Harmacotherapy Rinciples Ractice

PHARMACOTHERAPY
PRINCIPLES & PRACTICE

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NOTICE
Medicine is an ever-changing science. As new research and clinical experience broaden our knowledge,
changes in treatment and drug therapy are required. The authors and the publisher of this work have checked
with sources believed to be reliable in their efforts to provide information that is complete and generally
in accord with the standards accepted at the time of publication. However, in view of the possibility of human
error or changes in medical sciences, neither the editors nor the publisher nor any other party who has been
involved in the preparation or publication of this work warrants that the information contained herein is
in every respect accurate or complete, and they disclaim all responsibility for any errors or omissions or for
the results obtained from use of the information contained in this work. Readers are encouraged to conrm
the information contained herein with other sources. For example and in particular, readers are advised to
check the product information sheet included in the package of each drug they plan to administer to be
certain that the information contained in this work is accurate and that changes have not been made in the
recommended dose or in the contraindications for administration. This recommendation is of particular
importance in connection with new or infrequently used drugs.
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PHARMACOTHERAPY
PRINCIPLES & PRACTICE
EDITORS
MARIE A. CHISHOLM-BURNS, PHARMD, FCCP, FASHP
Professor and Head
Department of Pharmacy Practice and Science
The University of Arizona College of Pharmacy
Tucson, Arizona
BARBARA G. WELLS, PHARMD, FASHP, FCCP, BCPP
Professor and Dean
School of Pharmacy
The University of Mississippi
University, Mississippi
TERRY L. SCHWINGHAMMER, PHARMD, FCCP, FASHP,
BCPS
Professor and Chair of Clinical Pharmacy
School of Pharmacy
West Virginia University
Morgantown, West Virginia
PATRICK M. MALONE, PHARMD, FASHP
Assistant Dean and Professor of Pharmacy Practice
School of Pharmacy
University of Findlay
Findlay, Ohio
JILL M. KOLESAR, PHARMD, BCPS
Associate Professor
University of Wisconsin School of Pharmacy
Faculty Supervisor
Analytical Instrumentation Laboratory
Madison, Wisconsin
JOHN C. ROTSCHAFER, PHARMD, FCCP
Professor
Department of Experimental and Clinical Pharmacology
College of Pharmacy
University of Minnesota
Minneapolis, Minnesota
JOSEPH T. DIPIRO, PHARMD, FCCP
Professor and Executive Dean
South Carolina College of Pharmacy
University of South Carolina, Columbia
Medical University of South Carolina
Charleston, South Carolina
New York Chicago San Francisco Lisbon London Madrid Mexico City
Milan New Delhi San Juan Seoul Singapore Sydney Toronto
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PHARMACOTHERAPY PRINCIPLES & PRACTICE
Copyright 2007 by The McGraw-Hill Companies, Inc. All rights
reserved. Printed in the United States of America. Except as per-
mitted under the United States Copyright Act of 1976, no part of
this publication may be reproduced or distributed in any form or
by any means, or stored in a data base or retrieval system, without
the prior written permission of the publisher.
1 2 3 4 5 6 7 8 9 0 xxx/xxx 0 9 8 7
ISBN-13: 978-0-07-144880-2
ISBN-10: 0-07-144880-2
This book was set in Minion by International Typesetting and
Composition.
The editors were Michael Brown, Jason Malley, Robert Pancotti, and
Regina Y. Brown.
The production supervisor was Philip Galea.
The text designer was Joan OConnor.
The cover designer was __________.
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____________ was printer and binder.
This book is printed on acid-free paper.
Please tell the author and publisher what you think of this book by
sending your comments to [email protected].
Put the author and title of the book in the subject line.
Cover images copyright 2006 by Obi-Tabot Tabe, PharmD. The
images used on the cover and spine are taken from an 18'' 24'' oil
painting by Obi-Tabot Tabe, PharmD, a painter, graphic designer,
scientic illustrator, and pharmacist. Dr. Tabe, originally from
Cameroon, is a graduate of the University of Pittsburgh, School of
Pharmacy. The painting represents the use of loop diuretics in the
treatment of edema and hypertension. A schematic drawing of the
nephron and skeletal representations of molecular structures of two
loop diuretics (furosemide and ethacrynic acid) are incorporated into
the design. Two pharmacokinetic curves (IV bolus infusion and oral
drug administration) associated with drug monitoring and drug
regimen adjustments are also evident in this abstract design.
Library of Congress Cataloging-in-Publication Data
Pharmacotherapy principles & practice / editors,
Marie A. Chisholm-Burns . . . [et al.].
p. ; cm.
Includes bibliographical references and index.
ISBN-13: 978-0-07-144880-2 (alk. paper)
ISBN-10: 0-07-144880-2 (alk. paper)
1. ChemotherapyTextbooks. I. Chisholm, Marie A. II. Title:
Pharmacotherapy principles and practice.
[DNLM: 1. Drug Therapy. WB 330 P53592 2007]
RM262.P475 2007
615.58dc22
2006046830
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CONTENTS
v
Contributors ix
Reviewers xxi
Preface xxix
PART ONE. BASIC CONCEPTS
OF PHARMACOTHERAPY PRINCIPLES
AND PRACTICE 1
1. Introduction 3
Jack E. Fincham
PART TWO. DISORDERS OF ORGAN
SYSTEMS 7
Section 1. Cardiovascular Disorders 9
2. Hypertension 9
Robert J. Straka, R. Todd Burkhardt, and David Parra
3. Heart Failure 33
Orly Vardeny and Tien M. H. Ng
4. Ischemic Heart Disease 63
Larisa H. Cavallari and Robert J. DiDomenico
5. Acute Coronary Syndromes 83
Sarah A. Spinler and Simon de Denus
6. Arrhythmias 107
James E. Tisdale
7. Venous Thromboembolism 133
Stuart T. Haines and Edith A. Nutescu
8. Stroke 161
Susan R. Winkler
9. Hyperlipidemia 175
Matthew K. Ito
10. Hypovolemic Shock 195
Bradley A. Boucher and G. Christopher Wood
Section 2. Respiratory Disorders 209
11. Asthma 209
W. Greg Leader
12. Chronic Obstructive Pulmonary Disease 231
Tara R. Whetsel and Nicole D. Verkleeren
13. Cystic Fibrosis 245
Kimberly J. Novak
Section 3. Gastrointestinal Disorders 257
14. Gastroesophageal Reux Disease 257
Dianne B. Williams and Marie A. Chisholm
15. Peptic Ulcer Disease 269
Jeffrey J. Fong and John W. Devlin
16. Inammatory Bowel Disease 281
Brian A. Hemstreet
17. Nausea and Vomiting 295
Sheila Wilhelm
18. Constipation, Diarrhea, and Irritable
Bowel Syndrome 307
Beverly Mims and Clarence Curry
19. Portal Hypertension and Cirrhosis 323
Laurajo Ryan
20. Pancreatitis 337
Joseph J. Kishel
21. Viral Hepatitis 345
Juliana Chan
Section 4. Renal Disorders 361
22. Acute Renal Failure 361
Mary K. Stamatakis
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23. Chronic and End-Stage Renal Disease 373
Kristine S. Schonder
24. Fluids and Electrolytes 403
Mark A. Malesker and Lee E. Morrow
25. Acid-Base Disturbances 419
Lee E. Morrow and Mark A. Malesker
Section 5. Neurologic Disorders
26. Multiple Sclerosis 431
Melody Ryan
27. Epilepsy 443
Timothy E. Welty and Edward Faught
28. Status Epilepticus 461
Gretchen M. Brophy and Eljim P. Tesoro
29. Parkinsons Disease 473
Mary L. Wagner
30. Pain Management 487
Christine K. ONeil
31. Headache 501
Leigh Ann Ross and Brendan S. Ross
Section 6. Psychiatric Disorders
32. Alzheimers Disease 513
Gary M. Levin, Toya M. Bowles, and Megan J. Ehret
33. Substance-Related Disorders 525
Sally K. Guthrie, Kirk J. Brower,
and Maher Karam-Hage
34. Schizophrenia 549
Deanna L. Kelly and Elaine Weiner
35. Major Depressive Disorder 569
Marshall Cates, Angela Passero,
and Jacqueline Feldman
36. Bipolar Disorder 585
Brian L. Crabtree and Martha J. Faulkner
37. Generalized Anxiety Disorder, Panic Disorder,
