Journal of Biomedical Research, 2012, 26(4): 235-240

JBR
Research Paper
doi:10.7555/JBR.26.20120037
Abstract
We sought to determine risk factors associated with fetal macrosomia and to explore the long-term consequence
of infant macrosomia at the age of 7 years. A prospective population based cohort study was designed to examine
the associations between maternal and perinatal characteristics and the risk of macrosomia. A nested case-control
study was conducted to explore the long-term health consequence of infant macrosomia. The mean maternal age
of the macrosomia group was 24.743.32 years, which is slightly older than that in the control group (24.353.14
years, P = 0.000). The mean maternal body mass index (BMI) at early pregnancy was 22.752.81 kg/m
2
, which
was also higher than that in the control group (21.762.59 kg/m
2
, P = 0.000). About 64.6% of macrosomic ne-
onates were males, compared with 51.0% in the control group (P = 0.000). Compared with women with normal
weight (BMI: 18.5-23.9 kg/m
2
), women who were overweight (BMI: 24-27.9 kg/m
2
) or obese (BMI 28 kg/m
2
),
respectively, had a 1.69-fold (P = 0.000) and a 1.49-fold (P = 0.000) increased risks of having a neonate with
macrosomia, while light weight (BMI<18.5 kg/m
2
) women had an approximately 50% reduction of the risk. Fur-
thermore, macrosomia infant had a 1.52-fold and 1.50-fold risk, respectively, of developing overweight or obesity
at the age of 7 years (P = 0.001 and P = 0.000). Older maternal age, higher maternal BMI at early pregnancy and
male gender were independent risk factors of macrosomia. Macrosomic infant was associated with an increased
predisposition to develop overweight or obesity at the beginning of their childhood.
Keywords: risk factors, long-term, health consequences, macrosomia
Risk factors and long-term health consequences of macrosomia:
a prospective study in Jiangsu Province, China
Shouyong Gu
a
, Xiaofei An
b
, Liang Fang
a
, Xiaomin Zhang
c
, Chunyan Zhang
c
, Jingling Wang
c
, Qilan
Liu
d
, Yanfang Zhang
a
, Yongyue Wei
a
, Zhibin Hu
a
, Feng Chen
a
, Hongbing Shen
a,*
a
Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 210029,
China;
b
Department of Endocrinology, Jiangsu Province Hospital of Chinese Medicine, Nanjing, Jiangsu 210029, China;
c
Department of Science and Technology, Jiangsu Population and Family Planning Committee, Nanjing, Jiangsu 210008, China;
d
Genitalia Hygiene Research Center, Jiangsu Institute of Planned Parenthood Research, Nanjing, Jiangsu 210036, China.
Received 10 April 2012, Revised 08 May 2012, Accepted 24 May 2012, Epub 06 July 2012
This study was supported by grants from the Jiangsu Birth Defects
Intervention Program (No. JS200302) and the Natural Science Foundation
of Jiangsu Province (No. BK2008501).
*
Corresponding author: Hongbing Shen, M.D., Ph.D, Department of
Epidemiology and Biostatistics, School of Public Health, Nanjing
Medical University, 140 Hangzhong Road, Nanjing, Jiangsu 210029,
China, Tel/Fax: +86-25-86862745/+86-25-86527613, E-mail: hbshen@
njmu.edu.cn.
The authors reported no conflict of interest.
Available at http://elsevier.com/wps/find/journaldes-cription.cws_
home/723905/description#description.
c
2012 by the Journal of Biomedical Research. All rights reserved.
236
Gu S et al. / Journal of Biomedical Research, 2012, 26(4): 235-240
INTRODUCTION
Fetal macrosomia has attracted immense attention
because of the increased risk for both mothers and in-
fants. For mothers, it is well established that delivery
of a macrosomic newborn is a risk factor for protracted
labor, caesarean delivery and postpartum hemorrhage.
