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    Anemia Patho

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    Kathleen Eviza
    This document discusses the pathophysiology of severe anemia due to lower gastrointestinal bleeding from a distal descending colon mass in a patient with diabetes mellitus type 2. It identifies predisposing factors like family history, age, gender, and previous neoplasms. Precipitating factors include diet high in fat and low in fiber, stress, lack of exercise, and increased waist-hip ratio. Insulin resistance leads to hyperglycemia and cellular starvation, activating neoplastic cells and abnormal proliferation in the colon forming a mass. Obstruction and stasis of fecal matter leads to perforation and bleeding in the lower gastrointestinal tract, resulting in anemia.

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    Anemia Patho

    Uploaded by

    Kathleen Eviza
    144 views1 page
    This document discusses the pathophysiology of severe anemia due to lower gastrointestinal bleeding from a distal descending colon mass in a patient with diabetes mellitus type 2. It identifies predisposing factors like family history, age, gender, and previous neoplasms. Precipitating factors include diet high in fat and low in fiber, stress, lack of exercise, and increased waist-hip ratio. Insulin resistance leads to hyperglycemia and cellular starvation, activating neoplastic cells and abnormal proliferation in the colon forming a mass. Obstruction and stasis of fecal matter leads to perforation and bleeding in the lower gastrointestinal tract, resulting in anemia.

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    This document discusses the pathophysiology of severe anemia due to lower gastrointestinal bleeding from a distal descending colon mass in a patient with diabetes mellitus type 2. It identifies predisposing factors like family history, age, gender, and previous neoplasms. Precipitating factors include diet high in fat and low in fiber, stress, lack of exercise, and increased waist-hip ratio. Insulin resistance leads to hyperglycemia and cellular starvation, activating neoplastic cells and abnormal proliferation in the colon forming a mass. Obstruction and stasis of fecal matter leads to perforation and bleeding in the lower gastrointestinal tract, resulting in anemia.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    144 views1 page

    Anemia Patho

    Uploaded by

    Kathleen Eviza
    This document discusses the pathophysiology of severe anemia due to lower gastrointestinal bleeding from a distal descending colon mass in a patient with diabetes mellitus type 2. It identifies predisposing factors like family history, age, gender, and previous neoplasms. Precipitating factors include diet high in fat and low in fiber, stress, lack of exercise, and increased waist-hip ratio. Insulin resistance leads to hyperglycemia and cellular starvation, activating neoplastic cells and abnormal proliferation in the colon forming a mass. Obstruction and stasis of fecal matter leads to perforation and bleeding in the lower gastrointestinal tract, resulting in anemia.

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    Download as DOC, PDF, TXT or read online from Scribd
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    of 1

    XI.

    PATHOPHYSIOLOGY (SEVERE ANEMIA r/t Lower GI Bleeding t/c Distal Descending Mass, with comorbid DIABETES MELLITUS Type II)
    PREDISPOSING FACTORS PRECIPITATING FACTORS
     Familial History  Diet (↑Fat, ↓ Soluble Fiber)
     Age  Stress
     Gender  Lack of exercise
     Previous neoplasm (BPH)  Increased waist-hip ratio

    Activation of neoplastic cells and abnormal


    Insulin resistance cellular proliferation in the colon

    HYPERGLYCEMIA CELLULAR STARVATION FORMATION OF COLON MASS

    Fecal pathway obstruction


    gluconeogenesis
    ↑plasma osmolality ↓renal glucose threshold
    Stasis of fecal matter

    Minute sclerosis Ocular Osmotic Fat breakdown CHON


    Glycosuria Perforation of intestinal lumen and
    of glomerulus microangiopathy diuresis into fatty acids breakdown
    vascular erosion of the colon
    into amino
    acids
    Dominance of POLYURIA Formation of LOWER GASTROINTESTINAL BLEEDING
    ↑permeability superficial blood ketone bodies
    of the vessels and ↑creatine PO4 Acute isovolemic reduction
    glomerular ocular ↑ loss of metabolism
    basement microaneurysms fluids and ions ↑urine acidity ↓Hct, ↓Hgb, ↓RBC
    membrane ↑serum
    Leakage of blood creatinine
    and fats Dry skin and ↓decreased 02-carrying capacity
    mucous
    membranes
    Icteric to reddish ↑serum ↑BUN ↓tissue perfusion
    discoloration of NH3
    sclera Hypothalamic Involvement
     ↑stimulation of hunger Cellular fatigue Cold Peripheral
    and thirst center skin pallor ↓renal blood flow
     ↓response of satiety
    center Muscle weakness ↓GFR

    POLYDIPSIA POLYPHAGIA Urine concentration

    albuminuria ↑concentration mucus threads and turbidity of urine

    Page 38

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