and Social Anxiety Disorder 605
Sheila Botts, Tawny Bettinger, and Brian Greenlee
38. Sleep Disorders 621
John M. Dopp and Bradley G. Phillips
39. Attention-Decit Hyperactivity Disorder 633
Kevin W. Cleveland and John Erramouspe
Section 7. Endocrinologic Disorders
40. Diabetes Mellitus 643
Christopher L. Cook, John T. Johnson,
and William E. Wade
41. Thyroid Disorders 667
Michael D. Katz
42. Adrenal Gland Disorders 685
Devra K. Dang, Judy T. Chen, Frank Pucino, Jr.,
and Karim Anton Calis
43. Pituitary Gland Disorders 701
Judy T. Chen, Devra K. Dang, Frank Pucino, Jr.,
and Karim Anton Calis
Section 8. Gynecologic and Obstetric Disorders
44. Pregnancy and Lactation: Therapeutic
Considerations 721
Deborah Sturpe and Kari Alperovitz-Bichell
45. Contraception 737
Julie M. Koehler and Kathleen B. Haynes
46. Pharmacotherapy Essentials 751
Elena M. Umland, Lara C. Weinstein,
and Abby Morris
47. Hormone-Replacement Therapy in Menopause 765
Nicole S. Culhane and Melissa A. Somma
Section 9. Urologic Disorders
48. Erectile Dysfunction 779
Cara Liday and Catherine Heyneman
49. Benign Prostatic Hyperplasia 791
Mary Lee and Roohollah Shari
50. Urinary Incontinence and Pediatric Enuresis 803
David R.P. Guay
Section 10. Immunologic Disorders
51. Allergic and Pseudoallergic Drug Reactions 819
J. Russell May and Philip H. Smith
52. Solid-Organ Transplantation 829
Steven Gabardi and Ali J. Olyaei
vi CONTENTS
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Section 11. Bone and Joint Disorders 853
53. Osteoporosis 853
Beth Bryles Phillips
54. Rheumatoid Arthritis 867
Susan P. Bruce
55. Osteoarthritis 879
Benjamin J. Epstein, John G. Gums, and Karen Hall
56. Gout and Hyperuricemia 891
Geoffrey C. Wall
57. Musculoskeletal Disorders 899
Jill S. Burkiewicz
Section 12. Disorders of the Eyes, Ears, Nose, and Throat 909
58. Glaucoma 909
Mikael D. Jones
59. Allergic Rhinitis 925
Kristi N. Hofer and Michelle W. McCarthy
60. Minor Ophthalmic Disorders 935
Kendra J. Grande
Section 13. Dermatologic Disorders 949
61. Psoriasis 949
Rebecca M.T. Law
62. Common Skin Disorders 959
Angie L. Goeser
Section 14. Hematologic Disorders 975
63. Anemia 975
Edward C. Li and James M. Hoffman
64. Coagulation Disorders 987
Alma Hamidovic
65. Sickle Cell Disease 1003
Tracy M. Hagemann and Teresa V. Lewis
Section 15. Diseases of Infectious Origin 1019
66. Antimicrobial Regimen Selection 1019
Catherine M. Oliphan and Karl Madaras-Kelly
67. Central Nervous System Infections 1033
S. Diane Goodwin and Charles E. Hartis
68. Lower Respiratory Tract Infections 1049
Diane M. Cappelletty
69. Upper Respiratory Tract Infections 1061
Heather L. VandenBussche
70. Skin and Soft Tissue Infections 1075
A. Christie Graham and Randy Wesnitzer
71. Infective Endocarditis 1089
Ronda L. Akins
72. Tuberculosis 1105
Charles A. Peloquin and Rocsanna Namdar
73. Gastrointestinal Infections 1117
Elizabeth D. Hermsen and Ziba Jalali
74. Intraabdominal Infections 1129
Joseph T. DiPiro and Thomas R. Howdieshell
75. Parasitic Diseases 1139
J.V. Anandan
76. Urinary Tract Infection 1151
Brian A. Potoski
77. Sexually Transmitted Infections 1159
Marlon Honeywell and Michael Thompson
78. Osteomyelitis 1177
Melinda M. Neuhauser and Susan L. Pendland
79. Sepsis and Septic Shock 1185
S. Scott Sutton
80. Supercial Fungal Infections 1199
Lauren S. Schlesselman
81. Invasive Fungal Infections 1211
Russell E. Lewis and P. David Rogers
82. Antimicrobial Prophylaxis in Surgery 1231
Jeremy A. Schafer and John C. Rotschafer
83. Vaccines and Toxoids 1239
Marianne Billeter
84. Human Immunodeciency Virus Infection 1253
Amanda Corbett, Rosa Yeh, Julie Dumond,
and Angela D.M. Kashuba
CONTENTS vii
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Section 16. Oncologic Disorders 1277
85. Cancer Chemotherapy and Treatment 1277
Dianne Brundage
86. Breast Cancer 1303
Kristine Hahn and Laura Boehnke Michaud
87. Lung Cancer 1323
Val Adams and Justin Balko
88. Colorectal Cancer 1341
Patrick J. Medina
89. Prostate Cancer 1357
Jill M. Kolesar
90. Malignant Lymphomas 1371
Chris Fausel
91. Ovarian Cancer 1385
Judith A. Smith
92. Acute Leukemias 1397
Nancy Heideman
93. Chronic Leukemias and Multiple Myeloma 1415
Amy M. Pick and Timothy R. McGuire
94. Skin Cancer 1425
Trinh Pham
95. Hematopoietic Cell Transplantation 1447
Jeannine S. McCune
96. Oncologic Emergencies 1467
Brad L. Stanford
Section 17. Nutrition and Nutritional Disorders 1493
97. Parenteral Nutrition 1493
Michael D. Kraft and Imad F. Btaiche
98. Enteral Nutrition 1511
Sarah J. Miller
99. Overweight and Obesity 1529
Maqual R. Graham and Cameron C. Lindsey
Appendices 1541
Appendix A: Conversion Factors
and Anthropometrics 1541
Appendix B: Common Laboratory Tests 1545
Appendix C: Common Medical Abbreviations 1551
Appendix D: Glossary 1557
Index 0000
viii CONTENTS
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CONTRIBUTORS
ix
Val R. Adams, PharmD
Associate Professor
University of Kentucky
Oncology Clinical Specialist
Markey Cancer Center
Lexington, Kentucky
Chapter 87: Lung Cancer
Ronda L. Akins, PharmD
Assistant ProfessorInfectious Diseases
University of Louisiana at Monroe
College of Pharmacy
Monroe, Louisiana
Chapter 71: Infective Endocarditis
Kari Alperovitz-Bichell, MD, MPH
Assistant Professor
Family Medicine
University of Maryland School of Medicine
University of Maryland Medical System
Baltimore, Maryland
Chapter 44: Pregnancy and Lactation: Therapeutic Considerations
J. V. Anandan, PharmD
Adjunct Associate Professor of Pharmacy
Eugene Applebaum College of Pharmacy and Health Sciences
Wayne State University
Pharmacy Specialist
Henry Ford Hospital
Detroit, Michigan
Chapter 75: Parasitic Diseases
Justin M. Balko, PharmD
Graduate Student
Pharmacist
UK Chandler Medical Center
Lexington, Kentucky
Chapter 87: Lung Cancer
Tawny L. Bettinger, PharmD
Assistant Professor
University of Texas at Austin
College of Pharmacy
Austin, Texas
Chapter 37: Generalized Anxiety Disorder, Panic Disorder,
and Social Anxiety Disorder
Marianne Billeter, PharmD, BCPS
Clinical Pharmacy Specialist
Infectious Diseases
Ochsner Clinic Foundation
New Orleans, Louisiana
Chapter 83: Vaccines and Toxoids
Sheila R. Botts, PharmD, BCPP
Assistant Professor
University of Kentucky College of Pharmacy
Psychiatry
Lexington Veterans Affairs Medical Center
Lexington, Kentucky
Chapter 37: Generalized Anxiety Disorder, Panic Disorder,
and Social Anxiety Disorder
Bradley A. Boucher, PharmD, FCCP, FCCM
Professor of Pharmacy
Department of Pharmacy
University of Tennessee Health Science Center
Clinical Pharmacist
Regional Medical Center at Memphis
Memphis, Tennessee
Chapter 10: Hypovolemic Shock
Toya M. Bowles, PharmD, BCPP
Senior Medical Science Manager
Organon USA
Hallandale Beach, Florida
Chapter 32: Alzheimers Disease
Gretchen M. Brophy, PharmD, BCPS, FCCP, FCCM
Associate Professor of Pharmacy and Neurosurgery
Clinical Specialist
Neuroscience Intensive Care Unit
Virginia Commonwealth University
Medical College of Virginia Campus
Richmond, Virginia
Chapter 28: Status Epilepticus
Kirk J. Brower, MD
Associate Professor of Psychiatry
University of Michigan Medical School
Executive Director
Chelsea Arbor Addiction Treatment Center
Ann Arbor, Michigan
Chapter 33: Substance-Related Disorders
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Susan P. Bruce, PharmD, BCPS
Associate Professor of Pharmacy Practice
Albany College of Pharmacy
Clinical Pharmacist
The Center for Rheumatology
Albany, New York
Chapter 54: Rheumatoid Arthritis
Dianne Brundage, PharmD, FCCP, BCPS, BCOP
Oncology Clinical Pharmacy Specialist
Methodist Hospital/Park Nicollet Health Services
Methodist Hospital
Chapter 85: Cancer Chemotherapy and Treatment
Imad F. Btaiche, BS, PharmD, BCNSP
Clinical Associate Professor of Pharmacy
Department of Clinical Sciences
University of Michigan College of Pharmacy
