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    PUBMED-Endogenous and Exogenous Cardiac Glycosides

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    migueldelaquila5540
    Glucosydes Exogenous.

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    PUBMED-Endogenous and Exogenous Cardiac Glycosides

    Uploaded by

    migueldelaquila5540
    19 views2 pages
    Glucosydes Exogenous.

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    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    Glucosydes Exogenous.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    19 views2 pages

    PUBMED-Endogenous and Exogenous Cardiac Glycosides

    Uploaded by

    migueldelaquila5540
    Glucosydes Exogenous.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 2

    29/04/2015

    Endogenousandexogenouscardiacglycosides:theirrolesinhypertension,saltmetabolism,andcellgrowth.PubMedNCBI

    PubMed

    Abstract

    Fulltextlinks

    AmJPhysiolCellPhysiol.2007Aug293(2):C50936.Epub2007May9.

    Endogenousandexogenouscardiacglycosides:theirrolesin
    hypertension,saltmetabolism,andcellgrowth.
    SchonerW1,ScheinerBobisG.

    Authorinformation
    1

    InstitutfrBiochemieundEndokrinologie,FachbereichVeterinrmedizin,JustusLiebig
    UniversittGiessen,FrankfurterStr100,Giessen,[email protected]
    giessen.de

    Abstract
    Cardiotonicsteroids(CTS),longusedtotreatheartfailure,areendogenouslyproducedin
    mammals.Amongthemarethehydrophiliccardenolideouabainandthemorehydrophobic
    cardenolidedigoxin,aswellasthebufadienolidesmarinobufageninandtelecinobufagin.The
    physiologicaleffectsofendogenousouabainonbloodpressureandcardiacactivityare
    consistentwiththe"Na(+)lag"hypothesis.Thishypothesisassumesthat,incardiacandarterial
    myocytes,aCTSinducedlocalincreaseofNa(+)concentrationduetoinhibitionofNa(+)/K(+)
    ATPaseleadstoanincreaseofintracellularCa(2+)concentration([Ca(2+)](i))viaabackward
    runningNa(+)/Ca(2+)exchanger.Theincreasein[Ca(2+)](i)thenactivatesmusclecontraction.
    TheNa(+)laghypothesismaybestexplainshorttermandinotropicactionsofCTS.Yetalldata
    ontheCTSinducedalterationofgeneexpressionareconsistentwithanotherhypothesis,based
    ontheNa(+)/K(+)ATPase"signalosome,"thatdescribestheinteractionofcardiacglycosides
    withtheNa(+)pumpasmachineryactivatingvarioussignalingpathwaysviaintramembraneand
    cytosolicproteinproteininteractions.Thesepathways,whichmaybeactivatedsimultaneouslyor
    selectively,elevate[Ca(2+)](i),activateSrcandtheERK1/2kinasepathways,andactivate
    phosphoinositide3kinaseandproteinkinaseB(Akt),NFkappaB,andreactiveoxygenspecies.
    Arecentdevelopmentindicatesthatnewpharmaceuticalswithantihypertensiveandanticancer
    activitiesmaybefoundamongCTSandtheirderivatives:theantihypertensiverostafuroxin
    suppressesNa(+)resorptionandtheSrcepidermalgrowthfactorreceptorERKpathwayin
    kidneytubulecells.Itmaybetheparentcompoundofanewprincipleofantihypertensive
    therapy.BufalinandoleandrinorthecardenolideanalogUNBS1450blocktumorcell
    proliferationandinduceapoptosisatlowconcentrationsintumorswithconstitutiveactivationof
    NFkappaB.
    PMID:17494630[PubMedindexedforMEDLINE]

    Freefulltext

    PublicationTypes,MeSHTerms,Substances
    http://www.ncbi.nlm.nih.gov/pubmed/17494630

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    Endogenousandexogenouscardiacglycosides:theirrolesinhypertension,saltmetabolism,andcellgrowth.PubMedNCBI

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