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    Methyldopa Drug Study

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    milkv
    Baby Vellita is a 20 year old female admitted to the hospital on April 28, 2015 for severe preeclampsia at 31 weeks gestation. She is 5'2" tall and weighs 60kg. Her diagnosis is G1P1 PU 31 wks. AOG/LMP cephalic, IPTL, severe preeclampsia with pulmonary congestion. She is prescribed 250mg of Methyldopa three times daily to treat her pregnancy-induced hypertension. Methyldopa works by stimulating alpha-2 receptors in the central nervous system to lower blood pressure by decreasing sympathetic outflow. Nurses must carefully monitor the patient for any signs of adverse effects like hematologic issues, hepatic problems, or

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    Methyldopa Drug Study

    Uploaded by

    milkv
    13K views2 pages
    Baby Vellita is a 20 year old female admitted to the hospital on April 28, 2015 for severe preeclampsia at 31 weeks gestation. She is 5'2" tall and weighs 60kg. Her diagnosis is G1P1 PU 31 wks. AOG/LMP cephalic, IPTL, severe preeclampsia with pulmonary congestion. She is prescribed 250mg of Methyldopa three times daily to treat her pregnancy-induced hypertension. Methyldopa works by stimulating alpha-2 receptors in the central nervous system to lower blood pressure by decreasing sympathetic outflow. Nurses must carefully monitor the patient for any signs of adverse effects like hematologic issues, hepatic problems, or

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    a drug study about methyldopa

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    Baby Vellita is a 20 year old female admitted to the hospital on April 28, 2015 for severe preeclampsia at 31 weeks gestation. She is 5'2" tall and weighs 60kg. Her diagnosis is G1P1 PU 31 wks. AOG/LMP cephalic, IPTL, severe preeclampsia with pulmonary congestion. She is prescribed 250mg of Methyldopa three times daily to treat her pregnancy-induced hypertension. Methyldopa works by stimulating alpha-2 receptors in the central nervous system to lower blood pressure by decreasing sympathetic outflow. Nurses must carefully monitor the patient for any signs of adverse effects like hematologic issues, hepatic problems, or

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    13K views2 pages

    Methyldopa Drug Study

    Uploaded by

    milkv
    Baby Vellita is a 20 year old female admitted to the hospital on April 28, 2015 for severe preeclampsia at 31 weeks gestation. She is 5'2" tall and weighs 60kg. Her diagnosis is G1P1 PU 31 wks. AOG/LMP cephalic, IPTL, severe preeclampsia with pulmonary congestion. She is prescribed 250mg of Methyldopa three times daily to treat her pregnancy-induced hypertension. Methyldopa works by stimulating alpha-2 receptors in the central nervous system to lower blood pressure by decreasing sympathetic outflow. Nurses must carefully monitor the patient for any signs of adverse effects like hematologic issues, hepatic problems, or

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    Name of Patient

    Baby Vellita

    Age

    20 y.o

    Height

    52

    Diagnosis

    G1P1 PU 31 wks. AOG/LMP cephalic, IPTL, severe


    preeclampsia with pulmonary congestion

    Sex

    Female

    Weight

    60 kg

    Date of Admission

    April 28, 2015

    Body
    Build

    endomorph

    Doctor
    Dr. Karen Kris Balbosa, MD

    DRUG DATA
    Generic name:
    Methyldopa

    CLASSIFICATION
    Pharmacologic:
    Sympatholytic
    (centrally acting)

    Trade name/s:
    Methyldopa
    Patients dose:
    250mg 1tab TID

    Therapeutic:
    Antihypertensive

    MECHANISM OF
    ACTION

    Mechanism of action
    not conclusively
    demonsrated;
    probably due to drugs
    metabolism, which
    lowers arterial BP by
    stimulating the alpha2adrenergic receptors,
    which in turn
    decreases
    sympathetic outflow
    from the CNS

    Maximum dose:
    500mg/day in
    divided doses

    INDICATIONS

    General:
    > hypertension
    > IV
    methyldopate:
    acute
    hypertensive
    crisis; not drug of
    choice because
    slow onset of
    action
    > unlabeled use:
    hypertension of
    pregnancy

    Pregnancy Category
    Risk: B
    Minimum dose:
    250mg

    Onset: varies
    Peak: 2-4 hr

    Availability:
    Tablets 250,
    500mg; Injection
    50mg/ml

    Duration: 12-24 hr
    Metabolism: hepatic;
    1-8 hr

    Patients actual
    indication:
    Methyldopa is
    given to patient to
    treat pregnancyincduced
    hypertension

    Distribution: crosses
    placenta, enters
    breast milk
    Route:
    PO

    Source: 2011
    Lippincotts NDG

    Excretion: urine

    Source: 2011
    Lippincotts NDG

    Source: 2011
    Lippincotts NDG

    Source: 2011
    Lippincotts NDG

    CONTRAINDICATI
    ON

    Contraindicated with
    hypersensitivity to
    methyldopa, active
    hepatic disease,
    previous methyldopa
    therapy associated with
    liver disorders.

    Precaution:
    Use cautiously with
    previous liver disease,
    renal failure, dialysis,
    bilateral cerebrovascular
    disease; pregnancy,
    lactation

    ADVERSE
    EFFECTS

    CNS: sedation,
    headache,
    asthenia,
    weakness
    CV: bardycardia,
    myocarditis
    Dermatologic: rash
    seen as eczema or
    lichenoid eruption,
    toxic epidermal
    necrolysis fever
    Endocrine: breast
    enlargement,
    gynceomastia,
    lactation

    Interactions:
    > drug-drug: potentiation
    of the pressor effects of
    sympathomimetic
    amines; increased
    hypotension with
    levodopa, risk of
    hypotension during
    surgery with central
    anesthetics
    > drug-lab test:
    methyldopa may
    interfere with tests for
    urinary uric acid, serum
    creatinine, AST, urinary
    catecholamines

    GI: nausea,
    vomiting,
    distention,
    constipation,
    hepatic necrosis

    Source: 2011
    Lippincotts NDG

    Source: 2011
    Lippincotts NDG

    Hematologic:
    positive Coombs
    test, hemolytic
    anemia, bone
    marrow
    depression
    Other: nasal
    stuffiness, mild
    arthralgia, myalgia,
    septic shock-like
    symptoms

    NURSING
    RESPONSIBILITIE
    S

    Before:
    > check doctors order
    > assess sensitivity to methyldopa,
    hepatic disease, renal failure, dialysis
    > assess weight, skin color, lesions,
    mucous membrane color, lesions,
    orientation, affect
    > educate client about the drug, its
    purpose and importance
    During:
    > check the label twice
    > administer at the right dose and in
    the right time
    > do not crush nor chew tablets,
    swallow whole
    > discontinue drug if fever,
    abnormalities in liver function tests, or
    jaundice occurs
    > discontinue drug if Coombspositive hemolytic anemia occurs
    After:
    > monitor blood counts periodically to
    detect haemolytic anemia
    > monitor hepatic function, especially
    in the first 6-8 wk of therapy or if
    unexplained fever appears
    > ensure that methyldopa is not
    reinstated in such patients
    > report unexplained, prolonged
    general tiredness; yellowing of the
    skin or eyes; fever; bruising; rash.
    > document and record.

    Source: 2011 Lippincotts Nursing


    Drug Guide

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