Clinical Pharmacist
University of Michigan Hospitals and Health Centers
Ann Arbor, Michigan
Chapter 97: Parenteral Nutrition
R. Todd Burkhardt, PharmD
Research Fellow
Cardiovascular Pharmacotherapy
Experimental and Clinical Pharmacology Department
Chapter 2: Hypertension
Jill S. Burkiewicz, PharmD, BCPS
Associate Professor and Director
Primary Care Residency Program
Midwestern University Chicago College of Pharmacy
Clinical Pharmacist
Mercy Family Health CenterChicago
Chicago, Illinois
Chapter 57: Musculoskeletal Disorders
Karim Anton Calis, PharmD, MPH, BCPS, BCNSP, FASHP, FCCP
Clinical Professor
University of Maryland
Shenandoah University, and Medical College of Virginia
Virginia Commonwealth University
Clinical Specialist
Endocrinology and Womens Health
Director
Drug Information Service
Mark O. Hateld Clinical Research Center
National Institutes of Health
Bethesda, Maryland
Chapter 42: Adrenal Gland Disorders
Chapter 43: Pituitary Gland Disorders
Diane M. Cappelletty, PharmD
The University of Toledo College of Pharmacy
Adjunct Assistant Professor
Department of Medicine
Medical University of Ohio
Toledo, Ohio
Chapter 68: Lower Respiratory Tract Infections
Marshall E. Cates, PharmD, BCPP, FASHP
Samford University McWhorter School of Pharmacy
Clinical Pharmacist
Department of Psychiatry and Behavorial Neurobiology
University of Alabama at Birmingham
Birmingham, Alabama
Chapter 35: Major Depressive Disorder
Larisa H. Cavallari, PharmD
Assistant Professor
Department of Pharmacy Practice
University of Illinois at Chicago College of Pharmacy
Chicago, Illinois
Chapter 4: Ischemic Heart Disease
Juliana Chan, PharmD
Clinical Assistant Professor
College of Pharmacy
Sections of Digestive Diseases and Nutrition
Section of Hepatology
University of Illinois at Chicago
Chicago, Illinois
Chapter 21: Viral Hepatitis
Judy T. Chen, PharmD, BCPS
Assistant Professor of Pharmacy Practice
Purdue University
School of Pharmacy and Pharmaceutical Sciences
Pharmacotherapist
Tippecanoe Community Health Clinic
West Lafayette, Indiana
Marie A. Chisholm-Burns, PharmD, FCCP, FASHP
Professor and Head
The University of Arizona College of Pharmacy
Tucson, Arizona
Chapter 14: Gastroesophageal Reux Disease
Kevin W. Cleveland, PharmD
Idaho State University
Pocatello, Idaho
Chapter 39: Attention-Decit Hyperactivity Disorder
x CONTRIBUTORS
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Christopher L. Cook, PharmD, PhD
University of Georgia College of Pharmacy
Athens, Georgia
Chapter 40: Diabetes Mellitus
Amanda H. Corbett, PharmD, BCPS
School of Pharmacy
University of North Carolina
Clinical Pharmacist
University of North Carolina Health Care
Infectious Disease Clinic
Chapel Hill, North Carolina
Chapter 84: Human Immunodeciency Virus Infection
Brian L. Crabtree, PharmD, BCPP
Clinical Associate Professor of Psychiatry,
University of Mississippi School of Pharmacy
University of Mississippi Medical Center
School of Medicine
Psychopharmacologist
Mississippi State Hospital
Whiteld, Mississippi
Chapter 36: Bipolar Disorder
Nicole S. Culhane, PharmD, BCPS
Associate Professor
Pharmacy Practice
Wilkes University
Nesbitt College of Pharmacy and Nursing
Clinical Pharmacist Faculty
Wyoming Valley Family Practice Residency
Wilkes-Barre, Pennsylvania
Chapter 47: Hormone Replacement Therapy in Menopause
Clarence E. Curry, Jr., PharmD
Associate Professor
School of Pharmacy
CPNAHS
Howard University
Clinical Pharmacist
Ambulatory Care
Howard University Hospital Clinics
Washington, DC
Chapter 18: Constipation, Diarrhea, and Irritable Bowel Syndrome
Devra K. Dang, PharmD
Assistant Clinical Professor
University of Connecticut School of Pharmacy
Clinical Faculty
St. Francis Hospital/UCONN Primary Care Center
at Burgdorf Health Center
Instructor
University of Connecticut School of Medicine
Hartford, Connecticut
Simon de Denus, BPharm, MSc
Assistant Professor
Faculty of Pharmacy
University of Montreal Pharmacy Department
Fellow in Cardiovascular Research
Montreal Heart Institute
Montreal
Quebec, Canada
Chapter 5: Acute Coronary Syndromes
John W. Devlin, PharmD, BCPS, FCCM
Associate Professor
Northeastern University School of Pharmacy
Clinical Pharmacist
Medical Intensive Care Unit
Tufts-New England Medical Center
Boston, Massachusetts
Chapter 15: Peptic Ulcer Disease
Robert J. DiDomenico, PharmD
Clinical Associate Professor
University of Illinois
Cardiovascular Clinical Pharmacist
University of Illinois Medical Center at Chicago
Chicago, Illinois
Chapter 4: Ischemic Heart Disease
Joseph T. DiPiro, PharmD, FCCP
Professor and Executive Dean
University of South Carolina
Columbia
Chapter 74: Intraabdominal Infections
John M. Dopp, PharmD
Assistant Professor
University of Wisconsin-Madison School of Medicine
Clinical Pharmacist
University of Wisconsin Sleep Disorders Center
Madison, Wisconsin
Chapter 38: Sleep Disorders
Julie Dumond, PharmD
University of North CarolinaChapel Hill
School of Pharmacy
Megan J. Ehret, PharmD
Clinical Psychopharmacology and Pharmacogenomics Fellow
Nova Southeastern University
Fort Lauderdale, Florida
CONTRIBUTORS xi
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Benjamin J. Epstein, PharmD, BCPS
Departments of Pharmacy Practice and Internal Medicine
Colleges of Pharmacy and Medicine
University of Florida
Gainesville, Florida
Chapter 55: Osteoarthritis
John Erramouspe, PharmD, MS
Professor
Idaho State University College of Pharmacy
Pocatello, Idaho
Chapter 39: Attention-Decit Hyperactivity Disorder
Edward Faught, MD
Professor of Neurology
University of Alabama School of Medicine
Director
University of Alabama at Birmingham Epilepsy Center
Birmingham, Alabama
Chapter 27: Epilepsy
Martha J. Faulkner, BSN, MSW, MSN, LISW, CNP
Nurse Practitioner
University of New Mexico
Albuquerque, New Mexico
Chapter 36: Bipolar Disorder
Christopher A. Fausel, PharmD, BCOP
Adjunct Associate Professor of Medicine
Indiana University Cancer Center
Clinical Pharmacist
Hematology/Oncology/BMT
Indiana University Hospital
Indianapolis, Indiana
Chapter 90: Malignant Lymphomas
Jacqueline Maus Feldman, MD
Patrick H. Linton Professor
University of Alabama School of Medicine
Director
Division of Public Psychiatry
Community Psychiatry Program
Birmingham, Alabama
Jack E. Fincham, BS, PhD
A.W. Jowdy Professor of Pharmacy Care
The University of Georgia College of Pharmacy
Interim Department Chair
Department of Clinical and Administrative Pharmacy
Athens, Georgia
Chapter 1: Introduction
Jeffrey J. Fong, PharmD
Critical Care Fellow
Northeastern University School of Pharmacy
Tufts-New England Medical Center
Chapter 15: Peptic Ulcer Disease
Steven Gabardi, PharmD, BCPS
Northeastern University
Bouv College of Health Sciences
Renal Transplant Clinical Specialist
Brigham and Womens Hospital
Chapter 52: Solid Organ Transplantation
Angie L. Goeser, PharmD
Assistant Professor
Creighton University School of Pharmacy and Health Professions
Omaha, Nebraska
Chapter 62: Common Skin Disorders
S. Diane Goodwin, PharmD, FCCP
Clinical Pharmacist
Tex Healthcare
Raleigh, North Carolina
Chapter 67: Central Nervous System Infections
A. Christie Graham, PharmD
University of Wyoming School of Pharmacy
Casper, Wyoming
Chapter 70: Skin and Soft Tissue Infections
Maqual R. Graham, PharmD
University of MissouriKansas City
Veterans Affairs Medical CenterKansas City
Kansas City, Missouri
Chapter 99: Overweight and Obesity
Kendra J. Grande, RPh
Consultant Pharmacist
Abelian Consulting
Stevensville, Maryland
Chapter 60: Minor Ophthalmic Disorders
Brian A. Greenlee, MD
Assistant Professor of Psychiatry
Neuropsychiatry Clinic Director
Lexington, Kentucky
Chapter 37: Generalized Anxiety Disorder, Panic Disorder, and Social
Anxiety Disorder
David R. P. Guay, PharmD
Professor
College of Pharmacy
Consultant
Division of Geriatrics
HealthPartners Inc.
