DAVID G. MANGUM (4085) C. KEVIN SPEIRS (5350) KRISTINE EDDE JOHNSON (7190) MICHAEL R.

MCCARTHY (8850) PARSONS BEHLE & LATIMER One Utah Center 201 South Main Street, Suite 1800 Salt Lake City, UT 841111 Telephone: (801) 532-1234 Facsimile: (801) 536-6111 [email protected] BENJAMIN G. JACKSON (California Bar No 255358, pro hac vice motion to be filed) MATHEW GORDON (12526) MYRIAD GENETICS, INC. 320 Wakara Way Salt Lake City, UT 84108 [email protected] [email protected] Attorneys for Plaintiffs IN THE UNITED STATES DISTRICT COURT FOR THE DISTRICT OF UTAH, CENTRAL DIVISION UNIVERSITY OF UTAH RESEARCH FOUNDATION, a Utah nonprofit corporation; the TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, a Pennsylvania nonprofit corporation; HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP, a Canadian limited partnership organized under the laws of the Province of Ontario; ENDORECHERCHE, INC., a Canadian corporation organized under the laws of the Province of Quebec; and MYRIAD GENETICS, INC., a Delaware corporation; Plaintiffs, vs. AMBRY GENETICS CORPORATION, Defendant.
4840-2921-6276.2

COMPLAINT DEMAND FOR JURY TRIAL

Case No. 2:13-cv-00640-RJS

Judge Robert J. Shelby

COMPLAINT FOR PATENT INFRINGEMENT 1. Plaintiffs, University of Utah Research Foundation (University of Utah), The

Trustees of the University of Pennsylvania (University of Pennsylvania), HSC Research and Development Limited Partnership (Hospital for Sick Children), Endorecherche, Inc. (Endorecherche), and Myriad Genetics, Inc. (Myriad), complain against Defendant Ambry Genetics Corporation (Defendant) as follows: JURISDICTION AND VENUE 2. This civil action for patent infringement arises under the patent laws of the United

States, specifically under Title 35 of the United States Code, Sections 271, et seq. Subject matter jurisdiction in this Court is founded upon 28 U.S.C. 1331 and 1338(a). 3. This Court has personal jurisdiction over the Defendant because it regularly conducts

business in this district and has committed acts in this judicial district which give rise to this action. On information and belief, Defendant sells, offers for sale, and has sold genetic testing products to residents of this jurisdiction. On information and belief, Defendant has attended, advertised, and or presented at conferences and/or meetings held in this jurisdiction in which it sells, offers for sale, has sold, and advertises its genetic testing products. On information and belief, Defendant has business relationships and/or has collaborated with multiple business and/or research entities in this district to which it sells, offers for sale, has sold, and/or advertises its genetic testing products. On information and belief, Defendant is a participating Medicaid and health insurance provider in this district. 4. Venue is proper in this judicial district pursuant to 28 U.S.C. 1391(b), (c) and/or

28 U.S.C. 1400(b). PARTIES 5. The University of Utah is a Utah nonprofit corporation with an address at 421 Wakara

Way, Suite 170, Salt Lake City, Utah 84108. The University of Utah is the owner or co-owner 2
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of United States Patent Nos. 5,709,999; 5,747,282; 5,753,441; 5,837,492; and 6,033,857. 6. The University of Pennsylvania is a Pennsylvania nonprofit corporation with an The

address of 3160 Chestnut Street, Suite 200, Philadelphia, Pennsylvania 19104-6283.