For macrosomic infants, short-term consequence is
birth trauma
[1]
, and long-term consequences include
increased predisposition to develop obesity and type 2
diabetes later in life
[2]
. Birth weight varies depending
on several maternal characteristics, including racial
origin, age, body mass index (BMI), parity and ciga-
rette smoking. It also depends on medical conditions,
such as pre-pregnancy diabetes mellitus
[3-5]
.
A trend toward a higher birth weight has been
demonstrated in most developed countries in recent
decades
[6-8]
. Chinese national health services survey
showed that birth weight increased from 3,186 g in
1993 to 3,300 g in 2008
[9]
. A rapid increase in the rate
of macrosomia has been reported in China. For ex-
ample, Bao et al.
[10]
found that the incidence of mac-
rosomia increased from 8.31% in 2001 to 10.50% in
2005 in the city of Harbin. In Shanghai, the rate of
macrosomia increased by 50% from 1989 to 1999
[11]
.
However, few studies were performed on the contri-
butions of risk factors to the increased incidence of
macrosomia and the long-term health risks in adult-
hood and even childhood. In the present study, a
population-based survey was therefore conducted to
examine risk factors for macrosomia in Jiangsu prov-
ince, China. We also explored the long-term health
consequences of infant macrosomia.
SUBJECTS AND METHODS
Subjects
Ninety-five communities were randomly selected
as surveillance spots by stratified cluster sampling in
Jiangsu province, China. All pregnant women in the
communities at the first trimester were investigated.
Each woman was assigned a unique identification
number when she was at the first prenatal care visit.
The women were followed up during their pregnancy,
delivery and immediate postpartum period by local
family planning service professionals. We collected
information on parental demographics, maternal med-
ical, reproductive history, and medical conditions dur-
ing pregnancy and pregnancy outcome (such as gesta-
tional age, birth weight, birth length, gender of baby,
and congenital anomalies). In 2010, we conducted a
cross-sectional study of birth cohort that consisted of
macrosomia and the controls delivered in 2003. All
information on the children's growth and development
(weight, height) were collected. The protocol was ap-
proved by the local institutional review boards of each
author's affiliated institutions, and all subjects pro-
vided signed informed consent.
Women with multiple pregnancies, preterm births,
and insufficient information on birth weight at term
were not included in this present study. Cases with
congenital malformations and low birth weight were
excluded from the study. Any normal singleton baby
delivered at term that weighed 4,000 g or more was
classified as macrosomic, irrespective of gestational
age
[12]
. We carried out a comparison of factors related
to macrosomia between 2,488 macrosomic newborns
and a control group of 18,827 newborns, who weighed
from 2,500 g to 3,999 g, using an unmatched case-
control study design. We also performed a comparison
of the development at the age of 7 years between 700
children with macrosomia and a control group of 5137
with normal birth weight from the birth cohort, by us-
ing an unmatched nested case-control study design.
The study was approved by Jiangsu population and
family planning committee. Written informed consent
was obtained from the participants or their legal sur-
rogates.
We examined risk factors for macrosomia in the
context of maternal age, maternal education, maternal
residence, maternal BMI at early pregnancy (within
12 weeks of gestation), maternal smoking/drinking
during pregnancy, and infant gender. Maternal edu-
cation was categorized as elementary school or less,
junior middle school, high school or above. Maternal
BMI at early pregnancy was based on measured height
and weight at the first prenatal visit during the first
trimester. According to the Group of China Obesity
Task Force reference
[13]
, maternal BMI was grouped
into four categories: < 18.5 kg/m
2
, 18.5-23.9 kg/m
2
,
24-27.9 kg/m
2
, and 28 kg/m
2
; BMI for boys at the
age of 7 years was grouped into three categories: nor-
mal (< 17.4 kg/m
2
), overweight (17.4-19.2 kg/m
2
), and
obesity (19.2 kg/m
2
); BMI for girls at the age of 7
years was grouped into three categories: normal (<
17.2 kg/m
2
), overweight (17.2-18.9 kg/m
2
), and obes-
ity ( 18.9 kg/m
2
).
