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CKD Pathophysiology

The document summarizes the stages of chronic kidney disease. It describes how a streptococcal infection can lead to antibody formation and antigen-antibody complex deposition in the glomerulus, causing acute inflammation and damage. This results in acute glomerulonephritis which can progress to chronic glomerulonephritis due to repeated inflammation over time. As kidney function declines through 5 stages, the remaining nephrons undergo changes to try and compensate, but kidney reserve and non-excretory functions are lost, leading to numerous complications.

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14K views1 page

CKD Pathophysiology

The document summarizes the stages of chronic kidney disease. It describes how a streptococcal infection can lead to antibody formation and antigen-antibody complex deposition in the glomerulus, causing acute inflammation and damage. This results in acute glomerulonephritis which can progress to chronic glomerulonephritis due to repeated inflammation over time. As kidney function declines through 5 stages, the remaining nephrons undergo changes to try and compensate, but kidney reserve and non-excretory functions are lost, leading to numerous complications.

Uploaded by

lloyd_santino
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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STREPTOCCOCAL INFECTION

ANTIBODY FORMATION

ANTIGEN-ANTIBODY COMPLEX DEPOSIT IN GLOMERULUS

ACUTE INFLAMMATION AND DAMAGE

PERMEABILITY OF CAPILLARY GLOMERULUS SWELLING CELL PROLIFERATION

NON MODIFIABLE RISK FACTOR CONGESTION MODIFIABLE RISK FACTORS

• Age ACUTE GLOMERULONEPHRITIS LEADING TO CHORNIC GLOMERULONEPHRITIS • Diet


• Heredity • Nephrotoxins
• Gender REPEATED INFLAMMATION • Sedentary
lifestyle
STAGE 1 GFR (>90 mL/min/1.73 m2).ISCHEMIA, NEPHRON LOSS, SHRINKAGE OF KIDNEY

DEC. RENAL BLOOD FLOW

DEC. RENAL RESERVE

DAMAGE TO NEPHRONS

STAGE 2 GFR (60-89 mL/min/1.73 m2). 50% DAMAGE

STAGE 3 GFR (30-59 mL/min/1.73 m2). >75% DAMAGE

RENAL INSUFFICIENCY

REMAINING NEPHRONS UNDERGO CHANGES

REMAINING NEPHRONS FILTER MORE SOLUTES

STAGE 4 GFR (15-29mL/min/1.73 m2). HYPERTROPHY OF REMAINING NEPHRONS

FURTHER LOSS OF NEPHRON FUNCTIONS

LOSS OF NON EXCRETORY RENAL FUNCTION STAGE 5 ESRD LOSS OF EXCRETORY RENAL FUNCTION

DISTURBANCE in REPRODUCTION CALCIUM ABSORPTION HYPERPHOSPHATEMIA PHOSPHATE EXCRETION

IMMUNE DISTURBANCES HYPOCALCEMIA HYPERKALEMIA POTASSIUM EXCRETION

LIPID PRODUCTION HYPERPARATHYROIDISM METABOLIC ACIDOSIS HYDYOGEN EXCRETION

IMPAIRED INSULIN ACTION EDEMA WATER RETENTION SODIUM REABSORTION


HEART FAILURE IN TUBULE
ACTIVATION OF VIT D HYPERTENSION

FAILURE TO PRODUCE
ERYTHROPOIETIN EXCRETION OF NITROGENOUS WASTE

RBC PRODUCTION
BUN URIC ACID PERIPHERAL CNS CHANGES BLEEDING
NERVE TENDENCIES
HEMOGLOBIN CHANGES
CREATININE
PRURITUS ALTERED
ANEMIA PERICARDITIS TASTE

PALLOR PROTEINURIA
FATIGUE

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