University of Pennsylvania is a co-owner of United States Patent Nos. 6,033,857 and 5,837,492. 7. The Hospital for Sick Children is a Canadian limited partnership organized under the

laws of the Province of Ontario, with an address of 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. The Hospital for Sick Children is a co-owner of United States Patent Nos. 6,033,857 and 5,837,492. 8. Endorecherche is Canadian corporation organized under the laws of the Province of

Quebec, with a place of business at 2989 De La Promenade, Ste-Foy, Quebec, QC G1W 2J5, Canada. Endorecherche is a co-owner of United States Patent Nos. 6,033,857 and 5,837,492. 9. Myriad is a Delaware corporation, with its principal place of business at 320 Wakara

Way, Salt Lake City, Utah 84108. Myriad owns United States Patent Nos. 5,654,155; 5,750,400; 6,051,379; 6,951,721; and 7,250,497. Further, Myriad is the exclusive licensee of United States Patent Nos. 5,709,999; 5,747,282; 5,753,441; 5,837,492; and 6,033,857. 10. The Plaintiffs are informed and believe, and on that basis allege, that Defendant is a

California corporation that has its principal place of business at 15 Argonaut, Aliso Viejo, California 92656. GENERAL ALLEGATIONS 11. Myriad is a molecular diagnostic company that develops and uses proprietary

technologies that permit doctors and patients to understand the genetic basis of human disease and the role that genes play in the onset, progression and treatment of disease. Myriads technologies result in, and guide the development of, new molecular diagnostic products that assess an individual's risk for developing disease, identify a patients likely response to drug therapy, and assess a patients risk of disease progression and recurrence. 3
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12.

For healthcare providers, Myriad offers an array of genetic tests, prognostic tests and

personalized medicine tests to help healthcare providers assess a patients increased cancer risk, disease aggressiveness and optimize efficacy of chemotherapy. Myriads testing products provide healthcare providers with information to help make medical management decisions to reduce cancer risk and help make sure specific treatments are tailored for each individual patient. 13. For patients, Myriad offers tests that provide important clinical information to assist

patients and their healthcare providers in assessing cancer risk so the patient can take preventative action to reduce the risk of disease and in making treatment decisions if the patient is diagnosed with cancer. Myriad improves patient care through the development of new

products across multiple medical specialties. 14. In the early-to-mid 1990s, Plaintiffs discovered the genetic sequences of the BRCA1

and BRCA2 genes and mutations that increase a womans risk of developing breast and ovarian cancer. Since that time, Myriad has invested over $500 million to implement this discovery and create a molecular diagnostic test for hereditary breast and ovarian cancer related to the BRCA1 and BRCA2 genes. Plaintiffs efforts have revolutionized patient care and provided medical diagnosis and treatment options never thought possible. 15. Defendant offers laboratory services, including clinical diagnostic and genomic

services, including testing and analysis of BRCA1 and BRCA2 genes. 16. Defendant began offering its BRCA1 and BRCA2 analysis as part of its cancer-

testing menu on June 13, 2013. On information and belief, Defendant offers stand-alone tests comprising full gene sequencing and deletion/duplication analyses for the BRCA 1 and BRCA 2 genes. On information and belief, Defendant also offers full gene sequencing and

deletion/duplication analyses for the BRCA 1 and BRCA 2 genes as part of multiple hereditary cancer panels that test cancer susceptibility using next-generation sequencing technology.

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FIRST CLAIM FOR RELIEF (By the University of Utah and Myriad for Infringement of United States Patent No. 5,709,999) 17. Plaintiffs repeat and reallege the allegations set forth in preceding paragraphs 1

through 16, inclusive. 18. United States Patent No. 5,709,999 (the 999 Patent), was duly and legally issued

by the United States Patent and Trademark Office on January 20, 1998. The University of Utah is the owner and Myriad is the exclusive licensee of the 999 Patent. A true and correct copy of the 999 Patent is attached hereto and incorporated herein by reference as Exhibit 1. 19. Defendant is infringing, contributing to the infringement of, and/or inducing others to

infringe the 999 patent by making, manufacturing, promoting, marketing, advertising, distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claim of the 999 Patent literally and/or under the doctrine of equivalents: Claim 6. 20. Plaintiffs have been damaged and have suffered irreparable injury due to the

Defendants acts of infringement, and will continue to suffer irreparable injury unless Defendants acts are enjoined. 21. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as alleged herein. The University of Utah has suffered and will continue to suffer substantial damage in the form of reduced royalty payments by reason of Defendants acts of patent infringement and the resulting reduction in Myriads sales revenues. Plaintiffs are entitled to recover from Defendant the damages sustained as a result of Defendants acts. 22. Defendant has willfully infringed the 999 Patent.