Statistical analysis
Continuous data were described as meanstandard
deviation (SD), and categorical data were described
as proportion. Continuous variables in two independ-
ent groups were compared by Student's t test. The
chi-square test and rank sum test were used when
comparing dichotomous and rank data separately.
Logistic regression was used to examine the associa-
Risk factors and long-term health consequences of macrosomia
237
tions between maternal and perinatal characteristics
and the risk of macrosomia. Odds ratio (OR) with
95% confidence interval (95% CI) for each candidate
factor was calculated. P < 0.05 was considered as
statistically significant. Statistical analyses were con-
ducted using SAS Version 9.13 (SAS Institute Inc.,
Cary, NC, USA).
RESULTS
There were 27,001 live births from December 1,
2002 to May 31, 2005 in our study sites. We excluded
5149 births with congenital malformations, or miss-
ing birth weight, or gestational age values outside the
range of 20-44 weeks. After exclusion of 537 mul-
tiple births and low birth weight infants (< 2,500 g),
there were 21,315 live-born singletons 37 gesta-
tional weeks. In total, 21,315 maternal and neona-
tal records were analyzed. Among these newborns,
2,488 (11.67%) had macrosomia, and 417 (1.96%)
had a birth weight of 4500 g. The mean weight of
all newborns was 3,468419 g. The mean weight of
newborns in the macrosomia group and in the non-
macrosomia group was 4,207347 and 3,371318 g,
respectively.
Table 1 shows maternal and fetal characteris-
tics between the macrosomia and control groups.
The mean maternal age of the macrosomia group
was 24.743.32 years, which was older than that
in the control group (24.353.14 years, P = 0.000).
The mean maternal BMI at early pregnancy was
22.752.81 kg/m2, which was also higher than that
in the control group (21.762.59 kg/m
2
, P = 0.000).
About 62.5% of the macrosomic neonates were males,
compared with 51.0% in the control group (P = 0.000).
There was no statistical difference in maternal resi-
dence, maternal education, and smoking (or drinking)
during pregnancy.
By univariate logistic regression analyses, we found
that maternal age at delivery, first trimester maternal
BMI, and infant male gender were significantly associated
with the risk of neonate macrosomia (Table 2). There
was no statistically significant association between
macrosomia risk and other factors such as maternal
residence and maternal education. Multiple logistic
regression analyses showed that maternal age at de-
livery, first trimester maternal BMI and infant gender
were independent risk factors for macrosomia. Com-
pared with women with normal weight (BMI: 18.5-23.9
kg/m
2
), women who were overweight (BMI: 24-27.9
kg/m
2
) and obese (BMI 28 kg/m
2
), respectively, had
a 1.69-fold (95%CI: 1.51-1.88) and a 1.49-fold (95%CI:
1.31-1.69) risk of delivering a neonatal macrosomia.
Compared with female newborns, male newborns had a
1.61-fold (95%CI: 1.47-1.75) risk of being macrosomic.
In the nested case-control analysis by 2010, the
mean weight for boys in the macrosomia group
was 25.473.68 kg and in the control group was
24.633.87 kg. The difference between the two
groups was statistically significant (P = 0.000). Simi-
larly, the mean weight of the girls in the macrosomia
group was heavier than that in the control group
(24.433.61 kg versus 23.483.56 kg, P = 0.000).
*
for Student's t-test;
**
for Chi-squared test. BMI: body mass index.
