Peripheral Artery Disease

Peripheral Artery
Disease Legs
Peripheral artery disease is a condition
of the blood vessels that leads to
narrowing and hardening of the
arteries that supply the legs and feet.
The narrowing of the blood vessels leads
to decreased blood flow, which can
injure nerves and other tissues.
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Back to TopAlternative
Names
Peripheral vascular disease; PVD; PAD;

Arteriosclerosis obliterans; Blockage of leg
arteries; Claudication; Intermittent claudication;
Vaso-occlusive disease of the legs; Arterial

insufficiency of the legs; Recurrent leg pain and
cramping; Calf pain with exercise
Back to TopCauses
Peripheral artery disease is caused

by arteriosclerosis, or "hardening of the arteries."
This problem occurs when fatty material (plaque)
builds up on the walls of your arteries. This causes
the arteries to become narrower. The walls of the
arteries also become stiffer and cannot widen
(dilate) to allow greater blood flow when needed.
As a result, when the muscles of your legs are

working harder (such as during exercise or
walking) they cannot get enough blood and
oxygen. Eventually, there may not be enough blood
and oxygen, even when the muscles are resting.
Peripheral artery disease is a common disorder

that usually affects men over age 50. People are at
higher risk if they have a history of:
Abnormal cholesterol
Diabetes
Heart disease (coronary artery disease)
High blood pressure (hypertension)
Kidney disease involving hemodialysis
Smoking
Stroke (cerebrovascular disease)
Back to TopSymptoms
The classic symptoms are pain, achiness, fatigue,

burning, or discomfort in the muscles of your feet,
calves, or thighs. These symptoms usually appear
during walking or exercise and go away after
several minutes of rest.
At first, these symptoms may appear only

when you walk uphill, walk faster, or walk for
longer distances.
Slowly, these symptoms come on more quickly

and with less exercise.
Your legs or feet may feel numb when you are

at rest. The legs also may feel cool to the touch,
and the skin may look pale.
When peripheral artery disease becomes severe,
you may have:
Impotence
Pain and cramps at night
Pain or tingling in the feet or toes, which can
be so severe that even the weight of clothes or bed
sheets is painful
Pain that is worse when you raise the leg and

improves when you dangle your legs over the side
of the bed
Skin that looks dark and blue
Sores that do not heal

In-Depth Symptoms
Back to TopExams
and Tests
During an examination, the health care provider

may find:
A whooshing sound with the stethoscope over

the artery (arterial bruits)
Decreased blood pressure in the affected limb
Loss of hair on the legs or feet
Weak or absent pulses in the limb

When PAD is more severe, findings may include:
Calf muscles that shrink (wither or atrophy)

Hair loss over the toes and feet
Painful, non-bleeding sores on the feet or toes
(usually black) that are slow to heal
Paleness of the skin or blue color in the toes or

foot (cyanosis)
Shiny, tight skin

Thick toenails
Blood tests may show high cholesterol or diabetes.
Tests for peripheral artery disease:
Angiography of the arteries in the legs

(arteriography)
Blood pressure measured in the arms and legs

for comparison (ankle/brachial index, or ABI)
Doppler ultrasound exam of an extremity
Magnetic resonance angiography or CT

angiography
In-Depth Diagnosis
Back to TopTreatment
Balance exercise with rest. Walk or do another

activity to the point of pain and alternate it with
rest periods. Over time, your circulation may
improve as new, small (collateral) blood vessels
form. Always talk to the doctor before starting an
exercise program.
Stop smoking. Smoking narrows the arteries,

decreases the blood's ability to carry oxygen, and
increases the risk of forming clots (thrombi and
emboli).
Take care of your feet, especially if you also

have diabetes. Wear shoes that fit properly. Pay
attention to any cuts, scrapes, or injuries, and see
your doctor right away. Tissues heal slowly and are
more likely to get infected when there is decreased

circulation.
Make sure your blood pressure is well
controlled.
Reduce your weight, if you are overweight.
If your cholesterol is high, eat a lowcholesterol and low-fat diet.
Monitor your blood sugar levels if you have
diabetes, and keep them under control.
Medications may be needed to control the
disorder, including:
Aspirin or a medicine called clopidogrel

(Plavix), which keeps your blood from forming
clots in your arteries. Do NOT stop taking these
medications without first talking with your doctor.
Cilostazol, a medication to enlarge (dilate) the

affected artery or arteries for moderate-to-severe
cases that are not candidates for surgery
Medicine to help lower your cholesterol
Pain relievers
If you are taking medicines for high blood pressure
or diabetes, take them as your doctor has
prescribed.
Surgery may be performed if the condition is
severe and is affecting your ability to work or do
important activities, or you are having pain at rest.
Options are:
Angioplasty and stent placement of the

peripheral arteries (this is similar to the technique
used to open the coronary arteries, but it is
performed on the blood vessels of the affected leg)
Peripheral artery bypass surgery of the leg

Some people with peripheral artery disease may
need to have the limb removed (amputated).
In-Depth Treatment
Back to TopOutlook
(Prognosis)
You can usually control peripheral artery disease

of the legs without surgery. Surgery provides good
symptom relief in severe cases.
For complications, the affected leg or foot may
need to be amputated.
Back to TopPossible
Complications
Blood clots or emboli that block off small

arteries
Coronary artery disease
Impotence
Open sores (ischemic ulcers) on the lower legs
Tissue death (gangrene) -- see gas gangrene
Back to TopWhen
to Contact a Medical
Professional
Call your health care provider if you have:
A leg or foot that becomes cool to the touch,

pale, blue, or numb
Chest pain or shortness of breath with leg pain
Leg pain that does not go away, even when you
are not walking or moving (called rest pain)
Legs that are red, hot, or swollen
New sores/ulcers
Signs of infection (fever, redness, general ill
feeling)
Symptoms of arteriosclerosis of the extremities

Peripheral Artery Disease

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What are some risk factors for peripheral artery disease?

What are some risk factors for peripheral artery disease?

What are some common symptoms of peripheral artery disease?

What are some common symptoms of peripheral artery disease?

Peripheral Artery

Medicare Payments Surge for Stents to

Peripheral vascular disease; PVD; PAD;

Vaso-occlusive disease of the legs; Arterial

Peripheral artery disease is caused

As a result, when the muscles of your legs are

Peripheral artery disease is a common disorder

The classic symptoms are pain, achiness, fatigue,

At first, these symptoms may appear only

Slowly, these symptoms come on more quickly

Your legs or feet may feel numb when you are

Pain that is worse when you raise the leg and

Skin that looks dark and blue

Sores that do not heal

During an examination, the health care provider

A whooshing sound with the stethoscope over

Decreased blood pressure in the affected limb

Loss of hair on the legs or feet

Weak or absent pulses in the limb

Calf muscles that shrink (wither or atrophy)

Paleness of the skin or blue color in the toes or

Shiny, tight skin

Angiography of the arteries in the legs

Blood pressure measured in the arms and legs

Doppler ultrasound exam of an extremity

Magnetic resonance angiography or CT

Balance exercise with rest. Walk or do another

Stop smoking. Smoking narrows the arteries,

Take care of your feet, especially if you also

more likely to get infected when there is decreased

Aspirin or a medicine called clopidogrel

Cilostazol, a medication to enlarge (dilate) the

Medicine to help lower your cholesterol

Angioplasty and stent placement of the

Peripheral artery bypass surgery of the leg

You can usually control peripheral artery disease

Blood clots or emboli that block off small

A leg or foot that becomes cool to the touch,

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