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When Should HCV Be Treated First?

Treating HCV first is recommended for those with a CD4 count above 500 cells/mm3 to avoid potential drug interactions and increased side effects from dual treatment. Clearing HCV may also reduce future HIV drug side effects. While less effective, HCV treatment is possible for those on stable ARV with CD4 counts under 200 cells/mm3. It is best not to treat HIV and HCV simultaneously due to the risk of worsening side effects.

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Sameer Aum
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39 views1 page

When Should HCV Be Treated First?

Treating HCV first is recommended for those with a CD4 count above 500 cells/mm3 to avoid potential drug interactions and increased side effects from dual treatment. Clearing HCV may also reduce future HIV drug side effects. While less effective, HCV treatment is possible for those on stable ARV with CD4 counts under 200 cells/mm3. It is best not to treat HIV and HCV simultaneously due to the risk of worsening side effects.

Uploaded by

Sameer Aum
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Download as DOCX, PDF, TXT or read online on Scribd
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When should HCV be treated first?

In someone whose CD4 count is already strong (above 500 cells/mm 3)


there is no need to use HIV treatment before HCV treatment.
The advantage to treating HCV first if you have a strong immune
system is that you can do this without worrying about drug
interactions or increased risk of side effects from two sets of
treatment.
If you clear HCV, it may also reduce the risk of side effects from HIV
drugs when you use them in the future.
If HCV treatment is necessary, it is possible to treat people on a
stable ARV regimen even if their CD4 count is less than 200
cells/mm3. Studies using an older form on interferon suggested that
HCV treatment is less effective for people with low CD4 counts, but
in more recent studies of pegylated interferon plus ribavirin, CD4
cell count does not seem to be a factor in the success of treatment,
although the overall number of people with less than 200 cells/mm 3
was small.
It is better not to start treatment for both HIV and HCV at the same
time, because side effects can make each other worse.

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