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23. 285.

Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

SECOND CLAIM FOR RELIEF (By the University of Utah and Myriad for Infringement of United States Patent No. 5,747,282) 24. Plaintiffs repeat and reallege the allegations set forth in preceding paragraphs 1

through 23, inclusive. 25. United States Patent No. 5,747,282 (the 282 Patent), was duly and legally issued

by the United States Patent and Trademark Office on May 5, 1998. The University of Utah, along with the Public Health Service, through the National Institutes of Health (PHS), are the owners, and Myriad is the exclusive licensee, of the 282 Patent. A true and correct copy of the 282 Patent is attached hereto and incorporated herein by reference as Exhibit 2. 26. Defendant is infringing, contributing to the infringement of, and/or inducing others to

infringe the 282 patent by making, manufacturing, promoting, marketing, advertising, distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claims of the 282 Patent literally and/or under the doctrine of equivalents: Claims 6, 16, and 17. 27. Plaintiffs have been damaged and have suffered irreparable injury due to the

Defendants acts of infringement, and will continue to suffer irreparable injury unless Defendants acts are enjoined. 28. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as alleged herein. The University of Utah has suffered and will continue to suffer substantial damage in the form of reduced royalty payments by reason of Defendants acts of patent 6
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infringement and the resulting reduction in Myriads sales revenues. Plaintiffs are entitled to recover from Defendant the damages sustained as a result of Defendants acts. 29. 30. 285. THIRD CLAIM FOR RELIEF (By the University of Utah and Myriad for Infringement United States Patent No. 5,753,441) 31. Plaintiffs repeat and reallege the allegations set forth in preceding paragraphs 1 Defendant has willfully infringed the 282 Patent. Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

through 30, inclusive. 32. United States Patent No. 5,753,441 (the 441 Patent), was duly and legally issued

by the United States Patent and Trademark Office on May 19, 1998. The University of Utah and PHS are the owners, and Myriad is the exclusive licensee, of the 441 Patent. A true and correct copy of the 441 Patent is attached hereto and incorporated herein by reference as Exhibit 3. 33. Defendant is infringing, contributing to the infringement of, and/or inducing others to

infringe the 441 patent by making, manufacturing, promoting, marketing, advertising, distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claims of the 441 Patent literally and/or under the doctrine of equivalents: Claims 7, 8, 12, 23, and 26. 34. Plaintiffs have been damaged and have suffered irreparable injury due to the

Defendants acts of infringement, and will continue to suffer irreparable injury unless Defendants acts are enjoined. 35. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as 7
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alleged herein. The University of Utah has suffered and will continue to suffer substantial damage in the form of reduced royalty payments by reason of Defendants acts of patent infringement and the resulting reduction in Myriads sales revenues. Plaintiffs are entitled to recover from Defendant the damages sustained as a result of Defendants acts. 36. 37. 285. FOURTH CLAIM FOR RELIEF (By the University of Utah, the University of Pennsylvania, and the Hospital for Sick Children, Endorecherche, and Myriad for Infringement of United States Patent No. 5,837,492) 38. Plaintiffs repeat and reallege the allegations set forth in preceding paragraphs 1 Defendant has willfully infringed the 441 Patent. Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

through 38, inclusive. 39. United States Patent No. 5,837,492 (the 492 Patent), was duly and legally issued

by the United States Patent and Trademark Office on November 17, 1998. The University of Utah, the University of Pennsylvania, the Hospital for Sick Children, and Endorecherche are the owners, and Myriad is the exclusive licensee, of the 492 Patent. A true and correct copy of the 492 Patent is attached hereto and incorporated herein by reference as Exhibit 4. 40. Defendant is infringing, contributing to the infringement of, and/or inducing others to

infringe the 492 patent by making, manufacturing, promoting, marketing, advertising, distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claims of the 492 Patent literally and/or under the doctrine of equivalents: Claims 29 and 30. 41. Plaintiffs have been damaged and have suffered irreparable injury due to the

