13)
11-13
13:3015:30
Wed
10-13
7. Teaching staff: Contact information

Adamo Sergio (BIO/17 Istologia)
Department of Anatomical, Histological, Forensic and Orthopedic Sciences
Location: Section of Histology and Medical Embryology, Via A. Scarpa 14
: 06.49766756 - Fax: 06.49766643; E.mail: [email protected]
Reception hours: Monday 10 a.m.-14 p.m. and Wednesday 14 p.m.-16 p.m. and by appointment
Angeloni Antonio (MED/04 Patologia Generale)
Department of Experimental Medicine
Location: Viale Regina Elena 324
: 06.49970596- Fax: 06.49970596; E.mail: [email protected]
Reception hours: Tuesday, Wednesday, Thursday and Friday 10 a.m.-13p.m.
Antonelli Guido (MED/07 Microbiologia e Microbiologia Clinica)
Department of Molecular Medicine
Location: Section of Virology, V.le di Porta Tiburtina 28
Reception hours: Thursday 11 a.m.-13 p.m. and by appointment
Arca Marcello (MED/09 Medicina Interna)
Department of Internal Medicine and Allied Sciences
Location: I Medical Clinic, Policlinico Umberto I
: 06.4451354 ; E.mail: [email protected]
Reception hours: Tuesday 12 p.m.-14 p.m.
Bellelli Andrea (BIO/10 Biochimica)
Department of Biochemical Sciences Alessandro Rossi Fanelli
: 06.49910556; E.mail: [email protected]
Reception hours: Monday 3 p.m.- 6 p.m.
Bouch Marina (BIO/17 Istologia)
Location: Section of Histology and Medical Embryology, Via A. Scarpa 14
Reception hours: Tuesday 10 a.m.-13 p.m. and Thurday 14 p.m.-17 p.m.
Canettieri Gianluca (MED/04 Patologia Generale)
: 06.49255139 Fax: 06.4461974; E.mail: [email protected]
Reception hours: by appointment
Cangemi Roberto (MED/09 Medicina Interna)
Location: I Clinica Medica, II piano della Torre di Ricerca, stanza n.18
Reception hours: 1 p.m.-2 p.m.
Capocci Mauro (MED/02 Storia della Medicina)
Department of Medical-Surgical Sciences and Biotechnologies
Location: Section of History of Medicine, Viale dellUniversit 34/a
Cattaruzza Maria Sofia (MED/42 Igiene Generale ed Applicata)
Department of Public Health and Infectious Diseases
Location: Hospital S. Andrea, Servizio di Igiene e Tecnica Ospedaliera, 2nd floor
Citarella Franca (BIO/13 Biologia Applicata)
Department of Cellular Biotechnology and Hematology
Location: Section of Molecular Genetics, Viale Regina Elena 324
Reception hours: Wednesday 14 p.m.-16 p.m.
Consorti Fabrizio (MED/18 Chirurgia Generale)

Department of Surgical Sciences
E.mail: [email protected]
De Biase Daniela (BIO/10 Biochimica)
Department of Medico-Surgical Sciences and Biotechnologies
Reception hours: Thursday 10 a.m.-12 p.m. (Latina) and Friday 14 p.m.-15 p.m. (Rome)
De Smaele Enrico (MED/46 Scienze Tecniche di Medicina di Laboratorio)
Location: Viale Regina Elena 291, II floor
Reception hours: by e-email appointment
Devoto Marcella (MED/03 Genetica Medica)
Reception hours: by e-mail appointment
Di Tanna Gianluca (MED/01 Statistica Medica)
Familiari Giuseppe (BIO/16 Anatomia Umana)
Location: Section of Human Anatomy, Via Alfonso Borelli 50
Reception hours: Monday 10 a.m.-12 p.m. by appointment
Felli Maria Pia (MED/04 Patologia Generale)
Ferraina Stefano (BIO/09 Fisiologia)
Department of Physiology and Pharmacology Vittorio Erspamer
Location: Palazzo Fisiologia Umana, Citt Universitaria
Reception hours: Thursday 11 a.m.-1 p.m.
Fiori Nastro Paolo (MED/25 Psichiatria)
Department of Neurology and Psychiatry
Fortina Paolo (MED/03 Genetica Medica)
Reception hours: by e-mail appointment
Giannini Giuseppe (MED/04 Patologia Generale)
Gaudio Eugenio (BIO/16 Anatomia Umana)
Location: Section of Human Anatomy, Via Alfonso Borelli 50, II floor
Reception hours: Monday 13 p.m.-14 p.m. and Thursday 10.30 a.m.-11.30 a.m.
Giacomelli Laura (MED/18 Chirurgia Generale)

Department of Surgical Sciences
Location: DAI Chirurgia R. Paolucci, Viale Regina Elena 324
Reception hours: Monday 10 a.m.-12 a.m.
Grammatico Paola (MED/03 Genetica Medica)
Location: Medical Genetics Laboratory, San Camillo-Forlanini Hospital, Circ.ne Gianicolense 87
Reception hours: From Monday to Friday 9 a.m.-13 p.m. by appointment
Grassi Francesca (BIO/09 Fisiologia)
Location: Section of Human Physiology, P.le Aldo Moro 5, III floor
Gulino Alberto (MED/04 Patologia Generale)

Department of Molecular Medicina
Location: Viale Regina Elena 291, II floor
Levrero Massimo (MED/49 Scienze Tecniche Dietetiche Applicate)
Location: I Medical Clinic, Policlinico Umberto I
Limatola Cristina (BIO/09 Fisiologia)
Location: Section of Human Physiology, P.le Aldo Moro 5, I floor
Reception hours: Monday 9 a.m.-13 p.m.
Mainiero Fabrizio (MED/04 Patologia Generale)
Location: Viale Regine Elena 324
: 06.49970966 Fax : 06.4453244; E.mail: [email protected]
Malatesta Francesco (BIO/10 Biochimica)
Location: P.le Aldo Moro 5
Reception hours: Monday and Friday 14.30 p.m.-16 p.m.
Mancinelli Romina (BIO/16 Anatomia Umana)
Reception hours: Monday 13 p.m.-14 p.m. and Thursday 10.30 a.m.-11.30 a.m.
Mardente Stefania (MED/04 Patologia Generale)
Location: Istituto di Patologia Generale, 1st floor
Reception hours: Tuesday 10 a.m.-12 p.m.
Merli Manuela (MED/12 Gastroenterologia)
Department of Clinical Medicine
Location: Viale dellUniversit 37
Reception hours: by appointment (e-mail)
Miele Adriana Erica (BIO/10 Biochimica)

Reception hours: Wednesday 14 p.m.-16 p.m.
Mitterhofer Anna Paola (MED/09 Medicina Interna)
Reception hours: Friday 10.30 a.m.-12.00 p.m.
Modiano David (VET/06 Parassitologia)
Location: Section of Parasitology
Reception hours: Monday 8.30 a.m.-10.30 a.m.
Muscaritoli Maurizio (MED/09 Medicina Interna)
Reception hours: Monday 11 a.m.-13 p.m.
Nottola Stefania (BIO/16 Anatomia Umana)
Reception hours: Tuesday and Thursday 10 a.m.-11 a.m. by appointment
Osborn John (MED/42 Igiene generale ed applicata)
Palamara Anna Teresa (MED/07 Microbiologia e microbiologia clinica)
Reception hours: Thursday 12 p.m.-14 p.m.
Palange Paolo (MED/09 Medicina Interna)
Location: Section of Internal Medicine, Viale dellUniversit 37
Reception hours: Tuesday 12 p.m.-13 p.m.
Palmieri Gabriella (MED/04 Patologia Generale)
Location: Viale Regina Elena 324, Edificio di Patologia Generale, floor -1
:06.4468448; E.mail: [email protected]
Pani Roberto (FIS/07 Fisica Applicata)
Location: Building ex Tuminelli, last floor, Citt Universitaria
Reception hours: Thursday 9 a.m.-12 p.m. by appointment
Pannarale Luigi (BIO/16 Anatomia Umana)
Reception hours: Thursday 10 a.m.-11 a.m.
Perluigi Marzia (BIO/10 Biochimica)

