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Array

Array-comparative genomic hybridization (aCGH) is a technique that can detect copy number variations in genomic DNA at a higher resolution than traditional CGH, down to the level of 5-10 kilobases. Today's high-resolution CGH arrays can even detect structural variations as small as 200 base pairs. This method allows the identification of new recurrent chromosome changes like microdeletions and duplications that are associated with diseases such as cancer and birth defects caused by chromosome abnormalities.

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17 views1 page

Array

Array-comparative genomic hybridization (aCGH) is a technique that can detect copy number variations in genomic DNA at a higher resolution than traditional CGH, down to the level of 5-10 kilobases. Today's high-resolution CGH arrays can even detect structural variations as small as 200 base pairs. This method allows the identification of new recurrent chromosome changes like microdeletions and duplications that are associated with diseases such as cancer and birth defects caused by chromosome abnormalities.

Uploaded by

Figen Seymen
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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Array-comparative genomic hybridization (also CMA, Chromosomal microarray analysis, microarray-based comparative genomic hybridization, array CGH, a-CGH,

aCGH, or virtual karyotype) is a technique to detect genomic copy number variations at a higher resolution level than chromosome-based comparative genomic hybridization (CGH).[1] Using this method, copy number changes at a level of 510 kilobases of DNA sequences can be detected. Today even high-resolution CGH (HR-CGH) arrays are accurate to detect structural variations (SV) at resolution of 200 bp [2]. This method allows one to identify new recurrent chromosome changes such as

microdeletions duplications

in disease conditions such as cancer and birth defects due to chromosome aberrations.

http://www.transcriptome.ens.fr/sgdb/protocols/hybridisation.php#tutorial

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