Liver Abscesses and Cysts
Liver Abscesses and Cysts
Liver Abscesses and Cysts
Cysts
Liver cysts
Avoid percutaneous aspiration in the investigation of hepatic cysts and abscesses.
Evaluation of simple cyst fluid is non-diagnostic. There is also a small risk of inducing
anaphylaxis due to leakage from the hydatid cyst, or of causing abscess formation in
a previously sterile cyst.[1]
Epidemiology
Hepatic cysts are usually asymptomatic and are often found incidentally. Therefore, it
is difficult to predict the exact prevalence. It is estimated that about 5% of the
population have hepatic cysts.[1]
Cystic
Other cysts can occur in the liver region but these are separated from hepatic cysts
because they involve the bile ducts. They include:
Ductal cysts.
Choledochal cysts: a congenital dilatation of part or whole of the common bile
duct. See separate article entitled Choledochal Cysts.
Presentation: they are usually asymptomatic; they can cause right upper
quadrant pain and bloating symptoms if large. If very large, they may be
palpable abdominally. Rupture, torsion and jaundice caused by bile duct
obstruction are rare.
Treatment: this is only needed if symptoms occur. 'Deroofing' of the cyst can
be performed laparoscopically, excising the portion of the wall that extends to
the surface of the liver so that cystic fluid can drain into the peritoneal cavity. [3]
Prognosis: deroofing results in a cure rate of 90%.
Neoplastic cysts
Cystadenomas and cystadenocarcinomas are rare. Cystadenoma is the premalignant
lesion.
Liver abscesses[9]
Liver abscesses are caused by bacterial, parasitic, or fungal organisms. In developed
countries, pyogenic abscesses are the most common but worldwide, amoebae are
the most common cause.[10]
Epidemiology
A retrospective study over a 10-year period of patients >16 years old admitted to
the Royal Hallamshire Hospital in Sheffield with a diagnosis of liver abscess found 4
patients with amoebic liver abscesses and 65 with pyogenic liver abscesses. They
estimated an annual incidence for liver abscesses of 2.3 per 100,000 people per year
in the UK.[11] In children, liver abscess is rare except in underdeveloped countries
where the incidence remains high, mainly due to Staphylococcus aureus infection.[12]
Aetiology
This can be single or multiple. The right lobe is affected twice as often
as the left; 5% have bilateral involvement.[9]
Presentation
Multiple abscesses tend to present more acutely and single ones more
indolently.
Right upper quadrant pain, tenderness, hepatomegaly, possible palpable
mass.
Swinging fever.
Night sweats.
Nausea and vomiting.
Anorexia and weight loss.
Cough and dyspnoea due to diaphragmatic irritation.
Referred pain to the right shoulder.
Jaundice (in 25% of cases, more common with disease of the biliary tree and
multiple abscesses).[9]
Pyogenic liver abscesses can present as pyrexia of unknown origin (PUO) in
some people who may not have right upper quadrant pain; pain is a prominent
feature in amoebic liver abscess
Check history for travel to an E. histolytica endemic area.
Differential diagnosis
Causes of PUO).
Metastatic malignancy affecting the liver.
Hepatocellular carcinoma.
Biliary disease including cholecystitis.
Bacterial pneumonia.
Gastritis.
Investigations
Treatment
Antibiotics:
Most patients with pyogenic liver abscess and those with very large
amoebic abscesses, may not recover with antibiotics alone and need
drainage guided by ultrasonography or CT.
Open surgery may be necessary if the abscess has ruptured and there
are signs of peritonitis, if the abscess is larger than 5 cm or multiloculated,
or if there is a known abdominal pathology such as appendicitis.
Supportive measures:
Fluids
Nutrition
Pain relief
Complications
Overwhelming sepsis.
Prognosis
In the Hallamshire series, described under Epidemiology above, mortality rate was
12.3%.[11]
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