Reception hours: Monday and Wednesday 10 a.m.-12 p.m.
Polosa Antonio Davide (FIS/02 Fisica Teorica)
Reception hours: Tuesday 11 a.m.-13 p.m.
Relucenti Michela (BIO/16 Anatomia Umana)
Reception hours: Monday 9 a.m.-10 a.m. by appointment
Santoni Angela (MED/04 Patologia Generale)
Sarti Paolo (BIO/10 Biochimica)
Location: Department of Biochemical Sciences Alessandro Rossi Fanelli
Reception hours: Monday, Tuesday and Friday 15 p.m.- 16 p.m.
Tanzilli Gaetano (MED/11 Malattie dellapparato cardiovascolare)
Department of Cardiovascular, Respiratory, Nephrologic and Geriatric Sciences
Reception hours : by appointment
Valenti Piera (MED/07 Microbiologia e Microbiologia Clinica)
:; E.mail: [email protected]
Vallone Beatrice (BIO/10 Biochimica)
Location: Department of Biochemical Sciences Alessandro Rossi Fanelli
Reception hours: Monday 13 p.m.-16 p.m.
Vicini Elena (BIO/17 Istologia)
Section of Histology and Medical Embryology, Via A. Scarpa 14
Reception hours: Monday 8.30 a.m.-10.30 a.m.
8. Course Programs
Integrated Course of CHEMISTRY AND INTRODUCTION TO BIOCHEMISTRY
Main teaching objectives :

Knowledge of basic chemistry and of biochemical structures: glucides, proteins, lipids. At the end of the course, the
students should: i) know the chemical bases of pathophysiological processes, ii) address in molecular terms some
simple biomedical aspects, iii) be aware of the importance of the chemical instruments in the cultural formation of a
medical doctor.
Formal Teaching (subjects)
The matter: atomic and molecular orbitals; chemical bonds, strong and weak interactions, states of matter.
The behaviour of Gases: ideal gas laws, solubility of gases in liquids
Solutions: definition & properties; concentration; vapour pressure; electrolytes; dissociation equilibrium;
colligative properties; osmosis.
Redox reactions: defining oxidation and reduction, biological relevance
Thermodynamics: the T. Parameters enthalpy, entropy, free energy and temperature. Equilibrium and T.
Chemical reactions: equilibrium and kinetics; the mass action low and the equilibrium constant.
Water solutions: acids, bases strength and pH; buffers, the interaction of salts with water.
Bio-organic Chemistry
The biomolecules: classification, shape and conformation
Hydrocarbon compounds, linear & cyclic, saturated, insaturated, homocyclic
and heterocyclic: nomenclature,
classification, properties.
Functional groups, chemical properties and biomedical relevance: the carbonyl group, aldehides and ketons; the
carboxylic group, the alcoholic hydroxyl- , the amino- and the sulphydril- group; ethers and esters.
Glucides or saccharides: nomenclature and classification. Structure stabilization and stereochemistry, anomeric carbons
and mutarotation. Redox properties of saccharides.
Mono-, di- & polysaccharides: structural properties and stabilizing bonds.
Aminoacids: nomenclature and classification. Structure stabilization and stereochemistry. The functional groups and the
-Carbon properties. Protonation and deprotonation equilibria.
Proteins: primary, secondary, tertiary and quaternary structure; denaturation and folding.
Lipids: nomenclature and classification. Fatty acids, mono- di- tri-glycerides; basic structure of phospholipids and biomembranes. Cholesterol
Nucleic Acids: purines and pyrimidines, the nucleosides and nucleotides composition; keto-enolic tautomerism and
hydrogen bonds.
Interactive teaching (goals)

The student should learn how to solve basic problems, dealing with solutions and their properties.
Interactive teaching, practical course (20 hours)

The matter: structure/function relationships.
Molecular modelling (groups of max. 20 students)
Calculus (subjects):
Gas
Acqueous solutions
Colligative properties
Equilibrium properties
pH
Buffers
Hydrolysis
Tutorial Teaching Activities (small groups)

Clinical relevance of pH.
Acid-base titrations
Evaluation of the blood buffering capacity.

Clinical relevance of osmosis.
Osmometry and spectrophotometry
Induced hemolysis evaluation.

Apprenticeship (practical laboratory)
Educational tasks
observed
done
Know how
Spectrophotometric, amperometric and chromatographic
yes
yes
yes
Fundamental molecular biology
yes
yes
yes
Cell viability measurements by fluorescence microscopy
yes
yes
no
measurements, of biomedical relevant substances
Seminars:
The chemical-biochemical nomenclature: laboratory conventions.
Nitrogen monoxide in biology and medicine.
Exam:
written: multiple choice questions (quiz), chemical formulas, basic stoicheiometry and general chemistry
exercises.
oral.
Textbooks:
Chemistry for the Biosciences: The Essential concepts
Au: T. Bradshow & J. Crowe
Suggested Internet web sites:
http://www.chem.qmw.ac./iupac/; http://www.webelements.com/
http://www.chemistry.mcmaster.ca/faculty/bader/aim/
Integrated Course of MEDICAL PHYSICS
Main teaching objectives:
know the fundamentals of physics, only touched upon in secondary school, aimed at comprehension and study
of medical subjects in physics, such as fluidodynamics, diffusion, ionic currents applied to processes belonging
to the human system.
Intergrated Course of BIOLOGY AND GENETICS (I & II)

The aim of the integrated course is to give students the tools to be familiar with structure and function of the principal
components of the cell; to understand the molecular basis of cellular functions; to be aware of how the alteration of
cellular functions can bring about pathological states. Students will learn how the genetic information flows between
DNA, RNA, and proteins and how traits are inherited from one generation to the other. Concepts of classical and
molecular genetics will be taught.
Biology
Franca Citarella, Department of Cellular Biotechnology and Hematology , Sapienza University of Rome.
e-mail: [email protected] ; phone: 390649918243
Introduction to cellular biology: the diversity and similarity of living organisms.