Chapter 50: Urinary Incontinence and Pediatric Enuresis
xii CONTRIBUTORS
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John G. Gums, PharmD
Professor of Pharmacy and Medicine
Departments of Pharmacy Practice and Community Health
and Family Medicine
Sally K. Guthrie, PharmD
Associate Professor of Pharmacy
College of Pharmacy and Department of Psychiatry
The University of Michigan
The University of Michigan Hospitals
Ann Arbor, Michigan
Tracy M. Hagemann, PharmD
University of Oklahoma College of Pharmacy
Clinical Pediatric Specialist
Oklahoma City, Oklahoma
Chapter 65: Sickle Cell Disease
Kristine Hahn, PharmD
Postdoctural Fellow
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin
Chapter 86: Breast Cancer
Stuart T. Haines, PharmD, FCCP, FASHP
Professor and Vice Chair
Pharmacotherapy Specialist
University of Maryland School of Pharmacy Practice and Science
University of Maryland Medical Center-Antithrombosis Services
Baltimore, Maryland
Chapter 7: Venous Thromboembolism
Karen L. Hall, MD
Associate Professor and Residency Program Director
Department of Community Health and Family Medicine
Alma Hamidovic, PharmD
Postdoctoral Oncology Fellow
University of Wisconsin Comprehensive Cancer Center
Madison, Wisconsin
Chapter 64: Coagulation Disorders
Charles Hartis, PharmD
Antibiotic Management/Clinical Improvement Pharmacist
Forsyth Medical Center
Winston-Salem, North Carolina
Chapter 67: Central Nervous System Infections
Kathleen B. Haynes, PharmD, BCPS
Butler University
Disease Management Pharmacist
VEI/Community Health Network
Carmel, Indiana
Chapter 45: Contraception
Nancy Heideman, PharmD, BCPS
University of New Mexico College of Pharmacy
University of New Mexico Childrens Hospital
Chapter 92: Acute Leukemias
Brian A. Hemstreet, PharmD, BCPS
Assistant Professor
University of Colorado School of Pharmacy
Denver, Colorado
Chapter 16: Inammatory Bowel Disease
Elizabeth D. Hermsen, PharmD, MBA
Antimicrobial Specialist
The Nebraska Medical Center
University of Nebraska Medical Center College of Pharmacy
Omaha, Nebraska
Chapter 73: Gastrointestinal Infections
Catherine A. Heyneman, MS, PharmD
Director of Idaho Drug Information Service
Pocatello, Idaho
Chapter 48: Erectile Dysfunction
Kristi N. Hofer, PharmD
Scientic Project Manager
ASHP Advantage
Charlottesville, Virginia
Chapter 59: Allergic Rhinitis
James M. Hoffman, PharmD, MS
Medication Outcomes Coordinator
Pharmaceutical Department
St. Jude Childrens Research Hospital
Memphis, Tennessee
Chapter 63: Anemias
Marlon Honeywell, PharmD
Florida A&M University
Clinical Pharmacist
Bond Community Health Center
Tallahassee, Florida
Chapter 77: Sexually Transmitted Infections
CONTRIBUTORS xiii
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Thomas R. Howdieshell, MD, FACS, FCCP
Associate Professor of Surgery
Department of Surgery
University of New Mexico Health Science Center
Division of Trauma/Surgical Critical Care
Chapter 74: Intraabdominal Infections
Matthew K. Ito, PharmD, FCCP, BCPS
Chair, Department of Pharmacy Practice
Professor of Pharmacy Practice
College of Pharmacy
Oregon State University
Portland, Oregon
Chapter 9: Hyperlipidemia
Ziba Jalali, MD
University of Nebraska Medical Center
Omaha, Nebraska
Chapter 73: Gastrointestinal Infections
Tommy Johnson, PharmD, CDE
Athens Primary Care
Mercy Health Center
Athens, Georgia
Chapter 40 : Diabetes Mellitus
Mikael D. Jones, PharmD
Assistant Professor
Lexington, Kentucky
Chapter 58: Glaucoma
Maher Karam-Hage, MD
Assistant Professor of Psychiatry
University of Michigan
Medical Director
Chelsea Arbor Addiction Treatment Center
Ann Arbor, Michigan
Angela D. M. Kashuba, BScPharm, PharmD, DABCP
Associate Professor
School of Pharmacy
University of North Carolina at Chapel Hill
Michael D. Katz, PharmD
Associate Professor
University of Arizona College of Pharmacy
Tucson, Arizona
Chapter 41: Thyroid Disorders
Deanna L. Kelly, PharmD, BCPP
Associate Professor
Maryland Psychiatric Research Center
Baltimore, Maryland
Chapter 34: Schizophrenia
Joseph J. Kishel, Jr., PharmD, BCPS
Adjunct Instructor of Pharmacology
Penn State College of Medicine
Clinical Pharmacy SpecialistInfectious Diseases
M.S. Hershey Medical Center
Hershey, Pennsylvania
Chapter 20: Pancreatitis
Julie M. Koehler, PharmD
Associate Professor and Chair of Pharmacy Practice
Butler University College of Pharmacy and Health Sciences
Clinical Pharmacist
Family Medicine
Clarian Health Partner and the Indiana University-Methodist
Family Residency Program
Indiana University School of Medicine
Chapter 45: Contraception
Jill M. Kolesar, PharmD, BCPS, FCCP
Associate Professor
Faculty Supervisor
Analytical Instrumentation Laboratory
Madison, Wisconsin
Chapter 89: Prostate Cancer
Michael D. Kraft, PharmD
Clinial Assistant Professor
University of Michigan College of Pharmacy
Clincial Pharmacist-Surgery/Surgical ICU/Nutrition Support
University of Michigan Health System
Ann Arbor, Michigan
Chapter 97: Parenteral Nutrition
Rebecca M. T. Law, BScPharm, PharmD
Associate Professor
School of Pharmacy
Memorial University of Newfoundland
Newfoundland, Canada
Chapter 61: Psoriasis
Cara Lawless-Liday, PharmD
Associate Professor
Intermountain Medical Clinic
Pocatello, Idaho
Chapter 48: Erectile Dysfunction
xiv CONTRIBUTORS
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W. Greg Leader, PharmD
Associate Dean
Academic Affairs
University of Louisiana Monroe
College of Pharmacy
Monroe, Louisiana
Chapter 11: Asthma
Mary Lee, PharmD, BCPS, FCCP
Dean and Professor
Midwestern University Chicago College of Pharmacy
Chicago, Illinois
Chapter 49: Benign Prostatic Hyperplasia
Gary M. Levin, PharmD, BCPP, FCCP
Professor and Chairman
Nova Southeastern University
College of Pharmacy
Fort Lauderdale, Florida
Russell E. Lewis, PharmD
Associate Professor
University of Houston College of Pharmacy
Infectious Diseases
Department of Infectious Diseases
The University of Texas M.D. Anderson Cancer Center
Houston, Texas
Chapter 81: Invasive Fungal Infections
Teresa V. Lewis, PharmD
Pediatric Pharmacotherapy Fellow
OU Medical Center
Chapter 65: Sickle Cell Disease
Edward C. Li, PharmD
Assistant Professor
Wilkes UniversityNesbitt College of Pharmacy and Nursing
Wilkes-Barre, Pennsylvania
Chapter 63: Anemias
Cameron C. Lindsey, PharmD, BC-ADM
University of MissouriKansas City School of Pharmacy
Veterans Affairs Medical CenterKansas City
Kansas City, Missouri
Chapter 99: Overweight and Obesity
Karl Madaras-Kelly, PharmD
Associate Professor
College of Pharmacy
Boise, Idaho
Chapter 66: Antimicrobial Regimen Selection
Mark A. Malesker, PharmD
Associate Professor of Pharmacy Practice and Medicine
Creighton University Medical Center
Omaha, Nebraska
Chapter 24: Fluids and Electrolytes
Chapter 25: Acid-Base Disturbances
J. Russell May, PharmD, FASHP
Clinical Professor
Clinical Pharmacist
Medical College of Georgia Health System
Augusta, Georgia
Chapter 51: Allergic and Pseudoallergic Drug Reactions
Michelle W. McCarthy, PharmD
Drug Information Specialist
University of Virginia Health System
Charlottesville, Virginia
Chapter 59: Allergic Rhinitis
Jeannine S. McCune, PharmD
Associate Professor
University of Washington
Afliate Investigator
Fred Hutchinson Cancer Research Center
Seattle, Washington
Chapter 95: Hematopoietic Cell Transplantation
Timothy R. McGuire, BS, PharmD, FCCP
Associate Professor
Pharmacy Practice
College of Pharmacy
Omaha, Nebraska
Chapter 93: Chronic Leukemias and Multiple Myeloma
Patrick J. Medina, PharmD, BCOP
Associate Professor
Chapter 88: Colorectal Cancer
Laura Boehnke Michaud, PharmD
The University of Texas M.D. Anderson Cancer Center
Houston, Texas
Chapter 86: Breast Cancer
Sarah J. Miller, PharmD, BCNSP
University of Montana Skaggs School of Pharmacy
Pharmacy Clinical Coordinator
Saint Patrick Hospital
Missoula, Montana
Chapter 98: Enteral Nutrition
CONTRIBUTORS xv
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Beverly Mims, PharmD
Howard University School of Pharmacy
Clinical Pharmacist
Howard University Hospital
Washington, DC
Chapter 18: Constipation, Diarrhea, and Irritable
Bowel Syndrome
Abby Morris, MD
Family Medicine Resident
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania
Chapter 46: Menstruation-Related Disorders
Lee E. Morrow, MD, MS
Assistant Professor of Medicine
Creighton University Medical Center
Omaha, Nebraska
Chapter 24: Fluids and Electrolytes
Chapter 25: Acid-Base Disturbances
Rocsanna Namdar, PharmD
Assistant Professor
University of New Mexico
College of Pharmacy
Chapter 72: Tuberculosis
Melinda Margaret Neuhauser, PharmD
Infectious Diseases
U.S. Department of Veterans Affairs
Pharmacy Benets Management Strategic Health Group
Hines, Illinois
Chapter 78: Osteomyelitis
Tien M. H. Ng, BSPharm, PharmD, BCPS
Assistant Professor of Clinical Pharmacy and Pharmaceutical
Economics and Policy
Department of Pharmacy
University of Southern California
Los Angeles, California
Chapter 3: Heart Failure
Kimberly J. Novak, PharmD
Adjunct Clinical Assistant Professor
The Ohio State University College of Pharmacy
Clinical Pharmacy Specialist/Pediatric Pulmonary Medicine
