Patent Cooperation Treaty: International Search Report

PATENT COOPERATION TREATY
PCT
INTERNATIONAL SEARCH REPORT
(PCT Article 18 and Rules 43 and 44)
Applicant's or agent's file reference
INTMU.OSOVPC
International application No.
FOR FURTHER
ACTION
see Form PCT/ISA/220

as well as, where applicable, item 5 below.
International filing date (day/month/year)
PCT/US2009/040567
(Earliest) Priority Date (day/month/year)
14/04/2009
15/04/2008
Applicant
INTERMUNE, INC.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant
according to Article 18. A copy is being transmitted to the International Bureau.
This international search report consists of a total of _ ___,6_ _ _ _ sheets.
D
1.
It is also accompanied by a copy of each prior art document cited in this report.
Basis of the report

a.
With regard to the language, the international search was carried out on the basis of:
[i]
D
D
c.
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, see Box No. I.
Certain claims were found unsearchable (See Box No. II)
3.
With regard to the title,
6.
This international search report has been established taking into account the rectification of an obvious mistake
authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
Unity of invention is lacking (see Box No Ill)
[KJ
5.
a translation of the international application into

, which is the language
of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1 (b))
b.
2.
4.
the international application in the language in which it was filed
the text is approved as submitted by the applicant

the text has been established by this Authority to read as follows:
With regard to the abstract,
[KJ
the text is approved as submitted by the applicant
the text has been established, according to Rule 38.2(b), by this Authority as it appears in Box No. IV. The applicant
may, within one month from the date of mailing of this international search report, submit comments to this Authority
With regard to the drawings,

a.
the figure of the drawings to be published with the abstract is Figure No. _ _ _ _ __
D
D
b.
as suggested by the applicant

as selected by this Authority, because the applicant failed to suggest a figure
as selected by this Authority, because this figure better characterizes the invention
none of the figures is to be published with the abstract
Form PCT/ISA/21 0 (first sheet) (April 2007)
International application No
PCT/US2009/040567
A. CLASSIFICATION OF SUBJECT MATIER
INV.
C07D285/30
C07D491/12
C07D417/04
A61K31/5415
C07D471/04
A61P31/14
C07D487/04
C07D417/14
According to International Patent Classification (I PC) or to both national classification and IPC
B. FIELDS SEARCHED
Minimum documentation searched (classification system followed by classification symbols)
COlD A61K
A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched
Electronic data base consulted during the international search (name of data base and, where practical, search terms used)
EPO-Internal, WPI Data, BEILSTEIN Data, CHEM ABS Data
C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category
Citation of document, with indication, where appropriate, of the relevant passages
wo 2006/093801 A (ABBOTT LAB [US])

8 September 2006 (2006-09-08)
Relevant to claim No.
1-17'
117'
123-166
page 1' paragraph 1

claims 1,5,17-27
A
----us 2004/087577 A1 (PRATT JOHN K [US] ET

AL) 6 May 2004 (2004-05-06)
page 1' paragraph 2

example 122C
page 131' formulae 21-23
claims 1,52-62
-----
IT1
.
Further documents are listed in the continuation of Box C.
Special categories of cited documents :
"A" document defining the general state of the art which is not
considered to be of particular relevance
"E' earlier document but published on or after the international
filing date
"L" document which may throw doubts on priority claim(s) or
which is cited to establish the publication date of another
citation or other special reason (as specified)
"0" document referring to an oral disclosure, use, exhibition or

other means
"P" document published prior to the international filing date but
later than the priority date claimed
Date of the actual completion of the international search
22 January 2010
Name and mailing address of the ISAI
European Patent Office, P.B. 5818 Patentlaan 2

NL - 2280 HV Rijswijk
Tel. (+31-70) 340-2040,
Fax:(+31-70)340-3016
1-17,
117'
123-166
-1--
[]
See patent family annex.
"T" later document published after the international filing date

or priority date and not in conflict with the application but
cited to understand the principle or theory underlying the
invention
"X" document of particular relevance; the claimed invention
cannot be considered novel or cannot be considered to
involve an inventive step when the document is taken alone
"Y" document of particular relevance; the claimed invention
cannot be considered to involve an inventive step when the
document is combined with one or more other such documents, such combination being obvious to a person skilled
in the art.
"&" document member of the same patent family
Date of mailing of the international search report
28/01/2010
Authorized officer
Cortes, Jose
Form PCT/ISA/210 (second sheet) (Apnl2005)
page 1 of 2
PCT/US2009/040567
C(Continuation).
Category'
DOCUMENTS CONSIDERED TO BE RELEVANT
Citation of document, with indication, where appropriate, of the relevant passages
Relevant to claim No.
US 2004/162285 A1 (PRATT JOHN K [US] ET

AL) 19 August 2004 (2004-08-19)
1-17'
117'
page 1, paragraph 2
examples 425,426C
pages 170 to 172, formulae 48 and 57-60
claim 1
claim 41
N-[3-(4-hydroxy-2-oxo-1,2-dihydro-3-pyridi
nyl)-1,1-dioxido-4H-1,2,4-benzothiadiazin7-yl]methanesulfonamide
claims 57-67
T
WANG, GUANGYI ET AL: "HCV NS5B polymerase

inhibitors 1: Synthesis and in vitro
activity of
2-(1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-y
1)-1-hydroxynaphthalene derivatives"
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,
vol. 19, no. 15, 23 May 2009 (2009-05-23),
pages 4476-4479, XP002549849
table 1; compounds
123-166
1-17,
117'
123-166
9
Form PCT/ISN210 (conllnualion of second sheet)
(Apr~l2005)
page 2 of 2
International application No.