Biology and the scientific method, The Origin and Evolution of Cells
Cells As Experimental Models, Tools of Cell Biology
The Chemistry of Life
The Molecular Composition of Cells
Enzymes as Biological Catalysts
The Flow of Genetic Information
Nucleic acids, Chromatin and Chromosomes, DNA Replication, DNA Repair
RNA Synthesis and Processing: Transcription in Prokaryotes,
Eukaryotic RNA Polymerases and General Transcription Factors,
Regulation of Transcription in Eukaryotes, RNA Processing and Turnover
Protein Synthesis, Processing, and Regulation: Translation of mRNA,
Protein Folding and Processing, Regulation of Protein Function, Protein Degradation
Cell Structures and Function
The Cell Surface: Structure of the Plasma Membrane, Transport of Small Molecules
Protein Sorting and Transport - The Endoplasmic Reticulum, Golgi Apparatus, Lysosomes
The mechanism of Vesicular Transport (receptor mediated endocytosis)
The Cytoskeleton and cell junctions
Nucleus: The Nuclear Envelope, Traffic between the Nucleus and Cytoplasm, the Nucleolus
Bioenergetics and Metabolism - Mitochondria, The Mechanism of Oxidative Phosphorylation
Peroxisomes
Cell regulation
Cell Signaling: Signaling Molecules and Their Receptors, Functions of Cell Surface Receptors
Pathways of Intracellular Signal Transduction, Regulation of Programmed Cell Death
The Cell Cycle: The Eukaryotic Cell Cycle, Regulators of Cell Cycle Progression, Mitosis
Cancer: The Development and Causes of Cancer, Tumor Viruses, Oncogenes,
Tumor Suppressor Genes
Textbooks:
Cell and Molecular Biology Gerald Karp published by Wiley & Sons, Inc
World of the Cell Becker, Kleinsmith, Hardin, Bertoni published by Pearson Education
NCBI bookshelf on line: Molecular Biology of the Cell Bruce Alberts;
The Cell, a molecular approach Geoffrey M Cooper
Genetics
Marcella Devoto and Paolo Fortina
I SEMESTER
1. Structure and functions of genes and human genome
DNA, RNA, non-coding RNA, pseudo-genes
Anatomy of the human genome
2. Variation in the human genome
Mutations, polymorphisms, SNP, VNTR, repetitive DNA, CNV, LOH
3. Mendelian inheritance and its exceptions
Autosomal recessive and dominant, X-linked, and mitochondrial transmission
Imprinting, genetic heterogeneity, reduced penetrance, variable expressivity
Recurrence risk for Mendelian traits in human pedigrees
II SEMESTER
4. Molecular analysis of nucleic acids
DNA extraction
Restriction enzymes, electrophoresis and hybridization
Southern and Northern blotting
PCR, RT-PCR, TaqMan, ASO, ARMS, OLA, SSCP, DHPLC, MLPA
Sanger sequencing
Microarray
5. Human chromosomes and cytogenetic analysis
Karyotype
FISH, aCGH
6. Gene mapping and linkage analysis
Recombination and genetic distance
Genetic mapping of rare Mendelian disorders
Lod-score and model-free analysis in human pedigrees
7. Basic principles of population genetics
Allelic frequency
Hardy-Weinberg equilibrium
Consanguinity
Linkage disequilibrium
8. Complex genetic traits and genetic epidemiology
Multifactorial inheritance, threshold model
Twin and adoption studies, recurrence risk ratios
Common disease/common variant hypothesis
Association studies
Lessons learned from genome-wide association studies (GWAS) on common complex traits
9. High-throughput technologies and their applications
Genome-wide association study (GWAS)
Next-generation sequencing (NGS)
Whole genome sequencing (WGS)
Whole exome sequencing (WES)
Whole transcriptome (WT)
10. The Human Genome Project and its developments
HapMap Project
1000 Genomes Project
The Cancer Genome Atlas (TCGA)
11. Basic principles of clinical genetics
Chromosomal syndromes and genomic disorders
Dynamic mutations and mental retardation
Neuromuscular disorders and cardiomyopathies
Hemoglobinopathies, hemophilia, congenital errors of metabolism, cystic fibrosis, hearing loss
Clinical cancer genetics
Prenatal diagnosis of genetic disorders
Texbook:
Bruce Korf and Mira Irons, Human Genetics and Genomics, Fourth Edition, Wiley-Blackwell 2013
Integrated Course of HISTOLOGY AND EMBRYOLOGY

Through the integrated study of Cytology, Histology and Embryology, the student will learn the microscopic anatomy
of cells, tissues and organs, with an emphasis on relationships between structure and function, and to describe and
discuss, using a correct terminology, specific morphological organizations. The course will teach the fine mechanisms
of cell differentiation, histogenesis and embryogenesis. Through the study of gametogenesis, fertilization and the early
stages of embryonic development, the student will learn the mechanisms and processes of primitive embryonic layers
formation, and the development of organs and apparatus.
Introduction: Histological techniques: overview of methods in cytology and histology; tissue preparation for
microscopic examination; optical instruments for studying cells and tissues.
Cytology: Structural organization and function of the eukaryotic cell. Cytoplasm and nucleus. Cytoplasmic organelles.
Plasma membrane. Rough and smooth endoplasmic reticulum. Golgi apparatus and vesicle trafficking. Mitochondria.
Cytoskeleton and centrioles. Inclusions. Cytosol. Nucleus. Nuclear envelope. Chromatin. Nucleolus. Cell death and
division.
Histology: Introduction to tissues. Cell differentiation and histogenesis of tissue. Tissue engineering.
Epithelium. Specializations of cells surface and cell polarity. Lining epithelia: generalities and histological structure of
epidermis and digestive, respiratory, urogenital mucosae. Glands: histogenesis and structure of major exocrine and
endocrine glands (pancreas, liver, prostate, salivary, mammary, pituitary, thyroid, parathyroid, adrenal).
Connective tissues. General structure and functions of connective tissue; extracellular matrix, fibers, ground substance
and cells; Connective tissue proper.
Cartilage. Types of cartilage; chondrogenesis and cartilage growth
Bone. Osteogenesis; bone remodeling and homeostasis .
Blood: plasma, erythrocytes, leucocytes, platelets. Hemopoiesis.
Immune system and organs, including the histological structure of thymus, spleen and lymph nodes.
Muscle tissues: morphology and functional characteristics of skeletal, cardiac muscle and smooth muscle. Nervous
tissue. Neurons. Nerve fibers. Synapses. Neuroglia. Peripheral nerve terminals.
Embryology: Introduction. Gonads, gametogenesis and fertilization. In vitro fertilization. Embryonic and adult stem
cells, somatic cell reprogramming into pluripotent stem cells (iPS): concepts, definition and potentiality for tissue
regeneration and repair. Early stages of the embryo development. Segmentation. Morula. Blastocyst and implantation.
The embryonic disk. Timing and 3D development of primitive layers: endoderm, ectoderm and mesoderm. The
notochord and its role in embryo development. Further development and derivatives of ectoderm, endoderm and
mesoderm. Placenta. Embryo annexes. Morphogenetic mechanisms. Interactions between primitive layers and initial
organogenesis with some examples: central nervous system, circulatory, digestive, respiratory and urogenital systems.
Neural crest derivates. Teratogenesis.
Exam: oral
Textbooks:
Histology (including essential Cytology)
Gartner LP & Hiatt JL, Color Textbook of Histology, Lippincott Williams & Wilkins, 2009.
Ross MH & Pawlina W, Histology: a Text and Atlas, Lippincott Williams & Wilkins, 2010.
Young B & Others, Wheathers Functional Histology. Churchill Livingstone Elsevier, 2006.
Moore K.L. The developing Human. Clinically oriented Embryology, Saunders Elsevier, 9th ed.
Embriology
Sadler T.W. Langmans Medical Embryology, Lippincott Williams & Wilkins, 2010.
Shoenwolf G.C. Larsen's Human Embryology, Churchill Livingston Elsevier, 2009
Additional textbooks:
Alberts and Others, Molecular Biology of the Cell, Garland Science, 2008.
Ross MH, Pawlina W & Barnash TA, Atlas of descriptive Histology, Sinauer Associates, 2009
Eroschenko VP, Di Fiore's Atlas of Histology with functional correlations, Lippincott Williams &
Wilkins, 2007
Gartner LP & Hiatt JL, Color Atlas of Histology, Lippincott Williams & Wilkins, 2009.
Further informations at: http://w3.uniroma1.it/istologia/guiM&C-F.html
Integrated Course of BASIC MEDICAL-SCIENTIFIC METHODS (I, II and III)
have acquired method and learning appropriate towards a theoretical practical background based on scientific
bases and human relationships. The student should know the main stages of the evolution of medical thought,
including a multicultural perspective. The student should know the origin, evolution and current use of the
main terms used in medicine and be able to explain conceptual implications. The student should be aware of
the variability inherent in biological, clinical and instrumental data and the usefulness of statistical
methodology for synthesis and understanding of bio-medical phenomena.
be able to establish collaboration with different professionals in group work, respecting the various
autonomies. The student should use precise and appropriate medical terminology for a better understanding
and transmission of data. The student should correctly apply the method of gathering and recording
information: be able to discuss about quantitative methods in medicine and the measurement of biological
phenomena, be able to use statistical, probabilistic and data processing instruments in order to manage the
uncertainty connected with the nature of the medical process.
know how to establish a therapeutic alliance with the patient and be able to apply the principle of caring for.
The student should create a relationship with the patient, relatives and the personnel involved in assisting the
patient and other colleagues involved in the diagnostic-therapeutic programme.
Basic Medical-Scientific Methods (II)

know how to use methodology oriented towards information, communication and health education,
should be able to recognize main risk factors such as the causes of social unease and the characteristics of
different human groups.
be aware of relational, educational, social and ethical aspects involved in prevention and to be future
doctors professionally coherent with the health objectives of the WHO.
understand and interpret the basic techniques of demography and epidemiology used to measure the
health of a population and investigate the aetiology of diseases; compare and contrast strategies, based on
the individual person and on the population, for the prevention of ill-health and premature death.
Basic Medical-Scientific Methods (III)