Table 1 Maternal and fetal characteristics in the control group and the macrosomia group
Maternal characteristics
Maternal age at delivery
Maternal BMI at early pregnancy (kg/m
2
)
Infant gender
Male
Female
Maternal residence
Urban area
Rural area
Maternal education
Elementary school or less
Junior school
High school or above
Smoking during pregnancy
No
Yes
Drinking during pregnancy
No
Yes
Macrosomia (n=2488)
24.743.32
22.752.81
1,556(64.64%)
0,928(37.36%)
,0505(20.30%)
1,983(79.70%)
0,334(13.45%)
1,309(52.72%)
,0840(33.83%)
2,473(99.40%)
,015(0.60%)
2,426(98.14%)
,046(1.86%)
Control (n=18827)
24.353.14
21.762.59
09,575(51.00%)
09,198(49.00%)
03,631(19.29%)
15,196(80.71%)
02,571(13.69%)
09,992(53.20%)
06,219(33.11%)
18,664(99.22%)
,0150(0.78%)
18,337(98.48%)
0,284(1.52%)
P
0.000
**
0.000
**
0.000
**
0.231
**
0.768
**
0.772
**
0.202
**
238
Gu S et al. / Journal of Biomedical Research, 2012, 26(4): 235-240
The mean BMI of boys and girls in the macrosomia
group was higher than in the non-macrosomia group
(boys, 17.312.43 kg/m
2
vs 16.872.34 kg/m
2
, P =
0.000; girls, 16.772.04 kg/m
2
vs 16.302.12 kg/m
2
, P =
0.000). Compared with the non-macrosomia group,
macrosomic infant had a 1.52-fold (P = 0.001) and
1.50-fold (P = 0.000) risk, respectively, to develop-
ing overweight or obesity at the age of 7 years. After
stratification by gender, we found that male macro-
somia had a 1.53-fold and a 1.49-fold risk of devel-
oping overweight and obesity at the age of 7 years,
respectively. The risk of developing overweight and
obesity in female macrosomia was significantly higher
than that in the female unaffected group (OR=1.45;
95%CI: 1.06-1.99).
DISCUSSION
The present study has confirmed that the birth of
macrosomic neonates was related to certain maternal
and fetal characteristics in Chinese population. The
results that the risk for macrosomia increases with
maternal BMI at early pregnancy, maternal age and
male gender are compatible with the findings of other
investigators. Recent studies have suggested that high
pre-pregnancy BMI was the most important predic-
tor of delivering an infant with macrosomia
[14-18]
. The
magnitude of effect of maternal BMI on the risk of
macrosomia in non-diabetic pregnancies varies con-
BMI: body mass index.
Table 2 Univariate logistic regression analysis for the association of macrosomia
Maternal and fetal characteristics
Maternal age at delivery
Maternal BMI at early pregnancy (kg/m
2
)
< 18.5
18.5-23.9
24-27.9
> 28
Infant gender
Male
Female
Maternal residence
Urban area
Rural area
Maternal education
Elementary school or less
Junior school
High school or above
Smoking during pregnancy
No
Yes
Drinking during pregnancy
No
Yes
Macrosomia (n=2,488)
24.743.32
,080(3.22%)
1,519(61.05%)
,0540(21.70%)
0,349(14.03%)
1,556(64.64%)
,0928(37.36%)
,0505(20.30%)
1,983(79.70%)
,0334(13.45%)
1,309(52.72%)
,0840(33.83%)
2,473(99.40%)
,015(0.60%)
2,426(98.14%)
,046(1.86%)
Control (n=18,827)
24.353.14
1,388(7.37%)
12,830(68.15%)
02,631(13.97%)
01,978(10.51%)
09,575(51.00%)
09,198(49.00%)
03,631(19.29%)
15,196(80.71%)
02,571(13.69%)
09,992(53.20%)
06,219(33.11%)
18,664(99.22%)
,0150(0.78%)
18,337(98.48%)
,0284(1.52%)
OR(95%CI)
1.04(1.02-1.05)
0.49(0.39-0.61)
Ref
1.73(1.56-1.93)
1.49(1.31-1.69)
Ref
0.62(0.57-0.68)
Ref
0.94(0.85-1.04)
Ref
1.01(0.89-1.15)
1.04(0.91-1.19)
Ref
0.84(0.25-2.77)
Ref
1.23(0.89-1.68)
P
0.000
0.000
-
0.000
0.000
-
0.000
-
0.231
-
0.898
0.909
-
0.772
-
0.202
BMI: body mass index.
