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Rodica 2007

This study analyzed neonatal brain samples post-mortem to identify particular morphopathological aspects of cerebral hemorrhage. Immunohistochemistry revealed astrocyte activation, increased microglial cells, and neuronal death in brain samples from 2002-2007. Macroscopically, samples often showed cortical infarcts, multifocal white matter hemorrhagic infarcts, choroid plexus hemorrhage, and intraventricular hemorrhage. Few studies provide detailed pathological findings in neonatal brains related to signs of birth asphyxia. This study aims to investigate specific markers of neural injuries in neonates and correlate them with features of birth asphyxia.

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83 views1 page

Rodica 2007

This study analyzed neonatal brain samples post-mortem to identify particular morphopathological aspects of cerebral hemorrhage. Immunohistochemistry revealed astrocyte activation, increased microglial cells, and neuronal death in brain samples from 2002-2007. Macroscopically, samples often showed cortical infarcts, multifocal white matter hemorrhagic infarcts, choroid plexus hemorrhage, and intraventricular hemorrhage. Few studies provide detailed pathological findings in neonatal brains related to signs of birth asphyxia. This study aims to investigate specific markers of neural injuries in neonates and correlate them with features of birth asphyxia.

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Anonymous eson90
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PARTICULAR MORPHOPATHOLOGICAL ASPECTS

OF THE NEWNEW-BORN'S CEREBRAL HEMORRHAGE


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It occurs in hypoxic-ischemic complex brain injuries and not as an obstetric


mismanagement of term birth anoxia.
We consider that most cases of neonatal hypoxic-ischemic encephalopathy have
antenatal insults, difficult to pinpoint. We already can be sure about a great
number of vasculopathy alteration, such as :
[changes in the blood flow direction in circle of Willis;
[ decreased blood-flow velocity in the veins;
[changes in the flow of the riht vertebral artery, with isolated hemorrhagic
lesions;
[neonatal thrombotic vessels;
[vessels occlusion by an embolus with obstruction of the middle cerebral
artery.

This study pinpoint that the u u  


 u u 
    , to a important cohort of neonatal death, especially
premature.

STUDY
YEARS

PREMATURES

2002

(from all newborns)

|&*/ ,

AGE AT DEATH (days)

|&*/ ,

1 -7

8 -14

15 - 21

22 - 30

16

19

2003

22

21

2005

19

14

2006

15

16

2007

12

12

105

106

28

14

TOTAL

 

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( ()*(&*( +* |* ( |*,('&'*-|',-*|*|(* ||()*


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a 
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,
 0  %
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 %
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0%  0  0
 %

 
 ("
"2
  .3 %"" 
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  " .4.5   0
   6. 7
89
 % 


"" -   
 :

42 ;
* 6*9 "  




|(' 

YEAR

'|& '

ASTROCITE
intens

absence

MICROGLIAL
CELLS
intens

H&E

2/2002

GFAP

4/2003

Prot.
S -100

4/2005

CD68

10/2006

Vim
(entin)

11/2007

TOTAL

31

intens

ASTROCITE
intens

intens

 

NEURONAL
DEATH
intens

absence

+
|&*/ ,

 

+
+

|&*/ ,

+
+

absence

+
+

absence

MICROGLIAL
CELLS

+
+

absence

+
+

absence

NEURONAL
DEATH

+
3

Immunohistochemistry

( . 4  ',(*')+|

 0
     
*$ &
  84 | (

 
  " 
 : 0  "  &
8
& 4
8   

4
% 0 0 >

|('('&|&*/ ,

o  

%%
4)(+
6&
84
) & 4
89
o 
4,4?? 6&
8
4
  '1@ 
4
49
o  

4&A5 6&
8
)4 9 
o  



!  6&
8   $B9
 
!    
 
 " ,( 0
 ! 

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'ABB9

|(' 

CHOROID PLEXUS AND


EPENDIMA

BRAIN SAMPLES

STUDY

MARKER
CASES/
USED

MACROSCOPIC LESIONS AT AUTOPSIES


STUDY
YEARS

(
. 
',(*')+||('('&|&*/
,
Cortical
infarcts
Multifocal
Choroid plexus Germinal matrix

and petechial
white-matter
hemorrhage

hemorrhagic
white-matter
infarcts

and
subependymal
thrombosis

and
intraventricular
hemorrhage

2002

14

15

12

2003

17

18

15

2005

16

14

2006

15

16

11

2007

10

10

91

38

86

78

|('  


|(' 

TOTAL
(  PARTICULAR

MACROSCOPICAL ASPECTS OF NEONATAL CEREBROVASCULAR


INJURIES THEY ARE OFTEN ASSOCIATED AND VARIABLE

DISCUSSION
$  "0 
  
  
 
 "    

 %
  0 
 
 
  
 

 %


 
 0  
     " % 
2
       0    2
 0
   


2
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 %
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   !
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8  "  
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6    "     "  %   !
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    %
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  " % 
2




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% 

 %
   !   
         
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%  " 

  
 " 2
=


   
 


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