Scribd
Upload
75 views5 pages

PAtho Fracture

Predisposing factors for bone fractures include age, ethnicity, malnutrition, sensory problems, immobility, estrogen levels, smoking, alcohol, caffeine, medications, diseases, occupation, and gender. Precipitating factors are accidents, drug or alcohol influence, and violence. When a force exceeds bone resistance, a fracture occurs, forming dead tissue and bone fragments. This can lead to fat embolism, infection, malunion, nonunion, or delayed union depending on factors like adequate immobilization, space between fragments, nutrition status, and comorbidities. Mast cell degranulation releases inflammatory factors that cause symptoms like pain, swelling, fever, and purulent exudate as the bone heals.

Uploaded by

Bon Juvi
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
75 views5 pages

PAtho Fracture

Predisposing factors for bone fractures include age, ethnicity, malnutrition, sensory problems, immobility, estrogen levels, smoking, alcohol, caffeine, medications, diseases, occupation, and gender. Precipitating factors are accidents, drug or alcohol influence, and violence. When a force exceeds bone resistance, a fracture occurs, forming dead tissue and bone fragments. This can lead to fat embolism, infection, malunion, nonunion, or delayed union depending on factors like adequate immobilization, space between fragments, nutrition status, and comorbidities. Mast cell degranulation releases inflammatory factors that cause symptoms like pain, swelling, fever, and purulent exudate as the bone heals.

Uploaded by

Bon Juvi
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 5

Predisposing Factors

Precipitating Factors -accidents; -under influence in illegal drugs and alcohol; -violence

-Age, Asian and Caucasoid, Malnutrition -Sensory Neural Problems, Immobility and Sedentary lifestyle, Low estrogen Level/Postmenopausal women ,Smoking ,Excessive alcohol and caffeine intake, Medication, Rheumatoid Arthritis, Endocrine disorders, Gastrointestinal disorders, Malignant and benign tumors, Occupation, gender

Decrease tissue Integrity

Fracture
(Dead tissue and bone fragments ) Fat Embolus

Force that can exceeds the bone resistance

Mast Cells Degranulation

Infection

Malunion Impaired bone Healing

Mast Cells Activation

If Inadequate Immobilization

Distraction of bone Fragments

Nonunion

If Excessive space Between Fragments Comorbidity Poor nutrition

Delayed Union

Mast Cells Degranulation

Histamine
Rapid Constriction of Smooth Muscle Post capillary venules Dilation Retraction of endothelial lining Neutrophil Chemotactic Factor

Chemotatic Factors

Eosinophil chemotactic factor of anaphylaxis (ECF-A)

Muscle Spasm

blood flow

vascular permeability

Neutrophil Eosinophil

Hypovolemic Shock Fluid Exudates

Macrophage Chemotactic Factor

Phagocytosis of bacteria and debris ( Short term)

Histaminase

Macropages Hypothalamus Cytokines Phagocytosis of bacteria and debris for long term Purulent exudates and pus

Degrade histamine

Fever

Control of Infalammation

Mast Cells Activation

Synthesis of Inflammatory Mediators

Factor XIIa (Prekallikrein)

Leukotrines

Prostaglandins

Platelet activating Factor

Vasodilation

Smooth muscle contraction

Vascular permeability

Pain induction

Constrictive dressings and cast

Fluids and plasma proteins into compartment Fluid Exudates blood flow intracompartmental pressure

Pain/Compartment Syndrome

Increase lactic Acid

ischemia

RBCs and platelets emeshed in fibrin

Platelet activiating Factor

Adherence of nearby platelets Hematoma in bones

Platelet Activation

Activation of Osteoblast

Platelet binds with von willibrands factor and fibrinogen

Excess Callus are Reabsored and trabeculae are formed along the lines of stress by repair tissues

Callus Formation and esteoclasts destroy dead bone

Mineralization of collagen and calcium matrix

Simultaneous Activation of coagulations factors ,thrombin, and fibrin

You might also like