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PDS Vs PXs

This document compares and contrasts pigment dispersion syndrome and pseudoexfoliation syndrome. Pigment dispersion syndrome typically affects younger men with myopia and is caused by constant rubbing of the iris against the zonules, releasing pigment. Pseudoexfoliation syndrome typically affects older women and is caused by an abnormal basement membrane secretion depositing in the trabecular meshwork. Clinically, pigment dispersion syndrome presents with a heavily pigmented angle and reverse pupil block glaucoma with a good prognosis. Pseudoexfoliation syndrome presents with iris transillumination defects, lens deposits, and a higher risk of glaucoma requiring more aggressive treatment.

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277 views1 page

PDS Vs PXs

This document compares and contrasts pigment dispersion syndrome and pseudoexfoliation syndrome. Pigment dispersion syndrome typically affects younger men with myopia and is caused by constant rubbing of the iris against the zonules, releasing pigment. Pseudoexfoliation syndrome typically affects older women and is caused by an abnormal basement membrane secretion depositing in the trabecular meshwork. Clinically, pigment dispersion syndrome presents with a heavily pigmented angle and reverse pupil block glaucoma with a good prognosis. Pseudoexfoliation syndrome presents with iris transillumination defects, lens deposits, and a higher risk of glaucoma requiring more aggressive treatment.

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longuserid
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© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
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www.eophtha.

com online resources of ophthalmology


Differentiating features between Pigment dispersion syndrome & Pseudoexfoliation syndrome Pigment dispersion syndrome 30-50 years (a decade younger) Men Related to myopia Pigmented race Bilateral disease: 90% Pathology Posterior bowing of iris Constant rubbing of posterior pigment iris and zonules Release of pigments Trabecular block Pseudoexfoliation syndrome 60-70 years Common in women, glaucoma more in men Related to aortic aneurysms (abnormal BM) Scandinavian countries Bilateral disease: 30% Systemic disease of abnormal basement membrane Secretion of amyloid-like material (oxytalon) in AC Deposit in zonules and trabeculum Trabecular block

Demography

Bilaterality

Clinical Features

Krukenbergs spindle Deep AC, with iris bowing posteriorly (reverse pupil block) . Iris atrophy in periphery of iris Pigment deposit on lens

Gonioscopy

Prognosis

Heavily pigmented over wide, open angle Queer iris configuration Glaucoma risk: 10% Good prognosis Medical treatment same as POAG Argon laser trabeculoplasty more effective. Pilocarpine and laser PI may work sometimes (reverse pupil block) Trabeculectomy same as POAG

Pseudoexfoliative material, dandruff-like appearance throughout AC Pupil difficult to dilate Iris atrophy at edge of pupil margin (Moth eaten transillumination defect) Deposit on lens is characteristic (target like appearance, called hoarfrost ring) Len subluxation (weak zonules) Sampaolesis line (pigmented line anterior to Schwalbes line) Pseudoexfoliative material Glaucoma risk: 1% per year (5% in 5 years, 15% in 15 years) Fair prognosis Medical treatment not very effective Argon laser trabeculoplasty more effective in the short term Trabeculectomy same as POAG Cataract surgery is particularly difficult Weakened zonules Small pupil Raised IOP (risk of suprachoroidal hemorrhage)

Treatment

www.eophtha.com online resources of ophthalmology

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