know the development of scientific thought in relation to medical care based on reasoning and clinical method;
the methodological study of genetic diseases and the new frontiers of genetics for the development of
medicine; health as primary benefit of man and the community.
know how to apply scientific method in the medical field in order to define the basis of the formulation of
clinical reasoning, in the light of fundamental ethical models of reference.
be able to evaluate the close relationship between health-person-bioethics-genetic inheritance-symptoms and

objective examination in order to provide appropriate management of the patient.
Integrated Course of BIOCHEMISTRY (I & II)
knowing the structure and function of the main classes of biomolecules, and specifically of macromolecules
and supramolecular structures, and the main biochemical methodologies used in their study;
recognizing the structure-function relationships in biological macromolecules;
being aware that the study of molecular structures constitutes the conceptual basis for the understanding of
metabolic processes and cellular physiopathology;
knowing the main metabolic pathways, their regulation at the molecular and cellular level, and their
integration;
recognizing the rationale that governs the intermediate metabolite fluxes;
being conscious that perturbations in the structures of biological macromolecules, which carry out reactions
and which are involved in the regulation of metabolic pathways, are the onset of pathological cellular and
systemic conditions.
Biochemistry I (first year II semester aptitude test)

Chemical composition of the living matter. Properties of water. Biological buffer systems. .
Proteins: Amino acids. Classification, properties, dissociation, isoelectric point. Peptide bond. Natural peptides.
Glutathione. Neuropeptides. Structure of proteins. Structural organization levels. Collagen, elastin. Denaturation of
proteins. Hemoglobin and myoglobin. Hemoglobinopathies. Immunoglobulins. Blood composition. Biochemical basis
of muscle contraction.
Introduction to proteomics. Domains and structural motifs in proteins. Principles of macromolecules recognition:
protein-protein and protein-nucleic acid interactions. Thermodynamics and kinetics of protein folding. Molecular basis
-amyloids.
Nucleic acids. Nucleotides. DNA double helical structures: A, B and Z; DNA supercoiling; cruciform DNA structures;
RNA structure. Genetic code. Protein synthesis and its inhibition.
Principles of biochemical methods and molecular biology techniques. Macromolecules purification and
characterization methods: chromatography, electrophoresis, spectrophotometry, fluorimetry, mass spectrometry.
Methods for the determination of macromolecules molecular weight. DNA purification. Nucleic acid hybridizations.
Molecular cloning. PCR and its applications. Recombinant protein expression methods.
Carbohydrates. Mono-, oligo- and poly-saccharides. Storage and structural polysaccharides. Proteoglycans.
Peptidoglycan. Glycoproteins: blood groups.
Lipids. Classification. Fatty acids and neutral fats. Phospholipids and sphingolipids. Arachidonic acid and its
derivatives. Cholesterol and derivatives. Lipoprotein structure. Biological membranes. Membrane proteins: structure
and properties. Membrane transport. The Na+/K+ pump. Ion channels. Peptide antibiotics.
Vitamins. Natural sources. Active forms and function. Hypo- and hypervitaminosis.
Enzymes. Thermodynamic aspects of catalysis. Enzyme kinetics. Mechanisms of catalysis and regulation. Allostery.
Enzyme inhibition. Enzyme classification. Coenzymes. Proteases. Blood clotting: physiological role and involvement in
pathology.
Biochemistry II (second year I semester - exam)
Carbohydrate metabolism. Absorption and digestion. Glycolysis. Synthesis and degradation of glycogen.
Gluconeogenesis. The pentose phosphate pathway. Shuttle systems. Regulation and physiological implications.
Lipid metabolism. Absorption and digestion. Bile salts. Fatty acid oxidation. Ketone bodies. Fatty acid biosynthesis,
Cholesterol metabolism. Role of lipoproteins in lipid metabolism. Regulation and physiopathological implications.
Oxidation of pyruvate and acetyl-CoA. Citric acid cycle.
Protein metabolism. Absorption and digestion. Proteasome structure and function. Amino acid metabolism:
transamination, deamination, decarboxylation. Adrenalin and GABA biosynthesis. Urea cycle. Regulation and
physiopathological implications. Heme metabolism. Basics of purine and pyrimidine metabolism.
Electron transport and oxidative phosphorylation. Respiratory chain: complex I-IV and chemiosmotic theory. ATP
synthase. Inhibitors and uncouplers. Energetic yield of carbohydrate and lipid catabolism.
Integration and control of metabolic processes.
Signal transduction. Structural basis of receptor biochemistry. Receptor families. Adrenergic, nicotinic and tyrosinekinase receptors. Second messengers (cAMP, inositol, Ca2+). Meccanism of action of steroid hormones. Local
hormones (NO, eicosanoids). Meccanism of vision, taste and smell.
Interactive activities
Biochemistry (I-II): the goal is to let the student get acquainted with the basic techniques and methods used in a
biochemistry lab.
Exams:
Biochemistry I : written aptitude test
Biochemistry II : oral examnination
Texts:
Lehninger Principles of Biochemistry, DL Nelson & MM Cox Fifth Ed.
Biochemsitry, D. Voet & JG Voet, Biochemistry, Fourth Ed.
Integrated Course of HUMAN ANATOMY (I, II & III)

Knowledge of the structural organization of the human body with its main anatomo-clinical applications at the
macroscopic, microscopic, ultrastructural level, connecting the structural organisation and corresponding functions in a
medical profession perspective.
Human Anatomy (I)
General Anatomy: History of Anatomy. Anatomical terminology. General organization of the human body.
Skeletal and Muscular system: Generalities on bones, joints and muscles. External skull and intracranial
region. Vertebral column and Thoracic skeleton. Pectoral girdle and upper limb (arm, elbow, forearm, wrist
and hand). Abdominal wall. Pelvic girdle and lower limb (hip, knee, leg, ankle and foot). Muscles of the head,
neck, back, thorax, abdomen, pectoral and pelvic girdle, upper and lower limb.
Cardiovascular system: Generalities of the cardiovascular system. Mediastinum. Heart and great vessels.
Pericardium. Coronary circulation. Conduction system. Arteries; Capillaries, Veins.
Human Anatomy (II)
Lymphoid system: Bone marrow. Thymus. Spleen. Lymph nodes.
Respiratory system: Nose. Nasal cavities and paranasal sinuses. Pharynx. Larynx. Trachea and bronchi. Lungs
and pleura.
Digestive system: Oral cavity. Major salivary glands. Isthmus of fauces. Pharynx. Oesophagus. Stomach. Small
and large intestine. Rectum. Liver, gallbladder and biliary tree. Pancreas. Peritoneum and peritoneal cavity.
Urogenital system: Kidney and ureter. Bladder and urethra. Male reproductive system (testis and spermatic
tracts, prostate). Female reproductive system (ovary, uterine tubes and uterus). External genitalia.
Human Anatomy (III)
Neuroanatomy: Overview of the Central Nervous System. Spinal cord. Brain stem. Cerebellum. Diencephalon.
Basal ganglia. Cerebral hemisphere. Ventricular system, subarachnoid spaces and meninges. Motor pathways.
Pathways of the general and the specific sensibility.
Peripheral nervous system: Generalities. Spinal nerves. Plexuses. Cranial nerves. Organization of the
Autonomic Nervous System.
Visual apparatus: Orbit and accessory visual apparatus. Eyeball. Visual Pathway.
Auditory apparatus: External and middle ear. Internal ear. Pathway of sound reception.
Endocrine system: Generalities. Hypothalamus and its nuclei. Pituitary gland. Pineal gland. Thyroid and
parathyroid glands. Adrenal gland. Endocrine Pancreas. Interstitial glands of testis and ovary.
Suggested textbook:
GRAYS ANATOMY (fortieth edition) Churchill Livingstone.
Suggested atlases:
Atlas of Human Anatomy FH Netter - Saunders Elsevier.
Additional textbooks:
WHEATERS FUNCTIONAL HISTOLOGY Elsevier (Human Anatomy 2)
GRAYS CLINICAL NEUROANATOMY Mancall and Brock Elsevier (Human Anatomy 3)
GRAYS ANATOMY for student (second edition) - Churchill Livingstone
Integrated Course of MICROBIOLOGY

