CHAPTER 2
DRUG PROFILE
2. DRUG PROFILE
2.1. DRUG PROFILE OF DOMPERIDONE:
DOMPERIDONE31:
Domperidone is a medication developed by Janssen Pharmaceutical that is a
peripheral, specific blocker of dopamine receptors. It is administered orally, rectally,
or intravenously. Domperidone is given in order to relieve nausea and vomiting; to
increase the transit of food through the stomach (as a prokinetic agent through increase
in gastrointestinal peristalsis); and to increase lactation (breast milk production) by
release of prolactin. It is also used in the scientific study of the way dopamine (an
important neurotransmitter) acts in the body.
Structure32:
IUPAC name
: 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-
yl)propyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
Molecular formula
: C22H24ClN5O2
Molecular weight
Official in pharmacopeia :
Solubility
425.9
IP33, BP34, MARTINDALE, MERCK INDEX35
: slightly soluble in water
Sparingly soluble in dimethylformamide
Melting Point
: 242.5 C
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CHAPTER 2
DRUG PROFILE
MODE OF ACTION:
D2 and D3 receptor antagonist
Domperidone is a dopamine antagonist with antiemetic properties.
Domperidone does not readily cross the blood-brain barrier.
It also antagonises the behavioural effects of dopamine much more effectively when
administered intracerebrally than when given systemically.
Domperidone has no effect on gastric secretion.
Uses:
Anti-emetic and Anti-nauseant.
Formulation:
Generic Name
Domperidone
Brand Name
Domstal
Motilium
Molax
Abdopen
Motidon
Company
Torrent Pharmaceuticals
Janssen Pharmaceuticals
Janssen Pharmaceuticals
Health Saver Pharma
Abidi Pharmaceutical Co.
2.2. DRUG PROFILE OF RABEPRAZOLE SODIUM:
RABEPRAZOLE36:
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CHAPTER 2
DRUG PROFILE
Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It was
developed by Eisai Co. and is marketed by Janssen-Cilag as rabeprazole sodium under
the brand names AcipHex in the US, Pariet in Japan and Canada, & Rablet in India.
Structure37
Synonym
IUPAC name
Clofezone
InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-
11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,
(H,20,21)
Molecular formula
: C18H21N3O3S
Molecular weight
Official in pharmacopeia :
Solubility
359.4
IP38, BP, MERCK INDEX
: very soluble in water and methanol
freely soluble in ethanol, chloroform and ethyl acetate
insoluble in ether and n-hexane.
Melting Point
Category
: 140-141 C
: Anti-Ulcer Agents
Enzyme Inhibitors
MODE OF ACTION:
Rabeprazole is a selective and irreversible proton pump inhibitor.
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DRUG PROFILE
Rabeprazole suppresses gastric acid secretion by specific inhibition of the
hydrogen-potassium adenosine triphosphatase (H+, K+-ATPase) enzyme system
found at the secretory surface of parietal cells.
It inhibits the final transport of hydrogen ions (via exchange with potassium ions)
into the gastric lumen.
Since the H+, K +-ATPase enzyme system is regarded as the acid (proton) pump of
the gastric mucosa, rabeprazole is known as a gastric acid pump inhibitor.
diarrhea
Uses:
To treat non-erosive reflux disease (NERD)
To treat gastroesophageal reflux disease (GERD),
To treat duodenal ulcer,
To treat gastric ulcer.
To treat ulcer caused by Helicobacter pylori infection,
To treat Zollinger-Ellison syndrome
Formulation:
Generic Name
Rabeprazole Sodium
Brand Name
Kepreb 20
Elpizole
Rablet
Rabisiv 20
Rabeloc
Company
Kepler Healthcare
Orchid Chemicals &
Pharmaceuticals
Lupin Pharmaceuticals
Saharsh Biologicals
Duta Formulations
Dept. of Pharmaceutical Analysis - CARE COLLEGE OF PHARMACY
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CHAPTER 2
DRUG PROFILE
2.3 COMBINATION:
Use:
Domperidone and Rabeprazole Sodium are used to help reduce the amount of acid
produced by the stomach and it may cause side effects, such as nausea, dizziness and
stomach pain.
2.4. Combination Formulations:
Table:-3
S.no
1.
Brand name
Generic name
Formulatio
Razol-D
n
Domperidone and Tablet
Company
Rabeprazole
2.
Acera
Sodium
Domperidone(SR)
and
3.
Atradom SR
Capsule
IPCA Laboratories
Rabeprazole
Sodium
Domperidone and Tablet
Atlas
Rabeprazole
Pvt. Ltd.
Laboratories
Sodium
4.
Comvine
Domperidone(SR)
and
Rabeprazole
Capsule
Alkem Laboratories
Ltd.
Sodium
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