BLOOD DYSCRASIA A
BLOOD DYSCRASIA A
c
2 Diseases of the blood-forming organs. In most cases, this involves diseases of
the bone marrow, but it might also involve the spleen and/or the liver.
2 The term "dyscrasia" originated in earlier medical "science" and referred to the
"four humors." It has come to mean simply "disease" or "pathological condition".
2 Thus, blood dyscrasia is a pathological condition of the blood, usually involving
disorders of the cellular elements of the blood.
SYMPTOMS:
0 Symptoms associated with the following common blood dyscrasias (for in-depth
discussions of specific diseases, see the title headings):
1. Diseases of platelets:
- ITP (Idiopathic Thrombocytopenic Purpura) -- sudden onset of
small and large bleeding points in the skin; often following a virus
infection, or aspirin use.
- Sometimes, there are r or bleeding gums.
- TTP (Thrombotic Thrombocytopenic Purpura) -- anemia, fever, and
bleeding as in ITP
2. Diseases of clotting factors:
- ÷
-- significant bleeding during circumcision, bleeding
into the joints and muscles, easy bruising, significant bleeding
during surgery
-
-- frequently, a history of familial
bleeding tendency; bleeding gums,r , easy bruising
3. Diseases of red blood cells:
- Sickle cell anemia -- early symptoms are severe, recurrent
episodes of abdominal pain; bleeding into the joints; and
enlargement of the spleen.
4. Diseases of white blood cells:
0
-- early signs and symptoms are anemia, bleeding
tendency, bone pain, and serious infection.
p SES:
There are four types of blood disease. Coagulopathies are disorders which concern
bleeding and clotting, such as hemophilia. Anemias concern the lack of hemoglobin, a
substance in red blood cells which is vitally necessary for oxygen transport. Hematological
malignancies like leukemia are cancers which affect the blood andbone marrow, while
hemoglobinopathies are blood diseases which have to do with the structure of red blood cells.
Sickle cell anemiais a classic example of a hemoglobinopathy.
pOMPLIp TIONS:
0 ITP: complications include bleeding into a critical body part such as a major
organ.
0 TTP: complications are generally the same as ITP.
0 ÷
: complications include bleeding into various joints, bleeding into the
brain, and hemorrhage into the intestinal tract.
0
: complications are recurring r and
heavy menstrual periods. More serious cases of this disease may have more
serious bleeding, such as bleeding into a joint.
0 Sickle cell anemia: complications includeY , painful crises (blood clots inside
various blood vessels), aplastic crises (the bone marrow stops forming new blood
elements), and stroke (cerebrovascular accident).
0
: complications include bleeding into a critical body part, such as a
major organ; serious infections; and DIC. (See DIC, i.e., disseminated
intravascular coagulation).