The course will introduce students to basic principles of microbial pathogenesis, using some infectious agents as model.
The plan for conveying the knowledge in medical microbiology is to present, first, concepts of infectious agent structure
and morphology, and then relate them to principles of microbial growth, replication and/or multiplication. Together
these concepts will form the basis for understanding how infectious agents are classified, how their genetic apparatus
works and how they interact with and affect the host. The above molecular and cellular mechanisms are combined with
the concept of microbial pathogenesis, innate and adaptive immune response, immune evasion, persistent infections
and epidemiology, evolution, and control of infectious agents. The most important infectious agent families are then
discussed individually. At the end of the course, some students will be invited to make a presentation of 15 minutes.
The topic of the presentation will be chosen from recent articles on hot topics in medical microbiology which deserve
or may stimulate an interactive discussion. Opportunity of short laboratory research/diagnostic experience will also
offered to students who are particularly interested on such a subject.
General Mircobiology, Bacteriology, Mycology

Introduction to Microbiology.
Normal Microbiota, Host-Microrganism Relationships, Occasional Pathogens, Opportunistic Pathogens, Primary
Pathogens.
Bacterial structure, classification, and replication.
Microbial Nutrition and Growth.
Bacterial genetics.
Mechanisms of bacterial pathogenesis. Bacterial toxins.
Microbial Diseases and Their Control.
Basic concepts in Immune response: serums and vaccines.
Antimicrobial Chemotherapy: mechanisms of action and drug resistance.
Gram
positive
bacteria:
Staphylococci
(S.aureus,
S.epidermidis);
Streptococci
(S.pyogenes,
S.agalactiae,
S.pneumoniae); Spore forming bacilli (B.anthracis, B.cereus); Clostridium (C.tetani, C.botulinum, C.perfringens;
C.difficile); Listeria (L.monocytogenes); Corynebacterium (C.diphteriae)
Gram negative bacteria: Neisseria (N.gonorrhoeae, N.meningitidis); Enterobacteria (Escherichia, Salmonella, Shigella,
Yersinia);
Vibrio (V.cholerae); Helicobacter (H.pylori); Campylobacter; Brucella; Haemophilus (H.influenzae);
Bordetella (B.pertussis); Legionella (L.pneumophila);

Acid-alcohol resistant bacillus: Mycobacteria (M.tuberculosis)
Spirochetes (T.pallidum, B.burgdorferi, L.interrogans)
Mycoplasma, Rickettsia, Chlamydia (C.pneumoniae, C.trachomatis)
Fungal classification, structure, and replication.
Mechanisms of fungal pathogenesis.
Antifungal drugs.
Throughout the course, laboratories in microbiology will introduce students to some of basic techniques used in
diagnostic laboratories for the identification of infectious bacteria and fungi.
Parasitology
General Parasitology: basic terminology : parasites, obligate parasite, facultative parasite, ectoparasites, endoparasites;
commensal and pathogenic parasites. Host, definitive host, intermediate host, reservoir ; vector ; zoonosis,
zooparasitosis, antropoparasitosis.
Intestinal and urogenital protozoa: life cycle and pathology of intestinal amebae (Entamoeba histolytica) and outlines
of non-pathogenic amebae; intestinal flagellates (Giardia lamblia), intestinal coccidia (Cryptosporidium parvum) and
urogenital flagellates (Trichomonas vaginalis).
Blood and tissue protozoa: African Trypanosomiasis (Trypanosoma brucei gambiense and rhodesiense), American
Trypanosomiasis (Trypanosoma cruzi), Leishmaniasis, Malaria, Toxoplasmosis.
Helminths: classification and general concepts; morphology, life cycles, and pathogenic mechanisms of: liver, intestinal
and lung Trematodes (Fasciola, Opistorchis, Fasciolopsis, Paragonimus); blood trematodes (Schistosoma); Cestodes
(Taenia, Hymenolepis, Echinococcus); intestinal and tissue Nematodes (Enterobius, Ascaris, Trichuris, Ancylostoma,
Necator, Strongyloides Trichinella, Daracunculus, Wuchereria, Loa, Onchocerca).
Arthropods: basic concepts on arthropods of medical importance; temporary and permanent ectoparasites (Sarcoptes,
Argas, Ixodes, Pediculus, Pulex, hematophagous diptera).
Virology
General Virology: principles of viral structure, virus replication strategies, effect of viral replication on host cells and
cell transformation, immune response to viral infections, pathogenesis of viral infections, principles of diagnostic
virology, epidemiology, antiviral agents an control of viral infections.
Specific virus families:
Paramyxoviridae,
Picornaviridae, Caliciviridae, Astroviridae, Togaviridae, Flaviridae, Rabdoviridae,
Orthoviridae,
Arenaviridae,
Reoviridae,
Adenoviridae, Parvoviridae, Herpesviridae, Hepadnaviridae.
Retroviridae,
Polyomaviridae,
Papillomaviridae,
Textbooks:
Medical Microbiology - Jawetz Melnick&Adelbergs/ Mac Graw Hill 2012
Medical Microbiology - Murray, Rosenthal, Pfaller /Elsevier Saunders 2012
Integrated Course of HUMAN PHYSIOLOGY (I, II & III)

At the end of the course, students must know the function of the organs in the human body; the dynamical integration of
the various organs into systems; the general mechanisms of functional control under normal conditions; the normal
values of the main functional parameters in healthy humans; the medical application of biophysical and
biotechnological principles. They must also know some of the techniques used to measure physiological parameters.
Human Physiology (I)

What is physiology. Homeostasis. Body fluids.
Cell as unit: electrical parameters of cell membrane and circuitry; resting membrane potential; action potential. Voltagedependent ion channels. Biophysical methods to study electrical membrane events. Neurotransmitters. Electrical
synapses: structure and functions. Chemical synapses: structure and functions. Transmitter release spontaneous and
evoked. Synaptic potential, spatial and temporal summation. Membrane receptors. Families of ionotropic receptors:
structural analogies and functional characteristics. Families of metabotropic receptors: structural analogies and
functional differences. Second messengers and signal transduction mechanisms. Synaptic activity and cognitive
processes.
Muscle physiology: neuromuscolar junction. Muscles: structure and function of the different muscle types. Skeletal,
smooth and cardiac muscle contraction.
Blood physiology: Functions. Blood components: plasma, erythrocytes, leukocytes, platelets. Mechanisms of
hemostasis.
Autonomic nervous system. General organization and cardiocirculatory centers.
Heart and circulation: Laws of fluid mechanics applied to circulation. Arterial pressure and peripheral resistances. The
heart: myocardial physiology, cardiac cycle. Cardiac output, venous return.
Myocardial excitation and impulse
conduction; control mechanisms. Electrocardiography. Microcirculation and lymphatic system. Exchanges between
tissues and blood. Control of blood flow and arterial pressure. Methods to measure arterial pressure.
Exam: oral.
Textbooks:
Guyton & Hall: Medical physiology, Elsevier Imprint: Saunders
Berne e Levy: Medical Physiology, Imprint: Mosby
Silverthorn: Human Physiology, Publisher: Benjamin Cummings
Human Physiology (II)

