This document provides information on the generic and trade names, classification, mechanism of action, indications and dosages, adverse reactions, interactions, and nursing considerations for two antibiotics: penicillin G benzathine (Bicillin L-A) and amikacin sulfate (Amikin). Penicillin G benzathine is a penicillin antibiotic used to treat various bacterial infections like upper respiratory infections, syphilis, and yaws. It works by inhibiting bacterial cell wall synthesis. Amikacin is an aminoglycoside antibiotic used to treat infections caused by pseudomonas and other bacteria; it works by interfering with bacterial protein synthesis. Both drugs require monitoring for potential adverse effects and interactions with other medications.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online from Scribd
This document provides information on the generic and trade names, classification, mechanism of action, indications and dosages, adverse reactions, interactions, and nursing considerations for two antibiotics: penicillin G benzathine (Bicillin L-A) and amikacin sulfate (Amikin). Penicillin G benzathine is a penicillin antibiotic used to treat various bacterial infections like upper respiratory infections, syphilis, and yaws. It works by inhibiting bacterial cell wall synthesis. Amikacin is an aminoglycoside antibiotic used to treat infections caused by pseudomonas and other bacteria; it works by interfering with bacterial protein synthesis. Both drugs require monitoring for potential adverse effects and interactions with other medications.
This document provides information on the generic and trade names, classification, mechanism of action, indications and dosages, adverse reactions, interactions, and nursing considerations for two antibiotics: penicillin G benzathine (Bicillin L-A) and amikacin sulfate (Amikin). Penicillin G benzathine is a penicillin antibiotic used to treat various bacterial infections like upper respiratory infections, syphilis, and yaws. It works by inhibiting bacterial cell wall synthesis. Amikacin is an aminoglycoside antibiotic used to treat infections caused by pseudomonas and other bacteria; it works by interfering with bacterial protein synthesis. Both drugs require monitoring for potential adverse effects and interactions with other medications.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online from Scribd
This document provides information on the generic and trade names, classification, mechanism of action, indications and dosages, adverse reactions, interactions, and nursing considerations for two antibiotics: penicillin G benzathine (Bicillin L-A) and amikacin sulfate (Amikin). Penicillin G benzathine is a penicillin antibiotic used to treat various bacterial infections like upper respiratory infections, syphilis, and yaws. It works by inhibiting bacterial cell wall synthesis. Amikacin is an aminoglycoside antibiotic used to treat infections caused by pseudomonas and other bacteria; it works by interfering with bacterial protein synthesis. Both drugs require monitoring for potential adverse effects and interactions with other medications.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as DOC, PDF, TXT or read online from Scribd
Download as doc, pdf, or txt
You are on page 1/ 3
Generic Name
penicillin G benzathine
Trade Name Bicillin L-A
Classification Penicillin-Anti-infective
Mechanism of Action Inhibits biosynthesis of cell-wall mucopeptide; kills penicillin-susceptible bacteria during active multiplication stage
Indications and dosages
>Upper respiratory infections Adults: 1.2 million units I.M. as a single dose Children weighing 27 kg (60) or more: 900,000 units I.M. as a single dose Infants and children weighing less than 27 kg (60 lb): 300,000 to 600,000 units I.M. as a single dose >Early syphilis (primary, secondary, or latent) Adults: 2.4 million units I.M. as a single dose Children: 50,000 units/kg I.M. as a single dose, increased as needed up to adult dosage >Congenital syphilis Children younger than age 2: 50,000 units/kg I.M. as a single dose >Late (tertiary) syphilis and neurosyphilis Adults: 2.4 million units I.M. q week for up to 3 weeks, after aqueous penicillin G or procaine penicillin therapy >Gummas and cardiovascular syphilis Adults: 2.4 million units I.M. q week for 3 weeks >Yaws, bejel, and pinta Adults: 1.2 million units I.M. as a single dose >Prophylaxis of rheumatic fever and glomerulonephritis Adults: After acute attack, 1.2 million units I.M. q month or 600,000 units q 2 weeks
Nursing Considerations Watch closely for anaphylaxis and serum sickness. In long-term therapy, monitor electrolyte levels and CBC with white cell differential; watch for electrolyte imbalances and blood dyscrasias. Assess neurologic status, especially for seizures and decreasing level of consciousness. Watch for evidence of superinfection and pseudomembranous colitis.
Generic Name amikin sulfate
Trade Name Amikin
Classification Anti-infective- Aminoglycoside
Mechanism of Action Interferes with protein synthesis in bacterial cells by binding to 30S ribosomal subunit, leading to bacterial cell death
Indications and dosages
>Severe systemic infections caused by sensitive strains of Pseudomonas aeruginosa, Escherichia coli, or Proteus, Klebsiella, Serratia, Enterobacter, Actinobacter, Providencia, Citrobacter, or Staphylococcus species Adults, children, and older infants: 15 mg/kg/day I.V. or I.M. in two to three divided doses q 8 to 12 hours in 100 to 200 ml of dextrose 5% in water (D5W) over 30 to 60 minutes. Maximum dosage is 1.5 g/day. Neonates: Initially, 10 mg/kg I.M., then 7.5 mg/kg I.M. q 12 hours >Uncomplicated urinary tract infections caused by susceptible organisms
Interactions Acyclovir, amphotericin B, cephalosporin, cisplatin, diuretics, vancomycin: increased risk of ototoxicity and nephrotoxicity Depolarizing and nondepolarizing neuromuscular junction blockers, general anesthetics: increased amikacin effect, possibly leading to respiratory depression Dimenhydrinate: masking of ototoxicity signs and symptoms Indomethacin: increased trough and peak amikacin levels Parenteral penicillin: amikacin inactivation
Nursing Considerations Monitor kidney function test results and urine cultures, output, protein, and specific gravity. Monitor results of peak and trough drug blood levels. Evaluate for signs and symptoms of ototoxicity (hearing loss, tinnitus, ataxia, and vertigo). Assess for secondary superinfections, particularly upper respiratory tract infections.
Gentamicin _ a Drug Study Presented to the Faculty of the Nursing Department Mrs. Mylahrose Jovita N. Acaba, RN, MN _ in Partial Fulfillment of the Requirements in NCM 209-RLE INTEGRATED MANAGEMENT of CHILDHOON (1)