Defendants acts of infringement, and will continue to suffer irreparable injury unless 8
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Defendants acts are enjoined. 42. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as alleged herein. The University of Utah, the University of Pennsylvania, the Hospital for Sick Children, and Endorecherche have suffered and will continue to suffer substantial damage in the form of reduced royalty payments by reason of Defendants acts of patent infringement and the resulting reduction in Myriads sales revenues. Plaintiffs are entitled to recover from Defendant the damages sustained as a result of Defendants acts. 43. 44. 285. FIFTH CLAIM FOR RELIEF (By the University of Utah, the University of Pennsylvania, the Hospital for Sick Children, Endorecherche, and Myriad for Infringement of United States Patent No. 6,033,857) 45. Plaintiffs repeat and reallege the allegations set forth in preceding paragraphs 1 Defendant has willfully infringed the 492 Patent. Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

through 44, inclusive. 46. United States Patent No. 6,033,857 (the 857 Patent), was duly and legally issued

by the United States Patent and Trademark Office on March 7, 2000. The University of Utah, the University of Pennsylvania, the Hospital for Sick Children, and Endorecherche are the owners, and Myriad is the exclusive licensee, of the 857 Patent. A true and correct copy of the 857 Patent is attached hereto and incorporated herein by reference as Exhibit 5. 47. Defendant is infringing, contributing to the infringement of, and/or inducing others to

infringe the 857 patent by making, manufacturing, promoting, marketing, advertising, distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, 9
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BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claim of the 857 Patent literally and/or under the doctrine of equivalents: Claim 4. 48. Plaintiffs have been damaged and have suffered irreparable injury due to the

Defendants acts of infringement, and will continue to suffer irreparable injury unless Defendants acts are enjoined. 49. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as alleged herein. The University of Utah, the University of Pennsylvania, the Hospital for Sick Children, and Endorecherche have suffered and will continue to suffer substantial damage in the form of reduced royalty payments by reason of Defendants acts of patent infringement and the resulting reduction in Myriads sales revenues. Plaintiffs are entitled to recover from Defendant the damages sustained as a result of Defendants acts. 50. 51. 285. SIXTH CLAIM FOR RELIEF (By Myriad for Infringement of United States Patent No. 5,654,155) 52. Plaintiff Myriad repeats and realleges the allegations set forth in preceding Defendant has willfully infringed the 857 Patent. Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

paragraphs 1 through 51, inclusive. 53. United States Patent No. 5,654,155 (the 155 Patent), was duly and legally issued

by the United States Patent and Trademark Office on August 5, 1997. Myriad is the owner of the 155 Patent. A true and correct copy of the 155 Patent is attached hereto and incorporated herein by reference as Exhibit 6. 54. Defendant is infringing, contributing to the infringement of, and/or inducing others to 10
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infringe the 155 patent by making, manufacturing, promoting, marketing, advertising, distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claims of the 155 Patent literally and/or under the doctrine of equivalents: Claims 2, 3, and 4. 55. Myriad has been damaged and has suffered irreparable injury due to the Defendants

acts of infringement, and Myriad will continue to suffer irreparable injury unless Defendants acts are enjoined. 56. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as alleged herein, and Myriad is entitled to recover from Defendant the damages sustained as a result of Defendants acts. 57. 58. 285. SEVENTH CLAIM FOR RELIEF (By Myriad for Infringement of United States Patent No. 5,750,400) 59. Plaintiff Myriad repeats and realleges the allegations set forth in preceding Defendant has willfully infringed the 155 Patent. Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

paragraphs 1 through 58, inclusive. 60. United States Patent No. 5,750,400 (the 400 Patent), was duly and legally issued