The kidney and the body fluids. Body fluid compartments; water and salt equilibrium. Urine formation: glomerular
filtration, tubular transport of the electrolytes, tubular water reabsorption and the regulation of fluid osmolarity.
Mincturition. Renal mechanisms for the control of blood and extracellular fluid volume. Regulation of the concentration
of the principal electrolytes (sodium, potassium, calcium, magnesium, phosphate).
Respiration: structure of the lungs. Pulmonary pressure and ventilation; Pulmonary volumes. Mechanical properties of
the lungs. Pulmonary circulation. Gas exchange. Respiratory gas transport. Control of breathing.
Acid-base balance: Body buffer systems for extracellular pH: plasma proteins, bicarbonate, phosphate. Renal regulation
of the acid-base balance. Respiratory regulation of the acid-base balance. Disturbances of the acid-base balance.
Gastrointestinal physiology: motility, nervous control and blood circulation in the gastrointestinal tract. Food
progression and mixing in the digestive tract. Gastrointestinal secretion: salivary, gastric, pancreatic, biliary, intestinal
secretions. Food digestion. Absorption of water, nutrients and electrolytes in the small intestine. Absorption in the large
intestine. Main metabolic functions of the liver.
Endocrinology: hormone structure and action. Measurement of hormone levels. Pituitary hormones and hypothalamic
control mechanisms. Thyroid hormones. Adrenocortical steroid hormones. Endocrine pancreas: insulin and diabetes.
Parathyroid hormone and calcitonin: calcium and phosphate metabolism. Male and female sex steroid hormones.
Reproduction and pregnancy.
Textbooks:
BM Koeppen, BA Stanton: Berne & Levy Physiology. Mosby Elsevier 2010. ISBN: 978-0-32307362-2
JH Hall: Guyton and Hall Medical Physiology. Saunders Elsevier. ISBN: 978-1-4160-44574-8
DU Silverthorn: Human Physiology. 6th edition. Benjamin Cummings. ISBN: 978-0321750006

Sensory receptors: neural circuits for processing information.
Somatic Sensations: I. General organization: senses of touch and position.
Somatic Sensations: II. Pain, headache and temperature.
The Eye: I. Vision optics. The Eye II. Function of the eye and retinal nerve. The eye III. Central neurophysiology of
vision.
The sense of hearing. The chemical senses: taste and smell.
Motor functions of the spinal cord: spinal reflexes. Control of motor function in the cortex and the brainstem. The
cerebellum, basal ganglia and overall control of the movement.
The cerebral cortex: intellectual functions of the brain, learning and memory. Mechanisms of behavior and motivation
of the brain: the limbic system and hypothalamus. Brain activity states: sleep, brain waves, epilepsy, psychosis.
Exam: oral
Textbooks:
JH Hall: Guyton and Hall Medical Physiology. Saunders Elsevier. ISBN: 978-1-4160-44574-8
BM Koeppen, BA Stanton: Berne & Levy Physiology. Mosby Elsevier 2010. ISBN: 978-0-323-07362-2
DU Silverthorn: Human Physiology. 6th edition. Benjamin Cummings. ISBN: 978-0321750006
Integrated Course of CLINICAL SCIENTIFIC METHODS (IV, V & VI)

Methods of patients interviewing and health history taking
Adapting Interviewing Techniques to Specific Situations
Basics of clinical reasoning
Blood pressure measurement
Basic of surgical procedures
Physical Examination: General Survey and Vital Signs
TECHNIQUES OF EXAMINATION
Beginning the Examination: Setting the Stage; Approaching the Patient; Scope of the Examination: How Complete
Should It Be?; Choosing the Examination Sequence; Examining Position and Handedness
THE GENERAL SURVEY

Apparent State of Health; Level of Consciousness, Signs of Distress; Skin Color and Obvious Lesions, Facial
Expression; Odors of the Body and Breath Posture, Gait and Motor Activity; Examination of head and nek;
Examination of skin (Color, Moisture; Temperature), Eyes and Ear
The Thorax and Lungs examination
TECHNIQUES OF EXAMINATION
Initial Survey of Respiration and the Thorax
Examination of the Posterior Chest (Inspection,Palpation, Percussion, Auscultation); Examination of the Anterior Chest
(Inspection, Palpation, Percussion, Auscultation)
Special Techniques (Clinical Assessment of Pulmonary Function, Forced Expiratory Time

Identification of a Fractured Rib).
The Cardiovascular examination
TECHNIQUES OF EXAMINATION (Jugular Venous Pressure and Pulsations, Jugular Venous Pressure (JVP), Jugular
Venous Pulsations, The Carotid Pulse, Thrills and Bruits, The Brachial Artery)
SEQUENCE OF THE CARDIAC EXAMINATION

Inspection and Palpation, Percussion , Auscultation (Listening for Heart Sounds; Attributes of Heart Murmurs)
Special Techniques (Aids to Identify Systolic Murmurs, Pulsus Alternans, Paradoxical Pulse)
PRACTICAL ACTIVITY:
Practices of history taking and patients interviewing
Practices on physical examination general
Practice on physical examination cardiovascular system, lung and torax
Each group for practical activities will constituted by 5-6 students; the calendar and the locations of practical activities
will be explained during course presentation.
Exam: written (multiple choice)
Textbooks:
Bates' Guide to Physical Examination and History-Taking - Lippincott Williams & Wilkins - Lynn Bickley
MD (Author), or
Goldmans Cecil medicine 24th edition

Integrated Course of IMMUNOLOGY AND IMMUNOPATHOLOGY

To understand the molecular and cellular basis of the immune response. To understand the fundamental mechanisms
responsible for protection and for tissue damage, and to comprehend their specific role in the resistance against
pathogens, the immune surveillance against tumors, and immune-mediated diseases.
Formal teaching subjects:
General aspects of the immune system: cellular and molecular participants to innate and adaptive immune responses.
Cytokines and their receptors.
Innate immunity: cellular and molecular components, cell differentiation, activation, and effector functions.
The molecular basis of antigenicity, antigen receptors and the generation of diversity.
The Major Histocompatibility Complex and antigen presentation.
Maturation, activation and effector functions of B and T lymphocytes.
Biology of T cell subsets: helper (Th), cytotoxic (CTL), and regulatory (T reg).
Antibodies: molecular structure, effector functions, Fc receptors, the antigen/antibody reaction.
The complement cascade: activation pathways and regulation.
NK cells.
Hematopoiesis, lymphoid organs, leukocyte migration and trafficking.
Mucosal immunology.
Development and regulation of immune responses.
Immune responses against different classes of pathogens: viruses, bacteria, fungi and parasites, and mechanisms of
pathogen evasion.
Principles of vaccination.
Immune responses against tumors and principles of immunotherapy.
Type I hypersensitivity reactions (allergies).
Type II hypersensitivity reactions and elements of immunohematology.
Type III and type IV (delayed-type) hypersensitivity reactions.
Mechanisms of central and peripheral tolerance; autoimmune diseases.
Transplantation immunology.
Primary and acquired immunodeficiencies.
The most common immunological techniques.
Interactive teaching: guided discussion of clinical cases (with the participation of clinical teachers), as a mean to
illustrate the major subjects of immunopathology.
Exam: oral
Textbooks:
Cellular and Molecular Immunology, 7th Edition (2011, Elsevier)

Abul K. Abbas, Andrew H. Lichtman, & Shiv Pillai
Kuby Immunology, Seventh Edition (2012, W.H. Freeman and Company)

