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UNIVERSITY OF CAMBRIDGE INTERNATIONAL EXAMINATIONS

General Certificate of Education Advanced Level

9700/01

BIOLOGY
Paper 1 Multiple Choice

October/November 2008
1 hour

Additional Materials:

*4805473659*

Multiple Choice Answer Sheet

Soft clean eraser
Soft pencil (type B or HB is recommended)

READ THESE INSTRUCTIONS FIRST

Write in soft pencil.
Do not use staples, paper clips, highlighters, glue or correction fluid.
Write your name, Centre number and candidate number on the Answer Sheet in the spaces provided unless
this has been done for you.
There are forty questions on this paper. Answer all questions. For each question there are four possible
answers A, B, C and D.
Choose the one you consider correct and record your choice in soft pencil on the separate Answer Sheet.
Read the instructions on the Answer Sheet very carefully.
Each correct answer will score one mark. A mark will not be deducted for a wrong answer.
Any rough working should be done in this booklet.

This document consists of 17 printed pages and 3 blank pages.

IB08 11_9700_01/6RP
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1

Which eyepiece and objective lens combination enables you to see the greatest number of cells
in the field of view?
eyepiece

objective

10

10

10

40

10

40

From which cell organelle are nucleic acids absent?

A

chloroplast

Golgi apparatus

mitochondrion

ribosome

Mitochondria are thought to have evolved from prokaryotic cells that were ingested by an
ancestral cell.
Which feature have the prokaryotes lost during their evolution into mitochondria?
A

cell wall

circular chromosome

endoplasmic reticulum

ribosomes

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4

The diagram is a drawing made from an electron micrograph showing a cross-section of an

alveolus and two adjacent capillaries.

alveolar
air space

fibre-secreting
cell

2500

What is the shortest distance travelled by an oxygen molecule diffusing from the alveolar air
space into one of the red blood cells?
A
5

1.0 m

3.0 m

10.0 m

30.0 m

Which combination is found in a prokaryotic cell?

endoplasmic
reticulum

DNA

RNA

nucleus

key

= present

= absent

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6

Which diagram shows part of a structural polysaccharide?

A
..... O

..... O

O .....

O
O

C
..... O

O
O
O

O
O

D
O
7

Which substances contain carbon, hydrogen, oxygen and nitrogen?

1 amylopectin
2 collagen
3 deoxyribonucleic acid
A

2 only

1 and 2 only

2 and 3 only

1, 2 and 3

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O .....

O .....

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8

Sucrose is a disaccharide formed from two hexose sugars, -glucose (alpha-glucose) and
fructose.
Which pair of monosaccharide structures will be formed when sucrose is hydrolysed?

CH2OH

CH2OH
O H

H
A

H
OH
OH
H

H
OH
OH

H
OH
OH
H

O H

H
OH
OH
H

H
OH
OH

CH2OH
O H

H
C

H
OH
OH
H

H
D

H
OH
OH
H

O OH
H
H
OH

H
OH

OH

H
H
OH
OH
H

H
OH
OH

HOCH2 O

CH2OH
OH
OH

H
H

OH
OH

CH2OH

CH2OH

CH2OH
H

O OH

OH

HOCH2 O

CH2OH
OH
OH

H
H
OH

A number of different types of bonds maintain the structure of proteins. These include disulphide,
hydrogen and ionic bonds, as well as hydrophobic interactions. Some of these are stronger than
others.
Which are the strongest?
A

disulphide bonds

hydrogen bonds

hydrophobic interactions

ionic bonds

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10 Haemoglobin is a globular protein consisting of four polypeptide chains 2 alpha chains and 2
beta chains. In normal individuals, in the DNA which codes for each beta chain, the sixth triplet
has a code for glutamic acid.
In individuals with sickle cell anaemia this base triplet changes and codes for valine.
What aspect of the haemoglobin molecule does this mutation change?
A

the iron content

the primary structure

the quaternary structure

the secondary structure

11 Which type of molecule contains disulphide bonds and which contains glycosidic bonds?
disulphide bonds

glycosidic bonds

glycoprotein

polysaccharide

nucleic acid

glycoprotein

polysaccharide

nucleic acid

protein

triglyceride

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12 The rate of an enzyme controlled reaction was measured at temperatures within the range
10 - 60 C.
Which curve represents the most usual relationship between temperature and enzyme activity?

rate of
reaction

rate of
reaction

0
10
60
temperature / C

0
10
60
temperature / C

rate of
reaction

rate of
reaction

0
10
60
temperature / C

0
10
60
temperature / C

13 The water potential of three adjacent plant cells is shown.

X
250 kPa

Y
1000 kPa

Z
4000 kPa

In which direction will water move?