Childrens Hospital
Columbus, Ohio
West Virginia University School of Pharmacy
Chapter 13: Cystic Fibrosis
Edith A. Nutescu, PharmD
Director
Antithrombosis Center
Chicago, Illinois
Chapter 7: Venous Thromboembolism
Catherine M. Oliphant, PharmD
Clinical Pharmacist
St. Lukes Internal Medicine
Boise, Idaho
Chapter 66: Antimicrobial Regimen Selection
Ali J. Olyaei, PharmD, BCPS
Associate Professor of Medicine
Director
Clinical Research
Nephrology and Hypertension
Oregon Health and Sciences University
Clinical Pharamcotherapist
University Hospital
Portland, Oregon
Chapter 52: Solid Organ Transplantation
Christine K. ONeil, PharmD, BCPS, CGP, FCCP
Associate Professor
Duquesne University
Mylan School of Pharmacy
Director
Center for Pharmacy Care
Pittsburgh, Pennsylvania
Chapter 30: Pain Management
David Parra, PharmD, BCPS
Clinical Pharmacy Specialist in Cardiology
Department of Cardiology
Veterans Affairs Medical Center
Experimental and Clinical Pharmacology Department
Angela Ann Passero, PharmD
Auburn University
Harrison School of Pharmacy
Clinical Pharmacist
Department of Psychiatry and Neurobiology
University of Alabama at Birmingham
Birmingham, Alabama
xvi CONTRIBUTORS
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Charles A. Peloquin, PharmD
Adjoint Professor of Pharmacy and Medicine
University of Colorado
Director
Infectious Disease Pharmcokinetics Laboratory
National Jewish Medical and Research Center
Denver, Colorado
Chapter 72: Tuberculosis
Susan L. Pendland, MS, PharmD
Adjunct Associate Professor of Pharmacy Practice
Chicago, Illinois
Chapter 78: Osteomyelitis
Trinh Pham, PharmD, BCOP
Yale New Haven Hospital
New Haven, Connecticut
Chapter 94: Skin Cancer
Beth Bryles Phillips, PharmD, BCPS
Assistant Professor (Clinical)
University of Iowa College of Pharmacy
Ambulatory Care
University of Iowa Hospitals and Clinics
Iowa City, Iowa
Chapter 53: Osteoporosis
Bradley G. Phillips, PharmD
Associate Professor
University of Iowa
College of Pharmacy
Iowa City, Iowa
Chapter 38: Sleep Disorders
Amy Marie Pick, PharmD
Creighton University
Oncology Clinical Pharmacist
Nebraska Methodist Hospital
Omaha, Nebraska
Chapter 93: Chronic Leukemias and Multiple Myeloma
Brian A. Potoski, PharmD
Assistant Professor
University of Pittsburgh School of Pharmacy
Clinical Specialist
Antibiotic Management Program
University of Pittsburgh Medical Center
Presbyterian University Hospital
Chapter 76: Urinary Tract Infection
Frank Pucino, Jr., PharmD, BCPS, FASHP, FDPGEC
Ambulatory Care Clinical Pharmacy Team Leader
National Institutes of Health Clinical Center
Bethesda, Maryland
Phillip David Rogers, PharmD, PhD, FCCP
Assistant Professor of Pharmaceutical Sciences and Pediatrics
Member
Childrens Foundation Research Center of Memphis
University of Tennessee College of Pharmacy
Memphis, Tennessee
Chapter 81: Invasive Fungal Infections
Brendan S. Ross, MD
Assistant Professor
Staff Physician
G. V. (Sonny) Montgomery Veterans Affairs Medical Center
Jackson, Mississippi
Chapter 31: Headache
Leigh Ann Ross, PharmD, BCPS, CDE
Assistant Professor
Director
Pharmaceutical Care Services
Chapter 31: Headache
John C. Rotschafer, PharmD, FCCP
Professor
College of Pharmacy
Chapter 82: Antimicrobial Prophylaxis in Surgery
Laurajo Ryan, PharmD, BCPS, CDE
University of Texas at Austin
University of Texas Health Science Center San Antonio
San Antonio, Texas
Chapter 19: Portal Hypertension and Cirrhosis
Melody Ryan, PharmD
Associate Professor
Clinical Specialist in Neurology
Veterans Affairs Medical Center
Lexington, Kentucky
Chapter 26: Multiple Sclerosis
CONTRIBUTORS xvii
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Jeremy A. Schafer, PharmD
Infectious Diseases Research Fellow
University of Minnesota College of Pharmacy
Chapter 82: Antimicrobial Prophylaxis in Surgery
Lauren S. Schlesselman, PharmD
Storrs, Connecticut
Chapter 80: Supercial Fungal Infections
Kristine S. Schonder, PharmD
Assistant Professor
University of Pittsburgh School of Pharmacy
Clinical Specialist
Thomas E. Starzl Transplantation Institute
Chapter 23: Chronic and End-Stage Renal Disease
Roohollah Shari, MD, FACS
Professor of Urology
College of Medicine
Section Chief of Urology
Westside Veterans Administration Hospital
Chicago, Illinois
Chapter 49: Benign Prostatic Hyperplasia
Judith A. Smith, PharmD, BCOP
Assistant Professor
University of Texas M.D. Anderson Cancer Center
Houston, Texas
Chapter 91: Ovarian Cancer
Philip H. Smith, MD
Assistant Professor of Medicine
Allergy and Immunology
Medical College of Georgia
Assistant Professor
Childrens Medical Center
Augusta, Georgia
Chapter 51: Allergic and Pseudoallergic Drug Reactions
Melissa A. Somma, PharmD, CDE
Assistant Professor of Pharmacy and Family Medicine
University of Pittsburgh Schools of Pharmacy
and Medicine
Director
University of Pittsburgh/Rite Aid Patient Care Initiative
Rite Aid Corporation
Chapter 47: Hormone Replacement Therapy in Menopause
Sarah A. Spinler, PharmD, FCCP
Professor of Clinical Pharmacy
Residency and Fellowship Program Coordinator
Philadelphia College of Pharmacy
University of the Sciences in Philadelphia
Chapter 5: Acute Coronary Syndromes
Mary K. Stamatakis, BS, PharmD
Assistant Dean and Associate Professor
Chapter 22: Acute Renal Failure
Brad L. Stanford, PharmD, BCOP
Oncology Regional Medical Liaison
Amgen Medical Affairs
Wolfforth, Texas
Chapter 96: Oncologic Emergencies
Robert J. Straka, PharmD, FCCP
Associate Professor
College of Pharmacy
Deborah Sturpe, PharmD, BCPS
Assistant Professor
University of Maryland School of Pharmacy
Baltimore, Maryland
Chapter 44: Pregnancy and Lactation: Therapeutic Considerations
S. Scott Sutton, PharmD, BCPS
Associate Clinical Professor
University of South CarolinaSouth Carolina College of Pharmacy
Clinical Pharmacist
Dorn Veterans Affairs Medical Center
Columbia, South Carolina
Chapter 79: Sepsis and Septic Shock
Eljim P. Tesoro, PharmD
Pharmacotherapist
Department of Neurosurgery
University of Illinois at Chicago Medical Center
Chicago, Illinois
Chapter 28: Status Epilepticus
Michael D. Thompson, PharmD, BCNSP
Assistant Dean for Clinical Affairs and Professor
of Pharmacy Practice
Florida A&M University
Tallahassee, Florida
Chapter 77: Sexually Transmitted Infections
xviii CONTRIBUTORS
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James E. Tisdale, PharmD
Professor
School of Pharmacy and Pharmaceutical Sciences
Purdue University
Adjunct Professor
School of Medicine
Indiana University
Chapter 6: Arrhythmias
Elena M. Umland, BS, PharmD
Barbara H. Korberly Professor in Womens Leadership and Health
Associate Professor of Clinical Pharmacy
University of the Sciences in Philadelphia
Philadelphia College of Pharmacy
Adjunct Clinical Assistant Professor of Family Medicine
Department of Family Medicine
Thomas Jefferson University Hospital
Heather L. VandenBussche, PharmD
Ferris State University College of Pharmacy
Kalamazoo, Michigan
Chapter 69: Upper Respiratory Tract Infections
Orly Vardeny, PharmD
Assistant Professor
Pharmacy Practice Division
University of WisconsinMadison
School of Pharmacy
Madison, Wisconsin
Chapter 3: Heart Failure
Nicole D. Verkleeren, PharmD
Adjunct Clinical Professor
Pharmacy Practice Resident
West Virginia University Hospitals
Clinical Pharmacist
The Western Pennsylvania Hospital
Forbes Regional Campus
Monroeville, Pennsylvania
Chapter 12: Chronic Obstructive Pulmonary Disease
William E. Wade, PharmD
Professor
College of Pharmacy
University of Georgia
Clinical Pharmacist
Saint Marys Health Care Systems
Athens, Georgia
Chapter 40: Diabetes Mellitus
Mary Louise Wagner, MS, PharmD
Associate Professor
Ernest Mario School of Pharmacy
RutgersState University of New Jersey
Piscataway, New Jersey
Chapter 29: Parkinsons Disease
Geoffrey C. Wall, PharmD, BCPS
Drake University
College of Pharmacy and Health Sciences
Internal Medicine Clinical Pharmacist
Iowa Methodist Medical Center
Des Moines, Iowa
Chapter 56: Gout and Hyperuricemia
Elaine Weiner, MD
Assistant Professor
University of Maryland Medical School
Medical Director
Maryland Psychiatric Research Center
Outpatient Research Program
Catonsville, Maryland
Chapter 34: Schizophrenia
Lara Carson Weinstein, MD
Instructor
Department of Family and Community Medicine
Jefferson Medical College
Thomas Jefferson University
Jefferson Family Medicine
Timothy E. Welty, PSPharm, MA, PharmD
Professor
McWhorter School of Pharmacy
Samford University
Adjunct Associate Research Professor
Department of Neurology
University of Alabama Birmingham
Birmingham, Alabama
Chapter 27: Epilepsy
Randy Wesnitzer, BS Pharm, PharmD
Clinical Coordinator
Wyoming Medical Center
Casper, Wyoming
Chapter 70: Skin and Soft Tissue Infections
Tara Whetsel, PharmD
Chapter 12: Chronic Obstructive Pulmonary Disease
CONTRIBUTORS xix
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Sheila Wilhelm, PharmD
Assistant Professor
Wayne State University
Internal Medicine
Harper University Hospital
Detroit, Michigan
Chapter 17: Nausea and Vomiting
Dianne B. Williams, PharmD, BCPS
Drug Information and Formulary Coordinator
MCG Health, Inc.
