Scribd
Upload
43 views1 page

Abstract Arse P 2008

This document proposes an automatic method for detecting changes between diffusion-weighted MRI scans to monitor the evolution of multiple sclerosis lesions over time. It applies a generalized likelihood ratio test that accounts for non-stationary noise in the images. Validation involved simulating lesion appearances in real data, finding the method significantly reduces false detections by considering noise non-stationarity. The goal is to provide an objective way to characterize MS lesion evolution, especially in normal-appearing white matter, and study disease effects on brain connectivity.

Uploaded by

Toon Man
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
43 views1 page

Abstract Arse P 2008

This document proposes an automatic method for detecting changes between diffusion-weighted MRI scans to monitor the evolution of multiple sclerosis lesions over time. It applies a generalized likelihood ratio test that accounts for non-stationary noise in the images. Validation involved simulating lesion appearances in real data, finding the method significantly reduces false detections by considering noise non-stationarity. The goal is to provide an objective way to characterize MS lesion evolution, especially in normal-appearing white matter, and study disease effects on brain connectivity.

Uploaded by

Toon Man
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 1

ANAUTOMATICCHANGEDETECTIONMETHOD

INDIFFUSIONWEIGHTEDIMAGES:
APPLICATIONTOMULTIPLESCLEROSIS.
BOISGONTIERHerva,b,NOBLETVincenta,HEITZFabricea,
RUMBACHLucienb,c,CATTINFranoisedandARMSPACHJeanPaulb

LaboratoiredesSciencesdel'Image,del'InformatiqueetdelaTldtection,LSIIT,
UMRCNRSULP7005,BdSbastienBrant,BP10413,F67412IllkirchCedex,France.
b
Laboratoired'ImageriedeNeurosciencesCognitives,LINCIPB,Facultdemdecine,
UMRCNRSULP7191,4RueKirschleger,F67085StrasbourgCedex,France
c
ServicedeNeurologie,dServicedeRadiologie,CHUMinjoz,F25030BesanonCedex,France
[email protected]
a

Abstract
Magnetic Resonance Imaging (MRI) plays an important role in Multiple Sclerosis (MS) diagnosis and for
monitoringtheevolutionofthediseaseovertime[1].TheadventofnewquantitativeMRItechniquesandthe
constantimprovementinspatialresolutionyieldanincreasingamountof3Dimagedata,whoseinterpretationisa
tediousanderrorpronetask.TheautomaticanalysisofsubtlechangesbetweenMRIscansisanimportanttoolfor
assessing disease evolution over time. Methods have already been proposed to detect changes in serial
conventionalMRI[2].However,fewworksaddresschangedetectionindiffusionweightedimaging,whichisa
promisingtechniqueformonitoringneurodegenerativediseases.Weproposeanautomaticmethodforchange
detectionbetweenscalarimagesdiffusionweighted,withapplicationtothefollowupofmultiplesclerosislesion
evolution.Themethodreliesonthegeneralizedlikelihoodratiotest[3],whileaccountingforthenonstationarity
ofnoisethatcorruptstheseimages.Validationhasbeenconductedbysimulatinglesionappearancesinrealdata.
Theresultsshowthataccountingforthenonstationarityofnoiseallowstosignificantlyreducethenumberoffalse
detections.Furtherworkwillalsoconsiderchangedetectiondirectlyontensorimages. Suchautomaticmethods
forchangedetectionindiffusionweightedimagingmayprovideanobjectivewayforcharacterizingtheevolution
ofMSlesions,inparticularforthoselocatedinthenormalappearingwhitematter,andausefultoolforstudying
MSconsequencesonanatomicalandfunctionalbrainconnectivity.

References
[1]Y.Ge,Multiplesclerosis:TheroleofMRimaging,AmericanJournalofNeuroradiology,vol.27,no.6,pp.
11651176,JuneJuly2006.
[2]M.Bosc,F.Heitz,J.P.Armspach,I.Namer,D.Gounot,andL.Rumbach.Automaticchangedetectionin
multimodalserialMRI:applicationtomultiplesclerosislesionevolution.NeuroImage,20(2):643656,July2003.
[3]S.M.Kay,Fundamentalsofstatisticalsignalprocessing:detectiontheory,PrenticeHall,Inc.,UpperSaddle
River,NJ,USA,1998.

You might also like