A

from cell X to cell Y and then cell Z only

from cell X to both cells Y and Z

from cell Z to cell Y and then cell X only

from cell Z to both cells Y and X

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14 The table shows three processes that contribute to transport across cell surface membranes.
Which processes are the result of random movement of molecules?
diffusion

endocytosis

osmosis

key

= random

 = non random

15 The epithelial cells of people with cystic fibrosis have a defect in the structure of the cell surface
membrane. The ability of the cell to transport chloride ions out of the cell is affected.
Which membrane component is involved?
A

cholesterol

glycolipid

phospholipid

protein

16 The diagram shows part of the cell surface membrane.

1
2
3
4

5
Which components help to maintain the fluidity of the membrane?
A

1 and 3

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17 Which statement describes events during interphase of the mitotic cell cycle?
A

Chromatids are pulled apart by spindle fibres.

Chromosomes are replicated ready for the next division.

Chromosomes line up on the equator of the spindle.

Chromosomes start to coil, becoming shorter and fatter.

18 Chromosome telomeres promote DNA replication and are not completely replaced during mitosis.
A substance X is known that completely replaces telomeres during mitosis.
What will be the effect of growing a cell culture with and without substance X?
with substance X

without substance X

cells divide continually

cell division eventually slows

and stops

cells divide more rapidly

cells divide continually

cell division eventually slows

and stops

cell division stops immediately

cell division stops immediately

cells divide continually

19 What is a correct description of the centrioles, nuclear envelope and spindle during mitosis in
animal cells?
phase

centrioles

nuclear envelope

spindle

anaphase

replicate

absent

present

metaphase

present

reforms

present

prophase

move apart

breaks up

forms

telophase

replicate

breaks up

breaks up

20 Which diagram shows the bond linking the individual units of a nucleic acid?
A

H
C
C

C
O

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21 What is the function of the enzyme RNA polymerase?
A

to form a polypeptide using mRNA as a template

to form a strand of DNA using mRNA as a template

to form a strand of mRNA using DNA as a template

to form a strand of mRNA using tRNA as a template

22 The table gives the tRNA anticodons for four amino acids.
amino acid

anticodon (tRNA)

asparagine

UUA

glutamic acid

CUU

proline

GGA

threonine

UGG

A cell makes a polypeptide with the amino acid sequence:

glutamic acid asparagine threonine proline
What was the sequence of bases on the strand of the DNA which was complimentary to the
mRNA from which this polypeptide was formed?
A

CTTTTATGGGGA

CUUUUAUGGGGA

GAAAATACCCCT

GAAAAUACCCCU

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23 Four solutions, with different water potentials are listed.
1

endodermal cell solution

root hair cell solution

soil water solution

solution in a xylem vessel

Which list has the solutions in order from the highest (least negative) water potential to the lowest
(most negative) water potential?
highest

lowest

24 Which feature of a root hair cell is not an adaptation for water uptake from the soil solution?
A

lack of a waxy cuticle

large numbers of mitochondria

long, thin extension to the cell

thin cellulose cell wall

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25 The diagram shows a model to demonstrate the mass-flow hypothesis of translocation.

concentrated
sucrose solution

water
dilute sucrose solution
partially permeable
membrane

partially permeable
membrane

In a plant, what are the structures W, X, Y and Z and what is the direction of flow of solution along
W?
phloem

xylem

roots

leaves

direction of flow along W

From Z to Y

From Y to Z

From Y to Z

From Z to Y

26 The graph shows the dissociation curves for adult haemoglobin at two different (unidentified)
concentrations of carbon dioxide.
Which point represents the oxygen concentration in red cells as they leave a resting muscle?

100

% saturation
of haemoglobin
with oxygen

75

50

B
D

25
C
0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
partial pressure of O2 / kPa

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27 Which chamber of the heart shows the greatest pressure changes during one cardiac cycle?
A

left atrium

left ventricle

right atrium

right ventricle

28 What happens to the blood flow in the cardiac cycle?

A

Blood flows into the aorta through the semilunar valve due to contraction of the right
ventricle.