J. Owen, J. Punt, S. Stransford
IMMUNOLOGY, 8th Edition (2012, Elsevier)

David Male, Jonathan Brostoff, David Roth, Ivan Roitt
Janeways Immunobiology, 8th Edition (2011, Garland Science, Taylor Francis Group)
Kenneth M. Murphy
Integrated Course of LABORATORY MEDICINE (I+II)
understand the application of the most relevant techniques in Biochemistry, Molecular Biology, Microbiology,
Parasitology, Clinical Pathology, Immunology and Immunohematology;
be able to decide which clinical laboratory analyses are appropriate for the patient under study.
be aware of the usefulness and limits of the clinical information provided by the clinical laboratory analyses.
Formal Teaching (Topics)
The request of clinical analyses - Urgent and routine analyses- The concepts of prevention, early medical diagnosis
and follow up- Methods to obtain biological samples and their application. Collection and validity of biological
samples - Quality control in the clinical laboratory, between laboratory and on a global scale - Sensitivity and
specificity of clinical methods. Significance and diagnostic relevance of the analysis results - Methods for clinical
microbiology and parasitology. Timeline and interpretation of the results - Clinical microbiology of infectious diseases
of organs and apparatuses- Blood parasites; intestinal parasites.- Biochemical characterization of dysmetabolic
conditions- Laboratory medicine for the evaluation of the cardiovascular, renal, endocrine apparatuses; assays to
monitor liver pathophysiology; Transfusion Medicine - Laboratory Medicine of Immune Disorders. Histocompatibility
Testing and Transplantation.
Interactive teaching (goals)
Selection of the analysis to be carried out, in relation to the patient's disease.
Evaluation of the quantitative and qualitative alterations of the most relevant analytes.
Apprenticeship (practical laboratory)
How to effect a standard laboratory analysis of the urine (physical, chemical and microbiological).
How to prepare a blood smear; how to read a hemocytometric (non-pathological) test
Exam: oral
Textbook:
Michael Laposata: Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory (LANGE Basic
Science)
Integrated Course of PATHOLOGY AND PHYSIOPATHOLOGY (I+II)
Knowledge of the etiology and the pathogenetic mechanisms of human diseases, basic pathophysiological
mechanisms of major organs and systems.
Interpretation of basic pathophysiological and pathogenetic mechanisms of human disease.
Ability to analyze the fundamental pathophysiological mechanisms of human diseases and interpret their
results.
Knowledge of the pathogenetic basis of disease and pathophysiological processes as the essential substrate for
subsequent clinical approach to human diseases.
Pathology and Pathophysiology (I)
Etiology: Main concepts of health, pathologic process and disease; etiology, pathogenesis, evolution,
resolution (exitus). General environmental pathology. Pathology by physical and chemical agents. Biological
agents of disease: bacterial exotoxins and endotoxins. Non-hereditary congenital disease. Teratogenesis.
Genetic disorders: Gene mutation and disease. Genetic inheritance patterns. The major chromosomal and gene
disorders. Genetics of multifactorial diseases. Kariotype analysis and methods for genetic diseases. Models of
human genetic disorders.
Molecular Pathology: Molecular pathology of proteins. Hemoglobinopathies. Pathology by enzyme

deficiencies. Molecular pathology of the plasma membrane: receptors, channels, transduction mechanisms.
Molecular pathology of the components of the connective tissue. Molecular pathology of mitochondria.
Inflammation: The basics of inflammation, acute and chronic inflammation. Innate immunity and
inflammation. Inflammation as a transcriptional program. Inflammatory cells. Chemical mediators of
inflammation of cellular and plasma origins. Acute inflammation: the vascular phenomena of inflammation,
the mechanisms of formation of exudate, the various types of exudative inflammation. Chronic inflammation:
mechanisms of granuloma formation. Foreign-body granulomas. The main immunological granulomas.
Systemic manifestations of inflammation: acute phase proteins, erythrocyte sedimentation rate, and
leukocytosis. Pathophysiology of thermoregulation and fever. Tissue repair and granulation tissue.
Pathological aspects of wound healing: keloids, scars.
Pathology of cell structures: the cell's response to injury: cellular stress, cellular adaptations (hypertrophy,
hyperplasia, atrophy, metaplasia), intracellular storage diseases (steatosis, lysosomal diseases). Molecular
mechanisms of cellular damage. Cell death: necrosis and apoptosis. Renewal, regeneration and tissue repair.
Growth factors. Aging.
Abnormalities of the extracellular matrix: Beta-fibrillosis. Localized and systemic fibrosis. The diseases of
collagen and other basement membrane components.
Pathology and Pathophysiology (II)
Oncology: Cell/Tissue phenotypic changes: metaplasia, dysplasia, anaplasia and precancerous lesions.
Definition of cancer. Morphological and biochemical features of the neoplastic cell. Histogenetic classification
of tumors. Clinical criteria for the classification of tumors: grading and staging. Pathophysiology of replication
and of cell differentiation and growth factors. Physical, chemical, viral and hormonal cancerogenesis. Stages of
the neoplastic process: initiation, promotion and progression (invasion, metastasis, angiogenesis). Oncogenes
and their activation mechanisms. Tumor suppressor genes. Genomic instability. Heredityary tumors.
Immunity, inflammation and cancer. Biological basis of target antineoplastic therapy.
General Pathophysiology: Pathophysiology of metabolism (amino acids, purine and pyrimidine bases, lipids
and lipid disorders).
Pathophysiology of the Endocrine System: classes of hormones and receptors, secretion and transport.
Pathophysiology of the thyroid gland: epithelial cells and parafollicular C cells, thyroid hormones, transporters
iodine and TPO. Pathogenesis of hypothyroidism and hyperthyroidism, papillary thyroid cancer, follicular,
medullary and anaplastic (MTC).
Pathophysiology of diabetes mellitus: endocrine pancreas, definitions and etiological classification: type 1
diabetes, type 2 diabetes, other types of diabetes and gestational diabetes: Pathophysiology of complications of
the diabetic patient. The gut hormones: the incretin hormones GLP-1 and GIP. Atherogenesis and
atherosclerosis.
General pathophysiology of blood, blood-forming organs and haemostasis.
General pathophysiology of major systems: renal, respiratory, hepatic, cardiocirculatory systems; fluid and
electrolyte replacement; acid-base balance.
Exam: oral
Suggested texbooks:
1. Pathologic Basis of Disease. Robbins & Cotran. Eight Edition. Editor: W B Saunders Co, 2009
2. Understanding pathophysiology. S. Huether, K. McCance. Elsevier, 2012
3. Cells, Tissues and Disease. Principles of general pathology. G. Majno, I. Joris. Oxford University Press, 2004.
4. Rubins Pathology. Clinicopathologic foundation of medicine. Rubin & Straier. Lippincott Raven; 6 Har/Psc, ed. ,
2011.
9. Electives (ADE)
I YEAR
I SEMESTER
BIOLOGY AND GENETICS (I)

Teacher
Type of Elective
Subject
Credits
Hours
C. Battistelli
Seminar
From genetics to epigenetics:

the world beyond Mendels laws
0,2
BASIC MEDICAL SCIENTIFIC METHODS (I)

Teacher
Type of Elective
Subject
Credits
Hours
M. Capocci
Seminar
History of Medicine
(Visit to the Museum)
0,2
I YEAR
II SEMESTER
BIOCHEMISTRY (I)
Teacher
Type of Elective
Subject
Credits
Hours
M. Perluigi
F. Malatesta
D. De Biase
M. Perluigi
Seminar
Quantitative determination
of protein content in milk
Building molecular models at hand
0,2
0,2
Seminar
HISTOLOGY AND EMBRYOLOGY

Teacher
Type of Elective
Subject
Credits
Hours
S. Adamo
Seminar
Tissue Engineering
0,5
BASIC MEDICAL SCIENTIFIC METHODS (II)

Teacher
Type of Elective
Subject
Credits
Hours
M. Cattaruzza
Monographic Course
Tobacco
0,5
II YEAR
Credits
Hours
I SEMESTER
HUMAN ANATOMY (II)

Teacher
Type of Elective
Subject
S. Nottola
Seminar
Ultrastructural Anatomy
0,2
of Gametes in Assisted Reproduction:
From Oocyte to Blastocyst
HUMAN PHYSIOLOGY (I)

Teacher
Type of Elective
Subject
Credits
Hours
C. Limatola
Internship
Laboratory
1,0
30
S. Sensi
Seminar
Fighting Alzheimers diseas,

A tale of mice and humans
0,25
II YEAR
II SEMESTER
HUMAN ANATOMY (III)

Teacher
Type of Elective
Subject
Credits
Hours
E.Gaudio
C.Catalano
Seminar
In vivo imaging of the Human

Central Nervous System
0,2
E.Gaudio
E. Lezoche
Seminar
Living Anatomy:
Retroperitoneum
0,2
E.Gaudio
R.Delfini
Seminar
Living Anatomy:
Access to the cranial cavity
0,2
HUMAN PHYSIOLOGY (II)

Teacher
Type of Elective
Subject
Credits
Hours
F. Grassi
Seminar
Nicotine receptor
and smoke addiction
0,1
Subject
Credits
Hours
MICROBIOLOGY
Teacher
Type of Elective
G. Antonelli
Seminar
Chronic hepatitis viruses:

0,1
1
virological monitoring of the
infection and of its treatment
G. Antonelli
Seminar
Human immunodeficiency virus:
0,1
1
an update on etiopathogenesis
D. Modiano
Seminar
Genetics of susceptibility to
0,1
1
Plasmodium falciparum malaria
A. Palamara
Seminar
Human Microbiota in health and
0,1
1
disease
___________________________________________________________________________________________________________
III YEAR -
I SEMESTER
HUMAN PHYSIOLOGY (III)

Teacher
Type of Elective
Subject
Credits
Hours
S. Ferraina
Seminar
0,2
S. Ferraina
Internship
Neurophysiology approaches
to cognitive functions
Laboratory
Credits
Hours
IMMUNOLOGY AND IMMUNOPATHOLOGY

Teacher
Type of Elective
Subject
Seminar
Seminar
Tumor immunotherapy
0,2
Immunotherapy of
0,2
hematological malignancies
Osteoimmunology and
0,2
immune-mediated diseases of the bone
Laboratory
Seminar
Internship
2
2
2
PATHOLOGY AND PATHOPHYSIOLOGY (I)

Teacher
Type of Elective
Subject
Credits
Hours
M. Felli
A. Campese
Seminar
Animal models of
human disease
0,2
III YEAR -
II SEMESTER
PATHOLOGY AND PATHOPHYSIOLOGY (II)

Teacher
Type of Elective
A. Po
Seminar
L. Di Marcotullio
Subject
Credits
Emerging research areas in cancer:
0,5
microRNAs and the ubiquitin system
Hours
5
G. Giannini
Seminar
0,2
G. Canettieri
P. Trimboli
Seminar
New approaches in cancer therapy:

target therapies
Diagnosis and treatment of thyroid
tumors: molecular approaches
0,2
G. Giannini
Internship
Molecular Oncology I
G. Canettieri
Internship
Molecular Oncology II
Credits
0,2
Hours
Duration of specific
Conference
I, II AND III YEAR

ENGLISH CONFERENCES OF THE ACADEMIA MEDICA DI ROMA
Teacher
S. Filetti
Type of Elective
Seminar
Subject
Various
10. Registration to the following years

Exclusively those students who by the end of the exam session of September or, ultimately, by the 23rd of
December have finished all the exams scheduled by the table below, will be able to pass on to the following
year:
To be enrolled to
II year
III year
IV year
V year
VI year
it is mandatory to have passed

2 exams of the first year
All the exams of the first year
All the exams of the first and second year and 1 exam of the third year
All the exams of the first, second and third year
All the exams of the first, second, third and fourth year and 2 exams of
the fifth year *
* also the exam of Scientific English is counted here

Those students who, despite their certified and regular attendance of the courses scheduled for a specific year
of the programme, are behind on a number of exams superior to what is stipulated by the table above, will be
registered in the same year with the qualification ripetente (repeating) and be exempt from the attendance,
unless the responsible committee will adopt different directives.
Given the fact that the observation of the propaedeutics will be checked in the moment in which a
certification of the passed exams will be issued or the request for the final exam will be presented, it is the
students own responsibility and interest to observe the above mentioned standards.
Propaedeutics
To sit the exam of
Biochemistry
Human Anatomy
Human Physiology
Pathology and Pathophysiology
Applied Pathology (I, II + III), Pathological Anatomy
it is mandatory to have passed

Chemistry and Introduction to Biochemistry
Histology and Embryology
Biology and Genetics
Human Physiology
Pathology and Pathophysiology
Potential additional propaedeutics can be defined and suggested by the responsible committee of the
educational structure.
In order to avoid the obsolescence of the acquired credits it is forbidden to repeat more than 8 years inside of
the same degree programme. The interruption of the attendance for more than six years requires the
enrollment in a year determined by the decision of the responsible committee of the educational structure.
11. Legend and map of Policlinico Umberto I
1
2
3
4
5
6
7
8
9 - 18
14
19
20 - 21
22
23
24
25
26
27
28
29
30 - 35
36
37
38
39 - 41
42
43
Clinica Dermosifilopatica
I Clinica Medica
II Clinica Medica
Pal. Amministrazione e Pronto Soccorso
II Clinica Chirurgica
I Clinica Chirurgica Rep. B - IV Cl. Chirurgica
Clinica Oculistica
Clinica Otorinolaringoiatrica
(escluso 14) Padiglioni ed ex padiglioni
Cucina centrale
I Clinica Chirurgica
Clinica Urologica
Clinica Malattie Tropicali
V Clinica Medica e Biologia Generale
Clinica Radiologica
Palazzine ex SCRE: Presidenza di Facolt, Segreterie CLMMC A, D,
F, CL Professioni Sanitarie, Day Hospital Oncologico
Clinica Ostetrica e Ginecologica
Banca e Fisica Sanitaria
VI Clinica Medica
III Clinica Medica
Clinica Malattie Infettive
Patologia Generale ed Anatomia Patologica
Laboratorio Centrale di Analisi
III Clinica Chirurgica
Clinica Pediatrica
Clinica Odontoiatrica
Anatomia Umana
Map of Policlinico Umberto I
ANATOMIA UMANA
12. Legend and map of Citt Universitaria La Sapienza
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
Aulette prefabbricate Chimica Biologica

Aulette prefabbricate Ex Psicologia
Cappella Universitaria
Clinica Ortopedica
Chimica Nuova
Clinica Malattie Nervose e Mentali
Edifici Segreterie Generali
Farmacia
Facolt di Giurisprudenza
Facolt di Lettere e Filosofia
Fisica Nuova
Istituto di Botanica
Istituto di Chimica
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Istituto di Microbiologia
Istituto di Matematica G. Castelnuovo
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ex Tipografia Tuminelli
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Dean: Prof.

Academic Year 2013-2014

Dean: Prof. Eugenio Gaudio

Academic Year 2013-2014

1. Offices Degree Course F

3. Courses and course coordinators for each semester

5. Exams and ongoing examinations

6. Course organisation: Teaching staff

7. Teaching staff: Contact information

10. Registration to the following years

11. Legend and map of Policlinico Umberto I

12. Legend and map of Citt Universitaria

Greetings to students and teachers

1. Offices Degree Course F

Dean Prof. Eugenio Gaudio

Dott. Vincenzo Mancino

Prof. Paolo Sarti

Chemistry and introduction to biochemistry

Biology and genetics (I-II)

Histology and embriology

Basic medical scientific methods (I-II-III)

Human anatomy (I-II-III)

Human physiology (I-II-III)

Immunology and immunopathology

Clinical scientific methods (IV-V-VI)

Pathology and pathophysiology (I-II)

Laboratory medicine (I-II)

Applied pathology I - Diseases of the respiratory system and cardiovascular system

Applied pathology II - Diseases of kidney and urinary system

Applied medical scientific methods (VII-VIII)

Pathological anatomy and associations with clinical anatomy (I-II)

Applied pathology V - Infectious diseases and human reproduction

Diseases of the nervous system

Internal medicine and general surgery I - medical and surgical Oncology

Pharmacology (I-II) and toxicology

Psychiatry and cinical psychology

Movement disorders, rheumatology

Dermatology and plastic surgery

Diseases of the sensory organs

Scientific English (I-II-III-IV-V) - Journal Club

Medical-scientific methods: public health (IX-X)

Internal medicine and general surgery II

Obstestrics and Gynaecology

Medical-scientific methods: forensic medicine, medicine and the law (XI)

Emergency medicine and surgery

TOTAL CREDITS FOR EXAMS

CREDITS for preparation of final thesis

3. Courses and course coordinators for each semester

Human Anatomy (I)

Histology and Embryology

Human Anatomy (II)

Human Physiology (I)

Basic Medical Scientific Methods (III)

Human Anatomy (III)

Scientific English-Journal Club (II)

Clinical Scientific Methods (IV)

* Classroom L, Department of Human Anatomy ( Via Borelli, 50)

HISTOLOGY AND HISTOLOGY AND

HISTOLOGY AND HISTOLOGY AND