Box No. II
PCT/U$2009/040567
Observations where certain claims were found unsearchable (Continuation of item 2 of first sheet)
This international search report has not been established in respect of certain claims under Article 17(2)(a) for the following reasons:
1.
2.0
3.
Claims Nos.:
because they relate to subject matter not required to be searched by this Authority, namely:
Claims Nos.:
because they relate to parts of the international application that do not comply with the prescribed requirements to such
an extent that no meaningful international search can be carried out, specifically:
Claims Nos.:
because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4(a).
Box No. Ill
Observations where unity of invention is lacking (Continuation of item 3 of first sheet)
This International Searching Authority found multiple inventions in this international application, as follows:
see additional sheet
As all required additional search fees were timely paid by the applicant, this international search report covers all searchable
claims.
2.
3.
4.
GJ
As all searchable claims could be searched without effort justifying an additional fees, this Authority did not invite payment of
additional fees.
As only some of the required additional search fees were timely paid by the applicant, this international search report covers
only those claims for which fees were paid, specifically claims Nos.:
No required additional search fees were timely paid by the applicant. Consequently, this international search report is
restricted to the invention first mentioned in the claims; it is covered by claims Nos.:
1-6 (part), 7-17, 117, 122-166 (part)

Remark on Protest
D
D
D
The additional search fees were accompanied by the applicant's protest and, where applicable, the
payment of a protest fee.
The additional search fees were accompanied by the applicant's protest but the applicable protest
fee was not paid within the time limit specified in the invitation.
No protest accompanied the payment of additional search fees.
Form PCT/ISN21 0 (continuation of first sheet (2)) (April 2005)
International Application No.
FURTHER INFORMATION CONTINUED FROM
PCT/ISAI
PCT/US2009 /040567
210
This International Searching Authority found multiple (groups of)

inventions in this international application, as follows:
1. claims: 1-6 (part), 7-17, 117, 122-166 (part)
compounds wherein Rl is the 1st or the 8th group defined in
claim 1
2. claims: 1-6 (part), 18-29, 118, 119, 123-166 (part)
compounds wherein Rl is the 2nd group defined in claim 1
3. claims: 1-6 (part), 30-42, 120, 121, 123-166 (part)
compounds wherein Rl is the 3rd group defined in claim 1
4. claims: 1-6 (part), 43-49, 122-166 (part)
compounds wherein Rl is the 4th group defined in claim 1
5. claims: 1-6 (part), 50-63, 72-81, 99-103, 110-116, 122-166
(part)
compounds wherein Rl is the 5th, the 7th, the lith or the
13th group defined in claim 1
6. claims: 1-6 (part), 64-71, 82-92, 93-98, 123-166 (part)
compounds wherein Rl is the 6th, the 9th or the lOth group
defined in claim 1
7. claims: claims 1-6 (part), 104-109, 123-166 (part)
compounds wherein Rl is the 12th group defined in claim 1

Information on patent family members
Patent document
cited in search report
wo
Publication
date
2006093801
08-09-2006
us 2004087577
A1
06-05-2004
A1
Form PCT/ISA/210 (palent tam11y annex) (Apnl2005)
19-08-2004
PCT/US2009/040567
Patent family
member(s)
Publication
date
NONE
CN
us
ZA
us 2004162285
NONE
1735612 A
2004097492 A1
200504413 A
15-02-2006
20-05-2004
27-12-2006

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PATENT COOPERATION TREATY

see Form PCT/ISA/220

International filing date (day/month/year)

(Earliest) Priority Date (day/month/year)

Basis of the report

Certain claims were found unsearchable (See Box No. II)

With regard to the title,

Unity of invention is lacking (see Box No Ill)

a translation of the international application into

the international application in the language in which it was filed

the text is approved as submitted by the applicant

With regard to the abstract,

the text is approved as submitted by the applicant

With regard to the drawings,

as suggested by the applicant

none of the figures is to be published with the abstract

Form PCT/ISA/21 0 (first sheet) (April 2007)

INTERNATIONAL SEARCH REPORT

EPO-Internal, WPI Data, BEILSTEIN Data, CHEM ABS Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Citation of document, with indication, where appropriate, of the relevant passages

wo 2006/093801 A (ABBOTT LAB [US])

Relevant to claim No.

page 1' paragraph 1

----us 2004/087577 A1 (PRATT JOHN K [US] ET

page 1' paragraph 2

Further documents are listed in the continuation of Box C.

Special categories of cited documents :

"0" document referring to an oral disclosure, use, exhibition or

European Patent Office, P.B. 5818 Patentlaan 2

See patent family annex.

"T" later document published after the international filing date

Form PCT/ISA/210 (second sheet) (Apnl2005)

INTERNATIONAL SEARCH REPORT

DOCUMENTS CONSIDERED TO BE RELEVANT

Citation of document, with indication, where appropriate, of the relevant passages

Relevant to claim No.

US 2004/162285 A1 (PRATT JOHN K [US] ET

WANG, GUANGYI ET AL: "HCV NS5B polymerase

International application No.

INTERNATIONAL SEARCH REPORT

Box No. Ill

Observations where unity of invention is lacking (Continuation of item 3 of first sheet)

see additional sheet

1-6 (part), 7-17, 117, 122-166 (part)

Form PCT/ISN21 0 (continuation of first sheet (2)) (April 2005)

International Application No.

FURTHER INFORMATION CONTINUED FROM

This International Searching Authority found multiple (groups of)

INTERNATIONAL SEARCH REPORT

Form PCT/ISA/210 (palent tam11y annex) (Apnl2005)

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