Blood flows into the left atrium through the pulmonary artery when the walls of the left atrium
relax.

Blood flows into the right atrium through the vena cava when the walls of the right atrium
relax.

Blood flows into the right ventricle through the semilunar valve when the walls of the right
atrium contract.

29 The squamous epithelial cells of the alveoli form part of the gas exchange system.
How do these cells assist gas exchange?
1

They contain many mitochondria.

They have a large surface area.

They provide a short diffusion path.

1 and 2 only

1 and 3 only

2 and 3 only

1, 2 and 3

30 Which statements are correct effects of tar in tobacco smoke on the human gas exchange
system?
goblet cells are
stimulated to
secrete more mucus

mucus glands in
the trachea are
enlarged

mutations may occur

in epithelial cells
forming tumors

the activity of cilia

in the airays is
inhibited

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31 The diagram shows a record of a persons breathing. The person breathed normally at the start,
breathed in as deeply as possible and then breathed out as much as possible.
start

1 dm3

30 seconds
What is a valid conclusion from the graph?
A

The person breathed in 1000 cm3 during the first 50 seconds.

The person was carrying out strenuous exercise for the first 30 seconds.

The rate of breathing for the first 30 seconds was 18 breaths per minute.

The tidal volume was 500 cm3, the vital capacity was 3750 cm3.

32 Ciliated, goblet and squamous epithelial cells are found in various parts of the human lung and
associated structures.
Where are these cells located?
ciliated

goblet

squamous
epithelial

bronchiole

trachea

alveolus

bronchus

bronchiole

pulmonary vein

trachea

pulmonary vein

alveolus

trachea

bronchus

bronchiole

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33 Some antibiotics are used in animal feed to reduce disease.
What explains why these antibiotics should not be used in the treatment of human diseases?
A

Humans may be allergic to these antibiotics.

Human cells may stop responding to these antibiotics.

Pathogenic bacteria may develop resistance to these antibiotics.

Useful gut bacteria may be killed by these antibiotics.

34 Some children are born with Severe Combined Immune Deficiency (SCID). These children do not
normally have any T-lymphocytes and suffer from many diseases.
How can these children be cured?
A

bone marrow transplantation

continual use of antibiotics

transfusion of antibodies

vaccination against all diseases

35 The diagram represents the structure of a molecule of antibody.

Y
Z
X

Which arrangement of labels X, Y and Z correctly identifies its different parts?

X

antigen binding site

constant region

variable region

constant region

antigen binding site

variable region

constant region

variable region

antigen binding site

variable region

antigen binding site

constant region

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36 Which of the following are increasing the spread of malaria?
1

continued migration of people due to war and civil unrest

increasing carbon dioxide levels causing global warming

increasing resistance to antibiotics and other drugs

1 and 2 only

1 and 3 only

2 and 3 only

1, 2 and 3

37 Which examples show the different types of immunity?

active artificial

passive natural

immunity to measles after infection

receiving antibodies to measles in

colostrum

immunity to measles after infection

receiving antibodies to tetanus by

injection

immunity to smallpox after vaccination

receiving antibodies to measles in

colostrum

immunity to smallpox after vaccination

receiving antibodies to tetanus by

injection

38 The diagram shows a simplified nitrogen cycle.

During which stage does nitrification take place?

nitrogen in
atmosphere
A
plant
proteins

animal
proteins

D
death and
decay

ammonium
compounds
nitrites
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nitrates

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39 Grasshoppers eat only the leaves of grass. Grasshoppers are eaten by carnivorous beetles.
What does this description of grasshoppers give us sufficient information to define?
1

habitat

niche

trophic level

2 only

3 only

2 and 3 only

1, 2 and 3

40 Of the prey consumed by the lion, into which box does the largest amount of energy go?

B
energy used in growth,
repair and reproduction
A
energy lost
in urine

C
energy lost as
heat from
respiration

energy
assimilated
energy
consumed
energy
consumed

energy lost
in faeces
D

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University of Cambridge International Examinations is part of the Cambridge Assessment Group. Cambridge Assessment is the brand name of University of
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