Augusta, Georgia
Chapter 14: Gastroesophageal Reux Disease
Susan R. Winkler, PharmD, BCPS
Pharmacy Practice
Assistant Director
Ambulatory Clinical Services
Chicago, Illinois
Chapter 8: Stroke
G. Christopher Wood, PharmD
Clinical Pharmacist
Regional Medical Center at Memphis
Memphis, Tennessee
Chapter 10: Hypovolemic Shock
Rosa F. Yeh, PharmD
Assistant Professor
University of Houston College of Pharmacy
Houston, Texas
xx CONTRIBUTORS
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REVIEWERS
Beth Alexander, PharmD, BCPS
Associate Professor of Physician Assistant Studies
Augsburg College
Rita Alloway, PharmD, BCPS
Research Professor
University of Cincinnati College of Medicine
Cincinnati, Ohio
Buge Apampa, PhD, BPharm, MRPharmS
Clinical Lecturer
Pharmacy Practice
Universities of Kent and Greenwich at Medway
Chatham Maritime
Kent, United Kingdom
Laurel Ashworth, PharmD
Professor Clinical and Administrative Sciences & Director
Drug Information Center
Mercer University School of Pharmacy and Allied Health Sciences
Atlanta, Georgia
Sara Augustin, PharmD, BCPP
Clinical Pharmacist
Dekalb Regional Crisis Center
Decatur, Georgia
Ebrahim A. Balbisi, PharmD
St. Johns University College of Pharmacy & Allied Health Professions
Jamaica, New York
Phyllis Barks, PA, MPH
Assistant Professor & Technology Development Coordinator
Oregon Health & Science University School of Medicine
Division of Physician Assistant Education
Portland, Oregon
Bonnie Bata-Jones, MS, RN, FNP
Instructor
Excelsior, Minnesota
Kathryn R. Bauer, MA, MS, APRN
Instructor
University of Texas Health Science Center at San Antonio
San Antonio, Texas
Kathleen L. Becker, MS, CRNP
Assistant Professor and Coordinator
Adult Nurse Practitioner Program
The Johns Hopkins University School of Nursing
Adult Nurse Practitioner
Health Care for the Homeless
Baltimore, Maryland
Judith L. Beizer, PharmD, CGP, FASCP
Clinical Professor
St. Johns University College of Pharmacy & Allied Health Professions
Jamaica, New York
Renee Bellanger, PharmD, BSPharm
Assistant Professor
Pharmacy Practice
The University of the Incarnate Word
San Antonio, Texas
Mary Mescher Benbenek, MS, RN, CFNP, CPNP
Teaching Specialist
Marialice Bennett, RPh, FAPhA
Professor of Clinical Pharmacy
The Ohio State University
Columbus, Ohio
Heather K.T. Bidinger, MMS, PA-C
Clinical Coordinator and Assistant Professor
Department of Physician Assistant Education
Augsburg College
Sarah Bland, RPh
Clinical Instructor
University of Wisconsin-Madison
Madison, Wisconsin
Patricia J. Blumi, MSN, ARNP
Advanced Registered Nurse PractitionerRadiation Therapy
Via-Christi Cancer Center
Wichita, Kansas
xxi
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John A. Bosso, PharmD, FCCP, BCPS
Professor and Chair
Clinical Specialist in Infectious Diseases
Medical University of South Carolina Hospital
Margaret Bowers, MSN, APRN, BC
Duke University School of Nursing
Durham, North Carolina
Cleopatra Branch, BSc, PharmD, MRPharmS
Teacher & Practitioner
Medway School of Pharmacy
Chatham Maritime
Joyce Brewer, PhD, CNM, CFNP
Associate Professor
David M. Brissette, MMSc, PA-C
Assistant Professor
Yale University School of Medicine Physician
Associate Program
Physician Assistant
Internal Medicine
Yale New Haven Hospital
Cori M. Brock, PharmD
Clinical Assistant Professor of Pharmacy Practice
Xavier University College of Pharmacy
New Orleans, Louisiana
Denise Buonocore, MSN, APRN, CCRN
Acute Care Nurse Practitioner
Bridgeport Hospital, Bridgeport
Connecticut, and Yale University School of Nursing
Reamer L. Bushardt, PharmD, PA-C
Program Director and Assistant Professor
Department of Clinical Services
College of Health Professions
Wesley G. Byerly, PharmD
Executive Director for Research Regulatory Affairs
and Adjunct Assistant Professor
Wake Forest University School of Medicine
Cynthia Carnes, PharmD, PhD
Associate Professor of Pharmacy and Biophysics
The Ohio State University
Columbus, Ohio
Barry L. Carter, PharmD
Professor
Colleges of Pharmacy and Medicine
The University of Iowa
Iowa City, Iowa
Nina Cheigh, PharmD
University of Illinois and University of Florida Colleges
of Pharmacy
Rye, New York
Deborah Chyun, PhD, RN, FAHA
Associate Professor and Director
Adult Advanced Practice Nursing
Yale University School of Nursing
Lorraine Cicero, MS, PharmD
Associate Professor
Pharmacy Practice
Long Island University College of Pharmacy and Health Sciences
Brooklyn, New York
Donald Coerver, PhD, PA-C
Acting Instructor
MEDEX Northwest Division of Physician Assistant Studies
Spokane, Washington
Carmita A. Coleman, PharmD
Assistant Dean for Student Affairs and Associate Professor
of Pharmacy Practice
Feik School of Pharmacy
University of the Incarnate Word
San Antonio, Texas
Lynn Convery, RN, MS, CNP
Gerontological Nurse Practitioner
HealthPartners Partnering Care Senior Services
Keely L. Cook, MPAS, PA-C
Assistant Professor
Doisy College of Health Sciences
Saint Louis University
St. Louis, Missouri
Sarah Corlett, PhD, MRPharmS
University of Greenwich
Chatham Maritime
xxii REVIEWERS
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Joseph E. Crea, DO, MHA
Assistant Professor
The University of Findlay School of Pharmacy
Powell, Ohio
Patricia Cunningham, DNSc, APRN, BC
Assistant Professor
College of Nursing
Memphis, Tennessee
Petra Czarniak, BPharm, MPS
Lecturer in Pharmaceutics
Division of Health Sciences
Murcoch University School of Pharmacy
Murdoch
Western Australia, Australia
Bonnie A. Dadig, EdD, PA-C
Chair, Physician Assistant Department
Director
Physician Assistant Program
Medical College of Georgia Hospitals and Clinics
Augusta, Georgia
Larry Danziger, PharmD
Chicago, Illinois
Lawrence Davidow, PhD, RPh
University of Kansas School of Pharmacy
Lawrence, Kansas
Jillian H. Davis, PhD
Assistant Professor
Hampton University School of Pharmacy
Hampton, Virginia
Michelle Devereaux, MA, RN, CNP
Partnering Care Senior Services
Bloomington, Minnesota
Thomas C. Dowling, PharmD, PhD
Associate Professor
Baltimore, Maryland
Allan Ellsworth, PharmD, PA-C
Professor of Pharmacy and Family Medicine
University of Washington Schools of Pharmacy and Medicine
Seattle, Washington
Katherine Erdman, MPAS, PA-C
Assistant Director
Baylor College of Medicine
Houston, Texas
Jingyang Fan, PharmD, BCPS
University of Southern Nevada College of Pharmacy
Henderson, Nevada
Carl E. Fasser, PA
Associate Professor of Family & Community Medicine
and Physician Assistant
Houston, Texas
Maisha Kelly Freeman, PharmD, BCPS
Assistant Professor and Drug Information Specialist
Samford University McWhorter School of Pharmacy
Birmingham, Alabama
Mark Garrison, PharmD
Associate Professor of Pharmacotherapy & Assistant Dean
of Student Services
Washington State University-Spokane
Spokane, Washington
Margit B. Gerardi, MS, MSA, MSN, RN-WHNP
Clnical Instructor
San Antonio, Texas
Stuart Gill-Banham, MRPharmS, MCMHP
Teacher Practitioner
Chatham Maritime
Sveinbjrn Gizurarson, PhD
Professor of Pharmaceutics
Biopharmaceutics and Clinical Therapeutics
University of Iceland
Reykjavk, Iceland
Nancy Goldstein, MSN, CRNP, RNC
Instructor
Baltimore, Maryland
Justine Schuller Gortney, PharmD, BCPS
Mercer University
Atlanta, Georgia
Erich J. Grant, MMS, PA-C
Instructor
Hillary Wall Grillo, PharmD
Shenandoah University School of Pharmacy
Winchester, Virginia
REVIEWERS xxiii
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Sara Haddow, MSA, PA-C
Instructor
Physician Assistant Department
Augusta, Georgia
Robert Hadley, PhD, PA-C
Associate Professor
University of Kentucky Physician Assistant Program
Lexington, Kentucky
David Hawkins, PharmD
Senior Associate Dean
South University School of Pharmacy
Savannah, Georgia
Mary S. Hayney, PharmD, BCPS, FCCP
Madison, Wisconsin
Mark A. Heisler, PharmD, BCPS
Adjunct Faculty
Grand Canyon University College of Nursing
Phoenix, Arizona
Adjunct Faculty
Arizona State University College of Nursing