Table 3 Long-term health consequences of macrosomia for children at the age of 7 years
BMI
Normal
Overweight
Obesity
Normal
Overweight
Obesity
Normal
Overweight
Obesity
Macrosomia (n=700)
259(60.66%)
099(23.19%)
069(16.15%)
183(67.03%)
058(21.24%)
032(11.73%)
442(63.14%)
157(22.43%)
101(14.43%)
Control (n=5137)
1,838(69.99%),,
,459(17.52%)
,328(12.49%)
1,873(74.56%),,
,408(16.24%)
231(9.20%),
3,711(72.24%),,
,867(16.88%)
,559(10.88%)
OR (95%CI)
-
1.53(1.19-1.97)
1.49(1.14-1.99)
-
1.45(1.06-1.99)
1.42(0.95-2.11)
-
1.52(1.24-1.86)
1.50(1.19-1.92)
P
-
0.001
0.007
-
0.019
0.087
-
0.001
< 0.001
Male
Female
Total
Risk factors and long-term health consequences of macrosomia
239
siderably between different studies and has been re-
ported to range from 1.4- to 18-fold. Our result on
maternal BMI at early pregnancy is consistent with
these reports. We also found that mothers deliver-
ing macrosomic infants were significantly older (P =
0.000). This finding agrees with most domestic and
foreign scholars' reports
[10,19-21]
. However, Adesina
et al.
[22]
in Ibadan, Nigeria, did not find any signifi-
cant difference in maternal age. There was a male
predominance (64.6%) in our study group. This was
also reported by Wollschlaeger
[19]
from Germany and
Tomic
[23]
from Bosnia.
Furthermore, we found that macrosomic infants had
an increased predisposition to develop overweight and
obesity. Compared with the non-macrosomia group,
macrosomic infant had a 1.52-fold (P = 0.001) and
1.50-fold (P = 0.000) risk, respectively, of develop-
ing overweight or obesity at the age of 7 years. This
is also illustrated by the data indicating that exposure
to a diabetic state in utero, apparently independent of
genetic factors, increases the risk of obesity and dia-
betes in the next generation
[24-26]
. Catalano pointed out
that a vicious cycle may be established with profound
consequences for the health of future generations
[27]
.
Our study has important significance. The popula-
tion is a large sample of 21,315 mother-child pairs,
and the children were prospectively followed and
assessed for obesity 7 years after birth. On the other
hand, this study also has some limitations. Our sur-
veillance data did not record gestational age based on
ultrasound dating. Gestational age based on the first
date of last menstrual period has errors, particularly
among preterm and post term births
[28]
. In addition,
pre-pregnancy BMI and weight gain during pregnan-
cy were not recorded routinely in this study. We used
maternal height and weight during the first trimester
to calculate early pregnancy BMI, which was affected
by both gestational weight gain and pre-pregnancy
BMI. Finally, although reduction of maternal smok-
ing during pregnancy is an important factor for mac-
rosomia increase in developed countries
[14,17,29,30]
, we
did not find statistically significant association be-
tween smoking in pregnancy and macrosomia. The
prevalence of smoking in pregnancy in our population
was too low (0.77%; 165 out of 21,315 women) to
analyze its relationship with the occurrence of mac-
rosomia.
In conclusion, older maternal age, higher maternal
BMI at early pregnancy and male gender are independ-
ent risk factors of macrosomia. Macrosomic infants
show an increased predisposition to develop overweight
or obesity at the beginning of their childhood.
Acknowledgements
We sincerely appreciated the assistance with data
collection provided by the family planning service
professionals, data managers and other staff of the
95 surveillance spots, and the Jiangsu Population and
Family Planning Committee.
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