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Methamphetamine From Ephedrine

The document describes two methods for preparing a catalyst for the catalytic hydrogenation of methamphetamine. Method 1 involves adding hydrated cupric sulfate solution to a suspension of lime in water, heating the mixture, filtering the precipitate, drying and grinding it to produce 225 grams of catalyst. Method 2 involves adding cupric sulfate solution to a calcium hydroxide solution, heating and agitating the mixture, filtering, drying and grinding the precipitate to yield 30.1 pounds of finished catalyst.

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1K views1 page

Methamphetamine From Ephedrine

The document describes two methods for preparing a catalyst for the catalytic hydrogenation of methamphetamine. Method 1 involves adding hydrated cupric sulfate solution to a suspension of lime in water, heating the mixture, filtering the precipitate, drying and grinding it to produce 225 grams of catalyst. Method 2 involves adding cupric sulfate solution to a calcium hydroxide solution, heating and agitating the mixture, filtering, drying and grinding the precipitate to yield 30.1 pounds of finished catalyst.

Uploaded by

Denis Alex
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Methamphetamine from Ephedrine

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Methamphetamine from Ephedrine U sing Phosphorus and Hydriodic Acid


0.2 moles of ephedrine are mixed with 10 grams of red phosphorus and 85 mL. of 57% hydriodic acid. The mixture is refluxed for 24 hours and let stand for 12 hours. 350 cc. of water are added and the phosphorus is filtered (asbestos filter) from the the mixture. A few crystals of sodium thiosulfate are added (to remove iodine) and then basified with 40% sodium hydroxide. The methamphetamine is extracted with ether; the ether washed with water and dried with anhydrous sodium carbonate. The ether is reduced and cooled. Cold hydrochloric acid is added to precipitate the methamphetamine hydrochloride. The methamphetamine hydrochloride is dried over anhydrous sodium carbonate. Yields are 80 to 88%. References: Boswell 2002; Ho 1975; Shaw 1956: Zenitz 1948

Catalytic Hydrogenation Preparation of Methamphetamine


by John Tindall Preparation of Catalyst

Method 1. To a suspension of 80 grams of lime, technical, in 500 mL. water was added with agitation during a period of 50 minutes at room temperature one liter of a solution containing 250 grams of technical hydrated cupric sulfate in water. The mixture was then held at 90 C. for 3 hours and continuously agitated. The precipitate which formed was then recovered by filtration, dried at 70 C., and ground to pass a 120 mesh screen. The yield of catalyst was 225 grams. Method 2. A solution of 29.8 pounds of technical hydrated cupric sulfate in 119 pounds of water was added in a steady stream over a period of 25 minutes to 9.6 pounds of calcium h ydroxide in 60 pounds of water. The resulting mixture was then heated in a water bath to 90 C. and agitated at this temperature for 3 hours. The mixture was next cooled, filtered and the precipitate dried by heating with hot air for 19 hours at 70 C. The dried precipitate was ground and screened, yielding 30.1 pounds of finishe d catalyst.

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