The document discusses drugs used to treat thyroid diseases like hypothyroidism and hyperthyroidism. Levothyroxine, a sodium salt of T4, is commonly used to treat hypothyroidism and replace thyroid function. Antithyroid drugs like propylthiouracil and methimazole are used to treat hyperthyroidism by inhibiting thyroid hormone synthesis. Radioactive iodine can also be used to treat hyperthyroidism.
The document discusses drugs used to treat thyroid diseases like hypothyroidism and hyperthyroidism. Levothyroxine, a sodium salt of T4, is commonly used to treat hypothyroidism and replace thyroid function. Antithyroid drugs like propylthiouracil and methimazole are used to treat hyperthyroidism by inhibiting thyroid hormone synthesis. Radioactive iodine can also be used to treat hyperthyroidism.
The document discusses drugs used to treat thyroid diseases like hypothyroidism and hyperthyroidism. Levothyroxine, a sodium salt of T4, is commonly used to treat hypothyroidism and replace thyroid function. Antithyroid drugs like propylthiouracil and methimazole are used to treat hyperthyroidism by inhibiting thyroid hormone synthesis. Radioactive iodine can also be used to treat hyperthyroidism.
The document discusses drugs used to treat thyroid diseases like hypothyroidism and hyperthyroidism. Levothyroxine, a sodium salt of T4, is commonly used to treat hypothyroidism and replace thyroid function. Antithyroid drugs like propylthiouracil and methimazole are used to treat hyperthyroidism by inhibiting thyroid hormone synthesis. Radioactive iodine can also be used to treat hyperthyroidism.
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THYROID & ANTITHYROID
Akhmad Edy Purwoko
Bagian Farmakologi & Toksikologi FK - UMY
Drug used in thyroid disease
Hipothyroidism
Thyroxin T4
Triidothyronin T3
Hiperthyroidism
Thioamide Iodide Ipodate 131i
I-
I-
Io
MIT-DIT-T3-T4 Iodides
Proteolisis
Iodides, Thioamides
Peripheral Tissues T 4 T3 T3
T4 T3 Blood Ipodate, Beta-blokers
Thyroid Replacemen Therapy
Levothyroxin (a sodium salt of T4) is the most commonly used drug for thyroid replacement therapy drug of choice for treatmen of hypothyroidism Liothryronin (a salt of T3)and litotrix (a mixture of T3 and T4) have also been used to treat hypothyroidsm
Antithyroid drugs Propylthiourasil, Methimazole inhibit thyroid synthesis (inhibit iodinationof tyrosin group and coupling these group to form thyroid hormon. Prohylthiourasil also inhibits the peripheral conversion of T4 to T3)
