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    The document discusses cytokines and their roles in the innate and adaptive immune system. It lists cytokines produced by different immune cells, their primary cellular sources, and their main targets and effects. It also discusses cell surface receptors, adhesion molecules, and other proteins involved in immune cell communication and response.

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    The document discusses cytokines and their roles in the innate and adaptive immune system. It lists cytokines produced by different immune cells, their primary cellular sources, and their main targets and effects. It also discusses cell surface receptors, adhesion molecules, and other proteins involved in immune cell communication and response.

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    The document discusses cytokines and their roles in the innate and adaptive immune system. It lists cytokines produced by different immune cells, their primary cellular sources, and their main targets and effects. It also discusses cell surface receptors, adhesion molecules, and other proteins involved in immune cell communication and response.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as XLSX, PDF, TXT or read online from Scribd
    Download as xlsx, pdf, or txt
    76 views2 pages

    Null

    Uploaded by

    mcwnotes
    The document discusses cytokines and their roles in the innate and adaptive immune system. It lists cytokines produced by different immune cells, their primary cellular sources, and their main targets and effects. It also discusses cell surface receptors, adhesion molecules, and other proteins involved in immune cell communication and response.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as XLSX, PDF, TXT or read online from Scribd
    Download as xlsx, pdf, or txt
    of 2

    Cytokine Principal Cell Source Principal cellular targets and biologic effects Ligand L on

    Innate Immune System


    TNF Macrophage, T Cells Endothelial cells: inflammation, coagulation.
    Neutrophils: activation. Hypothalamus: fever, Liver:
    synthesis of actue phase proteins. Muscle, fat:
    catabolism. Many Cell types: apoptosis
    IL-1 Macrophages, endothelial cells, Endoth. Activation. Hypothalamus: fever. Liver:
    some epithelial cells synthesis of actue phase proteins
    Chemokines Macrophages, endothelial cells, t- Chemitaxis and activation of leukocytes
    lymphocytes, fibroblasts,
    platelets.
    IL-12 Macrophages, dentritic Cells Nk cells and T Cells: IFNg synthesis, increased
    cytosolic activity. T cells: th1 differentiation
    IFN-gamma NK cells, T lymphocytes (Th1) Activation of Macrophages, stimulates AB
    production to bind APC Fc receptors, activates
    complement production, stimulates co stimulatory
    molecule expression
    Type 1 IFNs IFNalpha: macrophages. All cells: antiviral state, increased class I MHC
    IFNbeta: fibroblasts expression. NK cells: activation
    IL-10 Macrophages, T cells (TH2) Macrophages: inhibition of Il-12 production, reduced
    exression of costimulators and class II MHC
    molecules. Enhance b-cell production
    IL-6 Macrophages, endothelial cells, t Liver: synthesis of acute phase proteins. B cells:
    cells proliferation of anibody-production cells
    IL-15 Macrophages, others NK cells: proliferation. T cells: proliferation
    IL-18 Macrophages Nk cells and T Cells: IFNg synthesis,
    IL-2 T-cells Stimulates t-cells
    IL-13 TH2 Stimulates class swithing to make IgE
    TGFbetta Mucosal surfaces Stimulates IgA isotype switching
    T-Lymphocytess
    CCL17 vascular Endothelium near skin Homes leukocytes to skin
    cells
    CCL27 Kerotinocytes Binds CCR10 on effector T-Cell, homes t-cell to skin

    MadCam-1 Binds T-cell to endo near gut Homes T cells to gut


    CCl25 Epithelium of SI Homes t cell to SI
    CCL28 Epithelium of LI Homes t cell to LI
    CD3 T-cells Signal Transduction
    CD4 T-cells Adhesion and signal transduction. MHC II
    APC
    CD8 T-cells Adhesion and Signal Transduction MHC IAPC
    CD28 T-cells Signal Transduction (costimulation) B7 APC
    CTLA-4 T-cells Signal Transduction (negative regulation) B7 APC
    LFA-1 T-cells Adhesion ICAM-1
    APC
    Enth
    VLA-4 T-cells Adhesion VCAM Enth
    CCR7 Dendritic cell Distinct to Activated Dentritic cell
    When bound to CD40, amplifies signal to maintain
    immune response. Activates macrophages and B cell
    CD40L T/B-cells isotype switching CD40 APC
    Stimulates Eosinophils, + LKT production and
    IL-5 Th2, Mast Cells cytotoxcity for parasites (in vitro)
    IL-3, GM-CSF Mast Cells Promotes survival and activation of eosinophils
    Stimulates Neutralizing IgG Ab (IgG4) production,
    TH2 differentiation. Inhibits Th1 response.
    IL-4 Th2 Stimulates IgE production
    IL-12 Act. Macrophages/Dendritic TH1 Differentiation
    FasL CTLs Induces apoptosis by binding FasR on target cell
    L-Selectin High endothelial venule in Low affinity binding of T-cell
    Ligand Lypmh node
    E/P Selectin Binds E/P selectin on activated Hgh affinity binding on endothelium
    Ligand endothelium and platelets (for P)
    CD31 Leukocytes binds to PECAM which is on activated leukocytes,
    endothelial cell-cell jxns.
    cd3 Bound to microbe Cd3 binds CR2 on b cell which leads to b cell
    activation via complement system
    FC Receptors
    FcƔRI Macrophages, neutrophils, Phagocytosis, activation of phagocytes
    eosinophils
    FCƔRIIIA Nk cells AB dependent cellular cytotoxicity
    FC€RI Mast cells, basophils, binds IgE and causes degranulation
    esosinophils
    PolyIgR Mucosal surfaces Binds IgA and transports it into lumen of GI
    FCRn Lumen of GI tract, Placenta Transfers mother's IgG into neonate via placenta or
    mother's milk
    Plasma
    Proteins
    C1 inhibitor Plasma inhibits C1 protease activity
    Factor I Plasma Cleaves c3b and c4b
    Membrane
    Proteins
    DAF Blood cells, endo/epi causes dissociation of c3 convertase
    CR1 Monnuclar phags, PMR's, B/T, Cissoc. Of c3 convertase. Cofactor for factor I
    RBC, Eosiniphills, FDCs
    Hypersensitivit Mast cells and Basophils Increases vasc. Permeability, causes sm contraction. H1R, H2R
    y Toxic to parasites
    Histamine Mast cells and Basophils Increases vasc. Permeability, causes sm contraction. H1R, H2R
    (heparin is Toxic to parasites
    similar)
    Histamine 1 Mast cells and Basophils Smooth muscle contraction, vasc. Permeability
    Histamine 2 Mast cells and Basophils Vascular Permeability
    Mast Cell
    Chemokines
    CCL3 Mast Cells chemotactic for CCR3
    monocytes/macrophages/neutrophils/tcells/eosinophil
    s
    CCL5 Mast Cells Chmotactic for T cells and Eosinophils CCR3
    CCL11 Mast Cells Eotaxin, found at sites of inflammation
    Mast Cell
    Lipid
    Mediators
    Leukotrienes Mast Cells Eosinophil migration, smc contraction, vasc.
    C4, D4, E4 Permeability, musucs hyperscecretion
    Leukotrienes Mast Cells Sm. Muscle Contraction, Increased permeability
    Eosinophil
    products
    MBP Eosinophil Mast cell activation, helminthotoxic
    ECP Eosinophil Sames as MBP plus neurtoxic
    PAF Eosinophil Bronchoconstriction and activates platelets
    LTC4 Eosinophil Bronchoconstriction, mucus hypersecretion, edema

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