Helicobacter Pylori
Helicobacter Pylori
Helicobacter Pylori
Introduction
Helicobacter pylori is the etiologic
agent of chronic active gastritis, gastric and
duodenal ulcers, also being involved in the
development of gastric cancer and MALT
lymphomas (Blaser and Berg, 2001). It was
recently included by OMS as a first degree
carcinogen, because its involvement in
atrophic gastritis with intestinal metaplasia
(considered
premalignant
lesions)
development (Graham, 2000]. Atrophic
chronic gastritis is associated with an
increased risk of developing intestinal type
gastric cancer; the most frequently met is
multifocal atrophic gastritis, usually
determined by Helicobacter pylori infection
and which is associated with intestinal
metaplasia. The highest risk of gastric
cancer development is associated with
incomplete type intestinal metaplasia (type
III) (Uemura et al, 2001).This paper tries to
review some of pathological particularities
Annals of RSCB
Conclusions
Gastric cancer can develop both in
infected with Helicobacter pylori and non
infected persons. Those with histological
findings of severe gastric atrophy,
predominantly in gastric corpus or intestinal
metaplasia
are
at
increased
risk.
Persons with Helicobacter pylori
infection, nonulcer dyspepsia, gastric ulcers
have an increased risk of developing gastric
cancer compared to those with duodenal
ulcers.
References
Blaser, M.J., and Berg, D.E. Helicobacter pylori
genetic diversity and risk of human disease. J
Clin. Invest, 107, 767-773, 2001
213
Annals of RSCB
214