Drug Data Classification Mechanism of Action Indication Contraindications Adverse Reaction Nursing Responsibilities

Generic Name Pharmacologic Bactericidal action against General Concentrations CNS: Lethargy, Before
Ampicillin Class sensitive organisms; inhibits Indications - Allergies to penicillins, hallucinations, seizures - Observe 15 rights in drug
Penicillin synthesis of bacterial cell wall, - Treatment of cephalosporins, or other administration.
Trade Name causing cell death. infections caused allergens CV: Heart failure - Assess for allergies to penicillins,
Principen Therapeutic Class by susceptible cephalosporins, or other allergens.
Antibiotic Pharmacokinetics strains of Shigella, Precaution GI: Glossitis, stomatitis, - Assess for renal disorders or lactation.
Minimum Dose D: Crosses placenta; enters Salmonella, - Renal disorders gastritis, sore mouth, - Culture infected area before treatment.
8 g/day Pregnancy Risk breast milk Escherichia coli, furry tongue, black - If patient is a woman and she uses
Factor M: Not known Haemophilus Drug interaction “hairy” tongue, nausea, hormonal contraceptive, she should use
Maximum B E: Urine, unchanged influenzae, Proteus Drug to drug vomiting, diarrhea, a second form of birth control for 1-2
Dose mirabilis, Neisseria - Increased ampicillin effect abdominal pain, bloody weeks while taking this drug.
14 g/day Drug Half Life gonnorhoeae, with probenecid diarrhea, enterocolitis,
1-2 hours enterococci, gram- - Increased risk of rash with pseudomembranous During
Contents positive organisms allopurinol colitis, nonspecific - Administer oral drug on an empty
Ampicillin (penicillin G- - Increased bleeding effect hepatitis stomach, 1 hour before or 2 hours after
sodium sensitive with heparin, oral meals.
staphylococci, anticoagulants GU: Nephritis - Administer with a full glass of water. Do
Availability streptococci, - Decreased effect with not give with fruit juice or soft drinks.
and color pneumococci) tetracyclines, Hematologic: Anemia, - Do not give IM injections in the same
Capsules: 250, - Meningitis caused chloramphenicol thrombocytopenia, site; atrophy can occur.
500 mg by Neisseria - Decreased efficacy of leukopenia, - For IV administration, give slowly over
Powder for oral meningitidis hormonal contraceptives, neutropenia, prolonged 3-5 mins.
suspension: - Unlabeled use: atenolol with ampicillin bleednig time - Use within 1 hour after preparation
125 mg/5 mL, Prophylaxis in because potency may decrease
250 mg/5 mL cesarean section in Drug to food Hypersensitivity: significantly after that.
Powder for certain high-risk - Oral ampicillin may be less Rash, fever, wheezing,
injection: 250, patients effective with food; take on anaphylaxis After
500 mg, 1, 2 g empty stomach - Dispose of used materials properly.
Local: Pain, phlebitis, - Educate patient about side effects.
Routes of Drug to lab test thrombosis at injection - Instruct to report pain or discomfort at
administration - False-positive Coombs' test site sites, unusual bleeding or bruising,
Oral if given IV mouth sores, rash, hives, fever, itching
Intramuscular - Decrease in plasma Other: Superinfections severe diarrhea, difficulty breathing.
Intravenous estrogen concentrations in – oral and rectal - Instruct patient not to use antibiotic to
pregnant women moniliasis, vaginitis self-treat other infections.
- False-positive urine glucose - Instruct to take the full course of drug
tests if Clinitest, Benedict's therapy.
solution or Fehling's solution - Do proper documentation.
is used
Source: Source: Source: Source: Source: Source: Source:
Karch, Amy: 2009 Karch, Amy: 2009 Karch, Amy: 2009 Lippincott’s Nursing Drug Karch, Amy: 2009 Karch, Amy: 2009 Lippincott’s Nursing Karch, Amy: 2009 Lippincott’s Karch, Amy: 2009 Lippincott’s Nursing Drug Guide,
Lippincott’s Nursing Lippincott’s Nursing Drug Guide, pp. 126-127 Lippincott’s Nursing Drug Drug Guide, pp. 127-128 Nursing Drug Guide, p. 128 pp. 127-128
Drug Guide, p. 126- Guide, p. 126 Guide, pp. 126-127
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