by the United States Patent and Trademark Office on May 12, 1998. Myriad is the owner of the 400 Patent. A true and correct copy of the 400 Patent is attached hereto and incorporated herein by reference as Exhibit 7. 61. Defendant is infringing, contributing to the infringement of, and/or inducing others to 11
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infringe the 400 patent by making, manufacturing, promoting, marketing, advertising, distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claims of the 400 Patent literally and/or under the doctrine of equivalents: Claims 2, 3, 4, 5, 6, and 7. 62. Myriad has been damaged and has suffered irreparable injury due to the Defendants

acts of infringement, and Myriad will continue to suffer irreparable injury unless Defendants acts are enjoined. 63. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as alleged herein, and Myriad is entitled to recover from Defendant the damages sustained as a result of Defendants acts. 64. 65. 285. EIGHTH CLAIM FOR RELIEF (By Myriad for Infringement of United States Patent No. 6,051,379) 66. Plaintiff Myriad repeats and realleges the allegations set forth in preceding Defendant has willfully infringed the 400 Patent. Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

paragraphs 1 through 65, inclusive. 67. United States Patent No. 6,051,379 (the 379 Patent), was duly and legally issued

by the United States Patent and Trademark Office on April 18, 2000. Myriad is the owner of the 379 Patent. A true and correct copy of the 379 Patent is attached hereto and incorporated herein by reference as Exhibit 8. 68. Defendant is infringing, contributing to the infringement of, and/or inducing others to 12
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infringe the 379 patent by making, manufacturing, promoting, marketing, advertising, distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claims of the 379 Patent literally and/or under the doctrine of equivalents: Claims 32 and 33. 69. Myriad has been damaged and has suffered irreparable injury due to the Defendants

acts of infringement, and Myriad will continue to suffer irreparable injury unless Defendants acts are enjoined. 70. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as alleged herein, and Myriad is entitled to recover from Defendant the damages sustained as a result of Defendants acts. 71. 72. 285. NINTH CLAIM FOR RELIEF (By Myriad for Infringement of United States Patent No. 6,951,721) 73. Plaintiff Myriad repeats and realleges the allegations set forth in preceding Defendant has willfully infringed the 379 Patent. Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

paragraphs 1 through 73, inclusive. 74. United States Patent No. 6,951,721 (the 721 Patent), was duly and legally issued

by the United States Patent and Trademark Office on October 5, 2005. Myriad is the owner of the 721 Patent. A true and correct copy of the 721 Patent is attached hereto and incorporated herein by reference as Exhibit 9. 75. Defendant is infringing, contributing to the infringement of, and/or inducing others to 13
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infringe the 721 patent by making, manufacturing, promoting, marketing, advertising, distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claim of the 721 Patent literally and/or under the doctrine of equivalents: Claim 5. 76. Myriad has been damaged and has suffered irreparable injury due to the Defendants

acts of infringement, and Myriad will continue to suffer irreparable injury unless Defendants acts are enjoined. 77. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as alleged herein, and Myriad is entitled to recover from Defendant the damages sustained as a result of Defendants acts. 78. 79. 285. TENTH CLAIM FOR RELIEF (By Myriad for Infringement of United States Patent No. 7,250,497) 80. Plaintiff Myriad repeats and realleges the allegations set forth in preceding Defendant has willfully infringed the 721 Patent. Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

paragraphs 1 through 79, inclusive. 81. United States Patent No. 7,250,497 (the 497 Patent), was duly and legally issued

by the United States Patent and Trademark Office on July 31, 2007. Myriad is the owner of the 497 Patent. A true and correct copy of the 497 Patent is attached hereto and incorporated herein by reference as Exhibit 10. 82. Defendant is infringing, contributing to the infringement of, and/or inducing others to

infringe the 497 patent by making, manufacturing, promoting, marketing, advertising, 14