Tempe, Arizona
Clinical Pharmacist
Banner Desert Medical Center
Mesa, Arizona
Pamela Helms, RN, MN, FNP-C
Assistant Professor & Clinical Director
UNACARE Health Center
University of Mississippi School of Nursing
Ridgeland, Mississippi
Elizabeth Hermsen, PharmD, MBA
Antimicrobial Specialist
The Nebraska Medical Center
University of Nebraska Medical Center College
of Pharmacy
Omaha, Nebraska
Michael K. Jensen, BSPharm, MS
Department of Pharmacy Services
John A. Moran Eye Center
University of Utah
Salt Lake City, Utah
Jill T. Johnson, PharmD, BCPS
Associate Professor
University of Arkansas for Medical Sciences College
of Pharmacy
Little Rock, Arkansas
June Felice Johnson, PharmD, BCPS, FASHP, CDM-diabetes
Associate Professor of Pharmacy Practice & Director of Faculty
& Site Development
Drake University College of Pharmacy & Health Sciences
Des Moines, Iowa
Nikki L. Katalanos, PhD, PA-C
Assistant Professor and Physician Assistant
Department of Family & Community Medicine
The University of New Mexico School of Medicine
Nancy Kawahara, PharmD, MSEd
Associate Professor and Chair
Loma Linda University School of Pharmacy
Loma Linda, California
Michael Kelsch, PharmD, BCPS
Assistant Professor
North Dakota State University College of Pharmacy
Fargo, North Dakota
Lynn G. Kirkland, DNSc, WHNP, CNM
Assistant Professor
Womens Health Nurse Practitioner/Certied Nurse Midwife
Memphis Obstetrics and Gynecological Association P.C.
Bartlett, Tennessee
Michael E. Klepser, PharmD, FCCP
Professor of Pharmacy
Ferris State University College of Pharmacy
and Borgess Medical Center
Kalamazoo, Michigan
Carrie Foust Koenigsfeld, PharmD
Drake College of Pharmacy and Health Sciences
Des Moines, Iowa
Annette C. Larson, MSPAS
Assistant Professor
University of North Dakota School of Medicine
Physician Assistant
Altru Health Care System
Grand Forks, North Dakota
Esther Law
Shoppers Drug Mart
North York
Ontario, Canada
Rebecca M. Law, BScPhm, PharmD
Associate Professor
School of Pharmacy
Memorial University of Newfoundland
St. Johns, Newfoundland, Canada
xxiv REVIEWERS
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Helen Leather, BPharm, Grad Dip Hosp Pharm (Dist)
Hematopoietic Stem Cell Transplantation/Leukemia Shands
at the University of Florida
University of Florida College of Pharmacy
Tom Lenz, PharmD, MA
Assistant Professor
Omaha, Nebraska
Sonia Lin, PharmD, BCPS
University of Rhode Island
Kingston, Rhode Island
Michael Mancano, PharmD
Associate Chair
Department of Pharmacy Practice, and
Temple University School of Pharmacy
Donald Maner, PharmD, MHSc, PA-C
Assistant Professor
Physician Assistant Department
Evans, Georgia
Harold J. Manley, PharmD, FASN, FCCP, BCPS
Associate Professor
Albany, New York
Henry J. Mann, PharmD, FASHP, FCCM, FCCP
Professor
Director
Center for Excellence in Critical Care
Academic Health Center
Karen F. Marlowe, PharmD, BCPS
Associate Professor
Auburn University Harrison School of Pharmacy
University of South Alabama School of Medicine
Mobile, Alabama
Phyllis Mason, MS, RN, CRNP
Instructor
Baltimore, Maryland
Jeanie McHugo, MS, PA-C
Assistant Professor
University of North Dakota Physician Assistant Program
Grand Forks, North Dakota
Kimberly Ann Meyer, MPAS
Infectious Diseases Physician Assistant
Omaha, Nebraska
Candis M. Morello, PharmD, CDE, FCSHP
Assistant Professor of Clinical Pharmacy
Skaggs School of Pharmacy and Pharmaceutical Sciences
University of California
San Diego
La Jolla, California
Carla Moschella, PA-C, MS, RD
Assistant Professor and Academic Coordinator
Department of Physician Assistant Studies
Massachusetts College of Pharmacy and Health Sciences
Jadwiga Najib, BS, PharmD
Arnold & Marie Schwartz College of Pharmacy
and Health Sciences
Long Island University
Brooklyn, New York
Jacquelin S. Neatherlin, RN, PhD, CNRN
Associate Professor
Baylor University
Dallas, Texas
Robert Nelson, PharmD, BCPS
Assistant Professor
North Dakota State University College of Pharmacy
Nursing, and Allied Sciences
Clinical Pharmacy Manager
MeritCare Health System
Fargo, North Dakota
Christopher Nemergut, PharmD
Clinical Pharmacist
Center for Drug Policy
University of Wisconsin Hospital and Clinics
Madison, Wisconsin
Ayman Noreddin, PhD, RPh
Associate Professor
Duluth, Minnesota
Deborah A. Opacic, EdD, PA-C
Assistant Professor
Rangos School of Health Sciences
Duquesne University
REVIEWERS xxv
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Victor A. Padron, RPh, PhD
Associate Professor
Department of Pharmacy Sciences
Omaha, Nebraska
Amy Pakyz, PharmD, MS
Assistant Professor
Virginia Commonwealth University School
of Pharmacy/Medical College of Virginia Campus
Richmond, Virginia
Cynthia Pentz, EdD, PA-C
Director
University of Findlay
Findlay, Ohio
Todd Pillen, PA-C/SA, MPAS
Manager
Solid Organ Transplant
Childrens Healthcare of Atlanta-Egleston
and Emory University Hospital
Atlanta, Georgia
Therese I. Poirier, PharmD, MPH, BCPS, FASHP, FCCP
Professor and Associate Dean
Academic Affairs
Southern Illinois University-Edwardsville
Edwardsville, IIllinois
Jane Pruemer, PharmD, BCOP, FASHP
Associate Professor of Clinical Pharmacy Practice
University of Cincinnati College of Pharmacy
Cincinnati, Ohio
Edward W. Randell, PhD, DCC, FCACB
Chief
Division of Biochemical Pathology Health Sciences Centre
Associate Professor
Laboratory Medicine
Faculty of Medicine
Memorial University
St. Johns, Newfoundland and Labrador
St. Johns, Newfoundland, Canada
Mette Rasmussen, PhD
Professor
Faculty of Pharmaceutical Sciences
University of Copenhagen
Copenhagen, Denmark
Michael D. Reed, PharmD, FCCP, FCP
Director
Pediatric Clinical Pharmacology and Toxicology
Rainbow Babies and Childrens Hospital
and Professor of Pediatrics
School of Medicine
Case Western Reserve University
Cleveland, Ohio
Kathleen Reeve, DrPH, AOCN, ANP
Associate Professor of Clinical Nursing
The University of Texas Health Science Center at Houston
Houston, Texas
Suzanne Reich, PA-C, MPAS
Assistant Professor
Warren Richards, BSPharm, MBA, PhD
Associate Professor
Lloyd L. Gregory School of Pharmacy
Palm Beach Atlantic University School of Pharmacy
West Palm Beach, Florida
Keith A. Rodvold, PharmD
Professor of Pharmacy Practice & Associate Professor
of Medicine in Pharmacy
Chicago, Illinois
Carol Rollins, PharmD, BCNSP
Program Director: Nutrition Support Pharmacy Practice
Arizona Health Sciences Center
College of Pharmacy
University of Arizona
Tucson, Arizona
Wendella Rose-Facey, APRN, CCRN, FNP, MSN
Adjunct Professor
Adelphi University
Critical Care Specialist at Kingsbrook Jewish Medical Center
Brooklyn, New York
Elaine Rosenblatt, MSN, APRN, BC
Clinical Professor
University of Wisconsin
Director of Health Services and Quality Improvement
University of Wisconsin Medical Foundation
Madison, Wisconsin
Polly Royal, MS, RN-BC
Purdue University School of Nursing
West Lafayette, Indiana
Michael Rybak, PharmD, MPH
Associate Dean for Research & Professor of Pharmacy and Medicine
Director of Anti-Infective Research Laboratory
Wayne State University College of Pharmacy & Health Sciences
Detroit, Michigan
xxvi REVIEWERS
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Kiranpal S. Sangha, PharmD
Clinical Pharmacy Specialist-CNS
The University Hospital
Cincinnati, Ohio
Adjunct Assistant Professor of Clinical Pharmacy
The University of Cincinnati College of Pharmacy
Cincinnati, Ohio
JoAnne M. Saxe, RN, MS, ANP
Clinical Professor & Director of the Adult Nurse
Practitioner Program
University of California
San Francisco School of Nursing
San Francisco, California
Dana Sayre-Stanhope, EdD, PA-C
Associate Professor
St. Louis, Missouri
Sarah L. Scarpace, PharmD, BCOP
Assistant Professor
Albany, New York
Denise Schentrup, MN, ARNP, BC
College of Nursing
Karin Schurrer-Erickson, MA, RN, CNP
Teaching Specialist
University of Minnesota School of Nursing
Catherine Shull, PA-C, MPAS
Instructor
