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    Tabular Data of Studies Enrolled in Meta-Analysis and Synthesis Study (Ttileauthors and Year of Publication)

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    Luwila Batoctoy-Estose
    This document provides a tabular summary of key features of studies included in a meta-analysis on hair growth and stress. It summarizes a 2013 study that investigated the impact of stress on hair biology in mice using a sonic stress model. The study found that stress triggers inhibitory changes in mast cell and macrophage activity and inhibits hair growth. It also found that topical minoxidil, a treatment already used for hair growth, effectively counters stress-induced hair growth inhibition in mice. This suggests minoxidil's potential use for managing stress-related hair loss in humans.

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    Tabular Data of Studies Enrolled in Meta-Analysis and Synthesis Study (Ttileauthors and Year of Publication)

    Uploaded by

    Luwila Batoctoy-Estose
    31 views3 pages
    This document provides a tabular summary of key features of studies included in a meta-analysis on hair growth and stress. It summarizes a 2013 study that investigated the impact of stress on hair biology in mice using a sonic stress model. The study found that stress triggers inhibitory changes in mast cell and macrophage activity and inhibits hair growth. It also found that topical minoxidil, a treatment already used for hair growth, effectively counters stress-induced hair growth inhibition in mice. This suggests minoxidil's potential use for managing stress-related hair loss in humans.

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    This document provides a tabular summary of key features of studies included in a meta-analysis on hair growth and stress. It summarizes a 2013 study that investigated the impact of stress on hair biology in mice using a sonic stress model. The study found that stress triggers inhibitory changes in mast cell and macrophage activity and inhibits hair growth. It also found that topical minoxidil, a treatment already used for hair growth, effectively counters stress-induced hair growth inhibition in mice. This suggests minoxidil's potential use for managing stress-related hair loss in humans.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    31 views3 pages

    Tabular Data of Studies Enrolled in Meta-Analysis and Synthesis Study (Ttileauthors and Year of Publication)

    Uploaded by

    Luwila Batoctoy-Estose
    This document provides a tabular summary of key features of studies included in a meta-analysis on hair growth and stress. It summarizes a 2013 study that investigated the impact of stress on hair biology in mice using a sonic stress model. The study found that stress triggers inhibitory changes in mast cell and macrophage activity and inhibits hair growth. It also found that topical minoxidil, a treatment already used for hair growth, effectively counters stress-induced hair growth inhibition in mice. This suggests minoxidil's potential use for managing stress-related hair loss in humans.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 3

    TABULAR DATA OF STUDIES ENROLLED IN META-ANALYSIS AND SYNTHESIS

    FEATURES

    1. Description of the Study and Key


    Variables

    STUDY
    (TtileAuthors and Year of Publication)
    Topical Minoxidil counter-acts stress induced hair growth inhibition in mice
    (Munksgaard et.al, 2013)
    The study indicated stress as the suspected possible cause of hair loss in
    various species. It indicated the excistence of a brain hair follicle axis
    (BHA) and further dissect the association between stress and hair growth in
    well-established stress response models. This study aimed at dissecting the
    impact of stress on well-defined parameters on skin and hair biology by
    employing a well-established murine stress model and exposure to sonic
    stress.

    2. Research Design and Time Frame

    a. Randomnized control study

    3. Respondents (sample, inclusion


    and exclusion criteria)

    Female mice were depilated and randomized in to two goups: control and
    sonic stress. These groups were further divided and either treated daily with
    5% minoxidil solution or vehicle alone, and was exposed to sonic stress for
    24 h starting 14 days after anagen induction by depilation.

    4. Operationalization of the Theory or


    Concept

    Prolonging the anagen phase of hair cycle prevent the premature onset of
    catagen, which then form the basis of stress-induced telogen effluvioum.
    Minoxidil is known to prolong anagen.
    The study specifically used this procedures:
    1. Anagen induction
    2. Application of stress

    5. Experimental Procedure

    3.
    4.
    5.
    6.
    7.
    8.
    9.
    6. Primary Literature and Studies of
    reference

    7. Cultural or Ethnic range

    8. Publication type

    None

    Tissue preparation
    Pharmaceutical intervention
    Assessment of hair cycle score
    Immunohistochemistry
    Giemsa staining
    TUNEL staining
    Quantitative histomorphometry and statistical anallysis

    9. Summary of results

    The study demonstrates that stress indeed triggers hair growth inhibitory
    changes in mast cell/ macrophage activities. The topical MXL effectively
    counteracts stress induced hair growth inhibition in mice strongly
    encourages one to explore whether this, clinicaly alsredy widely used, hair
    growth stimulator can be exploited as safe and effective tool for
    management of stress associated telogen effluvium in men.

    10. Conclusion and Recommendation

    Minoxidil 2% solution had better stimulatory effect on hair growth compaired


    to Tacrolimus 0.1% ointment in treatment of mild to moderate patchy
    alopecia areata. The combination treatment may yield a better clinical
    response than either of the agents used singly.

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