Scribd
Upload
32 views2 pages

Computational Multiscale Methods For Tissue Biomechanics: Michele Marino, Ginu U. Unnikrishnan and Giuseppe Vairo

The document discusses computational multiscale methods for tissue biomechanics. It provides an abstract on developing accurate constitutive models for tissues that account for nonlinear and time-dependent effects across different length scales using multiscale and multiphysics methods. The minisymposium aims to bring researchers together to discuss recent developments and future directions in computational methods for tissue biomechanics.

Uploaded by

rahuldbajaj2011
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
32 views2 pages

Computational Multiscale Methods For Tissue Biomechanics: Michele Marino, Ginu U. Unnikrishnan and Giuseppe Vairo

The document discusses computational multiscale methods for tissue biomechanics. It provides an abstract on developing accurate constitutive models for tissues that account for nonlinear and time-dependent effects across different length scales using multiscale and multiphysics methods. The minisymposium aims to bring researchers together to discuss recent developments and future directions in computational methods for tissue biomechanics.

Uploaded by

rahuldbajaj2011
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 2

11th. World Congress on Computational Mechanics (WCCM2014) 5th. European Conference on Computational Mechanics (ECCM V) 6th.

European Conference on Computational Fluid Dynamics (ECFD VI) July 20 - 25, 2014, Barcelona, Spain

COMPUTATIONAL MULTISCALE METHODS FOR TISSUE BIOMECHANICS


MICHELE MARINO*, GINU U. UNNIKRISHNAN AND GIUSEPPE VAIRO*
*

University of Rome Tor Vergata Department of Civil Engineering and Computer Science via del Politecnico, 1 00133 Roma (Italy) [email protected], [email protected]

Boston University Department of Mechanical Engineering 110 Cumming Street Boston, MA-02215, USA [email protected]

Key words: Tissue Biomechanics, Multiscale approaches, Constitutive modeling, Mechanobiology. ABSTRACT In the field of biomechanics and life sciences, tissue modelling and simulation can be surely considered as a frontier and challenging task. Both mineralized (e.g., bone, tooth enamel and dentin, cartilage) and soft tissues (e.g., skin, muscles, tendons, ligaments, blood vessels) exhibit a precise structured and hierarchical arrangement, characterized by organized biostructures with different length scales (from nano up to the macroscale) [1,2]. This is the case of collagen fibrils and fibers in soft connective tissues, of actin and myosin myofibrils in muscles sarcomere, of collagen lamellae in bones osteon. Tissue mechanics and physiological functions are highly affected by such a hierarchical and multiscale organization, as well as by a number of coupled biochemical and mechanobiological processes. Moreover, tissue disorders and diseases can be generally related with histological and biochemical alterations at different scales (e.g., [3-5]). The key goal of in-silico approaches in the field of tissue biomechanics is to develop computational methods and models that are able to integrate structural properties of the tissue and its physiological functions. In this way, reliable, predictive and patient-specific biomechanical analyses could be oriented for diagnosis and therapy optimization. In this context, there is a great need for the development of accurate tissue constitutive models accounting for highly nonlinear and time-depending effects, governed by different physics and involving mechanisms at different length scales. To this aim, multiscale and multiphysics methods are giving to-date the most promising results (e.g., [6-12]). Accordingly, advanced single-scale and single-physics models of typical tissue substructures, inter-scale and interphysics consistent relationships supported by experimental evidences, homogenization approaches, refined numerical methods and applications, can contribute towards the definition of accurate predictive theories and advanced computational formulations for tissue biomechanics. The Minisymposium aims to bring together front-line researchers in the field of Computational Methods in Tissue Biomechanics, proposing multidisciplinary, original and

Michele Marino, Ginu U. Unnikrishnan and Giuseppe Vairo

groundbreaking findings and contributions. The participants (about 15-20 invited contributions from Europe, USA and Asia) will also discuss recent developments and future directions. Participation is also open to researchers presenting experimental studies focused on, but not limited to, the validation of computational multiscale techniques in tissue biomechanics. REFERENCES
[1] P. Fratzl, Collagen : structure and mechanics, Springer-Verlag, New York, 2008. [2] J.Y. Rho, L. Kuhn-Spearing and P. Zioupos, Mechanical properties and the hierarchical

structure of bone, Med. Eng. Phys., Vol. 20, pp. 92-102, (1998).
[3] A. Bruel and H. Oxlund, Changes in biomechanical properties, composition of collagen

and elastin, and advanced glycation endproducts of the rat aorta in relation to age, Atherosclerosis, Vol. 127, pp. 155-165, (1996).
[4] M.J. Buehler, Nanomechanics of collagen fibrils under varying cross-link densities:

atomistic and continuum studies, J. Mech. Behav. Biomed. Mat., Vol. 1, pp. 59-67, (2008).
[5] V.U. Unnikrishnan, G.U. Unnikrishnan and J.N. Reddy, Biomechanics of breast tumor:

effect of collagen and tissue density, Int.J. Mech. Mater. Des., Vol. 8, pp. 257-267, (2012).
[6] G.A. Holzapfel, T.C. Gasser and R.W. Ogden, A new constitutive framework for

arterial wall mechanics and a comparative study of material models, J. Elasticity, Vol. 61, pp. 1-48, (2000).
[7] H. Tang, M.J. Buehler and B.A. Moran, A constitutive model of soft tissue: from

nanoscale collagen to tissue continuum, Ann. Biomed. Eng., Vol. 37, pp. 1117-1130, (2009).
[8] F. Maceri, M. Marino and G. Vairo, A unified multiscale mechanical model for soft

collagenous tissues with regular fiber arrangement, J. Biomech., Vol. 43, pp. 355-363 (2010).
[9] V.U. Unnikrishnan, G.U. Unnikrishnan and J.N. Reddy, Multiscale Computational

Analysis of Biomechanical Systems, IUTAM Symposium on Multi-Functional Material Structures and Systems, IUTAM Bookseries Vol. 19, pp 123-131, (2010).
[10] F. Maceri, M. Marino and G. Vairo, An insight on multiscale tendon modeling in

muscle-tendon integrated behaviour, Biomech. Model. Mechanobiol., Vol. 11, pp. 505517, (2011).
[11] F. Maceri, M. Marino and G. Vairo, Age-dependent arterial mechanics via a multiscale

elastic approach, Int. J. Comput. 10.1080/15502287.2012.744114, (2012).

Methods

Eng.

Sci.

Mech.,

doi:

[12] M. Marino and G. Vairo, Stress and strain localization in stretched collagenous tissues

via a multiscale modeling approach, Comput. Methods Biomech. Biomed. Engin., doi: 10.1080/10255842.2012.658043, (2012).

You might also like