Candace Smith, PharmD
Associate Clnical Professor
St. Johns University College of Pharmacy
& Allied Health Professions
Jamaica, New York
Susan M. Stein, MS, RPh
Assistant Dean for Clinical Education and Student Development
Pacic University School of Pharmacy
Hillsboro, Oregon
Henry Stoll, PA-C
Senior Lecturer
University of Washington School of Medicine
Seattle, Washington
Christopher J. Sullivan, MD, FACP
Adjunct Professor of Pharmacy
Birchwood Village, Minnesota
Marc A. Sweeney, RPh, MDiv, PharmD
Chair & Associate Professor
Pharmacy Practice
The University of Findlay School of Pharmacy
Findlay, Ohio
Mohammad J. Tafreshi, PharmD, BCPS
Associate Professor
Midwestern University College of Pharmacy-Glendale
Glendale, Arizona
Brenda J. J. Talarico, MPAS, PA-C
Assistant Professor
Augsburg College
Damary Castanheira Torres, PharmD, BCOP
Associate Clinical Professor
St. Johns University College of Pharmacy
& Allied Health Professions
Jamaica, New York
Mary Fran Tracy, PhD, RN, CCRN, CCNS, FAAN
Critical Care Clinical Nurse Specialist
University of Minnesota Medical Center
Fairview
Marianne Vail, MS, PA-C
Massachusetts College of Pharmacy & Health Sciences
Lee Vermeulen, RPh, MS, FCCP
Director
Center for Drug Policy
University of Wisconsin Hospital and Clinics
Madison, Wisconsin
Angie Veverka, BS, PharmD
Assistant Professor of Pharmacy
Wingate University School of Pharmacy
Wingate, North Carolina
Heather Vezina, PharmD
Assistant Professor
University of Minnesota School of Medicine
& College of Pharmacy
REVIEWERS xxvii
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Vicki Waters, MS, PA-C
Assistant Director for Experiential Learning
School of Allied Health Sciences
Houston, Texas
Christine Werner, PA-C, PhD
Assistant Professor
St. Louis, Missouri
Thomas White, JD, PA-C
Academic Coordinator
University of New Mexico School of Medicine
Siu-Fun Wong, PharmD, FASHP, FCSHP
Western University of Health Sciences
Faculty-in-Residence
Hematology-Oncology Medical Group of Orange County, Inc.
Pomona, California
Daniel Wood, MPAS, PA-C
San Antonio, Texas
Kathleen Woodruff, MS, CRNP
Instructor
Baltimore, Maryland
Monty Yoder, PharmD, BCPS
Pharmaceutical Care Coordinator
Wake Forest University Baptist Medical Center
Dawn Zwick, MSN, CRNP
Lecturer
Kent State University
Kent, Ohio
xxviii REVIEWERS
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PREFACE
Practitioners who design, implement, monitor, and evaluate
medication therapy bear an important responsibility to
their patients and society. Development of these abilities
requires an integration of knowledge, skills, attitudes, and
values that can be acquired only through a structured learning
process that includes classroom work, independent study,
hands-on practice, and, ultimately, involvement with actual
patients.
Pharmacotherapy Principles & Practice is designed to meet
the classroom and independent study needs of todays learners
in the health professions. Chapters are written or reviewed by
pharmacists, nurse practitioners, physician assistants, and
physicians who are authorities in their elds and were sub-
jected to rigorous review by experts. The book is written in a
concise style that facilitates an in-depth level of understanding
of the essential concepts. The disease states covered and the
drugs discussed in the text focus on those disorders most
often seen in actual practice.
Each chapter reviews etiology, epidemiology, pathophysio-
logy, and disease presentation, followed by clear therapeutic
recommendations for drug selection, dosing, and patient
monitoring. The learning features used in Pharmacotherapy
Principles & Practice were designed in collaboration with edu-
cational design specialists to enhance learning and retention.
These features include:
Structured learning objectives. These are listed at the begin-
ning of each chapter, and information in the text that corre-
sponds to each learning objective is identied by a vertical
rule in the margin, which allows the reader to nd content
related to each objective quickly.
Key concepts related to patient assessment and treatment.
Designed to help focus learning, these key concepts are listed at
the beginning of each chapter. Textual material that develops
these concepts is easily identied by numbered icons through-
out the chapter.
Patient encounter vignettes. Distributed throughout each chap-
ter, these case scenarios facilitate critical thinking skills and
lend clinical relevance to the scientic foundation provided.
Patient care and monitoring guidelines. This section, placed
near the end of each chapter, is designed to assist students in
their general approach to assessing, treating, and monitoring
patients for therapeutic response and adverse events.
Up-to-date literature citations. A comprehensive reference list
for each chapter is provided on the Online Learning Center
to substantiate treatment recommendations.
Key references and readings. Placed at the end of each
chapter, this list provides a mechanism to acquire a deeper
understanding of the subject matter.
Generous use of tables, gures, text boxes, and algorithms.
These visual features enhance understanding of pathophysio-
logy, clinical presentation, drug selection, pharmacokinetics,
and patient monitoring.
Medical abbreviations and their meanings. Placed at the end
of each chapter, these lists facilitate learning the accepted
shorthand used in real-world medical practice.
Glossary of medical terms. The glossary is one of the appen-
dices at the end of the book; the rst use of each glossary
term in a chapter appears in bold font.
Self-assessment questions and answers for each chapter.
Located in the Online Learning Center, these questions are
designed to evaluate student learning and may be used to
obtain approximately 170 hours of continuing education
credit for licensed pharmacists, nurse practitioners, physi-
cians, and physician assistants.
Laboratory values expressed as both conventional units and
System International (SI) units. Including both units of meas-
urement facilitates use of this book throughout the world.
Appendices useful to students and practitioners. These
appendices include: 1) conversion factors and anthropomet-
rics; 2) common laboratory tests and their reference ranges;
and 3) common medical abbreviations.
An electronic version of Pharmacotherapy Principles &
Practice can be downloaded to a desktop or laptop computer
using the access number that appears on the card inserted in the
middle of this book. The Online Learning Center [McGraw-Hill:
Please provide URL] provides the complete reference lists,
self-assessment questions, a testing center that has the ability to
grade and provide immediate feedback on the self-assessment
questions as well as reporting capabilities, and other features
designed to support learning.
Pharmacotherapy Principles & Practice is a valuable and
unique learning tool that combines state-of-the-art, compre-
hensive, yet concise chapters, unique learning features, and
the Online Learning Center.
xxix
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We would like to acknowledge the commitment and dedi-
cation of the 157 contributing authors and 142 reviewers of
the chapters contained in this text. (A list of contributors and a
list of reviewers are included in the frontmatter of this book.) We
also extend our thanks to the McGraw-Hill Medical Publishing
Division, especially Michael Brown, Maya Barahona, and Robert
Pancotti, for their dedication to this project. Finally, we thank our
families for their patience and support of this work and of our
goal to improve patient care by enhancing learning of pharma-
cotherapeutics across the health professions.
The Editors
January 2007
xxx PREFACE
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PHARMACOTHERAPY

PRINCIPLES & PRACTICE

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