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2010 Abstract Milstein

The document describes new catalytic reactions developed by David Milstein for green synthesis and sustainable energy. These reactions are catalyzed by pincer-type ruthenium complexes and involve aromatization-dearomatization of the ligand. The reactions allow for (a) coupling of alcohols to form esters and H2, (b) hydrogenation of esters to alcohols under mild conditions, (c) coupling of amines with alcohols to form amides with H2 liberation, (d) synthesis of primary amines from alcohols and ammonia, and (e) direct formation of acetals by coupling of alcohols, and proceed under neutral conditions without waste

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Saravanan Kumar P
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43 views1 page

2010 Abstract Milstein

The document describes new catalytic reactions developed by David Milstein for green synthesis and sustainable energy. These reactions are catalyzed by pincer-type ruthenium complexes and involve aromatization-dearomatization of the ligand. The reactions allow for (a) coupling of alcohols to form esters and H2, (b) hydrogenation of esters to alcohols under mild conditions, (c) coupling of amines with alcohols to form amides with H2 liberation, (d) synthesis of primary amines from alcohols and ammonia, and (e) direct formation of acetals by coupling of alcohols, and proceed under neutral conditions without waste

Uploaded by

Saravanan Kumar P
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as PDF, TXT or read online on Scribd
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Design of New Catalytic Reactions for Green Synthesis and

Sustainable Energy
David Milstein
Department of Organic Chemistry, The Weizmann Institute of Science
Rehovot 76100, Israel
E-mail: [email protected]

We have developed a new mode of metal-ligand cooperation, based on


aromatization-dearomatization

of

pincer-type

ligands,

and

have

designed

environmentally benign catalytic reactions based on such cooperation, including (a)


dehydrogenative coupling of alcohols to form esters and H2 (b) hydrogenation of
esters to alcohols under mild conditions (c) coupling of amines with alcohols to form
amides with liberation of H2 (d) selective synthesis of primary amines directly from
alcohols and ammonia (e) direct formation of acetals by dehydrogenative coupling of
alcohols. These reactions are efficient, proceed under neutral conditions and produce
no waste. They are catalyzed by pincer-type ruthenium complexes based on pyridine
and on acridine, and involve as a key mechanistic step aromatizationdearomatization of the hetero-aromatic ligand core. Metal-ligand cooperation of this
type has very recently led also to a distinct approach towards water splitting, based
on consecutive thermal H2 generation and light-induced O2 liberation.

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