distributing, offering for sale and selling and/or causing to be offered or sold certain BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products that infringe at least the following claims of the 497 Patent literally and/or under the doctrine of equivalents: Claims 3, 4, 5, 6, 7, 8, 11, 14, 17, 18, and 19. 83. Myriad has been damaged and has suffered irreparable injury due to the Defendants

acts of infringement, and Myriad will continue to suffer irreparable injury unless Defendants acts are enjoined. 84. Myriad has suffered and will continue to suffer substantial damage to its business,

including, without limitation, lost profits, loss of business reputation, loss of business opportunities, and loss of market share, by reason of Defendants acts of patent infringement as alleged herein, and Myriad is entitled to recover from Defendant the damages sustained as a result of Defendants acts. 85. 86. 285. DEMAND FOR JURY TRIAL 87. Plaintiffs demand a trial by jury on all matters herein so triable. RELIEF REQUESTED WHEREFORE, Plaintiffs pray for Judgment as follows: a. That Defendant has infringed, contributed to the infringement of, and induced Defendant has willfully infringed the 497 Patent. Defendants acts make this an exceptional case within the meaning of 35 U.S.C.

infringement of, literally and/or under the doctrine of equivalents, the asserted claims of the 999, 282, 441, 492, 857, 155, 400, 379, 721, and 497 patents; b. That Defendant and its subsidiaries, affiliates, parents, successors, assigns,

officers, agents, servants, employees, attorneys, and all other persons acting in concert or in participation with it, be temporarily and preliminarily enjoined during the pendency of this 15
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action, and permanently enjoined thereafter, from infringing the 999, 282, 441, 492, 857, 155, 400, 379, 721, and 497 patents, and specifically from directly or indirectly making, using, selling, offering for sale, or importing any products or services embodying the inventions of the 999, 282, 441, 492, 857, 155, 400, 379, 721, and 497 patents, including, without limitation, the Defendants BRCA1, BRCA2, BRCAPlus, BreastNext, OvaNext, and CancerNext products, during the life of the claims of the 999, 282, 441, 492, 857, 155, 400, 379, 721, and 497 patents without Plaintiffs express written authority; c. That Plaintiffs be awarded all damages attributable to Defendants infringement

of the 999, 282, 441, 492, 857, 155, 400, 379, 721, and 497 patents in an amount according to proof at trial, but not less than a reasonable royalty; d. That Defendant be ordered to deliver to Plaintiffs, for destruction at Plaintiffs

option, all products that infringe the 999, 282, 441, 492, 857, 155, 400, 379, 721, and 497 patents; e. That Defendant be required to account for all gains, profits, advantages, and

unjust enrichment derived from their violations of the law; f. g. That this case be deemed exceptional within the meaning of 35 U.S.C. 285; That Plaintiffs be awarded their reasonable attorneys fees incurred in connection

with this matter; h. That Plaintiffs be awarded enhanced damages and/or costs pursuant to 35 U.S.C.

285 and/or applicable law; i. j. That Plaintiffs be awarded the costs of suit, and an assessment of interest; and, That the Court award Plaintiffs such other, further, and different relief as the

evidence may require and as the Court deems proper under the circumstances.

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DATED this 9th day of July, 2013.

/s/ David G. Mangum DAVID G. MANGUM C. KEVIN SPEIRS KRISTINE EDDE JOHNSON MICHAEL R. MCCARTHY PARSONS BEHLE & LATIMER BENJAMIN G. JACKSON MATHEW GORDON Attorneys for Plaintiffs

Plaintiffs Addresses: University of Utah Research Foundation Technology Transfer Office 421 Wakara Way, Suite 170 Salt Lake City, UT 84108 University of Pennsylvania Center for Technology Transfer 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104-6283 HSC Research and Development Limited Partnership 555 University Avenue Toronto, Ontario M5G 1X8 Canada Endorecherche, Inc. 2989 De La Promenade Ste-Foy, Quebec, QC G1W 2J5 Canada Myriad Genetics, Inc. 320 Wakara Way Salt Lake City, UT 84108

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