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Pathophysiology (Glioma)

This document outlines the pathophysiology of tumor formation (glioma) in the brain. It lists predisposing factors like race and gender as well as precipitating factors such as lifestyle, diet, lack of exercise, and stress. It then describes the mutation and overgrowth of normal glial cells leading to tumor formation, increased intracranial pressure, and damage to brain cells if left untreated. Early detection through diagnostic tests and prompt treatment including surgery, radiation, chemotherapy, and medications can lead to a fair prognosis.

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peterjong
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2K views2 pages

Pathophysiology (Glioma)

This document outlines the pathophysiology of tumor formation (glioma) in the brain. It lists predisposing factors like race and gender as well as precipitating factors such as lifestyle, diet, lack of exercise, and stress. It then describes the mutation and overgrowth of normal glial cells leading to tumor formation, increased intracranial pressure, and damage to brain cells if left untreated. Early detection through diagnostic tests and prompt treatment including surgery, radiation, chemotherapy, and medications can lead to a fair prognosis.

Uploaded by

peterjong
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOC, PDF, TXT or read online on Scribd
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Predisposing Factors 1) 2) Race Gender

PATHOPHYSIOLOGY

Precipitating Factors Lifestyle: Diet (Carnivorous), No exercise Exposure to radiation (Phone calls) Stress

Mutation of normal cells (Glial cells) Formation of cancer cells

Normal cells affected

Number and growth of abnormal cells

Hypertrophy of gliomal layer

Persistent overgrowth of cells Metastasis to near area(Meninges)

If not treated:

TUMOR formation (GLIOMA)

Intracranial pressure MENINGIOMA Depletion of O2 and Nutrients Hypo perfusion in cerebral circulation Restlessness, Irritability, Anxiety

Lactic acid formation LIR (Local Inflammato ry Response) SIRS (Systemic Inflammat ory Response Syndrome Swelling of cerebral cells Damage to cells

Capillary Refill Permeability Headache, swelling of the affected area, Vomiting, Nausea, Dizziness

Formation of Edema

Stimulation of SNS (Constriction)

Compensatory Mechanism

Persistent depletion of O2 and nutrients Cell starvation

Sustained increase in capillary Cerebral Vasodilation Hypovolemia at cerebral Cell Death level

Acidity in cellular and tissue level Metabolic Acidosis

SHOCK

COMATOSE State

Persistent SIRS

Damage of various vital organs Multiple Organ Dysfunction Syndromes (MODS)

DEATH
If treated: Early Detection of Tumor Formation Diagnostic tests: MRI (Magnetic Resonance Imaging) SPECT (Singleproton Emission Computed Tomography EEG (Electroencephal ogram) Angiography ComputerTumor Formation (GLIOMA) Prompt Medical Management/ Treatment Surgical Therapy Radiation Therapy and Radiosurgery Chemotherapy Drug Therapy Neoplastic medications Osmotic Diuresis Corticosteroids

Fair Prognosis

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