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    Deoxofluor

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    leda_prandi
    Deoxo-Fluor is a versatile fluorinating reagent that rapidly converts alcohols, aldehydes, and ketones to the corresponding fluorinated compounds under mild conditions with efficiency and selectivity. It is packaged for R&D and commercial use and technical assistance is available. The reagent is a dark yellow liquid that is more thermally stable than traditional reagents and reacts violently with water.

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    Deoxofluor

    Uploaded by

    leda_prandi
    161 views2 pages
    Deoxo-Fluor is a versatile fluorinating reagent that rapidly converts alcohols, aldehydes, and ketones to the corresponding fluorinated compounds under mild conditions with efficiency and selectivity. It is packaged for R&D and commercial use and technical assistance is available. The reagent is a dark yellow liquid that is more thermally stable than traditional reagents and reacts violently with water.

    Original Description:

    chemistry fluororation

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    Deoxo-Fluor is a versatile fluorinating reagent that rapidly converts alcohols, aldehydes, and ketones to the corresponding fluorinated compounds under mild conditions with efficiency and selectivity. It is packaged for R&D and commercial use and technical assistance is available. The reagent is a dark yellow liquid that is more thermally stable than traditional reagents and reacts violently with water.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    161 views2 pages

    Deoxofluor

    Uploaded by

    leda_prandi
    Deoxo-Fluor is a versatile fluorinating reagent that rapidly converts alcohols, aldehydes, and ketones to the corresponding fluorinated compounds under mild conditions with efficiency and selectivity. It is packaged for R&D and commercial use and technical assistance is available. The reagent is a dark yellow liquid that is more thermally stable than traditional reagents and reacts violently with water.

    Copyright:

    © All Rights Reserved
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    of 2

    Deoxo-Fluor FLUORINATING REAGENT

    Deoxo-Fluor is a versatile, easy-to-use, nucleophilic fluorinating reagent with enhanced safety


    features. It rapidly deoxofluorinates a wide variety
    of alcohols, aldehydes and ketones under mild conditions to yield the corresponding fluorinated compounds with efficiency and selectivity. Deoxo-Fluor
    reagent is thermally less sensitive than DAST, the
    traditional deoxofluorinating agent, and is thus more
    amenable to large-scale use (see Summary of Applications
    and Thermal Stability Data).
    Deoxo-Fluor reagent is packaged in convenient
    quantities for R&D evaluation and commercial manufacturing.Technical assistance is available to provide a solution to your fluorination challenge. Call 800-233-4334
    to review your process with our fluorination experts.

    Chemical Properties
    Reactivity:

    Alcohols, aldehydes and ketones;


    reacts violently with H2O to form HF

    Activity for C-OH:

    85.9 g of active F/Kg or 4.5 mmol


    of F/g of Deoxo-Fluor reagent

    Activity for C-O:

    171.8 g of F/Kg or 9.0 mmol of F/g


    of Deoxo-Fluor reagent

    Purity:

    >95% F-Active

    Solubility:

    Hexane, ethers, halogenated


    organics, toluene and other
    organic solvents

    Compatibility:

    Stainless steel, Hastelloy,


    Monel, PTFE; HDPE;
    glass not recommended

    Stability:

    Stable at room temperature in the


    absence of moisture

    Decomposition:

    >95C by ARC

    Physical Properties
    Molecular Formula:

    C6H14F3NO2S

    Molecular Weight:

    221.23 g/mol

    Appearance:

    Dark yellow liquid at room


    temperature

    Melting Point:

    Not determined

    Storage: For long-term storage, refrigerate and


    store under nitrogen

    Boiling Point:

    Dec.

    Handling: Work in an inert, anhydrous atmosphere

    Flash Point:

    No flash observed up to 100C

    Precautions: Harmful if swallowed, inhaled or


    absorbed through the skin

    Density:

    1.2 g/mL

    Safety Precautions

    First Aid Measures: Flush eyes and skin with copious


    amounts of water for at least 15 minutes. Contact
    a physician.

    Summary of Fluorination Applications of Deoxo-Fluor Reagent

    Thermal Stability of Deoxo-Fluor Reagent vs Other Reagent

    References
    1.
    2.
    3.
    4.
    5.

    G. S. Lal, G.P. Pez, R.J. Pesaresi and F.M. Prozonic, Chem. Comm., 1999, 215
    G. S. Lal, G.P. Pez, R.J. Pesaresi, F.M. Prozonic and H. Cheng, J. Org. Chem., 1999, 64, 7048
    G. S. Lal, E. Lobach and A. Evans, J. Org. Chem., 2000, 65, 4830
    R. P. Singh, B. Twamley and J. M. Shreeve, J. Org. Chem., 2002, 67, 1918
    For a comprehensive review, see R. P. Singh and J. M. Shreeve, Synthesis, 2002, 2561.

    Deoxo-Fluor is a trademark of Air Products and Chemicals, Inc. Additionally, as such, it is covered by a composition of matter patent.
    Hastelloy is a registered trademark of Haynes International Incorporated.
    Monel is a registered trademark of Special Metals Corporation.

    For product information, contact us at: 800-233-4334

    6141 Easton Road Bldg. #3 P.O. Box 310


    Plumsteadville, PA 18949

    Helping You Achieve Breakthrough Success


    www.scottgas.com
    Tel: (215) 766-8861
    Fax: (215) 766-7250
    AP-001
    2005 Scott Medical Gases. All Rights Reserved 9/05 3.5M CW

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