Scribd
Upload
110 views2 pages

TUTORIAL Physical Pharmacy

The document discusses developing a microemulsion oral drug formulation of clindamycin hydrochloride that maintains therapeutic drug levels for 6-8 hours. Microemulsions can increase drug stability and effectiveness as oral medication by enhancing absorption and maintaining therapeutic levels over an extended time period. Stability tests necessary for developing an oral microemulsion dosage form include identifying the phase behavior of the microemulsion and testing how formulation factors like homogenization and preparation methods impact stability and drug release profile.

Uploaded by

kaveesh_93
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
110 views2 pages

TUTORIAL Physical Pharmacy

The document discusses developing a microemulsion oral drug formulation of clindamycin hydrochloride that maintains therapeutic drug levels for 6-8 hours. Microemulsions can increase drug stability and effectiveness as oral medication by enhancing absorption and maintaining therapeutic levels over an extended time period. Stability tests necessary for developing an oral microemulsion dosage form include identifying the phase behavior of the microemulsion and testing how formulation factors like homogenization and preparation methods impact stability and drug release profile.

Uploaded by

kaveesh_93
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
You are on page 1/ 2

1. What are the characteristics of microemulsions?

2. Why do we need to use homogenizers in the preparation of emulsion?

3. How can you identify the phase behaviour of microemulsion?

4. Different the methods of preparation of pharmaceutical emulsion.

5. How can microemulsion enhances to make a stable IV preparation?

6. Prophylactic antibiotic treatment is used to minimise the risk of

endocarditis in patients with hypertrophic cardiomyopathy. Your team


have been asked to formulate a new microemulsion oral drug
formulation for clindamycin hydrochloride that can maintain
therapeutic drug levels form 6-8 hours. You have been ask by the
company to have justification of your decision for formulating it into
microemulsion with other formulation scientists in your organisation.
i. How can microemulsion increase the stability and effectiveness of
the formulated drug as oral medication? Explain your answer

ii. What are the stability test necessary for the development of oral
microemulsion dosage form?

You might also like